LOCUS       NM_025877               3376 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier;
            phosphate carrier), member 23 (Slc25a23), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_025877
VERSION     NM_025877.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3376)
  AUTHORS   Juaristi,I., Llorente-Folch,I., Satrustegui,J. and Del Arco,A.
  TITLE     Extracellular ATP and glutamate drive pyruvate production and
            energy demand to regulate mitochondrial respiration in astrocytes
  JOURNAL   Glia 67 (4), 759-774 (2019)
   PUBMED   30623988
REFERENCE   2  (bases 1 to 3376)
  AUTHORS   Rueda,C.B., Traba,J., Amigo,I., Llorente-Folch,I.,
            Gonzalez-Sanchez,P., Pardo,B., Esteban,J.A., del Arco,A. and
            Satrustegui,J.
  TITLE     Mitochondrial ATP-Mg/Pi carrier SCaMC-3/Slc25a23 counteracts
            PARP-1-dependent fall in mitochondrial ATP caused by excitotoxic
            insults in neurons
  JOURNAL   J Neurosci 35 (8), 3566-3581 (2015)
   PUBMED   25716855
  REMARK    GeneRIF: SCaMC-3 KO neurons have higher vulnerability to in vitro
            excitotoxicity, and SCaMC-3 KO mice are more susceptible to
            kainate-induced seizures.
REFERENCE   3  (bases 1 to 3376)
  AUTHORS   Street,V.A., Kujawa,S.G., Manichaikul,A., Broman,K.W.,
            Kallman,J.C., Shilling,D.J., Iwata,A.J., Robinson,L.C.,
            Robbins,C.A., Li,J., Liberman,M.C. and Tempel,B.L.
  TITLE     Resistance to noise-induced hearing loss in 129S6 and MOLF mice:
            identification of independent, overlapping, and interacting
            chromosomal regions
  JOURNAL   J Assoc Res Otolaryngol 15 (5), 721-738 (2014)
   PUBMED   24952082
REFERENCE   4  (bases 1 to 3376)
  AUTHORS   Amigo,I., Traba,J., Gonzalez-Barroso,M.M., Rueda,C.B.,
            Fernandez,M., Rial,E., Sanchez,A., Satrustegui,J. and Del Arco,A.
  TITLE     Glucagon regulation of oxidative phosphorylation requires an
            increase in matrix adenine nucleotide content through Ca2+
            activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
  JOURNAL   J Biol Chem 288 (11), 7791-7802 (2013)
   PUBMED   23344948
  REMARK    GeneRIF: Glucagon regulation of oxidative phosphorylation requires
            an increase in matrix adenine nucleotide content through Ca2+
            activation of the mitochondrial ATP-Mg/Pi carrier SCaMC-3
REFERENCE   5  (bases 1 to 3376)
  AUTHORS   del Arco,A. and Satrustegui,J.
  TITLE     Identification of a novel human subfamily of mitochondrial carriers
            with calcium-binding domains
  JOURNAL   J Biol Chem 279 (23), 24701-24713 (2004)
   PUBMED   15054102
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CX566083.1, BC072660.1 and BC017139.1.
            
            On Dec 10, 2009 this sequence version replaced NM_025877.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC072660.1, SRR1660817.172504.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-133               CX566083.1         1-133
            134-3360            BC072660.1         130-3356
            3361-3376           BC017139.1         744-759
FEATURES             Location/Qualifiers
     source          1..3376
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.64 cM"
     gene            1..3376
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /note="solute carrier family 25 (mitochondrial carrier;
                     phosphate carrier), member 23"
                     /db_xref="GeneID:66972"
                     /db_xref="MGI:MGI:1914222"
     exon            1..343
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             191..1594
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     calcium-binding mitochondrial carrier protein SCaMC-3;
                     solute carrier family 25 member 23; small calcium-binding
                     mitochondrial carrier protein 3; short calcium-binding
                     mitochondrial carrier protein 3; mitochondrial adenyl
                     nucleotide antiporter SLC25A23"
                     /codon_start=1
                     /product="mitochondrial adenyl nucleotide antiporter
                     SLC25A23 isoform 1"
                     /protein_id="NP_080153.2"
                     /db_xref="CCDS:CCDS28923.1"
                     /db_xref="GeneID:66972"
                     /db_xref="MGI:MGI:1914222"
                     /translation="MRGGSSDAERRQRWGRLFEELDSNKDGRVDVHELRQGLARLGRG
                     DPDRAQQGVSSDWDADPDGGLSLEEFTRYLQEREQRLLLMFHSLDRNQDGHIDVSEIQ
                     QSFRALGISISLEQAEKILHSMDRDGTMTIDWQEWRDHFLLHSLENVEDVLYFWKHST
                     VLDIGECLTVPDEFSQEEKLTGMWWKQLVAGAVAGAVSRTGTAPLDRLKVFMQVHASK
                     SNRLNILGGLRNMIQEGGVLSLWRGNGINVLKIAPESAIKFMAYEQIKRAIRGQQETL
                     HVQERFVAGSLAGATAQTIIYPMEVLKTRLTLRRTGQYKGLLDCAKRILEREGPRAFY
                     RGYLPNVLGIIPYAGIDLAVYETLKNRWLQQYSHESANPGILVLLGCGTISSTCGQIA
                     SYPLALVRTRMQAQASIEGGPQVSMVGLLRHILSQEGVWGLYRGIAPNFMKVIPAVSI
                     SYVVYENMKQALGVTSR"
     exon            344..470
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            471..558
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..670
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            671..829
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            830..982
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1090
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1258
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1259..1409
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     exon            1410..3362
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3342..3347
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /note="hexamer: AATAAA"
     polyA_site      3347
                     /gene="Slc25a23"
                     /gene_synonym="2310067G05Rik; SCaMC-3"
                     /note="major polyA site"
ORIGIN      
        1 ctggcgcggg cggggacgac tagcatttat cacttccagc aagtgccgga gctcggcccc
       61 gcactgaaga ggctgcggtg cgggtgggcg cgggagctgg ctttgtgggg accccggggg
      121 ggagggggag ccagaaagcc cccgccgagg ccgtcgctgc ggggcctccc ctcccccctg
      181 ggcgggcgcc atgcgggggg gctcaagcga cgcggagcgg cggcagcgct ggggtcgcct
      241 gttcgaggaa ctagacagca acaaggacgg ccgcgtggac gtgcacgagt tgcgccaggg
      301 gctggccagg ctgggaaggg gagatccgga ccgtgcacag cagggtgtct cctctgactg
      361 ggatgctgat cctgatggtg gcctcagcct ggaggagttt actcgctacc tgcaggaacg
      421 ggagcagcgc cttctgctca tgtttcacag ccttgaccgg aaccaagatg gtcacataga
      481 tgtctctgag attcaacaga gcttccgagc actaggtatc tccatctcac tggagcaagc
      541 agagaaaatc ctacacagca tggaccgcga tggcaccatg accattgatt ggcaggaatg
      601 gcgagaccac tttctgttgc actctctgga gaacgtggag gatgtcctgt atttctggaa
      661 gcattctaca gtcctggaca tcggtgaatg cctgacggtg cctgatgagt tctcccagga
      721 agagaaactt acaggaatgt ggtggaaaca gctggtggct ggtgcagtgg ctggcgctgt
      781 gtcacggaca ggcacagctc ctctggaccg actcaaggta ttcatgcagg tccacgcctc
      841 aaagtccaac cggcttaaca ttctaggggg cctgagaaac atgattcaag aagggggtgt
      901 cttgtccctc tggcggggca acggcatcaa cgtgctcaag atagcccccg agtctgccat
      961 caaattcatg gcttatgaac agatcaagcg ggccatccgg gggcaacagg agacactgca
     1021 cgttcaggag cgcttcgtgg ctggttccct ggccggggcc acagctcaaa ccatcatata
     1081 ccccatggag gtactaaaga ctcggctgac tctacgcaga actggccaat acaaggggct
     1141 cctggattgt gcaaagcgga tcttagaacg tgaagggccc cgcgccttct accgtggcta
     1201 cctgcctaat gtgctgggca tcatccccta tgcaggaatc gacctagctg tctacgagac
     1261 cctgaagaat cgctggcttc agcagtacag ccacgaatcc gctaacccag gcattctcgt
     1321 gctcctaggc tgtggcacca tctccagcac ctgtggccag attgccagtt accctctggc
     1381 actggtccgt acccgaatgc aggcccaagc ctccattgag ggtggcccgc aggtctccat
     1441 ggtgggtcta cttcgacaca tcctgtccca ggagggtgta tggggcctct accggggcat
     1501 tgcccccaac ttcatgaagg tcattccagc cgtgagcatc tcctacgtgg tctacgagaa
     1561 catgaagcag gctctggggg tcacatccag gtgagggaca gggagcctgt ccccctaaaa
     1621 ctccctcatc ttcatcatgg tatcccctac gctgatatct tcaaccacag agactgatgg
     1681 cctgaccagt ggatcctaac cccacacccc aaggcactgg accccagtac ccaaatcccc
     1741 gatcctagcc ctgtgtcctg accatggtac cactgcaccc cacacttgag ccacaggatc
     1801 ccaggacttg atccccaact tcacaaccag acctcgaagc cccaaccact ggaccccaca
     1861 tatcagcagc ctgacacttg atatgtaaaa ctatccatac cctggcccca aacccttctt
     1921 cccaagcacc ttgaccctgt catctacacc ccaaagctgg accctgcttt tccctgcccc
     1981 actggttgct agacctcact atgcagcagc aggtgacccc aatgccccaa gcatgggaac
     2041 actcatccat gtaccccata gcccagctct cagagccctc aggcaccaga cccagtgccc
     2101 taatgccaca ctggaccaga gatccctaaa cttgctgctg agttccctgt aacctgcctc
     2161 acagcccagc ccctggattc taggagccaa gaactctcag ccacagggtc ctgacacagc
     2221 aaagccaaga tcctgggctc tgccactggg tccctggatc cctggattac aggtccctta
     2281 acccaaccaa tgcattttcc tctgtttgag gttccatatt cccccatttt tactgctagg
     2341 tctacattcc aagcaccacc ctcaatctct caccactgga ccccaagtcc caatccactg
     2401 gattctgtct cctggaagca tgggtgcgag agctccaggg tccctcatgt ggatcccaca
     2461 tgccccagct gctaaattcc agatcccaga ttccttcaac cccttctctg gaccacattc
     2521 atagaaggcc aaacttccaa acaccttcat actccaaggt ctttgctcct ataccccaaa
     2581 tgtcactccc caagtctaga tcccaatagc ccagtgacag catctcatat cccagacaca
     2641 ccctggagct gattcccaat gcatggaagc atgccatcca aagagtcttc tagaagctca
     2701 agacgccaga ccagtggctc cctaccaggc agtaaggaat gggacatatg aatgctgcat
     2761 tgcacctcag ctaggacaca cctcccttcc cacccccacc cccaaatcac tttgttcccc
     2821 gtccccctct ctctgcaatg tcttccacat tcccctgcct tccttccagg ctagtaactc
     2881 ccagatccca ggtccctctg ggagggctga atctgcttgt tcatgggttg ggagctacca
     2941 ggggaagtca gggacaccac caaggggacc acctgcctct cacactgcca gtcctgctca
     3001 ggcctcagaa agttgcaatc aaggaccaac acacaacatc cttcatgaaa cccagcatcc
     3061 agtatgcaaa ttaagtatcc ccaagctgac tcggagtcta tttttctacc agagaacaaa
     3121 gtcccctggc tcccaccaca ttcccatacc ctccacactt caagattgga ttctgagctt
     3181 agacctgggg taccccgctc cacctctcag tctttagggg gacctcatca agggactgag
     3241 aggaaaactg ggatgttggg ggggcatggt ttccacctct ccctccaacc tacaccaagt
     3301 cctacctccc tgcccatgtg tgtcatttca aggaaaaaaa gaataaattt tctaagctat
     3361 taaaaaaaaa aaaaaa
//
