LOCUS       NM_026646               2805 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            glutamate), member 22 (Slc25a22), transcript variant 1, mRNA;
            nuclear gene for mitochondrial product.
ACCESSION   NM_026646
VERSION     NM_026646.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2805)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2805)
  AUTHORS   Wong,C.C., Xu,J., Bian,X., Wu,J.L., Kang,W., Qian,Y., Li,W.,
            Chen,H., Gou,H., Liu,D., Yat Luk,S.T., Zhou,Q., Ji,F., Chan,L.S.,
            Shirasawa,S., Sung,J.J. and Yu,J.
  TITLE     In Colorectal Cancer Cells With Mutant KRAS, SLC25A22-Mediated
            Glutaminolysis Reduces DNA Demethylation to Increase WNT Signaling,
            Stemness, and Drug Resistance
  JOURNAL   Gastroenterology 159 (6), 2163-2180 (2020)
   PUBMED   32814111
  REMARK    GeneRIF: In Colorectal Cancer Cells With Mutant KRAS,
            SLC25A22-Mediated Glutaminolysis Reduces DNA Demethylation to
            Increase WNT Signaling, Stemness, and Drug Resistance.
REFERENCE   3  (bases 1 to 2805)
  AUTHORS   Casimir,M., Lasorsa,F.M., Rubi,B., Caille,D., Palmieri,F., Meda,P.
            and Maechler,P.
  TITLE     Mitochondrial glutamate carrier GC1 as a newly identified player in
            the control of glucose-stimulated insulin secretion
  JOURNAL   J Biol Chem 284 (37), 25004-25014 (2009)
   PUBMED   19584051
REFERENCE   4  (bases 1 to 2805)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC158224.6, AK010193.1 and BC050887.1.
            
            On Apr 17, 2010 this sequence version replaced NM_026646.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a). Variants 1, 2, and 3 all encode the same isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK010193.1, AK048389.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-256               AC158224.6         86848-87103         c
            257-2785            AK010193.1         3-2531
            2786-2805           BC050887.1         3262-3281
FEATURES             Location/Qualifiers
     source          1..2805
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 86.78 cM"
     gene            1..2805
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     glutamate), member 22"
                     /db_xref="GeneID:68267"
                     /db_xref="MGI:MGI:1915517"
     exon            1..306
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            307..480
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             461..1432
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /note="isoform a is encoded by transcript variant 1;
                     mitochondrial glutamate carrier 1; glutamate/H(+)
                     symporter 1; solute carrier family 25 member 22"
                     /codon_start=1
                     /product="mitochondrial glutamate carrier 1 isoform a"
                     /protein_id="NP_080922.1"
                     /db_xref="CCDS:CCDS22013.1"
                     /db_xref="GeneID:68267"
                     /db_xref="MGI:MGI:1915517"
                     /translation="MADKQISLPAKLINGGIAGLIGVTCVFPIDLAKTRLQNQQNGQR
                     MYASMSDCLIKTIRSEGYFGMYRGAAVNLTLVTPEKAIKLAANDFFRHQLSKDGQKLT
                     LPKEMLAGCGAGTCQVIVTTPMEMLKIQLQDAGRIAAQRKILAAQAQLSAQGGAQPSV
                     EAPAPPRPTATQLTRDLLRNHGIAGLYKGLGATLLRDVPFSIVYFPLFANLNQLGRPS
                     SEEKSPFYVSFLAGCVAGSAAAVAVNPCDVVKTRLQSLERGVNEDTYSGFLDCARKIW
                     RHEGPSAFLKGAYCRALVIAPLFGIAQVVYFLGIAESLLGLLQEPQA"
     exon            481..606
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..662
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            663..753
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            754..872
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1047
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1202
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1203..1278
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     exon            1279..2788
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2770..2775
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /note="hexamer: AATAAA"
     polyA_site      2775
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
     polyA_site      2788
                     /gene="Slc25a22"
                     /gene_synonym="1300006L01Rik; Gc1"
                     /note="major polyA site"
ORIGIN      
        1 atctctccta aagctccggg accaaacctt ccccagaccg tcccatcccc atgcttccct
       61 cctacctatt ctcagtcttt cagggctttg agataggaac aaggagggcc tagggatacg
      121 ccagaaagcc cactccctca agggtggcct gaggctgtgg tagtggccac gccggccggg
      181 agggggagcc gaaggcagca aaaacttagg gcggagcggg cgcgcctccg agagacgcgc
      241 ctccccgcct aggtgcaggc cccgcgcgcg gcacagcggg gaagcgatcc cggcggctgc
      301 agtgtggtgg cacaagactt gaaattgctt tgaaggtgag gacatcccct cccccaccgc
      361 cagccaccac caccagccac ctacatcgtc ctcatcagcc cctccccatc agtgcctcca
      421 ccaacatcac ccggcctgac tcctgcttca cttggtgtaa atggctgata agcagatcag
      481 cctgccggcc aagctcatca atggtggcat cgctgggcta atcggggtca cctgcgtgtt
      541 ccccatcgac ctggctaaga cacggctgca gaaccagcag aatggccagc gcatgtatgc
      601 cagcatgtct gattgcctca tcaagaccat ccgctccgag ggctacttcg gcatgtatag
      661 gggagcagca gtaaacctga ccctggtcac cccggagaag gccatcaagt tggcagctaa
      721 tgacttcttc agacaccagc tctctaagga tggacagaag ctgaccttgc ctaaggagat
      781 gctggcaggc tgcggggccg gcacctgcca ggtgattgtg accaccccca tggagatgct
      841 gaagatccag ttgcaagatg caggccgcat tgctgctcag aggaagattc tggctgccca
      901 ggctcagctc tcagcccagg gaggtgccca gccctcggta gaggctccag cccctcctcg
      961 gcccacggcc acccagctga cccgtgacct gctgcggaat catggcattg ctggcctcta
     1021 caagggactg ggggccacgc tactcaggga tgttcccttc tccattgtct acttccccct
     1081 gtttgccaac ctgaatcagc tgggccgccc atcctctgag gagaagtcgc ctttctatgt
     1141 gtccttccta gcaggctgcg tggctgggag tgcagccgct gtggccgtca acccttgtga
     1201 tgtggtgaag actcggctcc agtcccttga gagaggtgtt aatgaggaca cttactctgg
     1261 gtttctggac tgtgcaagga agatctggag acatgaaggt ccctcagcct tcctgaaagg
     1321 cgcatactgc cgtgcgctgg tcattgcccc gctgtttggc atcgcccagg tggtctactt
     1381 tctgggcatt gccgagtccc tgctggggct gctgcaagaa ccccaggcct gagcccatgg
     1441 ctgcttctct ccagcctatg ggcaggggcc agaacagggt gaccagcaca agcctgagga
     1501 ggagtggtct ctccccggtc ctcctcatta agatgggaag gcaaggggag ggtgcagggt
     1561 ccacatgggt gatgcacaca taagcccctg tgtggtcctg aagggacaac aaattgggat
     1621 caaggtctta tttatgtaga aaatgcagaa atctgtacat tcctcaagcc agttctgtcc
     1681 catccttgta cctcaaccca gtcccacctg gcctgaacac cccatgagac agagctggtc
     1741 tctgggctgg ggcccccagg cctggtttgg gcaggcagac cctaccctgt agtccactgg
     1801 ctctggtctc tgaggctctc ctggtctaca taggggaccc acacacaccc agaattattt
     1861 attgaatttt ccgtgcccat gtggctctcc tgtcctccgt ccatcagtct ttgcccctgc
     1921 tgctcttccc acctcatcca ggaccccact ctgcctcccc agccagcctt acaggaggcc
     1981 tggagggtct tagcctcatg tcaagctagg attcctaggc tgggtatgtt gccgtaatca
     2041 ggtgtcatcc caggcacccc acacatccac ttcccgctga gcctttggac ccccaccatg
     2101 tgggacccag gttgcttgag gtctttgtgt gcctgcggtg ggcagttgct cccccacccc
     2161 cagcagtcag ctggccaggc tgcttaggga tggggaccca taagggtaca gctgcctttt
     2221 cccgtggagt cagccaccct gtgcttgtgt gctgtttgtg cctcaggact cttctgctga
     2281 ccccgtccaa taatttagtt ctccagcttg gtgactcttc tgatagagcc ctactcctgg
     2341 acagagattg cttttgggag gtggagtggg ggcttgaagg tcaggcatga aggccagttt
     2401 agcgtctggg cctcccagct ctctgggcct ctgtccatgt ttggaaagcc ccacccctac
     2461 agccctggat cctctgttca gaatcaaagc agcccttccc tgccccggcc atgtgattgt
     2521 gtttggtgat tgactgaagt gctggtgctg tgtccctcaa gcccaacccc ctccatggag
     2581 gccccttccc agtgacacta cctggggctc cagtctgggc tgcccctagt tcaccgttgc
     2641 tcctgggagc cacccctcct cttacgtctg taccttgaaa gctgctgctg ctgcttacag
     2701 aattatattt ttttcttttg aagagtttta agaagttgta actttttgtg tcttgtcatg
     2761 taaaaaataa ataaatattc taaatagaaa aaaaaaaaaa aaaaa
//
