LOCUS       NM_172577               2609 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial
            oxodicarboxylate carrier), member 21 (Slc25a21), transcript variant
            1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_172577
VERSION     NM_172577.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2609)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2609)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2609)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   4  (bases 1 to 2609)
  AUTHORS   Maguire,S., Estabel,J., Ingham,N., Pearson,S., Ryder,E.,
            Carragher,D.M., Walker,N., Bussell,J., Chan,W.I., Keane,T.M.,
            Adams,D.J., Scudamore,C.L., Lelliott,C.J., Ramirez-Solis,R.,
            Karp,N.A., Steel,K.P., White,J.K. and Gerdin,A.K.
  CONSRTM   Sanger MGP Slc25a21 Project Team
  TITLE     Targeting of Slc25a21 is associated with orofacial defects and
            otitis media due to disrupted expression of a neighbouring gene
  JOURNAL   PLoS One 9 (3), e91807 (2014)
   PUBMED   24642684
  REMARK    GeneRIF: Disruption of Slc25a21 is associated with orofacial
            defects and otitis media due to diminished expression of a
            neighboring gene, pax9.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2609)
  AUTHORS   Ryder,E., Gleeson,D., Sethi,D., Vyas,S., Miklejewska,E., Dalvi,P.,
            Habib,B., Cook,R., Hardy,M., Jhaveri,K., Bottomley,J.,
            Wardle-Jones,H., Bussell,J.N., Houghton,R., Salisbury,J.,
            Skarnes,W.C. and Ramirez-Solis,R.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Molecular characterization of mutant mouse strains generated from
            the EUCOMM/KOMP-CSD ES cell resource
  JOURNAL   Mamm Genome 24 (7-8), 286-294 (2013)
   PUBMED   23912999
REFERENCE   6  (bases 1 to 2609)
  AUTHORS   Karp,N.A., Melvin,D. and Mott,R.F.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Robust and sensitive analysis of mouse knockout phenotypes
  JOURNAL   PLoS One 7 (12), e52410 (2012)
   PUBMED   23300663
REFERENCE   7  (bases 1 to 2609)
  AUTHORS   Niimi,M., Tao,L., Lin,S.H., Yin,J., Wu,X., Fukui,H., Kambayashi,J.,
            Ye,J. and Sun,B.
  TITLE     Involvement of an alternatively spliced mitochondrial
            oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells
  JOURNAL   J Biomed Sci 16 (1), 92 (2009)
   PUBMED   19825180
  REMARK    GeneRIF: ODC-AS may promote lipid accumulation during adipocyte
            differentiation and play an important role in the regulation of
            lipid metabolism in adipose tissues. [ODS-AS]
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK041694.1, AK162379.1 and AK167535.1.
            
            On Nov 21, 2009 this sequence version replaced NM_172577.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript, and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167535.1, AK041694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164143
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1034              AK041694.1         2-1035
            1035-1453           AK162379.1         862-1280
            1454-2609           AK167535.1         1162-2317
FEATURES             Location/Qualifiers
     source          1..2609
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 24.54 cM"
     gene            1..2609
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="solute carrier family 25 (mitochondrial
                     oxodicarboxylate carrier), member 21"
                     /db_xref="GeneID:217593"
                     /db_xref="MGI:MGI:2445059"
     exon            1..600
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            601..649
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            650..733
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            734..800
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            801..860
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            861..968
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1133
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1315
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            1316..1368
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..2609
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1885..1890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="hexamer: ATTAAA"
     polyA_site      1903
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="major polyA site"
     regulatory      2404..2409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="hexamer: AATAAA"
     regulatory      2411..2416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="hexamer: AGTAAA"
     polyA_site      2421
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="major polyA site"
     polyA_site      2429
                     /gene="Slc25a21"
                     /gene_synonym="9930033G19Rik; A630030I10"
                     /note="major polyA site"
ORIGIN      
        1 ctttgtaagt cagatctgct ctgatctagt tgctgtggcc ttcaatttct ggttgactaa
       61 cttggaggaa tttcctcact atcccttctt ttgaatagta ccgtatttta gcctgcctgg
      121 agggcaaggg tcacccgcgg ctacatcaca gtcgcagcta gctaaggcag cccttagata
      181 agcagccagc taaacaaact ccgcagtagg tctcgatagg caaattcata agcccctatc
      241 ttgaagctcg agcctgaccc accgagctag gtcaagtcta cccagccccc agttgtcagt
      301 gttccccctc cggtgccccg gtggaaaggg cagccttagg cagcgctggg caagttcgga
      361 ccccctccgc caacctcgcg gcgactcggt gcccgaaccg ccgcctttag ctggatcgca
      421 gccacaccgg gaagagttca gccccaggac cgacggggcc cggtctccat cggcggcggc
      481 cttcagagga gctcgctcgg gcaacttggt cacccggtcc cctggtcgcg aagatgtcgg
      541 cctccaacgt cagcttactg cacgagacct ccaggcaggt cgcggccgga gggtctgcag
      601 gtcttgtaga aatttgcctg atgcatcctc tcgatgtggt gaaaaccagg ttccaggtgc
      661 agagaagtgt aacagaccca caaagttata gaactgtaag aggcagcttc cagatgatct
      721 tccgaacaga ggggttgttt ggcttttaca agggaattat cccaccaatt ttagctgaaa
      781 caccaaaaag agcagtcaag ttttctacct ttgagctgta caagaaattt ctgggatata
      841 tgtcactatc accagggctg acatttctca tcgctggctt aggatcggga ctaacagaag
      901 ctgtcgtggt taaccctttc gaggtggtaa aagttggctt gcaagtcaat cggaacttgt
      961 tcaaagagca accatctact tttgcttatg caagacaaat cattaagaag gaaggcttgg
     1021 ggttccaggg cctcaacaaa ggattgacag caactctggg acgtcacgga attttcaaca
     1081 tggtttattt tggcttctac cacaacgtca aaaatattat tccatccagt aaggatccaa
     1141 ccttggagtt tttgagaaaa tttgggattg gttttgtctc agggacaatg ggctcagtgt
     1201 ttaacatccc ctttgatgtt gcaaagagtc ggatccaagg gccccagcca gttcctggag
     1261 agatcaagta ccgaagctgc ttcaaaacaa tggagatgat ctaccgggaa gaagggattt
     1321 tagccttata caaaggcctg gtccctaagg tgatgagact tggaccaggt ggtggggtga
     1381 tgttgctggt gtatgaatac acctatgcat ggctgcagga aaactggtga tggactgaga
     1441 agcgatttcc tcttgacaaa acagctctgc atccccagga aaagaagata agctagacac
     1501 acccgttaag aggggaagac aacgtgctca ggaacaaagc ctgttccagt gttttataaa
     1561 tttttagata aattgacatg gtagtttggg ccatatacat aacacaagtc aaaatttaaa
     1621 tatattttat aaggaattac ttttccatac gttatatttt aaaagagaag taagaaaaat
     1681 gtaaatacac caaaacagcc ttttaagaat gtttaatttt gtgagcgctg agttaaaatg
     1741 tgaatctatt ggttttcttt agtaattaat acaccctcag gctctatttc cctaaatgta
     1801 ttttatactt cacatggtga cttaagtgag tattttaaaa tcatgctatt tgaaaatttt
     1861 tattaaaggt agaatacata ttatattaaa cttctttaac atagttcatt ttgaaaacaa
     1921 gatttgttac taaaatattt tttttggggg ggggatgctt ctctgttgcc tgaatatgcc
     1981 tccaaacacc catccttaaa aaggatgtag ggaaataaaa ctatctccag attcctaggt
     2041 ttaagtcaca tgttgacata taaggctatt tagaatatta acatgtctac actaagtggc
     2101 aaacgtttca aaagtgaaaa cacattcttt agcatttcca agcactcttg cactaatatg
     2161 cactctagaa aaagaaaaga aaagatagtt ttttttggtc ttgatatacc caaagcttat
     2221 tcttatgtat gcactatata atgatgcttc tccagtagct atggtcacac acacacacac
     2281 acacacacac acacacacac acacacacac acaaatcaca acatgcttta aataacgcct
     2341 gttcttaact actcctgtgg ggtatttctg ctagaggcaa tctcaccacc aaaacatttt
     2401 gaaaataaac agtaaagatt acatggtaat tatttgtatt tattaactta gagcatctga
     2461 agtataaaaa taaaaggctt ttgacatacg ctatatacat acagagcctt ctgctgtaca
     2521 tctttcccaa catgattttt tttctttttc atttgtattt cagcccaata ttcaatatat
     2581 gggtcattaa agaacagaga gccaggagc
//
