LOCUS       NM_026071               2475 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial thiamine
            pyrophosphate carrier), member 19 (Slc25a19), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_026071
VERSION     NM_026071.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2475)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2475)
  AUTHORS   Srinivasan,P., Nabokina,S. and Said,H.M.
  TITLE     Chronic alcohol exposure affects pancreatic acinar mitochondrial
            thiamin pyrophosphate uptake: studies with mouse 266-6 cell line
            and primary cells
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 309 (9), G750-G758 (2015)
   PUBMED   26316591
  REMARK    GeneRIF: Chronic alcohol exposure negatively impacts pancreatic
            mitochondrial thiamin pyrophosphate transport, and this effect is
            exerted, at least in part, at the level of Slc25a19 transcription
            and appears to involve an epigenetic mechanism.
REFERENCE   3  (bases 1 to 2475)
  AUTHORS   Kang,J. and Samuels,D.C.
  TITLE     The evidence that the DNC (SLC25A19) is not the mitochondrial
            deoxyribonucleotide carrier
  JOURNAL   Mitochondrion 8 (2), 103-108 (2008)
   PUBMED   18280798
  REMARK    GeneRIF: We review the evidence that the function of the SLC25A19
            gene product, previously identified as the mitochondrial
            deoxyribonucleotide carrier (DNC), is actually the transport of
            thiamine pyrophosphate.[review]
            Review article
REFERENCE   4  (bases 1 to 2475)
  AUTHORS   Lindhurst,M.J., Fiermonte,G., Song,S., Struys,E., De Leonardis,F.,
            Schwartzberg,P.L., Chen,A., Castegna,A., Verhoeven,N.,
            Mathews,C.K., Palmieri,F. and Biesecker,L.G.
  TITLE     Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate
            depletion, embryonic lethality, CNS malformations, and anemia
  JOURNAL   Proc Natl Acad Sci U S A 103 (43), 15927-15932 (2006)
   PUBMED   17035501
  REMARK    GeneRIF: mitochondria of Slc25a19(-/-) and Amish lethal
            microcephaly cells have undetectable and markedly reduced thiamine
            pyrophosphate content, respectively
REFERENCE   5  (bases 1 to 2475)
  AUTHORS   Lewis,W., Haase,C.P., Miller,Y.K., Ferguson,B., Stuart,T.,
            Ludaway,T., McNaught,J., Russ,R., Steltzer,J., Santoianni,R.,
            Long,R., Fiermonte,G. and Palmieri,F.
  TITLE     Transgenic expression of the deoxynucleotide carrier causes
            mitochondrial damage that is enhanced by NRTIs for AIDS
  JOURNAL   Lab Invest 85 (8), 972-981 (2005)
   PUBMED   15951836
REFERENCE   6  (bases 1 to 2475)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   7  (bases 1 to 2475)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 2475)
  AUTHORS   Bettendorff,L.
  TITLE     The compartmentation of phosphorylated thiamine derivatives in
            cultured neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 1222 (1), 7-14 (1994)
   PUBMED   8186267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY276424.1, AK005710.1, CA322885.1, AV155885.2 and CF584740.1.
            
            On Nov 14, 2011 this sequence version replaced NM_026071.2.
            
            Transcript Variant: This variant (1) is a predominant transcript
            and encodes the longest isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.237940.1,
                                           SRR1660815.120958.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-156               BY276424.1         3-158
            157-1652            AK005710.1         2-1497
            1653-2030           CA322885.1         261-638
            2031-2453           AV155885.2         577-999
            2454-2475           CF584740.1         2-23                c
FEATURES             Location/Qualifiers
     source          1..2475
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 80.91 cM"
     gene            1..2475
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /note="solute carrier family 25 (mitochondrial thiamine
                     pyrophosphate carrier), member 19"
                     /db_xref="GeneID:67283"
                     /db_xref="MGI:MGI:1914533"
     exon            1..231
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     exon            232..401
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1226
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 25 (mitochondrial deoxynucleotide
                     carrier), member 19; mitochondrial thiamine pyrophosphate
                     carrier; solute carrier family 25 member 19"
                     /codon_start=1
                     /product="mitochondrial thiamine pyrophosphate carrier
                     isoform 1"
                     /protein_id="NP_080347.1"
                     /db_xref="CCDS:CCDS25644.1"
                     /db_xref="GeneID:67283"
                     /db_xref="MGI:MGI:1914533"
                     /translation="MVGYDAKADVRSNSKLEVAVAGSVSGFVTRALISPLDVIKIRFQ
                     LQIERLCPSDPNAKYHGIFQAAKQILQEEGPRAFWKGHVPAQILSIGYGAVQFLAFEE
                     LTELLYQANLYQTHQFSAHFVCGGLSAGTATLTVHPVDVLRTRLAAQGEPKIYNNLRE
                     AIRTMYKTEGPFVFYKGLTPTVIAIFPYAGLQFSCYRSLKRAYDWLIPPDGKQTGNLK
                     NLLCGCGSGVISKTFTYPLDLIKKRLQVGGFEHARSAFGQVRSYRGLLDLTQQVLQEE
                     GTRGFFKGLSPSLMKAALSTGFMFFWYELFCNLFHCIRREDR"
     exon            402..557
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     exon            558..728
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     exon            729..912
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     exon            913..1043
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..2454
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1636..1641
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /note="hexamer: ATTAAA"
     polyA_site      1653
                     /gene="Slc25a19"
                     /gene_synonym="2900089E13Rik; DNC; MUP1; TPC"
                     /note="major polyA site"
ORIGIN      
        1 gggggtgggg cttggaagcg gaagactaca gtacctagcg gtatctggac agtgacattg
       61 ggatgggacc ttcgacgtac aacgattcgt ccagcggcgg ccaaaagctg cacggtgatt
      121 ggcctagcag cctgtcagtt actggcaagt gctgttaagt tttgctgttg ggctacactg
      181 agagggaggg agaactgagc ttgaggagcc cggacgggcc tgaagtgtca gcttgatact
      241 catggacgtt ggacggacca gaggcaggga tggttggcta tgacgccaaa gcagatgtca
      301 ggagtaactc caagttggag gtggcggtgg cgggatcagt gtcaggattt gtcacccgtg
      361 ccctgatcag ccctttggac gtcatcaaga tccgtttcca gctccagatt gaacgcctgt
      421 gtccaagtga ccccaatgcc aaataccacg gaatcttcca ggcagccaag cagatcctgc
      481 aagaggaagg cccaagagca ttctggaaag gacacgttcc agcccagatt ctgtccatag
      541 gctacggagc tgtccaattt ttggcctttg aagagttgac tgagctgctc taccaagcca
      601 acttgtacca aacgcaccag ttctcagcgc actttgtgtg cggcggcctg tctgctggca
      661 ctgccaccct caccgtacac cctgtggacg tcctgcgtac ccgccttgcc gctcagggcg
      721 agcccaagat ctataacaat ctgcgagagg ccatacggac catgtataag accgagggcc
      781 ccttcgtctt ctacaaaggc ttgactccca ccgtgatcgc catcttcccc tacgcgggcc
      841 tgcagttctc ctgctaccgc tccttaaaac gtgcctatga ctggctcata ccaccagacg
      901 gaaagcaaac agggaacctt aaaaacctgc tttgtggctg tggttcggga gttatcagca
      961 agacctttac atatcccctg gacctcatca agaagcgcct gcaggtgggc gggttcgaac
     1021 atgcccggtc tgcctttggc caggtgcgga gctacagggg cctcctggac ctcacccagc
     1081 aggtactaca ggaagaaggc acccggggct tcttcaaggg cctgtccccc agcctgatga
     1141 aggctgcact ctccactggc ttcatgttct tctggtacga gctcttctgt aacctcttcc
     1201 actgcataag gagggaagac agatagttgt gaggcaggag gggcctaagg aggggcccga
     1261 caagacttgg ctctgagctc atactgaaca atggctgctg cctggttggc cttccaggcc
     1321 agctgccggg agcatgaagt catccggagc tgaaggcaga aggacgcaag ggccttcgct
     1381 gaacagaagg aagagagaag ggggtgcttg cactgtaaaa agaaggccta ggtggaggaa
     1441 cctggtgcgc atgcgtctca cctccgacca gcccaatcca gaaggaactg gccatccttt
     1501 tttgcagtcc tggctttggg gagaatgctc ctagtcctga taggaccaca ctggagtgca
     1561 gacggggccg ggctctttgc acagttctaa cctatacaac ttggtctgct cctcctacca
     1621 acttatttaa tagacattaa agtaaaacac gcattccttg tgtcactcct atagcttagg
     1681 aacacatccc atctgaggga ggatgatggg ggaggggcct ttctggcttg cagccctgag
     1741 gtagccatgc ttgtcagctt agggggagaa ccctgtcatg tgggtagctt ctgaactccc
     1801 aggcccaagc ctttgtgcct gtgaggctcc acaacaggtc agggaggaaa ctgagacaga
     1861 ggcggtgaag ggcagacagg agtggctcct ctccttcccc tcccactgga gtgcaggggc
     1921 catcaccagc tctgcacgca tgctgcacac catgtcctct aatcccagat gggcctcagg
     1981 cccagggcat gggatgtccg acagcctggt gaggtgtggt gggcgctgta ggcagagcca
     2041 gggatgcaga tgaagaggga gcttcctgtt cacgagaaga atcacatgac tgctgtcttt
     2101 cccatgctcg agcctagtgg tggggttggt ctaaagaagg aagggaggag agacttcttg
     2161 actttgtggg attccagccc ctgccataac ttggattgta atgcctgctg ggaatggccc
     2221 tgatcgtgaa aactggggct ctgccctgcc tgtcagttcc actctcccct ctgtggtcca
     2281 ctgtagccct cccctagtgg ttcacttttc tgatcttggc tcctgattct gaagacccag
     2341 ggtcacttgg gagggcttct gagatgggtg gcccgttggc ttcctgggct tggagcagca
     2401 gaagtgtttt gtgaccctat tgctggagag atgtgaataa atttatatac cagaaaaaaa
     2461 aaaaaaaaaa aaaaa
//
