LOCUS       NM_001417735            2013 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier),
            member 18 (Slc25a18), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001417735
VERSION     NM_001417735.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2013)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2013)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   3  (bases 1 to 2013)
  AUTHORS   Footz,T.K., Brinkman-Mills,P., Banting,G.S., Maier,S.A.,
            Riazi,M.A., Bridgland,L., Hu,S., Birren,B., Minoshima,S.,
            Shimizu,N., Pan,H., Nguyen,T., Fang,F., Fu,Y., Ray,L., Wu,H.,
            Shaull,S., Phan,S., Yao,Z., Chen,F., Huan,A., Hu,P., Wang,Q.,
            Loh,P., Qi,S., Roe,B.A. and McDermid,H.E.
  TITLE     Analysis of the cat eye syndrome critical region in humans and the
            region of conserved synteny in mice: a search for candidate genes
            at or near the human chromosome 22 pericentromere
  JOURNAL   Genome Res 11 (6), 1053-1070 (2001)
   PUBMED   11381032
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC084273.20.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR7345562.3347372.1,
                                           SRR14777534.1646593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               AC084273.20        114472-114690
            220-309             AC084273.20        123536-123625
            310-392             AC084273.20        125361-125443
            393-515             AC084273.20        126940-127062
            516-571             AC084273.20        127189-127244
            572-662             AC084273.20        129100-129190
            663-781             AC084273.20        130259-130377
            782-947             AC084273.20        132854-133019
            948-1102            AC084273.20        133278-133432
            1103-1178           AC084273.20        133816-133891
            1179-2013           AC084273.20        134408-135242
FEATURES             Location/Qualifiers
     source          1..2013
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 57.0 cM"
     gene            1..2013
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /note="solute carrier family 25 (mitochondrial carrier),
                     member 18"
                     /db_xref="GeneID:71803"
                     /db_xref="MGI:MGI:1919053"
     exon            1..219
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            220..309
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            310..392
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             358..1320
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /note="GC-2; glutamate/H(+) symporter 2; solute carrier
                     family 25 member 18"
                     /codon_start=1
                     /product="mitochondrial glutamate carrier 2"
                     /protein_id="NP_001404664.1"
                     /db_xref="GeneID:71803"
                     /db_xref="MGI:MGI:1919053"
                     /translation="MIACRMSSQDLSISAKLINGGIAGLVGVTCVFPIDLAKTRLQNQ
                     QGKDVYRGMTDCLMKTARAEGFLGMYRGAAVNLTLVTPEKAIKLAANDFLRQLLMQDG
                     TQRNLKMEMLAGCGAGICQVVITCPMEMLKIQLQDAGRLAVCHQASASATPTSRPYST
                     GSTSTHRRPSATLIARELLRTQGLSGLYRGLGATLLRDIPFSIIYFPLFANLNQLGVS
                     ELTGKASFTHSFVAGCTAGSVAAVAVTPLDVLKTRIQTLKKGLGEDTYSGVTDCARKL
                     WTQEGPAAFMKGAGCRALVIAPLFGIAQGVYFIGIGERILKCFE"
     exon            393..515
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            516..571
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            572..662
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            663..781
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            782..947
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1102
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1178
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1179..2013
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1846
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /note="major polyA site"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
                     /note="hexamer: AATAAT"
     polyA_site      2013
                     /gene="Slc25a18"
                     /gene_synonym="1500015I14Rik"
ORIGIN      
        1 atcctgtggg ctcatttctg accacatagg accattcacc ctggtctggc tgagcagagg
       61 ttttgaagca gtgaagccag ctcctcagat tgtatcacga gttttaactc tagggaagag
      121 ttaagtcttt ataggaagga aggcaaagac aagatccagc acagccgggc ctggagtata
      181 ccaaacacag atgtggagtg acccctaaac gccttgtccg ggtagggact aaaagatggc
      241 gacttcgtcc atctttgctg tttgagacag tttctcatgt ttgccaggtt tccaggtgct
      301 gggtgacagc agctgcctgt gagggcccca cagcctgcgt cctgggagct gccgtggatg
      361 atcgcctgca ggatgtccag ccaggacctg agcatctccg caaaactcat caatggaggt
      421 atagcaggtc ttgtgggggt gacctgcgtg tttcccattg accttgccaa gacccgacta
      481 cagaaccagc aggggaaaga tgtgtacaga ggaatgacag attgcctgat gaagactgca
      541 cgtgctgagg gcttcctggg catgtaccga ggggctgcag taaacctcac cctggtcact
      601 ccagagaagg caatcaagct ggcagccaat gacttcttgc ggcagctgct catgcaagat
      661 gggacgcagc ggaacctgaa gatggagatg ctggccgggt gtggggctgg aatatgccag
      721 gtggtgatta cctgtcccat ggaaatgctc aagattcagc tgcaggatgc tggccgctta
      781 gctgtctgtc atcaggcttc tgcctcagcc acacccacct cccggcccta cagcactggc
      841 tcgacttcca cccacaggcg cccatcggcc accctcattg cccgggagct gctccgcact
      901 cagggcctct ctggtctcta caggggcctg ggtgccacgc tcctcaggga cattcccttc
      961 tccatcatct acttcccttt gtttgcaaac ctgaaccaac tcggagtcag cgagctcacc
     1021 ggcaaggcct ccttcacaca ctcctttgta gcaggctgca cagcaggttc tgtggcagcg
     1081 gtagccgtca cccctctgga tgttctgaag actcgaattc agaccctcaa gaaaggcctg
     1141 ggtgaggaca cctacagcgg agtcactgac tgtgccagga agctctggac acaggagggg
     1201 ccagcagcct tcatgaaagg agcaggctgc cgtgccctgg tcatagcccc cctctttggg
     1261 atcgcccagg gcgtctactt cattggcatc ggagagcgca tcttgaagtg ctttgagtaa
     1321 tctatgtgtc acttcttgct gtcacctctg gccctaggga actaggtggc actgctggaa
     1381 gtataagatg ctggctctga cgtacgtggt ctctaacctg tagtgctacc tcagaagaaa
     1441 tgacccattt tactaagcga gtagagcctt catctccttt atgaaaacta aactttctga
     1501 accagagatg ttcggaagcc ccaacctctt atgtactatg gcaggaccgt gtgcagtaag
     1561 acagaagggc tcttccacac taacatcccc actgcaggca agtgtggcac agaatcgtcc
     1621 tgtgagggtt tagcgtcaat cctaaccttg ccgccctaac agatcagaag tgcacctgtg
     1681 ccctcgcggg catcagcaat agtctgagag cctgaatgaa cattctggcc acctcagcag
     1741 cggtcctgcc ccagatactc accctgaagt atgggcccag atcccttcca atagatgctt
     1801 gtgggacatg atctgaaata aagctggtta aatccttgtc ctgtaatcag catagcagat
     1861 gactgtcatt ctgcagagtc aagctgtgcc ttcttgggcc ccacagacag ttcattactg
     1921 tcttccaact gctgttctag agtggagagt ggttgggggg aaattgtaca ctgaaagagt
     1981 tcagctttta aaaaataatt atttactaat tta
//
