LOCUS       NM_181325               3469 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier
            ornithine transporter), member 15 (Slc25a15), transcript variant 1,
            mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_181325 NM_011017
VERSION     NM_181325.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3469)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3469)
  AUTHORS   Lumayag,S., Haldin,C.E., Corbett,N.J., Wahlin,K.J., Cowan,C.,
            Turturro,S., Larsen,P.E., Kovacs,B., Witmer,P.D., Valle,D.,
            Zack,D.J., Nicholson,D.A. and Xu,S.
  TITLE     Inactivation of the microRNA-183/96/182 cluster results in
            syndromic retinal degeneration
  JOURNAL   Proc Natl Acad Sci U S A 110 (6), E507-E516 (2013)
   PUBMED   23341629
REFERENCE   3  (bases 1 to 3469)
  AUTHORS   Calvo,S.E., Pagliarini,D.J. and Mootha,V.K.
  TITLE     Upstream open reading frames cause widespread reduction of protein
            expression and are polymorphic among humans
  JOURNAL   Proc Natl Acad Sci U S A 106 (18), 7507-7512 (2009)
   PUBMED   19372376
  REMARK    GeneRIF: Includes the study of an upstream ORF in this gene, and
            shows that it functions to reduce protein levels by ~55%.
REFERENCE   4  (bases 1 to 3469)
  AUTHORS   Evsikov,A.V., Graber,J.H., Brockman,J.M., Hampl,A., Holbrook,A.E.,
            Singh,P., Eppig,J.J., Solter,D. and Knowles,B.B.
  TITLE     Cracking the egg: molecular dynamics and evolutionary aspects of
            the transition from the fully grown oocyte to embryo
  JOURNAL   Genes Dev 20 (19), 2713-2727 (2006)
   PUBMED   17015433
REFERENCE   5  (bases 1 to 3469)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   6  (bases 1 to 3469)
  AUTHORS   Camacho,J.A., Obie,C., Biery,B., Goodman,B.K., Hu,C.A.,
            Almashanu,S., Steel,G., Casey,R., Lambert,M., Mitchell,G.A. and
            Valle,D.
  TITLE     Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is
            caused by mutations in a gene encoding a mitochondrial ornithine
            transporter
  JOURNAL   Nat Genet 22 (2), 151-158 (1999)
   PUBMED   10369256
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ172337.1, AK052758.1, AK142223.1, AK145966.1 and DV644804.1.
            
            On or before May 20, 2009 this sequence version replaced
            NM_011017.1, NM_181325.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145966.1, AK142223.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            regulatory uORF                    :: PMID: 19372376
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                CJ172337.1         1-68
            69-1660             AK052758.1         1-1592
            1661-2144           AK142223.1         1531-2014
            2145-3450           AK145966.1         2015-3320
            3451-3469           DV644804.1         301-319
FEATURES             Location/Qualifiers
     source          1..3469
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 11.26 cM"
     gene            1..3469
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /note="solute carrier family 25 (mitochondrial carrier
                     ornithine transporter), member 15"
                     /db_xref="GeneID:18408"
                     /db_xref="MGI:MGI:1342274"
     exon            1..182
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            183..297
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      187..246
                     /regulatory_class="uORF"
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /experiment="DESCRIPTION:regulatory uORF[PMID:19372376]"
                     /note="this uORF is predicted to encode a 19 aa peptide
                     (PMID:19372376)"
     exon            298..556
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            557..694
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            695..864
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            865..1023
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     exon            1024..3455
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /note="hexamer: ATTAAA"
     polyA_site      3455
                     /gene="Slc25a15"
                     /gene_synonym="D630044L02Rik; Ornt1"
                     /note="major polyA site"
ORIGIN      
        1 ttcgagaggg cgggccctca ggagggcgtg gcctccggag ggagggctgg tggagggggt
       61 ctcaggaggg agggcccgag ggccggaccc acagggcgac cttaaaaatt gcccgggggc
      121 ccgcggccgc cagcggagcg cgcgggcggc agagggcgag ccggacacag ccaggcgcgg
      181 cgggatatgt ggtacattcc cttccctcca gagaatcgcc ttccacagaa accagtaacg
      241 ccatgaaatc caatccagcc atccaagctg ccatcgacct cacagcaggg gctgcagggg
      301 gcacagcatg cgtactgact gggcagccct tcgacacgat gaaggtgaag atgcagacct
      361 ttccagacct ctaccggggc ctcacagact gctgcctcaa gacctactcc caggtgggct
      421 tccgtggctt ctacaagggc accagccccg ccctgattgc caatatagca gagaactcgg
      481 tgctgttcat gtgttacggc ttctgccagc aggtggtccg taaagtggtt ggattggatc
      541 agcaggcaaa actgagtgac cttcagaatg cagctgctgg ttcctttgcc tccgcctttg
      601 ccgcgctggt tctctgcccc acggagcttg tgaaatgccg gctgcagacc atgtatgaaa
      661 tggagacatc aggaaagata gcggccagtc agaatacagt ttggtcagtt gtgaaggaga
      721 tctttaggaa ggacggcccc ttgggcttct accatgggct ctcaagcact ttacttcgag
      781 aagtaccagg ctacttcttc ttctttggtg gctatgaact gagcaggtca ttcttcgcat
      841 cagggagatc aaaagacgaa ctaggtcctg tgccattgat gctgagtggt ggatttggtg
      901 ggatttgcct gtggcttgct gtgtatccgg tggattgtat caaatctaga attcaagttc
      961 tttctatgac tggaaagcag acaggactcg tcaggacctt cctgagtatc gtaaagaatg
     1021 aaggaataac agccttgtat tctggactga aacccaccat gatccgcgca ttccctgcca
     1081 acggggcact gtttttggcc tatgagtaca gcaggaagtt gatgatgaac caattggaag
     1141 catggtgaag tgtcctggtg tgcctggatt caaggcaggc gtttagtgac tggtcaactc
     1201 agggtttcag ggagtacaag aacaatgtag aattatgtga ttcactggaa ctttgaactt
     1261 gtcttccctt cttctattca aagtcttgga ttttttgtgg acggtcctcc attctacaca
     1321 gtataatttc tgcctgttat tgaacccaaa cagaaaagtc cacccttggt agagtgagta
     1381 tacaggggaa ctggtggcct tatacactag ccttatgcac cagcctcgtg cagactgcct
     1441 tcatttcagg acaaattcag tggaagtcag tggtacacat gcaattatga tggccctgtc
     1501 accacaggaa aacaagactt tgttctgggt ttaattataa atggtgacca atttttaggt
     1561 agatggttgt agatgattgc ttataaatga tcctagttag aaggctgttg ctaaaagctg
     1621 ctgagcctgt gcactaagag gctaactttt tttttttttt taaacttttt gtggtatatt
     1681 aaagctaaaa tatccctcta tatttttagg aaaacctata tgcatagttg tgtggcttct
     1741 acgttcttga tgaagtttca gggtggacat cctggatttt tctcatgacg tttattccct
     1801 cacagtgcag ttcatcttct aggtgggctt ctcattctac cctctggtac tgggaggtgt
     1861 ggccagagcg ttagacctct ggggggcagc agaggacaca ccgcctcctc actcagagct
     1921 tcctccctct gtgctgctcc tgaaagacag ggactgccct gccctgctct cttgaaaacc
     1981 aacagaggtt cttgcctgct ctcagcagga atccagggtg cacctttggt actggatctg
     2041 aggccactct gagcccactg tgtctcacca atcagacgcc ctttcaggaa gcagaaagga
     2101 agtctgggct ccccgctttg atcacagggt tctactaatg gagacatccg aaggagcccg
     2161 ttaactgggt accctttctg aagctcactt ttgggtccat gattccttga tctgcttctg
     2221 tatttggagc tggcagttta tgaatttcaa tgactgtaga tgatatataa ctttggaaag
     2281 cattgtgaca taataaaggt atttttatta aattagggta gtatgtatgt agcaaccaaa
     2341 aaactggacc ccacattttt cttctttggc tgtggggtct tctcgccata gagatcaggc
     2401 acattgtctg tactgctcca agaccagggg gatggtagtg ggcgctgttc ccactctgcc
     2461 tgtaaggctg aaggaggtag gttgacctta ccacagtgtc aggagtacaa gggtcaggaa
     2521 agcaaagtat ttccaaaagc ggggtgggga gggacacccg tcagcattcc tggagaaaat
     2581 tcggcattca tgagaaaact gtctttctac tccagtgctc tcagtgacca atggctactg
     2641 agtgctgctt catctgaact gatctgaatt gaggcaaatg tagggttggc ttcctgcagg
     2701 aagactgttc aaagccaagc tctttccctt ctaggtgcct gggtctagtg cacattagtc
     2761 ttgttggcag cgtgtctcct cagtctggct attgtgatct ttcccataga aagagtcagg
     2821 aacgagggga agggaaagat agaggcctaa ggtgaaattt taaaaaactc aatctgttgg
     2881 tttgatttgt ggtttcatgt ttgggtgcaa ttgttcttga gacaaaagta gaactttgaa
     2941 atactttatt taaagaaacg agtgctctgt cattattaaa taaacctaat gtaagtctat
     3001 gaagagtttc acttaaatac atttatataa agagccaatg ttaaagagtt atggataata
     3061 attcttcaag gtggtggttg tattggaaca agtgttcttt ctgtcagcta gattcctggt
     3121 ataaaataat ttgactgcag ggaagttgac agaaagcatt acttctgtat gctacaaccc
     3181 tttaaaattg tgctctgcct ccacccatgt ggtggtttga atgaaaatgt ggccatagtc
     3241 tcatatttgg atgtttaatc actagggaat ggacctgttt gataggatta gaaggattgg
     3301 aggcgaggcc tattggagga agtgccatac tgtggatggc ctttgcctag tctctcaacc
     3361 ccagagtttt catgcctgag tgctccctgc tggataatgg agtaaccctc tgaaactgta
     3421 agcaagctcc tgattaaatg ctttcatttc taagaaaaaa aaaaaaaaa
//
