LOCUS       NM_001403265            1137 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            brain), member 14 (Slc25a14), transcript variant 19, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001403265
VERSION     NM_001403265.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1137)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1137)
  AUTHORS   Ji,F., Shen,T., Zou,W. and Jiao,J.
  TITLE     UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap
            Alternation in the Developing Neocortex
  JOURNAL   Stem Cells 35 (6), 1479-1492 (2017)
   PUBMED   28276603
REFERENCE   3  (bases 1 to 1137)
  AUTHORS   Smorodchenko,A., Rupprecht,A., Sarilova,I., Ninnemann,O.,
            Brauer,A.U., Franke,K., Schumacher,S., Techritz,S., Nitsch,R.,
            Schuelke,M. and Pohl,E.E.
  TITLE     Comparative analysis of uncoupling protein 4 distribution in
            various tissues under physiological conditions and during
            development
  JOURNAL   Biochim Biophys Acta 1788 (10), 2309-2319 (2009)
   PUBMED   19646951
REFERENCE   4  (bases 1 to 1137)
  AUTHORS   Cioffi,F., Senese,R., de Lange,P., Goglia,F., Lanni,A. and
            Lombardi,A.
  TITLE     Uncoupling proteins: a complex journey to function discovery
  JOURNAL   Biofactors 35 (5), 417-428 (2009)
   PUBMED   19626697
  REMARK    Review article
REFERENCE   5  (bases 1 to 1137)
  AUTHORS   Echtay,K.S.
  TITLE     Mitochondrial uncoupling proteins--what is their physiological
            role?
  JOURNAL   Free Radic Biol Med 43 (10), 1351-1371 (2007)
   PUBMED   17936181
  REMARK    Review article
REFERENCE   6  (bases 1 to 1137)
  AUTHORS   Erlanson-Albertsson,C.
  TITLE     The role of uncoupling proteins in the regulation of metabolism
  JOURNAL   Acta Physiol Scand 178 (4), 405-412 (2003)
   PUBMED   12864746
  REMARK    Review article
REFERENCE   7  (bases 1 to 1137)
  AUTHORS   Yu,X.X., Mao,W., Zhong,A., Schow,P., Brush,J., Sherwood,S.W.,
            Adams,S.H. and Pan,G.
  TITLE     Characterization of novel UCP5/BMCP1 isoforms and differential
            regulation of UCP4 and UCP5 expression through dietary or
            temperature manipulation
  JOURNAL   FASEB J 14 (11), 1611-1618 (2000)
   PUBMED   10928996
REFERENCE   8  (bases 1 to 1137)
  AUTHORS   Adams,S.H.
  TITLE     Uncoupling protein homologs: emerging views of physiological
            function
  JOURNAL   J Nutr 130 (4), 711-714 (2000)
   PUBMED   10736318
  REMARK    Review article
REFERENCE   9  (bases 1 to 1137)
  AUTHORS   Stuart,J.A., Brindle,K.M., Harper,J.A. and Brand,M.D.
  TITLE     Mitochondrial proton leak and the uncoupling proteins
  JOURNAL   J Bioenerg Biomembr 31 (5), 517-525 (1999)
   PUBMED   10653479
  REMARK    Review article
REFERENCE   10 (bases 1 to 1137)
  AUTHORS   Sanchis,D., Fleury,C., Chomiki,N., Goubern,M., Huang,Q.,
            Neverova,M., Gregoire,F., Easlick,J., Raimbault,S.,
            Levi-Meyrueis,C., Miroux,B., Collins,S., Seldin,M., Richard,D.,
            Warden,C., Bouillaud,F. and Ricquier,D.
  TITLE     BMCP1, a novel mitochondrial carrier with high expression in the
            central nervous system of humans and rodents, and respiration
            uncoupling activity in recombinant yeast
  JOURNAL   J Biol Chem 273 (51), 34611-34615 (1998)
   PUBMED   9852133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669901.26 and AL672042.8.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253013.4677018.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-77                AL669901.26        195170-195246
            78-125              AL669901.26        199554-199601
            126-219             AL669901.26        200670-200763
            220-367             AL669901.26        202307-202454
            368-462             AL669901.26        206175-206269
            463-548             AL669901.26        208808-208893
            549-644             AL669901.26        211653-211748
            645-725             AL672042.8         7981-8061
            726-1137            AL672042.8         9175-9586
FEATURES             Location/Qualifiers
     source          1..1137
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 25.69 cM"
     gene            1..1137
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     brain), member 14"
                     /db_xref="GeneID:20523"
                     /db_xref="MGI:MGI:1330823"
     exon            1..77
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            78..125
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            126..219
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..767
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="isoform 6 is encoded by transcript variant 19;
                     brain mitochondrial carrier protein 1; mitochondrial
                     uncoupling protein 5"
                     /codon_start=1
                     /product="brain mitochondrial carrier protein 1 isoform 6"
                     /protein_id="NP_001390194.1"
                     /db_xref="GeneID:20523"
                     /db_xref="MGI:MGI:1330823"
                     /translation="MSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDVRF
                     KEIKYRGMFHALFRIYKEEGILALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLE
                     DETLLINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRG
                     LWRMWKHEGFFALYKGFWPNWLRLGPWNIIFFITYEQLKRLQI"
     exon            220..367
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            368..462
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            463..548
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            549..644
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            645..725
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            726..1137
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1116..1121
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="hexamer: ATTAAA"
     polyA_site      1137
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="major polyA site"
ORIGIN      
        1 gcttccgggt tggcgctgcg gtggcgtttc ctactgtggt agcctccgct tcccagtcgt
       61 ctgctgagct tgagcagaaa atggaggcag agaaagattg aattactttc ccagagccac
      121 gactacatca gaaaagttcc actttaagcc atgagatgtc tggtctgaac tggaaacctt
      181 ttgtgtatgg cggccttgcc tctattgttg ccgagttcgg cactttccct gtggatctta
      241 ctaaaacacg gctgcaagtc caaggccaga gtatcgatgt tcgtttcaaa gaaataaaat
      301 atagagggat gtttcatgcc ttgttccgaa tctataaaga agaagggatc ttggctctgt
      361 attcaggaat tgcccctgcg ttactaagac aggcatcata tggcaccatc aaaattggta
      421 tttatcaaag cttgaagcga ttatttgtag aacgtttgga agatgagact ctcctaatta
      481 acatgatctg tggggtagtg tcaggagtga tttcctctac tattgccaat cccactgatg
      541 ttctaaagat tcgaatgcag gctcaaggaa gtttgttcca agggagcatg attggcagct
      601 tcattgacat ataccagcaa gaaggtacca ggggtctgtg gaggatgtgg aagcatgagg
      661 gattttttgc actctataaa ggattttggc caaactggct tcgacttgga ccctggaaca
      721 tcattttttt tattacctat gagcagctca agaggcttca gatctaagac ctggaaaccc
      781 atcagcccag ccctgccacc gtttctaccg gtcctctttg tgttcctgat gtattttgac
      841 aaagatgttt gtgtttacag aagcagcggg ctgaagagtt gtagggtgac tgaaggttgt
      901 tttgcatttg tgttgcctct tccctgagag gaagtatcga ctttgagagt gtgaccccag
      961 attggtgtct tctgtgaaga tggatactgg tgggtgacat tcaaaagggc cttcttttca
     1021 actgtgagtt aaacgtagtt ggttttcccc agacaggcta cagcagcagg ctaccagcac
     1081 agttcctgct atgtatgctt ttgaccttgg ttctcattaa agtatttatt ggttgaa
//
