LOCUS       NM_001290705            1481 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            brain), member 14 (Slc25a14), transcript variant 5, mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001290705 XM_006541446 XM_006541447
VERSION     NM_001290705.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1481)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1481)
  AUTHORS   Ji,F., Shen,T., Zou,W. and Jiao,J.
  TITLE     UCP2 Regulates Embryonic Neurogenesis via ROS-Mediated Yap
            Alternation in the Developing Neocortex
  JOURNAL   Stem Cells 35 (6), 1479-1492 (2017)
   PUBMED   28276603
REFERENCE   3  (bases 1 to 1481)
  AUTHORS   Smorodchenko,A., Rupprecht,A., Sarilova,I., Ninnemann,O.,
            Brauer,A.U., Franke,K., Schumacher,S., Techritz,S., Nitsch,R.,
            Schuelke,M. and Pohl,E.E.
  TITLE     Comparative analysis of uncoupling protein 4 distribution in
            various tissues under physiological conditions and during
            development
  JOURNAL   Biochim Biophys Acta 1788 (10), 2309-2319 (2009)
   PUBMED   19646951
REFERENCE   4  (bases 1 to 1481)
  AUTHORS   Cioffi,F., Senese,R., de Lange,P., Goglia,F., Lanni,A. and
            Lombardi,A.
  TITLE     Uncoupling proteins: a complex journey to function discovery
  JOURNAL   Biofactors 35 (5), 417-428 (2009)
   PUBMED   19626697
  REMARK    Review article
REFERENCE   5  (bases 1 to 1481)
  AUTHORS   Echtay,K.S.
  TITLE     Mitochondrial uncoupling proteins--what is their physiological
            role?
  JOURNAL   Free Radic Biol Med 43 (10), 1351-1371 (2007)
   PUBMED   17936181
  REMARK    Review article
REFERENCE   6  (bases 1 to 1481)
  AUTHORS   Erlanson-Albertsson,C.
  TITLE     The role of uncoupling proteins in the regulation of metabolism
  JOURNAL   Acta Physiol Scand 178 (4), 405-412 (2003)
   PUBMED   12864746
  REMARK    Review article
REFERENCE   7  (bases 1 to 1481)
  AUTHORS   Yu,X.X., Mao,W., Zhong,A., Schow,P., Brush,J., Sherwood,S.W.,
            Adams,S.H. and Pan,G.
  TITLE     Characterization of novel UCP5/BMCP1 isoforms and differential
            regulation of UCP4 and UCP5 expression through dietary or
            temperature manipulation
  JOURNAL   FASEB J 14 (11), 1611-1618 (2000)
   PUBMED   10928996
REFERENCE   8  (bases 1 to 1481)
  AUTHORS   Adams,S.H.
  TITLE     Uncoupling protein homologs: emerging views of physiological
            function
  JOURNAL   J Nutr 130 (4), 711-714 (2000)
   PUBMED   10736318
  REMARK    Review article
REFERENCE   9  (bases 1 to 1481)
  AUTHORS   Stuart,J.A., Brindle,K.M., Harper,J.A. and Brand,M.D.
  TITLE     Mitochondrial proton leak and the uncoupling proteins
  JOURNAL   J Bioenerg Biomembr 31 (5), 517-525 (1999)
   PUBMED   10653479
  REMARK    Review article
REFERENCE   10 (bases 1 to 1481)
  AUTHORS   Sanchis,D., Fleury,C., Chomiki,N., Goubern,M., Huang,Q.,
            Neverova,M., Gregoire,F., Easlick,J., Raimbault,S.,
            Levi-Meyrueis,C., Miroux,B., Collins,S., Seldin,M., Richard,D.,
            Warden,C., Bouillaud,F. and Ricquier,D.
  TITLE     BMCP1, a novel mitochondrial carrier with high expression in the
            central nervous system of humans and rodents, and respiration
            uncoupling activity in recombinant yeast
  JOURNAL   J Biol Chem 273 (51), 34611-34615 (1998)
   PUBMED   9852133
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL669901.26 and AL672042.8.
            
            On or before Mar 29, 2022 this sequence version replaced
            XM_006541446.2, NM_001290705.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17253014.5435007.1,
                                           SRR17253011.1039898.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL669901.26        194874-194926
            54-208              AL669901.26        195092-195246
            209-302             AL669901.26        200670-200763
            303-450             AL669901.26        202307-202454
            451-545             AL669901.26        206175-206269
            546-631             AL669901.26        208808-208893
            632-727             AL669901.26        211653-211748
            728-852             AL669901.26        223348-223472
            853-988             AL669901.26        224785-224920
            989-1069            AL672042.8         7981-8061
            1070-1481           AL672042.8         9175-9586
FEATURES             Location/Qualifiers
     source          1..1481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 25.69 cM"
     gene            1..1481
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     brain), member 14"
                     /db_xref="GeneID:20523"
                     /db_xref="MGI:MGI:1330823"
     exon            1..53
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            54..208
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     CDS             77..1111
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="isoform 5 is encoded by transcript variant 5; brain
                     mitochondrial carrier protein 1; mitochondrial uncoupling
                     protein 5"
                     /codon_start=1
                     /product="brain mitochondrial carrier protein 1 isoform 5"
                     /protein_id="NP_001277634.1"
                     /db_xref="GeneID:20523"
                     /db_xref="MGI:MGI:1330823"
                     /translation="MAAPLLPRRRLGYFRRFQCFRVGAAVAFPTVVASASQSSAELEQ
                     HQKSSTLSHEMSGLNWKPFVYGGLASIVAEFGTFPVDLTKTRLQVQGQSIDVRFKEIK
                     YRGMFHALFRIYKEEGILALYSGIAPALLRQASYGTIKIGIYQSLKRLFVERLEDETL
                     LINMICGVVSGVISSTIANPTDVLKIRMQAQGSLFQGSMIGSFIDIYQQEGTRGLWRG
                     VVPTAQRAAIVVGVELPVYDITKKHLIVSGMLGDTILTHFVSSFTCGLAGALASNPVD
                     VVRTRMMNQRAIVGHVDLYKGTLDGILKMWKHEGFFALYKGFWPNWLRLGPWNIIFFI
                     TYEQLKRLQI"
     exon            209..302
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            303..450
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            451..545
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            546..631
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            632..727
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            728..852
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            853..988
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1069
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1481
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1460..1465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="hexamer: ATTAAA"
     polyA_site      1481
                     /gene="Slc25a14"
                     /gene_synonym="BMCP1; UCP5; UCP5L; UCP5S"
                     /note="major polyA site"
ORIGIN      
        1 ggctggtaaa tgcagcgtgg gcgggtgaca aggcgcctcc tctgctctca ctggctagga
       61 gtgggcggag tttaggatgg ctgcgccact gttgccgagg cgacgccttg gttacttccg
      121 tcggtttcaa tgcttccggg ttggcgctgc ggtggcgttt cctactgtgg tagcctccgc
      181 ttcccagtcg tctgctgagc ttgagcagca tcagaaaagt tccactttaa gccatgagat
      241 gtctggtctg aactggaaac cttttgtgta tggcggcctt gcctctattg ttgccgagtt
      301 cggcactttc cctgtggatc ttactaaaac acggctgcaa gtccaaggcc agagtatcga
      361 tgttcgtttc aaagaaataa aatatagagg gatgtttcat gccttgttcc gaatctataa
      421 agaagaaggg atcttggctc tgtattcagg aattgcccct gcgttactaa gacaggcatc
      481 atatggcacc atcaaaattg gtatttatca aagcttgaag cgattatttg tagaacgttt
      541 ggaagatgag actctcctaa ttaacatgat ctgtggggta gtgtcaggag tgatttcctc
      601 tactattgcc aatcccactg atgttctaaa gattcgaatg caggctcaag gaagtttgtt
      661 ccaagggagc atgattggca gcttcattga catataccag caagaaggta ccaggggtct
      721 gtggaggggt gtggtcccaa ctgctcagcg tgctgcaatc gttgtgggag tagagctgcc
      781 cgtttatgat attaccaaga agcacctgat agtttcagga atgctgggag acacaatttt
      841 aacacacttt gtttccagtt tcacctgtgg tttggctggg gctctggcat ctaaccctgt
      901 ggatgtggtg agaactcgaa tgatgaatca gagggcaata gtgggacatg tggacctcta
      961 caagggtact ttggatggta ttttaaagat gtggaagcat gagggatttt ttgcactcta
     1021 taaaggattt tggccaaact ggcttcgact tggaccctgg aacatcattt tttttattac
     1081 ctatgagcag ctcaagaggc ttcagatcta agacctggaa acccatcagc ccagccctgc
     1141 caccgtttct accggtcctc tttgtgttcc tgatgtattt tgacaaagat gtttgtgttt
     1201 acagaagcag cgggctgaag agttgtaggg tgactgaagg ttgttttgca tttgtgttgc
     1261 ctcttccctg agaggaagta tcgactttga gagtgtgacc ccagattggt gtcttctgtg
     1321 aagatggata ctggtgggtg acattcaaaa gggccttctt ttcaactgtg agttaaacgt
     1381 agttggtttt ccccagacag gctacagcag caggctacca gcacagttcc tgctatgtat
     1441 gcttttgacc ttggttctca ttaaagtatt tattggttga a
//
