LOCUS       NM_015829               3092 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            adenine nucleotide translocator), member 13 (Slc25a13), transcript
            variant 1, mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_015829
VERSION     NM_015829.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3092)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3092)
  AUTHORS   Gonzalez-Moreno,L., Santamaria-Cano,A., Paradela,A.,
            Martinez-Chantar,M.L., Martin,M.A., Perez-Carreras,M.,
            Garcia-Picazo,A., Vazquez,J., Calvo,E., Gonzalez-Aseguinolaza,G.,
            Saheki,T., Del Arco,A., Satrustegui,J. and Contreras,L.
  TITLE     Exogenous aralar/slc25a12 can replace citrin/slc25a13 as malate
            aspartate shuttle component in liver
  JOURNAL   Mol Genet Metab Rep 35, 100967 (2023)
   PUBMED   36967723
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3092)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3092)
  AUTHORS   Saheki,T., Moriyama,M., Kuroda,E., Funahashi,A., Yasuda,I.,
            Setogawa,Y., Gao,Q., Ushikai,M., Furuie,S., Yamamura,K.I.,
            Takano,K., Nakamura,Y., Eto,K., Kadowaki,T., Sinasac,D.S.,
            Furukawa,T., Horiuchi,M. and Tai,Y.H.
  TITLE     Pivotal role of inter-organ aspartate metabolism for treatment of
            mitochondrial aspartate-glutamate carrier 2 (citrin) deficiency,
            based on the mouse model
  JOURNAL   Sci Rep 9 (1), 4179 (2019)
   PUBMED   30862943
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3092)
  AUTHORS   Johnson,K.R., Gagnon,L.H., Tian,C., Longo-Guess,C.M., Low,B.E.,
            Wiles,M.V. and Kiernan,A.E.
  TITLE     Deletion of a Long-Range Dlx5 Enhancer Disrupts Inner Ear
            Development in Mice
  JOURNAL   Genetics 208 (3), 1165-1179 (2018)
   PUBMED   29301908
REFERENCE   6  (bases 1 to 3092)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   7  (bases 1 to 3092)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   8  (bases 1 to 3092)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 3092)
  AUTHORS   del Arco,A., Morcillo,J., Martinez-Morales,J.R., Galian,C.,
            Martos,V., Bovolenta,P. and Satrustegui,J.
  TITLE     Expression of the aspartate/glutamate mitochondrial carriers
            aralar1 and citrin during development and in adult rat tissues
  JOURNAL   Eur J Biochem 269 (13), 3313-3320 (2002)
   PUBMED   12084073
  REMARK    GeneRIF: Expression of the aspartate/glutamate mitochondrial
            carriers aralar1 and citrin during development(CITRIN)
REFERENCE   10 (bases 1 to 3092)
  AUTHORS   Sinasac,D.S., Crackower,M.A., Lee,J.R., Kobayashi,K., Saheki,T.,
            Scherer,S.W. and Tsui,L.C.
  TITLE     Genomic structure of the adult-onset type II citrullinemia gene,
            SLC25A13, and cloning and expression of its mouse homologue
  JOURNAL   Genomics 62 (2), 289-292 (1999)
   PUBMED   10610724
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC091396.4 and AC023175.4.
            
            On Aug 13, 2022 this sequence version replaced NM_015829.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF164632.1, AK002829.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-148               AC091396.4         125785-125932       c
            149-202             AC091396.4         100053-100106       c
            203-345             AC091396.4         89760-89902         c
            346-461             AC091396.4         61197-61312         c
            462-601             AC091396.4         40418-40557         c
            602-748             AC091396.4         25888-26034         c
            749-887             AC091396.4         23759-23897         c
            888-981             AC091396.4         23014-23107         c
            982-1066            AC091396.4         22727-22811         c
            1067-1154           AC091396.4         18726-18813         c
            1155-1313           AC091396.4         17970-18128         c
            1314-1366           AC023175.4         187561-187613       c
            1367-1447           AC023175.4         186038-186118       c
            1448-1588           AC023175.4         164293-164433       c
            1589-1727           AC023175.4         143656-143794       c
            1728-1886           AC023175.4         133632-133790       c
            1887-1977           AC023175.4         133450-133540       c
            1978-3092           AC023175.4         132109-133223       c
FEATURES             Location/Qualifiers
     source          1..3092
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.3 cM"
     gene            1..3092
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     adenine nucleotide translocator), member 13"
                     /db_xref="GeneID:50799"
                     /db_xref="MGI:MGI:1354721"
     exon            1..148
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     CDS             134..2164
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /note="isoform 1 is encoded by transcript variant 1;
                     citrin; solute carrier family 25, member 13;
                     calcium-binding mitochondrial carrier protein Aralar2;
                     mitochondrial aspartate glutamate carrier 2; electrogenic
                     aspartate/glutamate antiporter SLC25A13, mitochondrial"
                     /codon_start=1
                     /product="electrogenic aspartate/glutamate antiporter
                     SLC25A13, mitochondrial isoform 1"
                     /protein_id="NP_056644.1"
                     /db_xref="CCDS:CCDS39421.1"
                     /db_xref="GeneID:50799"
                     /db_xref="MGI:MGI:1354721"
                     /translation="MAAAKVALTKRADPAELKAIFLKYASIEKNGEFFMSPHDFVTRY
                     LNIFGESQPNPKTVELLSGVVDQTKDGLISFQEFVAFESVLCAPDALFMVAFQLFDKA
                     GKGEVTFEDVKQIFGQTTIHQHIPFNWDSEFVQLHFGKERKRHLTYAEFTQFLLEIQL
                     EHAKQAFVQRDNAKTGKVSAIDFRDIMVTIRPHVLTPFVEECLVAAAGGTRSHQVSFS
                     YFNGFNSLLNNMELIRKIYSTLAGNRKDVEVTKEEFALAAQKFGQVTPMEVDILFQLA
                     DLYEPRGRMTLADIERIAPLEEGMLPFNLAEAQRQQKASGDAARPFLLQLAESAYRFG
                     LGSIAGAVGATAVYPIDLVKTRMQNQRSTGSFVGELMYKNSFDCFKKVLRYEGFFGLY
                     RGLLPQLLGVAPEKAIKLTVNDFVRDKFMHKDGSVPLLAEIFAGGCAGGSQVIFTNPL
                     EIVKIRLQVAGEITTGPRVSALSVVRDLGFFGIYKGAKACFLRDIPFSAIYFPCYAHV
                     KASFANEDGQVSPGSLLLAGAIAGMPAASLVTPADVIKTRLQVAARAGQTTYNGVTDC
                     FRKILREEGPKALWKGVAARVFRSSPQFGVTLLTYELLQRWFYVDFGGVKPVGSEPVP
                     KSRITLPAPNPDHVGGYKLAVATFAGIENKFGLYLPLFKPSASTSKVTAGDS"
     exon            149..202
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            203..345
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            346..461
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            462..601
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            602..748
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            749..887
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            888..981
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1066
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1154
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1155..1313
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1366
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1367..1447
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1448..1588
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1589..1727
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1728..1886
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1887..1977
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     exon            1978..3092
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3072..3077
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /note="hexamer: AATAAA"
     polyA_site      3092
                     /gene="Slc25a13"
                     /gene_synonym="Ctrn"
                     /note="major polyA site"
ORIGIN      
        1 aggccaggcg cgcacgctgc cgggcagaat caccgccccc acctctgctc gggacgggaa
       61 gtgagtcgcc ggggtccccg gtgcaatcca accagagagc aggtctcaaa gccgcctgta
      121 ccccggccga agcatggcgg ccgccaaggt ggctttaacc aagagagccg atccagctga
      181 gcttaaagca atatttttga agtatgcgag cattgaaaaa aatggtgaat tttttatgtc
      241 tcctcatgac tttgtcactc ggtatttgaa tatttttgga gaaagccagc ccaacccgaa
      301 aactgtggaa cttttaagtg gtgtagtgga tcagaccaaa gatgggttaa tatccttcca
      361 agagtttgta gcctttgagt ctgtcctgtg tgctccggat gccttgttta tggtggcgtt
      421 ccagctgttt gacaaagctg gcaaaggaga ggttactttt gaggatgtca agcaaatttt
      481 tggacagact acaattcatc aacatattcc atttaactgg gattcagaat ttgtgcagct
      541 acattttgga aaagaaagaa aaaggcacct tacatatgcg gagttcactc agtttttgtt
      601 ggaaatacag ttggagcacg cgaagcaagc ctttgtgcaa cgagacaatg ccaagacagg
      661 caaagtctca gccattgact tccgggacat catggtcacc atccgtcccc atgtcctgac
      721 gccttttgtt gaggaatgtc tagtagctgc tgctggaggc actaggtccc atcaagttag
      781 cttctcctat tttaatggat ttaattcgct ccttaacaac atggaactca ttaggaagat
      841 ctacagtact ctggctggca acaggaaaga cgtggaggtg actaaggagg agttcgcttt
      901 ggcagcccag aagtttggtc aggttacacc catggaagtt gacatcttgt ttcagttagc
      961 agatttatat gagccgaggg ggcgcatgac cttagcagac attgagcgga tcgcccctct
     1021 agaggaagga atgttaccct tcaacttggc cgaggcccag aggcagcaga aggcctcggg
     1081 tgatgctgct cggccctttc ttctgcagct cgcagagtca gcctacaggt ttggactggg
     1141 ttctattgct ggagctgtcg gagccactgc cgtgtatcct atcgatcttg taaagactcg
     1201 aatgcagaac cagagatcaa ccggctcttt tgtgggcgag ctcatgtata aaaacagctt
     1261 tgactgcttt aagaaggtgc tccgctacga aggcttcttt ggactgtacc gaggtttgct
     1321 gccacagtta ctgggagtcg ccccggagaa ggccataaaa cttacagtga acgattttgt
     1381 gagagataaa tttatgcaca aagatggctc cgtcccactt ttggcagaga tttttgctgg
     1441 aggctgtgct ggaggctccc aagtgatttt cacaaatcct ttagagattg tgaaaatccg
     1501 cttacaagtg gccggagaga tcaccactgg cccccgagtc agcgccctgt cggtggtacg
     1561 agacctgggg ttctttggca tctacaaggg cgccaaagca tgcttcctga gggacattcc
     1621 tttctcagcc atctacttcc cgtgctatgc ccacgtgaag gcttcctttg caaatgaaga
     1681 cgggcaggtc agccccggaa gcctgctctt agccggtgct attgctggta tgcctgcggc
     1741 atctttagtg acccctgctg atgttatcaa gactagatta caggtggctg cccgggctgg
     1801 ccaaaccact tacaacggtg tgaccgactg cttcagaaag atacttcgag aagagggccc
     1861 caaagcattg tggaaaggag ttgctgctcg tgtcttccgc tcctcgcccc agtttggtgt
     1921 caccttgctt acgtatgaat tgctgcagcg gtggttctat gtcgattttg gaggcgtgaa
     1981 gcccgtggga tctgagccgg ttcctaaatc ccggattact ctgcccgctc ccaatcctga
     2041 ccacgtaggg ggctacaaac tggccgttgc cacattcgca gggattgaga acaaatttgg
     2101 actttaccta cctctcttta agccatcagc atctacctca aaagtgactg ctggggactc
     2161 ctagagtgac tgacctggat gtgcctgtaa aatgattgga accacaataa gcctcatctg
     2221 ggtctgaggc ctggctccgt cccttccaca tctgtcccat ttaaattcag gtcaatgctt
     2281 cctatattaa atgcaatcat tcatttttct ggatgttttt gtagcaagat catggggaat
     2341 tattcctaat tatcctttgg cactttgccc acaacctgtg tttgtatctt ttaaatactg
     2401 ggatttggtc aatactaact tgatgtggag taagtctgaa gggaaattaa ggaggtctcc
     2461 tacctggatg atggtctcac taatgctact gaaaggcggc catggtttcc aaaagacttc
     2521 tgagtatgtt taaagtagta gaaagcaaag tatatattta taaaaatgaa aaacactgga
     2581 aaggaaaaaa aaacccaaat atctagcctg gactcaaatt ttaaacatgc acaaatttgg
     2641 cctctggatt atattatgaa ggttttatgt gaaacatgtt ttttcataat gaaaaccaca
     2701 ttcaggatgt ttagcaatca tattctcttg ctatagcaag tctactaggg aaaagtctcg
     2761 aatgctaagg aagtgctttg ggccgtttta ttatagagac agaagaaaca caattctgct
     2821 cctgggtgta ctgatttgaa ataaatatgt atatgatgaa cacatgctga ttccaatttt
     2881 aacagacact gtaagaataa cagacacccc tttttgctgg taccaccctc ctcgagtccc
     2941 catggttggc acccttttgc cttaaaaatc aactttctct tgaatcatgt cagacagata
     3001 tgctctaagt ttataattga tttggggtgc cttgtatcat ggtcagaggc ttgtgtgttt
     3061 gtgaagggaa aaataaacta tttttaaagc ta
//
