LOCUS       NM_024211               1869 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier
            oxoglutarate carrier), member 11 (Slc25a11), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_024211 XM_001471709
VERSION     NM_024211.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1869)
  AUTHORS   Yuan,Y., Zhu,C., Wang,Y., Sun,J., Feng,J., Ma,Z., Li,P., Peng,W.,
            Yin,C., Xu,G., Xu,P., Jiang,Y., Jiang,Q. and Shu,G.
  TITLE     alpha-Ketoglutaric acid ameliorates hyperglycemia in diabetes by
            inhibiting hepatic gluconeogenesis via serpina1e signaling
  JOURNAL   Sci Adv 8 (18), eabn2879 (2022)
   PUBMED   35507647
REFERENCE   2  (bases 1 to 1869)
  AUTHORS   Bailis,W., Shyer,J.A., Zhao,J., Canaveras,J.C.G., Al Khazal,F.J.,
            Qu,R., Steach,H.R., Bielecki,P., Khan,O., Jackson,R., Kluger,Y.,
            Maher,L.J. 3rd, Rabinowitz,J., Craft,J. and Flavell,R.A.
  TITLE     Distinct modes of mitochondrial metabolism uncouple T cell
            differentiation and function
  JOURNAL   Nature 571 (7765), 403-407 (2019)
   PUBMED   31217581
  REMARK    Erratum:[Nature. 2019 Sep;573(7773):E2. doi:
            10.1038/s41586-019-1490-y.. PMID: 31447485]
REFERENCE   3  (bases 1 to 1869)
  AUTHORS   Lee,J.S., Lee,H., Lee,S., Kang,J.H., Lee,S.H., Kim,S.G., Cho,E.S.,
            Kim,N.H., Yook,J.I. and Kim,S.Y.
  TITLE     Loss of SLC25A11 causes suppression of NSCLC and melanoma tumor
            formation
  JOURNAL   EBioMedicine 40, 184-197 (2019)
   PUBMED   30686754
  REMARK    GeneRIF: Cancer cells critically depended on the oxoglutarate
            carrier SLC25A11 for transporting NADH from cytosol to mitochondria
            as a malate form for the purpose of ATP production
REFERENCE   4  (bases 1 to 1869)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   5  (bases 1 to 1869)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   6  (bases 1 to 1869)
  AUTHORS   Watters,J.W. and Dietrich,W.F.
  TITLE     Genetic, physical, and transcript map of the Ltxs1 region of mouse
            chromosome 11
  JOURNAL   Genomics 73 (2), 223-231 (2001)
   PUBMED   11318612
  REMARK    Erratum:[Genomics 2002 Mar;79(3):462]
REFERENCE   7  (bases 1 to 1869)
  AUTHORS   Sluse,F.E., Goffart,G. and Liebecq,C.
  TITLE     Mechanism of the exchanges catalysed by the oxoglutarate
            translocator of rat-heart mitochondria. Kinetics of the
            external-product inhibition
  JOURNAL   Eur J Biochem 32 (2), 283-291 (1973)
   PUBMED   4687397
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY006289.1, AI931249.1, AK009487.1 and AI196845.1.
            
            On Nov 14, 2011 this sequence version replaced NM_024211.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660817.59229.1, BC019631.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-43                BY006289.1         3-45
            44-55               AI931249.1         5-16
            56-1688             AK009487.1         2-1634
            1689-1869           AI196845.1         1-181               c
FEATURES             Location/Qualifiers
     source          1..1869
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 43.21 cM"
     gene            1..1869
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /note="solute carrier family 25 (mitochondrial carrier
                     oxoglutarate carrier), member 11"
                     /db_xref="GeneID:67863"
                     /db_xref="MGI:MGI:1915113"
     exon            1..272
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1122
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /note="OGCP; solute carrier family 25 member 11;
                     alpha-oxoglutarate carrier"
                     /codon_start=1
                     /product="mitochondrial 2-oxoglutarate/malate carrier
                     protein"
                     /protein_id="NP_077173.1"
                     /db_xref="CCDS:CCDS24958.1"
                     /db_xref="GeneID:67863"
                     /db_xref="MGI:MGI:1915113"
                     /translation="MAATASPGAGRMDGKPRTSPKSVKFLFGGLAGMGATVFVQPLDL
                     VKNRMQLSGEGAKTREYKTSFHALTSILKTEGLKGIYTGLSAGLLRQATYTTTRLGIY
                     TVLFERLTGADGTPPGFLLKALIGMTAGATGAFVGTPAEVALIRMTADGRLPADQRRG
                     YKNVFNALVRIAREEGVPTLWRGCIPTMARAVVVNAAQLASYSQSKQFLLDSGYFSDN
                     ILCHFCASMISGLVTTAASMPVDIVKTRIQNMRMIDGKPEYKNGLDVLLKVVRYEGFF
                     SLWKGFTPYYARLGPHTVLTFIFLEQMNKAYKRLFLSG"
     exon            273..425
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     exon            426..632
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     exon            633..723
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     exon            724..814
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     exon            815..914
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     exon            915..966
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1869
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1543..1548
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /note="hexamer: AATAAA"
     polyA_site      1565
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /note="major polyA site"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /note="hexamer: AAGAAA"
     polyA_site      1692
                     /gene="Slc25a11"
                     /gene_synonym="2310022P18Rik; 2oxoc"
                     /note="major polyA site"
ORIGIN      
        1 ccccggctgc ctttgcgctc cgagcctgcg cccgccccag cttccagctg gagccagatt
       61 tgcctgtcgg aggggcgtgc gcgcgcgcgc cctcaccctg ttgcgcgctg gtgtcacctt
      121 gggcgcgagc ggggctgtac gtgcacggga cccaaagccg agggccatca aggggcgatg
      181 gcggcgacgg cgagtcctgg ggctggccgg atggacggga aaccccgtac ctcccctaag
      241 tctgtcaagt tcctgtttgg gggcctggct gggatgggtg ctacagtctt tgtgcagccc
      301 ctggacctgg tgaagaaccg gatgcagttg agtggtgaag gggccaagac tcgagagtac
      361 aaaaccagtt tccatgccct caccagcatc ctgaagacag aaggcctgaa gggcatttac
      421 actgggctgt cagctggtct actgcgccag gccacctaca ccactactcg ccttggaata
      481 tatactgtgt tgtttgagcg cctgactggg gctgatggta caccccctgg ctttcttctg
      541 aaagccctga ttggcatgac tgcaggtgca actggtgcat ttgtgggaac gccagctgag
      601 gtggctctca tcaggatgac tgctgatggt cggcttccag ctgaccagcg ccgtggctac
      661 aaaaatgtgt ttaatgccct agttaggatt gccagggaag aaggagtccc cacactgtgg
      721 cggggctgca tccctaccat ggctcgagct gtcgttgtca atgccgccca gcttgcctct
      781 tactctcaat ctaagcagtt cttgctggac tcaggctact tctctgacaa tattctctgc
      841 cacttctgcg ccagcatgat cagtggcctc gttaccactg ctgcttccat gcctgtggac
      901 atcgtcaaaa ctaggatcca gaatatgcgg atgattgatg ggaagccaga atacaagaat
      961 gggctggatg tgctgctgaa agtcgtccgc tatgagggtt tcttcagcct gtggaagggc
     1021 ttcacaccat actatgcccg actgggcccc cacactgtcc tcaccttcat cttcttggaa
     1081 cagatgaaca aggcctacaa gcgtctcttc ctcagtggct gatctggcat ggtcccagga
     1141 ctagtgtgcc aggcttccaa gccatccact gctattacag tcgctatgcc ctggaggacc
     1201 tggattctgc taccctgggc tattctattt attttccctc tccagtgtgg ttttctcctt
     1261 tgcggtaaag aacttagtct gttctccccc tactccagcc tgcctgctgt gcttgcctga
     1321 tgcttagaat cactttgccc ctggctcttc ctgaggagac ctaagacaca caccaaggat
     1381 ttctagtctc ctcttgggtg ttagattcag ggcacaccag acagcagatc cctctctctg
     1441 gggaatccaa ggcagagctg aggagacagg agaaagcaga agctgtcaag atgacaaagg
     1501 gtctatggtg gaagatgtgg ccttcctcct ccctgaggac ttaataaatt ggattgaaat
     1561 accaacccca aatctggata gtcttaagga tcataggggg aggtagctgc acaaagaagc
     1621 ttatatctct ggaaaacaaa ctggagtttt aacaaaataa ttaaagaaag tcacctactg
     1681 gttttatgaa aatgctgtgt aaagtcgtaa ctcaacagct gacagaaaag aagaagaagc
     1741 agcagcgctg ggcagtggtg gctcaggcct ttaatcccag cactcgggag gcagagacag
     1801 gcagatttct gagttcgagg ccatcttggc tatacagaga aaccctgtgt caaaaaacca
     1861 aaaaaaaaa
//
