LOCUS       NM_013770               4000 bp    mRNA    linear   ROD 24-DEC-2024
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            dicarboxylate transporter), member 10 (Slc25a10), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_013770
VERSION     NM_013770.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4000)
  AUTHORS   Xu,T. and Chen,G.
  TITLE     MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac Injury
            through Maintaining SLC25A10-Mediated Mitochondrial Glutathione
            Import
  JOURNAL   Int J Mol Sci 25 (19), 10832 (2024)
   PUBMED   39409161
  REMARK    GeneRIF: MPV17 Prevents Myocardial Ferroptosis and Ischemic Cardiac
            Injury through Maintaining SLC25A10-Mediated Mitochondrial
            Glutathione Import.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4000)
  AUTHORS   Dearden,L., Furigo,I.C., Pantaleao,L.C., Wong,L.W.P.,
            Fernandez-Twinn,D.S., de Almeida-Faria,J., Kentistou,K.A.,
            Carreira,M.V., Bidault,G., Vidal-Puig,A., Ong,K.K., Perry,J.R.B.,
            Donato,J. Jr. and Ozanne,S.E.
  TITLE     Maternal obesity increases hypothalamic miR-505-5p expression in
            mouse offspring leading to altered fatty acid sensing and increased
            intake of high-fat food
  JOURNAL   PLoS Biol 22 (6), e3002641 (2024)
   PUBMED   38833481
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4000)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4000)
  AUTHORS   An,Y.A., Chen,S., Deng,Y., Wang,Z.V., Funcke,J.B., Shah,M.,
            Shan,B., Gordillo,R., Yoshino,J., Klein,S., Kusminski,C.M. and
            Scherer,P.E.
  TITLE     The mitochondrial dicarboxylate carrier prevents hepatic
            lipotoxicity by inhibiting white adipocyte lipolysis
  JOURNAL   J Hepatol 75 (2), 387-399 (2021)
   PUBMED   33746082
REFERENCE   5  (bases 1 to 4000)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4000)
  AUTHORS   Mizuarai,S., Miki,S., Araki,H., Takahashi,K. and Kotani,H.
  TITLE     Identification of dicarboxylate carrier Slc25a10 as malate
            transporter in de novo fatty acid synthesis
  JOURNAL   J Biol Chem 280 (37), 32434-32441 (2005)
   PUBMED   16027120
  REMARK    GeneRIF: Slc25a10 plays an important role in supplying malate for
            citrate transport required for fatty acid synthesis and its
            inhibition might effectively reduce lipid accumulation in adipose
            tissues
REFERENCE   7  (bases 1 to 4000)
  AUTHORS   Mootha,V.K., Bunkenborg,J., Olsen,J.V., Hjerrild,M.,
            Wisniewski,J.R., Stahl,E., Bolouri,M.S., Ray,H.N., Sihag,S.,
            Kamal,M., Patterson,N., Lander,E.S. and Mann,M.
  TITLE     Integrated analysis of protein composition, tissue diversity, and
            gene regulation in mouse mitochondria
  JOURNAL   Cell 115 (5), 629-640 (2003)
   PUBMED   14651853
REFERENCE   8  (bases 1 to 4000)
  AUTHORS   Da Cruz,S., Xenarios,I., Langridge,J., Vilbois,F., Parone,P.A. and
            Martinou,J.C.
  TITLE     Proteomic analysis of the mouse liver mitochondrial inner membrane
  JOURNAL   J Biol Chem 278 (42), 41566-41571 (2003)
   PUBMED   12865426
REFERENCE   9  (bases 1 to 4000)
  AUTHORS   Das,K., Lewis,R.Y., Combatsiaris,T.P., Lin,Y., Shapiro,L.,
            Charron,M.J. and Scherer,P.E.
  TITLE     Predominant expression of the mitochondrial dicarboxylate carrier
            in white adipose tissue
  JOURNAL   Biochem J 344 Pt 2 (Pt 2), 313-320 (1999)
   PUBMED   10567211
REFERENCE   10 (bases 1 to 4000)
  AUTHORS   Fiermonte,G., Palmieri,L., Dolce,V., Lasorsa,F.M., Palmieri,F.,
            Runswick,M.J. and Walker,J.E.
  TITLE     The sequence, bacterial expression, and functional reconstitution
            of the rat mitochondrial dicarboxylate transporter cloned via
            distant homologs in yeast and Caenorhabditis elegans
  JOURNAL   J Biol Chem 273 (38), 24754-24759 (1998)
   PUBMED   9733776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK151645.1 and AK083831.1.
            
            On Jul 29, 2009 this sequence version replaced NM_013770.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083831.1, AK050282.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1970              AK151645.1         1-1970
            1971-3598           AK083831.1         1949-3576
            3599-3649           AK083831.1         3578-3628
            3650-4000           AK083831.1         3630-3980
FEATURES             Location/Qualifiers
     source          1..4000
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.19 cM"
     gene            1..4000
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     dicarboxylate transporter), member 10"
                     /db_xref="GeneID:27376"
                     /db_xref="MGI:MGI:1353497"
     exon            1..240
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..1014
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /note="solute carrier family 25 member 10; solute carrier
                     family 25 (mitochondrial carrier; adenine nucleotide
                     translocator), member 10; dicarboxylate ion carrier"
                     /codon_start=1
                     /product="mitochondrial dicarboxylate carrier"
                     /protein_id="NP_038798.2"
                     /db_xref="CCDS:CCDS25738.1"
                     /db_xref="GeneID:27376"
                     /db_xref="MGI:MGI:1353497"
                     /translation="MAEARASRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMT
                     GMALQVVRTDGFLALYNGLSASLCRQMTYSLTRFAIYETMRDYMTKDSQGPLPFYNKV
                     LLGGISGLTGGFVGTPADLVNVRMQNDMKLPPSQRRNYSHALDGLYRVAREESLRKLF
                     SGATMASSRGALVTVGQLSCYDQAKQLVLSTGYLSDNIFTHFVSSFIAGGCATFLCQP
                     LDVLKTRLMNSKGEYQGVFHCAMETAKLGPQAFFKGLFPAGIRLIPHTVLTFMFLEQL
                     RKHFGIKVPTT"
     exon            241..360
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            361..475
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            476..524
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            525..566
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            567..610
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            611..681
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            682..774
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            775..852
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            853..909
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     exon            910..4000
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1985..1990
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /note="hexamer: AATAAA"
     polyA_site      2026
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
                     /note="major polyA site"
     polyA_site      2042
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
     polyA_site      2512
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
     polyA_site      2593
                     /gene="Slc25a10"
                     /gene_synonym="Dic"
ORIGIN      
        1 ggcggagtcc ataggccccg cccccggggc tgcgcgggcg cattggctgt accgggcgcg
       61 ggcgctcggt agcactttga accgggcgtt gagcagctgg gaccggagtt gtgctcaccg
      121 gggtcgggcc aggtcgctgc tgctctggcc atggccgagg cacgcgcatc tcgctggtac
      181 tttggggggc tggcttcctg cggagccgct tgctgcacgc acccgctgga cctgctcaag
      241 gtgcatctac agacccaaca ggaggtgaag ctgcgcatga ctggaatggc actgcaggtg
      301 gtgcgaaccg atggcttcct ggcgctctac aacggcctga gtgcctcgct gtgcaggcag
      361 atgacctact ctctgactcg gttcgcaatc tacgagacca tgcgggacta catgaccaag
      421 gactcccagg ggcctctccc cttctacaac aaggtgttgc tgggcggcat cagtggttta
      481 actggaggct tcgtggggac cccagcagat ttggtcaatg tcaggatgca gaacgacatg
      541 aagctgcccc cgagccaacg acgcaactac tctcatgccc tggatggtct gtaccgtgta
      601 gcccgtgaag aaagcctgag gaagctcttc tctggagcaa ctatggcgtc cagccgtggg
      661 gccctcgtca ctgtgggcca gctgtcctgc tatgaccagg ccaagcaact ggtcctcagc
      721 actgggtacc tgagtgacaa catattcacc cactttgtct ccagtttcat tgccggcgga
      781 tgtgccacgt ttctgtgcca gcccctcgat gtgctgaaga ctcgcctgat gaactccaag
      841 ggcgagtacc agggtgtttt ccactgtgcc atggagacag caaagcttgg accccaggcc
      901 tttttcaagg gtctctttcc cgcgggcatc cgtctcatcc cccacactgt gctcactttc
      961 atgttcctgg agcagcttcg gaagcacttt ggcatcaaag tgccaaccac ctgacatggc
     1021 cagggacacc tgggccaggc tcggtcgctg tgctgagctc cttggaagag tgggaaggga
     1081 acgggctctc ttccttggcc tgggcccatg ctggtcccca gcaggctcct gctcttccct
     1141 gccttgggct gctggctatg ccttccgacc ctgccttggc cccactcaag tggcacctct
     1201 gccctactta ctcccaggct ctccccactg ggtcaccccg tcttcctatc cgatgattca
     1261 ctcagaagag gtctggcctg gctggtgtca ctgtccccac ctccctggct gctaccgtgc
     1321 cctgcctggc aagcccagcg aagccgagtt cgtttcctgc tcccgctggc cctctgtgca
     1381 gggagcagtt tccgcccaga acttgggtag tgtggcaggg tacggcccgt ggcagcttct
     1441 gcttaccaaa tgactagagc acacacacaa gcactttgtc acaagaggga ccaccgtgct
     1501 gtgttctgga aggtagtgcc ttcaggagag gggacaggca ggcagcgcag attaccagca
     1561 gaagccatga ccgtggagtc cagagaaagt gcctggggtt cccgagcgca cctcctgtat
     1621 gcagccttgg ctgctctaat ggtcagtttt gctgaaccct cctgctcagc ggctactgcc
     1681 gtcaccagga actgtctgtg tccctcacac gcctgtgccc tcccttgcct ggcttcccca
     1741 gggccaggtg ggcatgctgg cagagctggg gcagtgatgg attcatcgtt tgtgccctcc
     1801 caggacctgg cttcctgtat ggcaggcatc acccttcacc atccctcagg cttcgaagca
     1861 gcctgttttc cctcaaatgg ggttgtgtgt atcaaaacga ggttcggccc tgtgcctccc
     1921 acaggtcctc ccccaggaag tggcagcagc ccaggggcac tgcctacacc tctcttcagg
     1981 atctaataaa ccaagtggcc tgggaggcct ttctgtcttc cctgcacact tgggggctgg
     2041 cagatctttg agctccttca ccgctaagga caatgctgtc acctttgtat ccactaagtc
     2101 aggactacct tacaggatag agcctatggg aagaattctt agacgtctgt gagcaggagg
     2161 aaatggaaat aacaacagaa gcaggcctct ctagagccag tcccatgcag ctgctcactg
     2221 gccagatggc cggcaagcat gggagaacta aggatgccct ggggtgcaga cagactgaga
     2281 tgcccaggct atgacagttg tactggctta ggctgggcct aagagtattc aagtacgtaa
     2341 gcagaaacag gatgtcaact aggggtacca ggaccacagc tctgaacaca actgatgctt
     2401 gggtcagaag aaacccagtg cacttcactt caggggccac agcccaggta cgatcatgtc
     2461 ataggtataa acagttccgt ggacatttct gaagacacca agtttgccaa aactagagta
     2521 atttgttact tgggtaatgc aaggaagcct aatgttgcat ttccactcca gaatccagaa
     2581 cacctaacaa ctagactgtg tgggttttag tctctacagt gttgggtcaa accgtaggct
     2641 ttacacttgg tagccatgca ctgtggcagc cacatgccca gcctctcctg tatacctcac
     2701 agaaggggct gcaacccacc tggcctccta tgtgattgat attctgcctc agccttccca
     2761 ttactaagag gtcaagtgtg gactagctcc ttgtctagat accaagttct aggctagcca
     2821 aggctacatt gtgtggacta gccttgcaca caaacgtctc aagaaaacac gttctgtgtg
     2881 tggtggcttg tacctgccat ccctgcagat cagcatgtgt cgaaggccag ccctgggtac
     2941 tgagtgaggt cctcactcaa gggaacaggt gggtggagcc acaaggtcta accctaaagc
     3001 cagcggagaa aattatactg gtgtcccacc tgttgaccac aaaaacagat ctgtacatac
     3061 tactgcatct cggataggca ttctggttgg ggtagcgcag tgggagacac agatgagcag
     3121 gccattctag gttagaatcc acccttgtgg ctccccagaa gaactgtttc tccagatccc
     3181 agccagcttc caagaacttg ctcctaaacc agaaaccact ggctggtcaa gctcttcaca
     3241 gagcagcttt gatttggagc ccagaacagg tcttatctgt ggcaccaggg ctactgggga
     3301 agctgatact acacaccttt cctcccaggc agcctcactg gcggccagcc ctacccagca
     3361 aagtctccct ggaggcgaga aagtacccaa tctggtttgg tggggtcaga cctggcaaca
     3421 ggccctgcag ggcaaagggc ataagcttaa ggcaggcacc ttggcttccc taccacaggg
     3481 gagggcagct agaagagctt cctgccccct gcagagagag ctactgaggg aagggggaac
     3541 aactagggca ggtcagagga cggggagcag tcccattcca cttggaccct gggcacagtt
     3601 tcaaggcctc agctgtcagc acttttctgt caaccttagg cctttttttc cctaaaggat
     3661 gactttatag ttcaccaaaa ggtgaaaagt gactttttta ctgccaacag aggtgctggg
     3721 acatgtgtac aaaggaaaaa aaaaaatcac tttttgtgct tgctgtgtga acaagaacta
     3781 agttttgggt ccctgggtgg atggggggtg gtgggagggc agatgctctg accagcagcc
     3841 aatccagtca aattggcaag atccaggtag gtctggtgag agacactgtc tcgagatgga
     3901 gagaggaaga ctctgatatt gacctccagc ctctaaacat gcatacatgg gcacatgtgt
     3961 acacacacat ctttccaata aatgccaccg tgagagttgc
//
