LOCUS       NM_153150               1695 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus solute carrier family 25 (mitochondrial carrier,
            citrate transporter), member 1 (Slc25a1), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_153150
VERSION     NM_153150.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Rauckhorst,A.J., Sheldon,R.D., Pape,D.J., Ahmed,A.,
            Falls-Hubert,K.C., Merrill,R.A., Brown,R.F., Deshmukh,K.,
            Vallim,T.A., Deja,S., Burgess,S.C. and Taylor,E.B.
  TITLE     A hierarchical hepatic de novo lipogenesis substrate supply network
            utilizing pyruvate, acetate, and ketones
  JOURNAL   Cell Metab 37 (1), 255-273 (2025)
   PUBMED   39471817
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Ohanele,C., Peoples,J.N., Karlstaedt,A., Geiger,J.T., Gayle,A.D.,
            Ghazal,N., Sohani,F., Brown,M.E., Davis,M.E., Porter,G.A. Jr.,
            Faundez,V. and Kwong,J.Q.
  TITLE     The mitochondrial citrate carrier SLC25A1 regulates metabolic
            reprogramming and morphogenesis in the developing heart
  JOURNAL   Commun Biol 7 (1), 1422 (2024)
   PUBMED   39482367
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Zhang,R., Peng,X., Du,J.X., Boohaker,R., Estevao,I.L.,
            Grajeda,B.I., Cox,M.B., Almeida,I.C. and Lu,W.
  TITLE     Oncogenic KRASG12D Reprograms Lipid Metabolism by Upregulating
            SLC25A1 to Drive Pancreatic Tumorigenesis
  JOURNAL   Cancer Res 83 (22), 3739-3752 (2023)
   PUBMED   37695315
  REMARK    GeneRIF: Oncogenic KRASG12D Reprograms Lipid Metabolism by
            Upregulating SLC25A1 to Drive Pancreatic Tumorigenesis.
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Lund,J., Roe,B., Chen,F., Budarf,M., Galili,N., Riblet,R.,
            Miller,R.D., Emanuel,B.S. and Reeves,R.H.
  TITLE     Sequence-ready physical map of the mouse chromosome 16 region with
            conserved synteny to the human velocardiofacial syndrome region on
            22q11.2
  JOURNAL   Mamm Genome 10 (5), 438-443 (1999)
   PUBMED   10337614
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Sutherland,H.F., Kim,U.J. and Scambler,P.J.
  TITLE     Cloning and comparative mapping of the DiGeorge syndrome critical
            region in the mouse
  JOURNAL   Genomics 52 (1), 37-43 (1998)
   PUBMED   9740669
REFERENCE   8  (bases 1 to 1695)
  AUTHORS   Puech,A., Saint-Jore,B., Funke,B., Gilbert,D.J., Sirotkin,H.,
            Copeland,N.G., Jenkins,N.A., Kucherlapati,R., Morrow,B. and
            Skoultchi,A.I.
  TITLE     Comparative mapping of the human 22q11 chromosomal region and the
            orthologous region in mice reveals complex changes in gene
            organization
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14608-14613 (1997)
   PUBMED   9405660
REFERENCE   9  (bases 1 to 1695)
  AUTHORS   Botta,A., Lindsay,E.A., Jurecic,V. and Baldini,A.
  TITLE     Comparative mapping of the DiGeorge syndrome region in mouse shows
            inconsistent gene order and differential degree of gene
            conservation
  JOURNAL   Mamm Genome 8 (12), 890-895 (1997)
   PUBMED   9383280
  REMARK    Erratum:[Mamm Genome 1998 Apr;9(4):344]
REFERENCE   10 (bases 1 to 1695)
  AUTHORS   Galili,N., Baldwin,H.S., Lund,J., Reeves,R., Gong,W., Wang,Z.,
            Roe,B.A., Emanuel,B.S., Nayak,S., Mickanin,C., Budarf,M.L. and
            Buck,C.A.
  TITLE     A region of mouse chromosome 16 is syntenic to the DiGeorge,
            velocardiofacial syndrome minimal critical region
  JOURNAL   Genome Res 7 (1), 17-26 (1997)
   PUBMED   9037598
  REMARK    Erratum:[Genome Res. 1997 Apr;7(4):399.. PMID: 9110179]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ078562.1, AK159289.1, BB698147.1 and BU758271.1.
            
            On May 21, 2009 this sequence version replaced NM_153150.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK170191.1, BC037087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-39                CJ078562.1         2-40
            40-1322             AK159289.1         3-1285
            1323-1664           BB698147.1         115-456
            1665-1695           BU758271.1         1-31                c
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 11.11 cM"
     gene            1..1695
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /note="solute carrier family 25 (mitochondrial carrier,
                     citrate transporter), member 1"
                     /db_xref="GeneID:13358"
                     /db_xref="MGI:MGI:1345283"
     exon            1..234
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1076
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /note="DiGeorge syndrome gene j; citrate transport
                     protein; tricarboxylate carrier protein; solute carrier
                     family 25 member 1"
                     /codon_start=1
                     /product="tricarboxylate transport protein, mitochondrial"
                     /protein_id="NP_694790.1"
                     /db_xref="CCDS:CCDS28014.1"
                     /db_xref="GeneID:13358"
                     /db_xref="MGI:MGI:1345283"
                     /translation="MAAPRGPRALSAAAPGSGKPKLTHPGKAILAGGLAGGIEICITF
                     PTEYVKTQLQLDERANPPRYRGIGDCVRQTVRSHGVLGLYRGLSSLLYGSIPKAAVRF
                     GMFEFLSNHMRDAQGRLDSRRGLLCGLGAGVAEAVVVVCPMETIKVKFIHDQTSSNPK
                     YRGFFHGVREIIREQGLKGTYQGLTATVLKQGSNQAIRFFVMTSLRNWYQGDNHNKPM
                     NPLITGVFGATAGAASVFGNTPLDVIKTRMQGLEAHKYRNTLDCGLKILKNEGPKAFY
                     KGTVPRLGRVCLDVAIVFIIYDEVVKLLNKVWKTD"
     exon            235..342
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            343..442
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            443..581
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            582..666
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            667..771
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            772..887
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            888..961
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     exon            962..1678
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1646..1651
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /note="hexamer: AATAAA"
     polyA_site      1666
                     /gene="Slc25a1"
                     /gene_synonym="1300019P08Rik; 2610100G11Rik; Ctp; Dgsj;
                     Slc20a3"
                     /note="major polyA site"
ORIGIN      
        1 gggagctgac gtgaccaccc cgcctcccgg accagaattg gtcgtggtct cagtagcctc
       61 cggctccgct gcttcccgag aaccccgcgc cggaggctcg gacccgaggt cgacgccggg
      121 cgcctctcct cctgcccgct atggctgcgc ctcgcgggcc ccgcgctctg tcggccgccg
      181 cgccggggtc cgggaagccc aaactgacgc accccgggaa ggcaatccta gcaggcggcc
      241 tggctggagg catcgaaatc tgcatcacct tcccgaccga atacgtgaag acgcagctgc
      301 agctagatga acgagcgaac ccaccgcggt accggggcat cggagactgc gtgcggcaaa
      361 ctgtccgcag ccatggcgtc ctgggcctgt accgcggcct cagctccttg ctctacggct
      421 ccatccccaa ggcggctgtc aggtttggga tgttcgagtt cctcagcaac cacatgcggg
      481 atgcccaagg taggctcgac agcaggagag gactattgtg cggtctgggt gccggcgtgg
      541 cagaagcagt ggtagtcgtg tgccctatgg agaccatcaa ggtgaagttc atccatgacc
      601 agacttcctc caaccccaag taccgaggat ttttccacgg ggttagagag attattcggg
      661 aacaagggct aaagggaaca taccaaggcc ttactgcgac tgtactgaag cagggctcaa
      721 accaagccat ccgattcttt gtcatgacct ccctacgcaa ctggtaccaa ggagacaacc
      781 acaacaaacc tatgaaccca ctgatcacgg gggtctttgg agctactgcg ggtgcagcca
      841 gtgtctttgg aaacacacct ttggatgtga tcaagaccag gatgcagggc ctggaggcac
      901 acaaataccg gaacaccctg gactgcggct tgaagatcct aaagaatgag gggccaaagg
      961 cattctacaa gggcaccgtt ccccggctgg gccgagtctg cctggatgtg gccatcgtat
     1021 tcatcatcta cgatgaagtg gtgaagctgc tcaataaagt gtggaagaca gactaaccct
     1081 ggaggatgca gtggggtatc ccagctcctc cattccagac cccccgccac ctactctgat
     1141 gattccagtg cagtagtgcc aaaaggcccc ttcctttgtc cctcaagttc tgtggcctgg
     1201 tgtgtcccat agttctgtat atcccatgtg gtctgtgtgt gtgtaacact accattgtat
     1261 ctgtgtccag cctggccatg gctgggtgtc tctttggcct gtgaatatgt gctcacttat
     1321 ccatgtgctt gcttgtgagc cacatgcctg tttcgtgttc tctgtcatgt gaccctgtgc
     1381 cccacttcct ggggtgccta tgtgccctgg ttcatggcct tggagccatg gtcaggtcac
     1441 agtccggtgc cttccacccc ctatggcaag ggcgccctgc cttggcctac cacagctgcc
     1501 tccaggctta gacctggctt caccgcattc caggggctat aggcccccct gcttttcccg
     1561 ccattggcct taaatggccc tcgggccctc cctccgcccg gaacagggtg gcacctgcca
     1621 ctctcaggac caccttgcca aggagaataa accggatcct gttgcactct cctgtccaaa
     1681 aaaaaaaaaa aaaaa
//
