LOCUS       NM_175034               1641 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus solute carrier family 24, member 5 (Slc24a5), mRNA.
ACCESSION   NM_175034 XM_001002142
VERSION     NM_175034.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1641)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1641)
  AUTHORS   Zhang,Z., Gong,J., Sviderskaya,E.V., Wei,A. and Li,W.
  TITLE     Mitochondrial NCKX5 regulates melanosomal biogenesis and pigment
            production
  JOURNAL   J Cell Sci 132 (14) (2019)
   PUBMED   31201282
  REMARK    GeneRIF: NCKX5 is localized to mitochondria, not to melanosomes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1641)
  AUTHORS   De Maria,A., Zhao,H. and Bassnett,S.
  TITLE     Expression of potassium-dependent sodium-calcium exchanger in the
            murine lens
  JOURNAL   Exp Eye Res 167, 18-24 (2018)
   PUBMED   29128492
REFERENCE   4  (bases 1 to 1641)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 1641)
  AUTHORS   Szerencsei,R.T., Ginger,R.S., Green,M.R. and Schnetkamp,P.P.
  TITLE     Identification and Characterization of K(+)-Dependent Na(+)-Ca(2+)
            Exchange Transport in Pigmented MEB4 Cells Mediated by NCKX4
  JOURNAL   Biochemistry 55 (19), 2704-2712 (2016)
   PUBMED   27093457
REFERENCE   6  (bases 1 to 1641)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1641)
  AUTHORS   Vogel,P., Read,R.W., Vance,R.B., Platt,K.A., Troughton,K. and
            Rice,D.S.
  TITLE     Ocular albinism and hypopigmentation defects in Slc24a5-/- mice
  JOURNAL   Vet Pathol 45 (2), 264-279 (2008)
   PUBMED   18424845
  REMARK    GeneRIF: Mutation of Slc24a5 results in marked hypopigmentation of
            melanosomes in optic cup-derived pigmented epithelium in the eyes.
REFERENCE   8  (bases 1 to 1641)
  AUTHORS   Ginger,R.S., Askew,S.E., Ogborne,R.M., Wilson,S., Ferdinando,D.,
            Dadd,T., Smith,A.M., Kazi,S., Szerencsei,R.T., Winkfein,R.J.,
            Schnetkamp,P.P. and Green,M.R.
  TITLE     SLC24A5 encodes a trans-Golgi network protein with
            potassium-dependent sodium-calcium exchange activity that regulates
            human epidermal melanogenesis
  JOURNAL   J Biol Chem 283 (9), 5486-5495 (2008)
   PUBMED   18166528
  REMARK    GeneRIF: non-synonymous single nucleotide polymorphism in SLC24A5
            alters a residue that is important for NCKX5 and NCKX2 activity
REFERENCE   9  (bases 1 to 1641)
  AUTHORS   Lamason,R.L., Mohideen,M.A., Mest,J.R., Wong,A.C., Norton,H.L.,
            Aros,M.C., Jurynec,M.J., Mao,X., Humphreville,V.R., Humbert,J.E.,
            Sinha,S., Moore,J.L., Jagadeeswaran,P., Zhao,W., Ning,G.,
            Makalowska,I., McKeigue,P.M., O'donnell,D., Kittles,R., Parra,E.J.,
            Mangini,N.J., Grunwald,D.J., Shriver,M.D., Canfield,V.A. and
            Cheng,K.C.
  TITLE     SLC24A5, a putative cation exchanger, affects pigmentation in
            zebrafish and humans
  JOURNAL   Science 310 (5755), 1782-1786 (2005)
   PUBMED   16357253
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928902.16.
            
            On Jan 5, 2023 this sequence version replaced NM_175034.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094232.1, AK089225.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849388, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-146               AL928902.16        140373-140518
            147-326             AL928902.16        140989-141168
            327-410             AL928902.16        152838-152921
            411-514             AL928902.16        153011-153114
            515-615             AL928902.16        153444-153544
            616-899             AL928902.16        155248-155531
            900-1106            AL928902.16        157874-158080
            1107-1208           AL928902.16        159637-159738
            1209-1641           AL928902.16        160181-160613
FEATURES             Location/Qualifiers
     source          1..1641
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 61.14 cM"
     gene            1..1641
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /note="solute carrier family 24, member 5"
                     /db_xref="GeneID:317750"
                     /db_xref="MGI:MGI:2677271"
     exon            1..146
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            147..326
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            327..410
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            411..514
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            515..615
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            616..899
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            900..1106
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1208
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     exon            1209..1641
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1611..1616
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /note="hexamer: AATAAA"
     polyA_site      1641
                     /gene="Slc24a5"
                     /gene_synonym="F630045L20Rik; JSX; NCKX5; NCX5; Oca6"
                     /note="major polyA site"
ORIGIN      
        1 acacactgca aagagcacgc tggaaatgcg gacaaaatgg ggcccaactt ggacaaggag
       61 ggtcctgctg ctggggatct tttgggtctc tgcatacctg cctgtccgtg gtgtctccct
      121 gcccccgcgc ctcccaaggg ccacaggaaa cagcacgcaa tgtgctgtct ctccagcatc
      181 ggagtttccc gaagggttct tcaccaagca ggagagcacg gatggaggta tcgtaatcta
      241 cttcctcatt atcctctaca tgtgcatggc catctccatc gtctgcgaca agtacttctt
      301 gccctccctg gaaatcatca gtgactccct tggactgtcg caggatgttg caggtgcaac
      361 tttcatggca gctggtagct ccgcccctga actagttacc gccttcttgg gtgtatttat
      421 cacaaaggga gatattggta tcagcaccat actaggatct gcaatttata atctcctcgg
      481 catctgtgct gcctgcggcc tcctgtccaa catggtttca acactctcct gctggcccct
      541 cttccgagac tgtgcagtgt atgcagttag tgtaggagca gtttttggca taatatttga
      601 caaccgaatt tactggtacg aaggagcagg gctgctactg atatatgggc tctatgttct
      661 gctgctgtgt tttgacacca cgatcagccg gcatgtcatg aaaacatgca gtccctgttg
      721 tccctgcctt gccagagcta tggaggagag aattgaacag cagacactgt tgggatggga
      781 ggatgagagc cagctcttca ttcgtcgcca gtcaaggaca gacagtggaa tatttcagga
      841 agattccggt tactcccaac tttctctaag cttgcatggt cttagtcagg tttctgaaga
      901 tccaccaagt gttttcagca tgccagaagc agacttaaga agaatttttt gggttctctc
      961 tcttcctatt attacattac ttgctctgac aacaccagac tgcaggagaa agttttggaa
     1021 aaattacttt gtgataacct ttttcatgtc tgcactatgg atatctgcat tcacatacat
     1081 cctagtttgg atggtcacag taacagggga aacactaggg atcccagaca cagtgatggg
     1141 ccttactttg ttggcagcag ggacaagcat accagataca gtcacaagtg tgttagttgc
     1201 aagaaaaggt aaaggagaca tggctatatc taacatcgtg ggatccaatg tgtttgatat
     1261 gctatgccta ggtcttccct ggtttattaa gactgcattt acgaatgcat ctgctcctat
     1321 agaagtgaat agcaagggac tcacatatat aacaatctct ctcaacattt caattttatt
     1381 tctgttctta gcagttcatt ttaatggctg gaaactagac cgaaagttgg gggtggtctg
     1441 cctagtgtta tacttaggac ttgctacttt atcagttcta tatgaaattg gaattattgg
     1501 aaataataga ataaggggtt gtggagtttg atatttttta atagtgttat gtggaaagat
     1561 ggaatggtag aggggcaaaa agaagaaaat tcatgtcttc atttaggtca aataaaaagc
     1621 atcttcaact ttagagtcta a
//
