LOCUS       NM_172426              10606 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus solute carrier family 24 (sodium/potassium/calcium
            exchanger), member 2 (Slc24a2), transcript variant 1, mRNA.
ACCESSION   NM_172426
VERSION     NM_172426.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10606)
  AUTHORS   Gomez-Del Arco,P., Isern,J., Jimenez-Carretero,D.,
            Lopez-Maderuelo,D., Pineiro-Sabaris,R., El Abdellaoui-Soussi,F.,
            Torroja,C., Vera-Pedrosa,M.L., Grima-Terren,M., Benguria,A.,
            Simon-Chica,A., Queiro-Palou,A., Dopazo,A., Sanchez-Cabo,F.,
            Jalife,J., de la Pompa,J.L., Filgueiras-Rama,D., Munoz-Canoves,P.
            and Redondo,J.M.
  TITLE     The G4 resolvase Dhx36 modulates cardiomyocyte differentiation and
            ventricular conduction system development
  JOURNAL   Nat Commun 15 (1), 8602 (2024)
   PUBMED   39366945
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10606)
  AUTHORS   Ding,Y., Lang,D., Yan,J., Bu,H., Li,H., Jiao,K., Yang,J., Ni,H.,
            Morotti,S., Le,T., Clark,K.J., Port,J., Ekker,S.C., Cao,H.,
            Zhang,Y., Wang,J., Grandi,E., Li,Z., Shi,Y., Li,Y., Glukhov,A.V.
            and Xu,X.
  TITLE     A phenotype-based forward genetic screen identifies Dnajb6 as a
            sick sinus syndrome gene
  JOURNAL   Elife 11, e77327 (2022)
   PUBMED   36255053
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10606)
  AUTHORS   Moriguchi,S., Kita,S., Yabuki,Y., Inagaki,R., Izumi,H., Sasaki,Y.,
            Tagashira,H., Horie,K., Takeda,J., Iwamoto,T. and Fukunaga,K.
  TITLE     Reduced CaM Kinase II and CaM Kinase IV Activities Underlie
            Cognitive Deficits in NCKX2 Heterozygous Mice
  JOURNAL   Mol Neurobiol 55 (5), 3889-3900 (2018)
   PUBMED   28547530
  REMARK    GeneRIF: both CaMKII autophosphorylation and CaMKIV phosphorylation
            significantly decreased in hippocampal CA1 regions of NCKX2+/-
            relative to control mice.
REFERENCE   4  (bases 1 to 10606)
  AUTHORS   De Maria,A., Zhao,H. and Bassnett,S.
  TITLE     Expression of potassium-dependent sodium-calcium exchanger in the
            murine lens
  JOURNAL   Exp Eye Res 167, 18-24 (2018)
   PUBMED   29128492
REFERENCE   5  (bases 1 to 10606)
  AUTHORS   Vinberg,F., Wang,T., De Maria,A., Zhao,H., Bassnett,S., Chen,J. and
            Kefalov,V.J.
  TITLE     The Na+/Ca2+, K+ exchanger NCKX4 is required for efficient
            cone-mediated vision
  JOURNAL   Elife 6, e24550 (2017)
   PUBMED   28650316
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 10606)
  AUTHORS   Ginger,R.S., Askew,S.E., Ogborne,R.M., Wilson,S., Ferdinando,D.,
            Dadd,T., Smith,A.M., Kazi,S., Szerencsei,R.T., Winkfein,R.J.,
            Schnetkamp,P.P. and Green,M.R.
  TITLE     SLC24A5 encodes a trans-Golgi network protein with
            potassium-dependent sodium-calcium exchange activity that regulates
            human epidermal melanogenesis
  JOURNAL   J Biol Chem 283 (9), 5486-5495 (2008)
   PUBMED   18166528
  REMARK    GeneRIF: non-synonymous single nucleotide polymorphism in SLC24A5
            alters a residue that is important for NCKX5 and NCKX2 activity
REFERENCE   7  (bases 1 to 10606)
  AUTHORS   Cuomo,O., Gala,R., Pignataro,G., Boscia,F., Secondo,A.,
            Scorziello,A., Pannaccione,A., Viggiano,D., Adornetto,A.,
            Molinaro,P., Li,X.F., Lytton,J., Di Renzo,G. and Annunziato,L.
  TITLE     A critical role for the potassium-dependent sodium-calcium
            exchanger NCKX2 in protection against focal ischemic brain damage
  JOURNAL   J Neurosci 28 (9), 2053-2063 (2008)
   PUBMED   18305240
  REMARK    GeneRIF: NCKX2 is involved in brain ischemia, and it may represent
            a new potential target to be investigated in the study of the
            molecular mechanisms involved in cerebral ischemia.
REFERENCE   8  (bases 1 to 10606)
  AUTHORS   Pyrski,M., Koo,J.H., Polumuri,S.K., Ruknudin,A.M., Margolis,J.W.,
            Schulze,D.H. and Margolis,F.L.
  TITLE     Sodium/calcium exchanger expression in the mouse and rat olfactory
            systems
  JOURNAL   J Comp Neurol 501 (6), 944-958 (2007)
   PUBMED   17311327
REFERENCE   9  (bases 1 to 10606)
  AUTHORS   Li,X.F., Kiedrowski,L., Tremblay,F., Fernandez,F.R., Perizzolo,M.,
            Winkfein,R.J., Turner,R.W., Bains,J.S., Rancourt,D.E. and Lytton,J.
  TITLE     Importance of K+-dependent Na+/Ca2+-exchanger 2, NCKX2, in motor
            learning and memory
  JOURNAL   J Biol Chem 281 (10), 6273-6282 (2006)
   PUBMED   16407245
REFERENCE   10 (bases 1 to 10606)
  AUTHORS   Tsoi,M., Rhee,K.H., Bungard,D., Li,X.F., Lee,S.L., Auer,R.N. and
            Lytton,J.
  TITLE     Molecular cloning of a novel potassium-dependent sodium-calcium
            exchanger from rat brain
  JOURNAL   J Biol Chem 273 (7), 4155-4162 (1998)
   PUBMED   9461611
  REMARK    GeneRIF: Mouse ortholog of rat Slc24a2 solute carrier family 24,
            encoding a potassium-dependent sodium-calcium exchanger (partial
            cds)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ121602.1, AK083127.1, AL807763.7, AL954377.12 and AW492765.1.
            
            On Feb 2, 2007 this sequence version replaced NM_172426.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript but encodes the shorter isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK083127.1, ERR3363660.980600.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               CJ121602.1         4-120
            118-3946            AK083127.1         2-3830
            3947-6849           AL807763.7         2001-4903           c
            6850-10099          AL954377.12        55900-59149         c
            10100-10606         AW492765.1         1-507               c
FEATURES             Location/Qualifiers
     source          1..10606
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 40.69 cM"
     gene            1..10606
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /note="solute carrier family 24 (sodium/potassium/calcium
                     exchanger), member 2"
                     /db_xref="GeneID:76376"
                     /db_xref="MGI:MGI:1923626"
     exon            1..225
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            226..1306
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..2374
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     retinal cone Na-Ca+K exchanger; solute carrier family 24
                     member 2; Na(+)/K(+)/Ca(2+)-exchange protein 2;
                     sodium/potassium/calcium exchanger 2"
                     /codon_start=1
                     /product="sodium/potassium/calcium exchanger 2 isoform 1"
                     /protein_id="NP_766014.1"
                     /db_xref="CCDS:CCDS18312.1"
                     /db_xref="GeneID:76376"
                     /db_xref="MGI:MGI:1923626"
                     /translation="MDLHQSPTARLLQKWCSHESPFGCRRHYNSRKKLKLIRVIGLVM
                     GLVAVSTVPFSISAFTETDSQSNRGEASDMSGPRVAQGHRQRTLLDLNDKIRDYTPQP
                     PASQEDQAENSTEHTQGDYPKDIFSLEERRKGAIILHVIGMIYMFIALAIVCDEFFVP
                     SLTVITEKLGISDDVAGATFMAAGGSAPELFTSLIGVFIAHSNVGIGTIVGSAVFNIL
                     FVIGMCALFSREILNLTWWPLFRDVSFYIVDLLMLITFFLDNVIMWWESLLLLTAYFA
                     YVVFMKFNVQVERWVKQMISRNNVIKVTVPEAQAKSPTAGDKDGPTLPSKPRLQRGGS
                     SASLHNSLMRNSIFQLMIHTLDPLAEELGSYGKLKYYDTMTEEGRFREKASILHKIAK
                     KKCQVDENERQNGAANHVEKIELPNSTSTEVEMTPSSEASEPVQNGNLSHNIEAADAP
                     KATETAEEEDDQPLSLSWPTNTRKQATFLIVFPIVFPLWITLPDVRKPASRKFFPITF
                     FGSITWIAVFSYLMVWWAHQVGETIGISEEIMGLTILAAGTSIPDLITSVIVARKGLG
                     DMAVSSSVGSNIFDITVGLPLPWLLYTIIHRFSPVTVSSNGLFCAIVLLFIMLLFVIL
                     SIALCKWRMNKILGFIMFGLYFVFLVVSVLLEDKVLVCPVSI"
     exon            1307..1345
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1454
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1455..1505
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1604
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1723
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1724..1867
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1957
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            1958..2124
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..10594
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10572..10577
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /note="hexamer: AATAAA"
     polyA_site      10594
                     /gene="Slc24a2"
                     /gene_synonym="2810021B17Rik; 6330417K15Rik; Nckx2"
                     /note="major polyA site"
ORIGIN      
        1 ccgcgcagga ggcgcgcaag gcgggagggc gccgagctgc ggctactccc gcgccgccga
       61 gagggagggg cccagcgccg tccgccagcc tggctcacca ccgctcgccc gctgctcagt
      121 gtcctcgcga gcccagcttc ggccggcgaa ggcgacgtcc atcgcgagcc cgggcgaggc
      181 gcgtccccga gcggcccggc gtgtgagcct tgctcaacag tgctggtgga gctattttcc
      241 ccgtgaagag taaagatccc caactgtaga agtgcccata agcatcatcg actgggaagc
      301 aaggagcagt atgccagagc catctgtctg agtctaaagt gtgaagacca ccatatccac
      361 cagaaaagca aggatggatc tccaccaaag ccccacagcc aggctcctgc agaaatggtg
      421 ttcccatgag tcaccatttg gctgcaggag acattataat agcaggaaaa aactgaagct
      481 aattcgagtc attggccttg tcatgggcct ggtagctgtg agcactgtcc cattttcaat
      541 cagtgccttt actgagacag actctcagag caacagagga gaagccagtg atatgagtgg
      601 ccccagagta gcacagggtc accgtcaaag aactctctta gacttaaatg acaagattcg
      661 agattacacc ccacagccac ctgcttctca ggaagaccaa gctgagaaca gtactgagca
      721 cacccaggga gactacccaa aggacatctt ttccctggag gagcgaagga aaggtgccat
      781 cattctgcat gtcattggga tgatctatat gttcatagca ttagccatcg tctgtgatga
      841 gttctttgtt ccttctctaa ctgtcatcac tgaaaaactg ggaatctctg atgatgtggc
      901 tggagccacc ttcatggctg caggcgggtc agccccagaa cttttcacgt ctcttatagg
      961 ggtcttcatt gctcacagca atgtcggcat tggcaccatc gtgggttccg ccgtgttcaa
     1021 tattctcttt gttattggca tgtgtgctct gttttctaga gaaatcctaa acctgacctg
     1081 gtggccgctc tttcgggatg tgtccttcta catcgttgat ttgctcatgt tgatcacatt
     1141 tttcctggat aacgttatca tgtggtggga aagcttactc ctcttaacag cttatttcgc
     1201 ctatgtggtt ttcatgaagt tcaacgtcca agtagagaga tgggtgaagc aaatgatatc
     1261 tcgcaataat gttatcaagg tgacagtgcc agaagcccaa gcaaagtcac ctacagctgg
     1321 ggacaaggat gggccaactt taccgtcgaa gccacgcctc caacgaggcg gaagctctgc
     1381 ctccctccac aacagtctca tgaggaatag catcttccag ctcatgatac acacccttga
     1441 cccactcgct gaagaacttg gatcatatgg aaaactaaaa tattatgaca caatgactga
     1501 agaagggagg ttcagagaaa aagcttcaat tctccacaag atcgccaaga agaaatgcca
     1561 agtggatgag aatgagaggc agaatggggc tgccaatcat gtggaaaaaa ttgaactccc
     1621 caacagcaca agcacagagg tggaaatgac gccatcgagc gaagcttcgg aacccgtcca
     1681 gaatggaaac ctctcccaca acattgaagc tgcagatgcc ccgaaggcca cagagactgc
     1741 cgaggaagaa gatgaccagc ccctcagctt gtcctggccg accaacaccc gcaagcaagc
     1801 caccttccta atcgtttttc ccattgtgtt ccctctctgg atcaccttac ctgacgtccg
     1861 aaaacctgct tccaggaagt tcttccctat cacattcttc ggctccatca cctggattgc
     1921 agttttctca tacctgatgg tgtggtgggc acaccaggtt ggagagacaa tcggcattag
     1981 tgaagaaatc atgggtctga ccatcttggc tgctgggacc tctatccctg atcttatcac
     2041 cagtgtcata gtggcccgaa agggcctggg ggacatggct gtgtccagct ctgttggaag
     2101 caacatcttt gacatcactg tggggctccc actgccctgg ctcctctaca ccatcatcca
     2161 cagattcagc ccagtgactg tcagcagcaa tggcctcttc tgtgccatcg tccttctctt
     2221 catcatgttg ctttttgtca ttctctccat cgccctctgc aaatggcgga tgaacaaaat
     2281 cctcggcttc atcatgtttg gcctctactt cgtgttcctg gtggtcagcg tcctcctgga
     2341 agacaaagtt ctcgtgtgcc ctgtctccat ctagtggaaa agccatatct taaaccaaca
     2401 gcatggatgg tccctcccgg ctctgggctc caggctcctt gcagtcttga gaagaggcag
     2461 cttgtgcaca gccctgggag gcaagtatcc ctccttggaa ggttggagga aggatggatt
     2521 cccatgggga cattcacttc acaggcacct cgcccttgcc tgatgaaatg actccgtgta
     2581 agaggcaaag aggacctcca tcaccactga caggtactcc tcgctggtcg gaggtacgtt
     2641 cattgtgatg acacaataga ggacagaggc tatgcataca tataaataca aatattataa
     2701 atatatatac atgagcataa agatcttgcc tgtttctgta ctatacctct tctcctatac
     2761 ctatagatta atacataact gtacacaaac agaaagaaaa tatatatata ttaaaaaaca
     2821 tatatttaag tgcaaatgca tcttttcagg gatagctcta gtatatttat agtacctatt
     2881 tgaagagggg catcaacctt caaccttcag tttgtgcttt gcccctcaag tgcaaaagct
     2941 gaattaacag aatcggtagg caaagcgctc tttgctgtgg tctctagcct gcttcggata
     3001 cactgagttt agtgaaattc tttgcagaag gagagcttaa tagagggagt ctgtaggagc
     3061 cccagttaga acctctaaaa tactctcaca agccaaaaag aatcacctgg ctcctcccca
     3121 ctggggtgct ctgagaccct cgggactcca taagacagat gacattcaga ctgggtgaca
     3181 aggagaggtg tctgctgagg gttgggcagt tttggtttgg tttgttttct tgtaatgccc
     3241 cagcatgcaa gtagatggta tgaatgaaaa acaaaattag tgcttttcta ggacagcaaa
     3301 aattatagaa actgaaccta tcatgttcca gtgcacggcc cattatcatc aaaagaacaa
     3361 gggcaatctt agccatgatt gtcatctgac atgttttaat gccaagggct cccacacagt
     3421 ccaaagtcct gccaagagcg ctgagatgtg tgctgaaaat caccgtccag cagaggtgct
     3481 cagtgggggt tgccacccaa tgggaacata agggcatagc tccttagagc atttttcagt
     3541 gcagtcacaa agggctgcag tgtctacaga tcattcccag gagatctaaa ctaaagactg
     3601 gcagtgtttg gttgaggctg ttcaggtttg tttgcagagg cccccacccc ccacccccac
     3661 cccagaacag tttccaagtc ctgtgtcatg gatttggtct gtagatccgt acaacatctg
     3721 tatcctgcct cccatcataa ccccatctgg aactttagca ttccaagcac agtggagaca
     3781 gtacatgttc catcgtttct ttacgctact tggaagcagt cactctgata tcttgctcag
     3841 cttcacatgg ggtcatctca ttcactgagt gtcctcaagc tctgtctgac atcttgtatg
     3901 acttctacaa ggtttatttc agtagaaaat gggactggct ggcagcaaat tacattgaaa
     3961 aaaatatgca gggtttttca tttccctaaa ccatactttc tccctaaaat caactgaaaa
     4021 agtgaagaga gagtgacccc gagtgtaaat tggcacacat catgcacgga gaatgtcgcc
     4081 gcgtattcat gccctgatct ggcactatgc ctattctgac tgttgtgaac accccttaac
     4141 acagggacgc aggcaggatg cagaactcaa agctgaattt aaaaggtctg gtaacccaat
     4201 actgcagctg aagttcagca ttccatctac aaaccctcca tttacagagc agggcaacag
     4261 caggcagagc aagcccatta cctctcttca ctcttaagca aaaggcactt caaagtggag
     4321 gccccctgag gacacaagaa ataaaaaggt ctgctgccta agaaactggc tttcaagtct
     4381 ctccaacaat gcagagttgg gatttcaatg gtgaaagaga aatccatgcc ccatttatca
     4441 agggttggac tttgtatggg gcaagtatct gggttgcttc cttacagaga atggcaaagg
     4501 aaaagtgagt tttcagtttt aaaaatctca gattcttgtc ctggctgctc agatgagagc
     4561 aggacgattg ttggatacat tctgatttct ggttggttta ttgctgaaaa cggataattt
     4621 ttttaaaaac caactgcaaa tagactgtaa agtaagaaag gtcagagaat gtcttctccc
     4681 atcattactg tcccctcctc accaggaagc caggaagcac tccaggggcc tcagagctag
     4741 gagttctgct ttgaggaaga gttgtggtcc tgaacaaaag ttgctttgag aagacaacat
     4801 tcccaaagcc agctcccact tccatggtgt cccccctccc tgagaggtgc aggcaccacc
     4861 tatctgctgc tagcccttgc tgccttgtct gaggagtgtg tggctatgtg gccatatgtt
     4921 gtcctggaat cattcacatc gttgtaaaac tgcttcctac aggatagact taggtcatct
     4981 ccaatttctt tcttgcatgg cagtgtgtgc aagtctactg ggtctgctga cagacaatat
     5041 caagggtggc atcaccctac tggtccgatc acacttggaa tcccaaagca aagagcatca
     5101 gatttgacag tcaaggaaga ggaaactcat gcacactgac caaagtgaac atttttgaac
     5161 aaaagggtta ttttttttat tctgtgcaca tatacacaca aacactcgca taccattcaa
     5221 acacttcaac ccacagaatg tagggaatgg gcagcagtgt ccctgttgct ttcagagaag
     5281 taaaaatatg caacaagagg catgggagaa gaatatgaga ccgctgtctc tttgcttctc
     5341 cggagcaggg tatgaaatac tatcaaaagt tcaagccaaa attttaccac tcatcctaaa
     5401 ataaagtaat tgtacccaaa tgggaaattt ggtactcaga gaaaaaccaa gccagtcttg
     5461 cttgctgtca tctctcctat agccttaggc aaccctgaaa caggagagaa acttagttca
     5521 gaccaaggaa tctaaaatag aaactcctag attcgaattt gagagtgtcc atgacacatc
     5581 cacctgccct ctggacctgg ccagtctctg atgggatgaa gcatcagatt aatggtgtta
     5641 ttcaacttcc caggacctaa acatgccagg gagagtcagc agggcagagt ccatgcgcag
     5701 aggctcagag atggggttat tcatcagctc ggcagatgat gcagaatatc tgaagcctca
     5761 ctcgggtgtc ataaaaagag acaaggacca tctcatagtc aaggaaaatg ctttttcaaa
     5821 ggcctctgac aggggccatt agaaattatt tcatagggaa gacatgagtc aggtagtttg
     5881 gaggcctttc agcaaaacac agctgcctcc gtgattagat ttttggtgac attaatatat
     5941 atctactcct gaccagagag agttggccaa ctcccctaca ccgccaattc ccacatcttt
     6001 taaatgcctc tgtgacttga gatgaagtaa gatagtgtgt gtaaaagaag gttatccaca
     6061 cccagaccac cttaacagaa agttgatcac aggagaggca actgttagac ctactggcca
     6121 gtcagagagg gagatggaat ttaaagtatt ctattgagag aattgcactg aagcatttga
     6181 tagggtttga tgcctgtctg aatgaagcat ttcagagaat ttcggtgtgc tttaatacaa
     6241 acacacatgc acacacactt gagcactcgg gcacacacac aaattctatt cttccttgca
     6301 cccagaaaga ttgggactcc aacaagtagc aagttacaga cagcaggtct gttccagaaa
     6361 aagcattcta tagaaactaa cacctactct taatgtattc acttggccta ataattttta
     6421 agctgtcatc ctcaattccc atgcctctca caacattctt ttcaattagc agacaaggtc
     6481 ttcccattaa gagagagttg gtagaaaaat ttaaaactca aagggggagg gggaaagaga
     6541 agataattta tttataatag gattcctaag aaagcaacca aatatattta tggtgtttaa
     6601 aatggttatg aataacagac atttttaaac agttactaga gtctatacat attctacatt
     6661 tatttgaaaa gcacatgtca agaaggactc aggaaagaaa ggtacctgtg ccttgcccca
     6721 gtgtctgtct gagttcagtt tactgccttt ggatctttgt ggtccttttt aatctcacag
     6781 cttcgtattc tttgaaatat atagctaaga aaagcaataa aggaaataca gccagctcag
     6841 atcaaataca tattattgca ccttcgagct atttctctca tatcacttgg cactttgggt
     6901 ccacagaggc tgtggttgcc gcaacaagga ggacatagac ctctgtgcaa tcacagatgt
     6961 gctcatgttc gctacatctg gaagtagctt gcttcccatg tagactgccc agacagcatg
     7021 catccacatg cctttctcac acatagacaa tcaacctcgc tttagactac ctaaatggca
     7081 ccaaagtctt taatcttgtt tgtgagtctt ttcttaagaa agggtgggag aaagggccac
     7141 acaaaggaca aacaaaagga taaacaaatg catgacctag ccaggctttg agagatcaac
     7201 gcagtcctga aagtttaggc acatgggctc aaattattgt acaatgaggg actgaatgga
     7261 gaagcgtggt gcctaagcca aagcactttt cctgagagac tgatgggctg ggctagaaaa
     7321 ttaataagta cctaaggatg aaggaatgct gtggacttgc atgggctccc accagagact
     7381 gattccactg ggagaatctg ttgctggttg ctaaagtaca aaggaccact gatcataagt
     7441 caccatggga tatcagcaaa aagttcctag tgtaaccaag gtcaatgttt gacgctgcca
     7501 gaagagtcca tccaactaag accccacagc tgatgacttt ttttatttgt ttgctttgct
     7561 ttgctttgct tttctgtgtt tcctttgtgg cagaagtcaa ctgcttttga acactttttg
     7621 atctttatcc atgacatggt taaaagttgc cactgtagga ccctgtacct attttcatca
     7681 gaagcatcct tgaatttgtg ttcatttgtt taggtgtttt cttcttcctt ctcctcttcc
     7741 tccatctcct ttctctcctc ttccttttct tcctgctatt gtcacagtgt aaatattcaa
     7801 aagttctagg cctttacccc caaccacact tccctgtgga tgactaatcc ttgaagaagt
     7861 gcactctaat tgctgttgga tggcaggcag aatctgtaac cacagaggtg cacagtagtg
     7921 caaatacctt ccaaggacca gtagacttga atacggatcc aatgggagtt ggttgtctgg
     7981 tgtcaagatg agcactgggc acagcattat catagagggc cagtgaggtc aaggttgcag
     8041 ctctttttgt atcttgcatc ttctttgttc catatagtca aaagggaaac gggaaaggag
     8101 ccacatcaaa ttgctccaag actctgtgtg tgtgcttgcc tacattgatc ctgggaggaa
     8161 aacatttcaa atgggaagtc agagaaagga ctggagagac ccttgttatg agtcccatgg
     8221 agtctctact tcctcgtgca gtaggttcct agaaacagta aggtcacttc ctgctgtttt
     8281 gggatgggaa ttttctcttt ggttgcagtt tcaacataat agagatataa aaaatgaaga
     8341 ccttgaacac tgacaggtct ctaaaacacc cagctagcca aaagagatac taaatttctt
     8401 aaataatgtt acatacacac aaacaagaga aaagtgaaat accatttcca ggatgaaatt
     8461 gcatgcgcta attaagggca gaaaattcct tgccagttaa ctcaatgact ctccaactct
     8521 taccatcagg ataaaactga aggacaaagg atgccttttg gcttttttaa tttttttaat
     8581 attgcacttt atagtatttc ataagagact attgtcttaa ttaaagccat aaaataccaa
     8641 taatgcatat attcagggct tctggatata gtcaataaac agtccacggg tcattctgtg
     8701 tgttgttcgt tgtaaaatga agtttatctg ttctgttttt attacttaaa ctactgttct
     8761 agacaatcct aatcaactaa aaaattttag gtgtgtagtt taatcaaact ttgaaaatca
     8821 aagaaattat tcatttcatg aaagaattct tcatttccaa agcagctagt tgcatggttt
     8881 ctttaaatag caagttccac tgttgcactg aaaatatttc cttttaaaaa tcctagatta
     8941 ttttacagga atccatttgt tatgttaagt aagattcacc catgtggata ttggagtgga
     9001 tgattagcta acatgcctga aaatattaga atgtacttgt gtttttatat aaatatatga
     9061 tgtgtctaag aagttccctt ataaaaatgg caagcagata tataacctgt caataatatc
     9121 ttatacctat atttgtatac atcactggga ggacaagcaa aagcaatgga cttcatggtg
     9181 gactgggtga tcaatttcct tttctatcaa aacagtttct gactgaggat ggtgagctgt
     9241 tcatgtatag atatggacag aagctctcaa gactaaaacc cttaatattt cactttgtaa
     9301 tgcaatcaga gtgatagctg agaagattac taaagggcac ataatagcct agaacaatcc
     9361 accacagcag ggtagctagg tcatctatgt aagccccagt attaaataga acaaccccat
     9421 caataatctt aggcttgaac agacaacttg tcctaaagaa aaatatctga atgcagagtc
     9481 agtgacattc ctctatcaca ggctgtgtgg aggcccaagg tcctcaaaaa gtcagaccgt
     9541 ccatcagagc ttctgttgaa ttcggcagag tccaccttga tccctgtacc taaccttgtt
     9601 cttccaagtc tcaatagcaa cagcttccat cttcacaatg cagacacaga gaggtgcatg
     9661 aaaacatata tgactcgcaa accaggcata atggcacacc tgcaatccga gaagtgagga
     9721 agtagaggca ggaggattgg aagatcctgg tcagctttgg ctacatgaga ccctgtctca
     9781 aaaaaaacaa atcaaaacaa aaaacaaaaa caaaacaaaa acaaaacact atcttcttag
     9841 tttgatgaag cactgctggc acaaaagata agttatatat ttttaagaca gaaatattat
     9901 taatgttgat cctaacatag atatataccc tacaaggtat aacctgcctt ttaaatgggt
     9961 catttataag tataaaactg tgcccaagat cttctgtttg gggttacata atcaattcct
    10021 gccaaccaga acctatgacc cagatttggt catgatatgc acaccataaa tatgtacagt
    10081 aactatacca atcaaaagaa taaaacagct tttagaattt ttaaatgaat atattttaga
    10141 aagaccaaaa cttatcggaa tgccattttt gtgaaggatc tttttagggg cggtctgggt
    10201 ctcacacggc ctttgtttgc ctgcactcta aagaagtatc ctaggccctg tcttcacccc
    10261 tccagactcc ggggggggtg cactttaaag tcatcttcgt cattttgtgt ttgttgtgag
    10321 cagttttctc tggctggcta gacgtacagc gactccgtgt catttactct gtgactctgt
    10381 ctgtacataa ctggaattcg gatggcaaac tgtacatagg ctgtttggag tggtgtgctt
    10441 gggtcacgtg gtctcactct ggtaaagggt ttccttccat gttccactgt ctgcatcctt
    10501 gtgcttatac tgctgataac ttactgaata cactttatgt aactaagtct cctcagtgta
    10561 aaagtaataa taataaaaca attgactcca aaaaaaaaaa aaaaaa
//
