LOCUS       NM_144813               5217 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus solute carrier family 24 (sodium/potassium/calcium
            exchanger), member 1 (Slc24a1), transcript variant 1, mRNA.
ACCESSION   NM_144813 XM_979236
VERSION     NM_144813.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5217)
  AUTHORS   Maddala,R., Gao,J., Mathias,R.T., Lewis,T.R., Arshavsky,V.Y.,
            Levine,A., Backer,J.M., Bresnick,A.R. and Rao,P.V.
  TITLE     Absence of S100A4 in the mouse lens induces an aberrant
            retina-specific differentiation program and cataract
  JOURNAL   Sci Rep 11 (1), 2203 (2021)
   PUBMED   33500475
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5217)
  AUTHORS   Bisbach,C.M., Hutto,R.A., Poria,D., Cleghorn,W.M., Abbas,F.,
            Vinberg,F., Kefalov,V.J., Hurley,J.B. and Brockerhoff,S.E.
  TITLE     Mitochondrial Calcium Uniporter (MCU) deficiency reveals an
            alternate path for Ca2+ uptake in photoreceptor mitochondria
  JOURNAL   Sci Rep 10 (1), 16041 (2020)
   PUBMED   32994451
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5217)
  AUTHORS   Collin,G.B., Gogna,N., Chang,B., Damkham,N., Pinkney,J., Hyde,L.F.,
            Stone,L., Naggert,J.K., Nishina,P.M. and Krebs,M.P.
  TITLE     Mouse Models of Inherited Retinal Degeneration with Photoreceptor
            Cell Loss
  JOURNAL   Cells 9 (4), 931 (2020)
   PUBMED   32290105
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5217)
  AUTHORS   De Maria,A., Zhao,H. and Bassnett,S.
  TITLE     Expression of potassium-dependent sodium-calcium exchanger in the
            murine lens
  JOURNAL   Exp Eye Res 167, 18-24 (2018)
   PUBMED   29128492
REFERENCE   5  (bases 1 to 5217)
  AUTHORS   Vinberg,F., Wang,T., Molday,R.S., Chen,J. and Kefalov,V.J.
  TITLE     A new mouse model for stationary night blindness with mutant
            Slc24a1 explains the pathophysiology of the associated human
            disease
  JOURNAL   Hum Mol Genet 24 (20), 5915-5929 (2015)
   PUBMED   26246500
  REMARK    GeneRIF: The deletion of NCKX1 in mice results in malformed outer
            segment disks, suppressed expression and function of rod cGMP-gated
            channels and a subsequent 100-fold reduction in rod responses,
            while preserving normal cone responses.
REFERENCE   6  (bases 1 to 5217)
  AUTHORS   Jia,L., Oh,E.C., Ng,L., Srinivas,M., Brooks,M., Swaroop,A. and
            Forrest,D.
  TITLE     Retinoid-related orphan nuclear receptor RORbeta is an early-acting
            factor in rod photoreceptor development
  JOURNAL   Proc Natl Acad Sci U S A 106 (41), 17534-17539 (2009)
   PUBMED   19805139
REFERENCE   7  (bases 1 to 5217)
  AUTHORS   Pyrski,M., Koo,J.H., Polumuri,S.K., Ruknudin,A.M., Margolis,J.W.,
            Schulze,D.H. and Margolis,F.L.
  TITLE     Sodium/calcium exchanger expression in the mouse and rat olfactory
            systems
  JOURNAL   J Comp Neurol 501 (6), 944-958 (2007)
   PUBMED   17311327
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC140243.2.
            
            On Aug 9, 2022 this sequence version replaced NM_144813.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC016094.1, SRR17784646.276811.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-143               AC140243.2         3061-3203
            144-2064            AC140243.2         4928-6848
            2065-2118           AC140243.2         17393-17446
            2119-2227           AC140243.2         18658-18766
            2228-2311           AC140243.2         22431-22514
            2312-2403           AC140243.2         23410-23501
            2404-3159           AC140243.2         25968-26723
            3160-3249           AC140243.2         27429-27518
            3250-3416           AC140243.2         28346-28512
            3417-5217           AC140243.2         30011-31811
FEATURES             Location/Qualifiers
     source          1..5217
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 35.0 cM"
     gene            1..5217
                     /gene="Slc24a1"
                     /note="solute carrier family 24 (sodium/potassium/calcium
                     exchanger), member 1"
                     /db_xref="GeneID:214111"
                     /db_xref="MGI:MGI:2384871"
     exon            1..143
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            144..2064
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2065..2118
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2227
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2228..2311
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2312..2403
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            2404..3159
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3160..3249
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3250..3416
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     exon            3417..5217
                     /gene="Slc24a1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5200..5205
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc24a1"
                     /note="hexamer: ATTAAA"
     polyA_site      5212
                     /gene="Slc24a1"
     polyA_site      5217
                     /gene="Slc24a1"
                     /note="major polyA site"
ORIGIN      
        1 atacccttga attaggattc ctaagggagc cggcaggagg agaatggggt gttccttgtg
       61 gttccacttc acacctactc ttcgagaccc cggattctga caagtttccc gaacttggaa
      121 gacccagatg tcaaggtctg aaggtttggg gataccccca ggctgggctt catggagaaa
      181 cctttcctga ttactaacat gaatcccaga gcagcctctg cctctccctg gacaggatga
      241 gaggccaact gtaaccagac ctaaccggcc atcatgggga aactgatcag gatggggaca
      301 caggagaggc ggttactccg accaaagagg cttcattgga gtcgccttct tttcctcttg
      361 ggaatgttga tcattggctc tacttatcag cacctgagga gaccccagaa tcccccctca
      421 atgtggacaa aggtctcctc ccagcagcct attaaactgg ccgtcaggga cctccccaac
      481 aatgaaatgg cagtggcagg cagtgaccct ccagaggcta gctctgaagt ggaggatggg
      541 atgctagcag cccaagacac agtgatcatg gatgaagcag cacctagcat agcaatggag
      601 gacaccccca atccacccag aacaaccaag atccctccag catcactaaa gaacagttat
      661 agccctacaa cagctggcac aagaagacaa aaagaaaaca tcccacccac acctagtgga
      721 gcaccaagtc acttcatctc aactccaggc agacagaggg taaaaagcta tatcccaaaa
      781 cccaggggag aaaggaagaa ctccagccca actcacgcca gggaaaaagg aaggacgcat
      841 accccatctc cagcaggtgc tcacaccatc agccccacag caactgtgag agacagagaa
      901 accatggcaa cctataggct gttagagacc agatttgaga gaacagcagg agaaaccaca
      961 gcagcttctc tcaagagaat ggttctgaac acaccgacct tcttaacaca tgaagtagaa
     1021 acaaacctca tgacttcttc aagtttggtg ggaaagaaca ctgcggtaag tcttagaaaa
     1081 ggggaaagaa acatctctac cactccccag ggagcggtcc cacagcacac ccctgccacc
     1141 tctgaggagc aaatgacagt aagcaccagg atgggtagca tcccagccac catcgaaggc
     1201 tctactgctg cccggagaat taacaatccc ttgtccagaa ccagtgcacc agccattaga
     1261 attgcctcgg ccaccaacag ggaaaagaga ccttctacag cacccagcac cctcgtaact
     1321 cccaaggcaa ccatgagcac acaagtccac cgatgtgtgg ttgtggagcc agccccagct
     1381 gtacccatga ccccatctcc aggcgtgaca agcatcctgt tcccagagac acccagttcc
     1441 ggtccctcgg ctttgccacc cggctggcca aatctccacc ccaaggcgga gtatccccca
     1501 gacctgttca gtgtggagga tcgacgacag ggctgggtgg tcctacacat cttcggcatg
     1561 atgtatgtgt tcgtggcctt ggccatcgtg tgcgacgagt actttgtccc agccttggga
     1621 gtcatcacac acaagctgca gatctccgag gatgtggcag gggccacatt catggctgcc
     1681 ggaggctcgg ccccggagct cttcacctct ctcattggtg tctttatctc ccacagcaat
     1741 gtgggtattg gtaccatcgt gggctctgct gtgttcaaca tcctttttgt catcggcacc
     1801 tgtgccctct tctcccggga gatcctcaac ctcacctggt ggcccctgtt ccgagacgtc
     1861 tccttctaca tccttgactt gtctatgctc attgtcttct tcctggacag tttcattgcc
     1921 tggtgggaga gcctgctgct gctgttggcc tacgctctct atgtgttcac catgaagtgg
     1981 aacaagcaga ttgagctctg ggtgaaagag cagcttagca ggaggcccgt agccaaagtc
     2041 atggccctgg gagacctcag caagcccagt gaggatgctg tcgaggaaaa cgagcaacag
     2101 gacagcaaga aactgaagct cccgtctgtg ctgacccgag ggagtagctc ggcctcgctg
     2161 cacaacagta tcatccgcaa caccatctac cacctcatgc tccacagcct ggaccccctg
     2221 ggggaagccc gcccctccaa ggacaagcag gagagcttga atcaggaagc cagagttctc
     2281 tcccagacca aagcagaaag cagcccagac gaggatgagc cagccgagct ccctgcggtc
     2341 acggtcactc cagcccctgc tccagacgcc aagggagatc aggaggacga tccaggctgc
     2401 caggaagatg tggatgaggc tgaacgcaga ggagaaatga caggtgaaga gggtgaaaag
     2461 gaaaccgaga cggaaggaaa aaaagatgaa caagaagggg aaactgaggc agaaaggaaa
     2521 gaagatgagc aagaagaaga aactgaggca gaaggaaaag aacaagaagg ggaaactgag
     2581 gcagaaggaa aagaagatga acaagaaggg gaaacagagg cagaaggcaa aaaagatgaa
     2641 caagaagggg aaactgaggc agaaggcaaa gaggaacaag aaggggaaac tgaggcagaa
     2701 ggaaaagaag atgaacaaga aggggaaact gaggcagaag gcaaagagga acaagaaggg
     2761 gaaactgagg cagaaagcaa agaagttgaa caagaaaggg aaactgaggc agaaggcaaa
     2821 gataagcatg aagggcaagg tgaaacccaa ccagacgaca ctgaggtgaa agatggtgag
     2881 ggtgaaacag aagccaatgc tgaagatcaa tgtgaggcca cccaaggtga gaagggtgca
     2941 gatggtggag gggaaagtga tggaggggac agtgaggaag aggaggatga agaagatgaa
     3001 gaggaggaag aggaggaaga tgaggaagag gaggaggagg aaaatgagga gcctctgtct
     3061 ctggaatggc ctgacagcag gcagaagcag gccatctacc tcttcctcct gcccatcgtg
     3121 ttcccactgt ggctgacaat acctgatgta cggaggcagg agtccaggaa gttttttgtc
     3181 atcaccttcc tgggatccat catctggata gccatgttct catacctcat ggtatggtgg
     3241 gctcaccagg ttggcgaaac cattgggatt tctgaagaga ttatgggttt gacaatctta
     3301 gcagcaggca cttcaattcc tgacctcatc accagtgtga tcgttgcccg gaaaggcctg
     3361 ggagacatgg ctgtgtcaag ctcagtgggc agtaacatat ttgacatcac agtgggcttg
     3421 cctgttccgt ggctcctctt ctccctcatc aatgcgctgc agcctgttcc tgtcagcagc
     3481 aacggcctgt tctgtgcaat cgtcttgctg tttctcatgc tcctgtttgt gatcttctca
     3541 attgcatcgt gtaaatggag aatgaacaag atcctgggct tcacgatgtt ccttctttac
     3601 tttgtgttct tggtaatcag tgtgatgtta gaagatcgaa tcatatcctg ccctgtgtct
     3661 gtctgattca gccactgatg ctcaagatgg acatagagga gaggactatg ccagaagtta
     3721 ccgtccctct taccatacca atcaaataat gaacatgatc aggaatgtga gccgggcagc
     3781 gtagaccctc agaggtgact gtcattatga ctgaggcttc tctctgcaaa cacctgcagc
     3841 ttcaggtgga ttaagaacgt taccttggaa gggagagttt ttatcactca ggcaagcagc
     3901 tgtcatgcag tcagaggact tcctgtatga gacctgaagt tacagttggg atggcagaaa
     3961 ttagacaagt acccttgctc acaattccct tgtcactcct gaagagccat ggtgcagcat
     4021 gcaggggtca aaggcttgtt ctcctgaaca ctgccctaaa cacacactgc cacacgctat
     4081 ttattcctcc tggtggaatt gtgaagccac atcaggtttg ctgtcattgt gagttcagtt
     4141 aatgagttta agaagggaag gcttggaggc aggggcagga ataaatttat cattctaccc
     4201 cacagtcctg tgaaaacgca tgccaatgct ttctgtgtca aaaggaagat aatagctttt
     4261 attgttgcat ttctgaaaaa tgaaattaga acagaaagca gcctagggaa tgaaagtctg
     4321 taatttgact tgaattggag gcaaggattt gaggaagaaa actactctta gggctatgta
     4381 aacatatgca cttcctggaa aatccacatt tgtttgtctc catcagtggc cacttcaaag
     4441 gattattctg acacagctgc cctgctgccc ttgggcattt tcttgcccag gagtgacaac
     4501 tgtcactgaa gagccaaagg gatgcatttg cagagggcca aatctggcgg atgcatgaag
     4561 agatctaggg ctcagtgcta tgcttatatg ccaacctaga ctagactgta aagcaagaag
     4621 gctagtcctt tgaatagttt atcagtgggt cttaagagag tttacaaagg agaaatttca
     4681 aaactgctta gcgcaatgac gacacagcaa gaaatgaaag agtactgctc gttacacaga
     4741 ccaggctggc cttggagtca cacacctacc tgcccctgcc tcctgagtgc cgggattaaa
     4801 agatggccac tacatctggt tgagtatgta tttttaaggg cacaaaggat accttaagaa
     4861 gtcatggtta aatattttcg atgacgtttc acatgcttgc atattaacta tctttggcca
     4921 ctgcttttcc tacaatcaag ctgaggagaa tgttagaaat aaaactttca cgtctttggt
     4981 ttcagagcac aaggaacatg agcgtctgca gattatgatg caaatgatgt atgtcataga
     5041 caccaggagt gatgtggtag cctgtgagaa aatagtgggg tgggtgggaa agaaaagcaa
     5101 tggttcattc tggtgatgga gggtggaggt actcaagtat tcatctttta agatgggctg
     5161 tacttcttca aaattcccat ttttttggaa gtaactttta ttaaatttca atgaaaa
//
