LOCUS       NM_011397               3009 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 23 (nucleobase transporters),
            member 1 (Slc23a1), mRNA.
ACCESSION   NM_011397
VERSION     NM_011397.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3009)
  AUTHORS   Toyoda,Y., Miyata,H., Uchida,N., Morimoto,K., Shigesawa,R.,
            Kassai,H., Nakao,K., Tomioka,N.H., Matsuo,H., Ichida,K.,
            Hosoyamada,M., Aiba,A., Suzuki,H. and Takada,T.
  TITLE     Vitamin C transporter SVCT1 serves a physiological role as a urate
            importer: functional analyses and in vivo investigations
  JOURNAL   Pflugers Arch 475 (4), 489-504 (2023)
   PUBMED   36749388
  REMARK    GeneRIF: Vitamin C transporter SVCT1 serves a physiological role as
            a urate importer: functional analyses and in vivo investigations.
REFERENCE   2  (bases 1 to 3009)
  AUTHORS   Wang,M., He,J., Li,S., Cai,Q., Zhang,K. and She,J.
  TITLE     Structural basis of vitamin C recognition and transport by
            mammalian SVCT1 transporter
  JOURNAL   Nat Commun 14 (1), 1361 (2023)
   PUBMED   36914666
  REMARK    GeneRIF: Structural basis of vitamin C recognition and transport by
            mammalian SVCT1 transporter.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3009)
  AUTHORS   Ishii,N., Homma,T., Takeda,Y., Aung,N.Y., Yamada,K.I., Miyata,S.,
            Asao,H., Yamakawa,M. and Fujii,J.
  TITLE     Developmental retardation in neonates of aldehyde reductase
            (AKR1A)-deficient mice is associated with low ascorbic acid and
            high corticosterone levels
  JOURNAL   J Nutr Biochem 91, 108604 (2021)
   PUBMED   33549889
REFERENCE   4  (bases 1 to 3009)
  AUTHORS   Eck,P.K., Corpe,C. and Levine,M.A.
  TITLE     Temporo-spacial microanatomical distribution of the murine
            sodium-dependent ascorbic acid transporters Slc23a1 and Slc23a2 in
            the kidney throughout development
  JOURNAL   Biochem Cell Biol 95 (3), 421-427 (2017)
   PUBMED   28177761
REFERENCE   5  (bases 1 to 3009)
  AUTHORS   Kaminski,M.M., Tosic,J., Kresbach,C., Engel,H., Klockenbusch,J.,
            Muller,A.L., Pichler,R., Grahammer,F., Kretz,O., Huber,T.B.,
            Walz,G., Arnold,S.J. and Lienkamp,S.S.
  TITLE     Direct reprogramming of fibroblasts into renal tubular epithelial
            cells by defined transcription factors
  JOURNAL   Nat Cell Biol 18 (12), 1269-1280 (2016)
   PUBMED   27820600
REFERENCE   6  (bases 1 to 3009)
  AUTHORS   Hogue,D.L. and Ling,V.
  TITLE     A human nucleobase transporter-like cDNA (SLC23A1): member of a
            transporter family conserved from bacteria to mammals
  JOURNAL   Genomics 59 (1), 18-23 (1999)
   PUBMED   10395795
REFERENCE   7  (bases 1 to 3009)
  AUTHORS   Faaland,C.A., Race,J.E., Ricken,G., Warner,F.J., Williams,W.J. and
            Holtzman,E.J.
  TITLE     Molecular characterization of two novel transporters from human and
            mouse kidney and from LLC-PK1 cells reveals a novel conserved
            family that is homologous to bacterial and Aspergillus nucleobase
            transporters
  JOURNAL   Biochim Biophys Acta 1442 (2-3), 353-360 (1998)
   PUBMED   9804989
REFERENCE   8  (bases 1 to 3009)
  AUTHORS   Klingenspor,M., Bodnar,J., Welch,C., Xia,Y.R., Lusis,A.J. and
            Reue,K.
  TITLE     Localization of ubiquitin gene family members to mouse chromosomes
            5, 11, and 18
  JOURNAL   Mamm Genome 8 (10), 789-790 (1997)
   PUBMED   9321482
REFERENCE   9  (bases 1 to 3009)
  AUTHORS   Welch,C.L., Xia,Y.R., Shechter,I., Farese,R., Mehrabian,M.,
            Mehdizadeh,S., Warden,C.H. and Lusis,A.J.
  TITLE     Genetic regulation of cholesterol homeostasis: chromosomal
            organization of candidate genes
  JOURNAL   J Lipid Res 37 (7), 1406-1421 (1996)
   PUBMED   8827514
  REMARK    Erratum:[J Lipid Res 1996 Oct;37(10):2269]
REFERENCE   10 (bases 1 to 3009)
  AUTHORS   Warden,C.H., Mehrabian,M., He,K.Y., Yoon,M.Y., Diep,A., Xia,Y.R.,
            Wen,P.Z., Svenson,K.L., Sparkes,R.S. and Lusis,A.J.
  TITLE     Linkage mapping of 40 randomly isolated liver cDNA clones in the
            mouse
  JOURNAL   Genomics 18 (2), 295-307 (1993)
   PUBMED   8288233
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143959.1 and AC121821.3.
            
            On Mar 20, 2010 this sequence version replaced NM_011397.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143959.1, AK085499.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2908              AK143959.1         2-2909
            2909-3009           AC121821.3         105182-105282       c
FEATURES             Location/Qualifiers
     source          1..3009
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 19.17 cM"
     gene            1..3009
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="solute carrier family 23 (nucleobase transporters),
                     member 1"
                     /db_xref="GeneID:20522"
                     /db_xref="MGI:MGI:1341903"
     exon            1..126
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..1908
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="solute carrier family 23 (nucleobase transporters),
                     member 2; yolk sac permease-like molecule 3;
                     sodium-dependent vitamin C transporter 1; Na(+)/L-ascorbic
                     acid transporter 1"
                     /codon_start=1
                     /product="solute carrier family 23 member 1"
                     /protein_id="NP_035527.3"
                     /db_xref="CCDS:CCDS29144.1"
                     /db_xref="GeneID:20522"
                     /db_xref="MGI:MGI:1341903"
                     /translation="MKTPEDPGSPKQHEVVDSAGTSTRDRQAPLPTEPKFDMLYKIED
                     VPPWYLCILLGFQHYLTCFSGTIAVPFLLAEALCVGRDQHMVSQLIGTIFTCVGITTL
                     IQTTVGIRLPLFQASAFAFLVPAKSILALERWKCPSEEEIYGNWSMPLNTSHIWHPRI
                     REVQGAIMVSSMVEVVIGLMGLPGALLSYIGPLTVTPTVSLIGLSVFQAAGDRAGSHW
                     GISACSILLIVLFSQYLRNLTFLLPVYRWGKGLTLFRVQIFKMFPIVLAIMTVWLLCY
                     VLTLTDVLPADPTVYGFQARTDARGDIMAISPWIRIPYPCQWGLPTVTVAAVLGMFSA
                     TLAGIIESIGDYYACARLAGAPPPPVHAINRGIFTEGICCIIAGLLGTGNGSTSSSPN
                     IGVLGITKVGSRRVVQYGAGIMLILGAIGKFTALFASLPDPILGGMFCTLFGMITAVG
                     LSNLQFVDMNSSRNLFVLGFSMFFGLTLPNYLDSNPGAINTGIPEVDQILTVLLTTEM
                     FVGGCLAFILDNTVPGSPEERGLIQWKAGAHANSETSASLKSYDFPFGMGMVKRTTFF
                     RYIPICPVFRGFSKKTQNQPPVLEDTPDNIETGSVCTKV"
     exon            127..261
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            262..419
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            420..508
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            509..576
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            577..758
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            759..879
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1036
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1184
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1185..1290
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1291..1420
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1421..1564
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1660
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1925
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     exon            1926..3009
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2383..2388
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="hexamer: AATAAA"
     polyA_site      2405
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="major polyA site"
     regulatory      2896..2901
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="hexamer: AATAAA"
     polyA_site      2921
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="major polyA site"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="hexamer: ATTAAA"
     polyA_site      3009
                     /gene="Slc23a1"
                     /gene_synonym="D18Ucla2; Slc23a2; SVCT1; YSPL3"
                     /note="major polyA site"
ORIGIN      
        1 aatgtctgat gagtggagta aagtcctcct tggccttggg aaagccctct tcttttctcc
       61 tcagaggttt ctcaaacttg tgcctcagag atgaaaactc cggaggaccc cgggagccca
      121 aagcagcatg aggtcgtgga ttcagcaggg acttccacca gggaccggca ggcacctttg
      181 cccacggagc ccaagtttga catgttgtac aagattgagg atgtgccacc atggtacctg
      241 tgcatcctgc tgggcttcca gcattacctg acgtgcttca gtggcaccat cgccgtgccc
      301 ttcctcctgg ctgaggcgct gtgtgtgggc cgtgaccagc acatggtcag tcagctcatt
      361 ggtaccatct tcacctgtgt gggtatcacc actctcatcc agactacagt gggcatccgg
      421 ctgccgttgt tccaggccag tgcctttgcc tttctggttc cagccaagtc aatcctggcc
      481 ttggagaggt ggaagtgtcc ttcagaagaa gagatctacg gtaactggag tatgcctctc
      541 aacacctccc atatctggca tcctcgtatc cgggaggtcc agggtgcaat catggtgtcc
      601 agtatggtgg aggtggtgat tgggctgatg gggctgcctg gggccctgct cagctacatt
      661 gggcctctca ccgtcacccc cactgtctcc cttattgggc tctctgtttt ccaagctgct
      721 ggtgaccgag ctggctctca ttggggtatt tcggcttgct ccattctcct gatagtcttg
      781 ttctcccagt atctgcgcaa cctcaccttc ctgttacctg tttaccgatg gggcaagggt
      841 ctcactctct tccgagtcca gatctttaag atgtttccga ttgtgctggc catcatgacc
      901 gtgtggctgc tctgctacgt gttgaccctg acagatgtgc tgcccgcaga ccccacagtc
      961 tatggcttcc aggctcgaac tgatgcccga ggggacatca tggctatctc tccctggatc
     1021 cgaatcccct atccatgtca gtggggccta cccacagtga ctgtggctgc agttctgggg
     1081 atgttcagtg ccacactggc gggcatcatt gagtccatcg gtgattacta tgcctgtgcc
     1141 cggttggctg gagcaccacc ccctccagta catgccatca acaggggaat tttcactgaa
     1201 ggcatctgct gcattatcgc tgggctactg ggcacaggca acgggtccac ctcatccagt
     1261 cccaacattg gggtcctagg gattaccaag gtgggcagcc gaagagtcgt gcagtacggt
     1321 gcaggtatca tgctaatcct gggtgccatt ggcaaattca cagctctctt tgcctcactg
     1381 ccagacccca tcctgggagg aatgttctgc actctttttg gtatgatcac tgctgtggga
     1441 ctgtccaatc tgcagtttgt ggacatgaac tcttctcgca acctctttgt attgggattc
     1501 tccatgttct ttggcctcac actacccaac tacctggatt ccaacccagg tgctatcaac
     1561 acaggcattc ctgaagtgga tcagatccta actgtgctgc tgaccacaga gatgtttgtt
     1621 ggcgggtgcc ttgctttcat actggacaac acagtgccag ggagcccaga ggaaagaggc
     1681 ctgatacagt ggaaggctgg agcccacgcc aacagtgaga cgtcagccag tctcaagagc
     1741 tacgatttcc cctttgggat gggcatggta aaaaggacca cctttttcag atacatcccc
     1801 atctgcccag tcttcagagg attttctaaa aagacacaaa atcagcctcc agttctagaa
     1861 gacactccag acaatataga aactgggtct gtgtgtacca aggtctgaag ccacctcaat
     1921 gaaaggaggc actgtgtgta acaggaaaag aaaactacat aggagacaga agacctgagt
     1981 tggagatctc agctctacct attcaaaatt cccatggaag cttgaacaga tcaccctctc
     2041 tgtgactctg tttccatgtc agcccaagtc tccaagtact ctaagagacc tggactgcat
     2101 tcctctgtct catttccact tccctaaaca tgaagtcaat ataaagaaga agaactgaag
     2161 atcctctatg ctgagtgttg ataaaaaaga aacctggaga tattccaggg gtagatgaag
     2221 acaggaagat taaaaaacaa aaaaccaaaa ccaaaccaaa caaacaaaca cacccctgaa
     2281 ttccaatgcc atgtatttta agaccaaaac ataatattaa atgacatact ggaccaataa
     2341 tttaaaaaag tttagataag tgttctccct tcacataggg gaaataaatc tatactttca
     2401 gactagctca gtgattaaaa tgtctattta gaatgttcta ggcctgggct tgaccttcaa
     2461 cattaaatat acagaaataa aaacccttaa aagaaagaaa aagtgccggg cagtggtggc
     2521 tcctggcact ctgtggaggc agaggcagag gcaggtggat ttctgagttt gaggccatcc
     2581 tggtctacag agtgagttcc aggacagcca gggctacaca gagaaatcct gtctcaaaaa
     2641 aaccaaaaag taagaaaagc aagcatggtt taattgttaa aaaaataaaa acagggctgg
     2701 tgagatggct cagtgggtaa gagcacccga ctgctcttcc gaaggtccag agttcaaatc
     2761 ccagcaacca catggtgact cacaaccacc cgaaatgaga tctgatgccc tcgtctggtg
     2821 tgtctgagga cagctacggt gggtgtactt acatataata aataaataaa tctttaaaaa
     2881 aaataaaaaa ataaaaataa aaacaatcaa aaacaaaaaa agggcagaat tcttgaatat
     2941 gtaatcttct ggaaactaga gaagtctaaa aatgaattaa agtaatctcg aaaagtttga
     3001 gtcaagcaa
//
