LOCUS       NM_144856               2007 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus solute carrier family 22 (organic anion transporter),
            member 7 (Slc22a7), mRNA.
ACCESSION   NM_144856 XM_001002761
VERSION     NM_144856.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2007)
  AUTHORS   Arakawa,H., Ishida,N., Nakatsuji,T., Matsumoto,N., Imamura,R.,
            Shengyu,D., Araya,K., Horike,S.I., Tanaka-Yachi,R., Kasahara,M.,
            Yoshioka,T., Sumida,Y., Ohmiya,H., Daikoku,T., Wakayama,T.,
            Nakamura,K., Fujita,K.I. and Kato,Y.
  TITLE     Endoplasmic reticulum transporter OAT2 regulates drug metabolism
            and interaction
  JOURNAL   Biochem Pharmacol 225, 116322 (2024)
   PUBMED   38815630
REFERENCE   2  (bases 1 to 2007)
  AUTHORS   Alpern,D., Langer,D., Ballester,B., Le Gras,S., Romier,C.,
            Mengus,G. and Davidson,I.
  TITLE     TAF4, a subunit of transcription factor II D, directs promoter
            occupancy of nuclear receptor HNF4A during post-natal hepatocyte
            differentiation
  JOURNAL   Elife 3, e03613 (2014)
   PUBMED   25209997
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2007)
  AUTHORS   Islam,R., Anzai,N., Ahmed,N., Ellapan,B., Jin,C.J., Srivastava,S.,
            Miura,D., Fukutomi,T., Kanai,Y. and Endou,H.
  TITLE     Mouse organic anion transporter 2 (mOat2) mediates the transport of
            short chain fatty acid propionate
  JOURNAL   J Pharmacol Sci 106 (3), 525-528 (2008)
   PUBMED   18344607
  REMARK    GeneRIF: propionate (3-carbon SCFA) was transported by mOat2 in a
            time-dependent manner.
REFERENCE   4  (bases 1 to 2007)
  AUTHORS   Baur,J.A., Pearson,K.J., Price,N.L., Jamieson,H.A., Lerin,C.,
            Kalra,A., Prabhu,V.V., Allard,J.S., Lopez-Lluch,G., Lewis,K.,
            Pistell,P.J., Poosala,S., Becker,K.G., Boss,O., Gwinn,D., Wang,M.,
            Ramaswamy,S., Fishbein,K.W., Spencer,R.G., Lakatta,E.G., Le
            Couteur,D., Shaw,R.J., Navas,P., Puigserver,P., Ingram,D.K., de
            Cabo,R. and Sinclair,D.A.
  TITLE     Resveratrol improves health and survival of mice on a high-calorie
            diet
  JOURNAL   Nature 444 (7117), 337-342 (2006)
   PUBMED   17086191
REFERENCE   5  (bases 1 to 2007)
  AUTHORS   Kobayashi,Y., Ohbayashi,M., Kohyama,N. and Yamamoto,T.
  TITLE     Mouse organic anion transporter 2 and 3 (mOAT2/3[Slc22a7/8])
            mediates the renal transport of bumetanide
  JOURNAL   Eur J Pharmacol 524 (1-3), 44-48 (2005)
   PUBMED   16256982
  REMARK    GeneRIF: Results indicate that mOAT2 plays a role for the transport
            of bumetanide on the luminal membranes of kidney proximal tubules.
REFERENCE   6  (bases 1 to 2007)
  AUTHORS   Willnow,T., Antignac,C., Brandli,A., Christensen,E., Cox,R.,
            Davidson,D., Davies,J., Devuyst,O., Eichele,G., Hastie,N.,
            Verroust,P., Schedl,A. and Meij,I.
  TITLE     The European renal genome project: an integrated approach towards
            understanding the genetics of kidney development and disease
  JOURNAL   Organogenesis 2 (2), 42-47 (2005)
   PUBMED   19521566
REFERENCE   7  (bases 1 to 2007)
  AUTHORS   Monte,J.C., Nagle,M.A., Eraly,S.A. and Nigam,S.K.
  TITLE     Identification of a novel murine organic anion transporter family
            member, OAT6, expressed in olfactory mucosa
  JOURNAL   Biochem Biophys Res Commun 323 (2), 429-436 (2004)
   PUBMED   15369770
REFERENCE   8  (bases 1 to 2007)
  AUTHORS   Kobayashi,Y., Ohshiro,N., Shibusawa,A., Sasaki,T., Tokuyama,S.,
            Sekine,T., Endou,H. and Yamamoto,T.
  TITLE     Isolation, characterization and differential gene expression of
            multispecific organic anion transporter 2 in mice
  JOURNAL   Mol Pharmacol 62 (1), 7-14 (2002)
   PUBMED   12065749
  REMARK    GeneRIF: there exists a sex- and species-related differential gene
            expression of the OAT2 isoform.
REFERENCE   9  (bases 1 to 2007)
  AUTHORS   Barbot,W., Dupressoir,A., Lazar,V. and Heidmann,T.
  TITLE     Epigenetic regulation of an IAP retrotransposon in the aging mouse:
            progressive demethylation and de-silencing of the element by its
            repetitive induction
  JOURNAL   Nucleic Acids Res 30 (11), 2365-2373 (2002)
   PUBMED   12034823
REFERENCE   10 (bases 1 to 2007)
  AUTHORS   Pavlova,A., Sakurai,H., Leclercq,B., Beier,D.R., Yu,A.S. and
            Nigam,S.K.
  TITLE     Developmentally regulated expression of organic ion transporters
            NKT (OAT1), OCT1, NLT (OAT2), and Roct
  JOURNAL   Am J Physiol Renal Physiol 278 (4), F635-F643 (2000)
   PUBMED   10751225
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082865.1 and AK143949.1.
            
            On Jul 31, 2009 this sequence version replaced NM_144856.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143949.1, BC026597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               AK082865.1         2-177
            177-2007            AK143949.1         165-1995
FEATURES             Location/Qualifiers
     source          1..2007
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 22.9 cM"
     gene            1..2007
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /note="solute carrier family 22 (organic anion
                     transporter), member 7"
                     /db_xref="GeneID:108114"
                     /db_xref="MGI:MGI:1859559"
     exon            1..481
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1711
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /note="mOAT2; organic anion transporter 2"
                     /codon_start=1
                     /product="solute carrier family 22 member 7"
                     /protein_id="NP_659105.2"
                     /db_xref="CCDS:CCDS28829.1"
                     /db_xref="GeneID:108114"
                     /db_xref="MGI:MGI:1859559"
                     /translation="MGFEELLHKVGGFGPFQLRNLVLLALPRFLLPMHFLLPIFMAAV
                     PAHHCALPDAPANLSHQDLWLKTHLPRETDGSFSSCLRFAYPQALPNVTLGTEVYNSG
                     EPEGEPLTVPCSQGWEYDRSEFSSTIATEWDLVCQQRGLNKVTSTCFFIGVLLGAVVY
                     GYLSDRFGRRRLLLVAYVSTLALGLMSAASVNYIMFVTTRMLTGSALAGFTIIVLPLE
                     LEWLDVEHRTVAGVISTTFWTGGVLLLTLVGYLIRSWRWLLLAATLPCVPGIISIWWV
                     PESARWLLTQGRVEEAKKYLSICAKLNGRPISEDSLSQEALNKVITMERVSQRPSYLD
                     LFRTSQLRHVSLCCMMMWFGVNFSYYGLTLDASGLGLTVYQTQLLFGAVEVPSKITVF
                     FLVRLVGRRLTEAGMLLATALTFGISLLVSSDTKSWITALVVIGKAFSEAAFTTAYLF
                     TSELYPTVLRQTGMGFTALIGRLGASLAPLVVLLDGVWLLLPKLAYGGISFLAACTVL
                     LLPETKKAQLPETIQDVERKGRKIDRSGTELA"
     exon            482..585
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            586..740
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            741..909
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            910..1033
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1143
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1358
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1359..1467
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1468..1674
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1675..2007
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1915..1920
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /note="hexamer: AATAAA"
     polyA_site      1953
                     /gene="Slc22a7"
                     /gene_synonym="NLT; OAT2"
                     /note="major polyA site"
ORIGIN      
        1 attcccacct ccagagtcca agggcacatg tagcaagcag gttgaccgat cctaggtact
       61 atagaggcac acctggtggg tggagggcat gggcttcgaa gagctgctgc acaaggtggg
      121 tggctttggg cctttccaac tgcggaatct ggtgctgctg gccctgcccc gattcctgct
      181 cccgatgcat tttctcctgc ccatcttcat ggctgctgtg cctgcccatc attgtgccct
      241 gcctgatgcc ccagccaacc tcagtcacca ggacttgtgg ctgaaaaccc atctaccccg
      301 ggagactgac ggcagcttta gttcctgcct ccgctttgcc tatccccagg ctcttcccaa
      361 tgtcaccttg ggaacagagg tgtacaactc tggggagcct gagggtgagc ccctcacagt
      421 gccctgctcc cagggctggg agtacgaccg ctcagaattc tcttccacca ttgcaactga
      481 gtgggatctg gtgtgtcagc agagaggcct gaacaaagtt acatccacgt gcttcttcat
      541 cggcgtgctg ctgggggctg tggtgtacgg atacttgtct gacaggtttg gccggcgccg
      601 gcttctgctg gtggcctacg tgagcaccct ggcgctgggc ctgatgtctg cagcctcggt
      661 caactacatc atgtttgtca ccacccgcat gctcaccggc tcagccctgg ctggttttac
      721 catcattgta cttccgttgg agttagagtg gctggatgtg gagcaccgca ctgtggctgg
      781 ggtcatcagc accaccttct ggacaggagg ggtgctgctg ctgaccctgg ttgggtacct
      841 gatacggagc tggcggtggc ttctgctagc tgccactctg ccatgtgttc cgggcatcat
      901 tagcatctgg tgggtacctg agtctgcacg atggcttcta acccagggtc gtgtggagga
      961 ggcaaaaaag tacctgtcca tctgtgccaa gctcaatggg cggcccataa gtgaggacag
     1021 cctgagccag gaggctctga acaaagtgat caccatggaa agggtgtcgc aaagaccctc
     1081 gtacttagac ctgttccgga catcgcagct ccgacatgtc tcactgtgct gcatgatgat
     1141 gtggtttgga gtgaactttt cttactacgg cctgactctg gacgcgtccg ggctggggct
     1201 gaccgtgtac cagacacagc tgctgttcgg ggctgtggag gtgccttcca aaattacggt
     1261 cttcttcctt gtgcgtctcg tgggacgccg cctcacagag gctgggatgc tgctggccac
     1321 tgctctgacc ttcggcatca gcctgctggt gtcctcggac accaagtctt ggatcactgc
     1381 tctggtggtg atagggaaag ctttttctga agcagccttt actacagcct acctgttcac
     1441 gtctgagttg taccctactg tgctcagaca gacaggaatg ggattcactg cactcatagg
     1501 ccggctaggg gcctctctgg ccccactggt ggtcttgctg gatggagtgt ggctgttact
     1561 gcccaaactt gcttatgggg ggatttcttt cctggctgcc tgcactgtac tcctgctgcc
     1621 tgagacgaag aaagcacagc tgccagagac catccaggac gtggaaagaa aggggaggaa
     1681 gatagacaga tccgggactg aattagccta gggacagctc accaagtagc tggaaataga
     1741 aggcaggctc ttgtgactgg gacatcaaat tcctctgcct aaggatggag ctgctactgg
     1801 tgctgtctgc ctgtgtttat ccagtctcca aaaacaggac aactcctgca gcactgggct
     1861 gttggggatc ctgggcaccc ctctcatggt ggcggtgggt gggggacttc tgtaaataaa
     1921 gatagatgct catgggttgg ggcagctgtg gcatttgggg aagtcattga cttgatcctc
     1981 agctctgatt ccagctgtgc cacagtg
//
