LOCUS       NM_008766               4026 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 22 (organic anion transporter),
            member 6 (Slc22a6), mRNA.
ACCESSION   NM_008766
VERSION     NM_008766.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4026)
  AUTHORS   Ermakov,V.S., Granados,J.C. and Nigam,S.K.
  TITLE     Remote effects of kidney drug transporter OAT1 on gut microbiome
            composition and urate homeostasis
  JOURNAL   JCI Insight 8 (21), e172341 (2023)
   PUBMED   37937647
  REMARK    GeneRIF: Remote effects of kidney drug transporter OAT1 on gut
            microbiome composition and urate homeostasis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4026)
  AUTHORS   Granados,J.C., Ermakov,V., Maity,K., Vera,D.R., Chang,G. and
            Nigam,S.K.
  TITLE     The kidney drug transporter OAT1 regulates gut microbiome-dependent
            host metabolism
  JOURNAL   JCI Insight 8 (2), e160437 (2023)
   PUBMED   36692015
  REMARK    GeneRIF: The kidney drug transporter OAT1 regulates gut
            microbiome-dependent host metabolism.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4026)
  AUTHORS   Litke,C., Hagenston,A.M., Kenkel,A.K., Paldy,E., Lu,J., Kuner,R.
            and Mauceri,D.
  TITLE     Organic anion transporter 1 is an HDAC4-regulated mediator of
            nociceptive hypersensitivity in mice
  JOURNAL   Nat Commun 13 (1), 875 (2022)
   PUBMED   35169129
  REMARK    GeneRIF: Organic anion transporter 1 is an HDAC4-regulated mediator
            of nociceptive hypersensitivity in mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4026)
  AUTHORS   Granados,J.C., Nigam,A.K., Bush,K.T., Jamshidi,N. and Nigam,S.K.
  TITLE     A key role for the transporter OAT1 in systemic lipid metabolism
  JOURNAL   J Biol Chem 296, 100603 (2021)
   PUBMED   33785360
  REMARK    GeneRIF: A key role for the transporter OAT1 in systemic lipid
            metabolism.
REFERENCE   5  (bases 1 to 4026)
  AUTHORS   Granados,J.C., Richelle,A., Gutierrez,J.M., Zhang,P., Zhang,X.,
            Bhatnagar,V., Lewis,N.E. and Nigam,S.K.
  TITLE     Coordinate regulation of systemic and kidney tryptophan metabolism
            by the drug transporters OAT1 and OAT3
  JOURNAL   J Biol Chem 296, 100575 (2021)
   PUBMED   33757768
  REMARK    GeneRIF: Coordinate regulation of systemic and kidney tryptophan
            metabolism by the drug transporters OAT1 and OAT3.
REFERENCE   6  (bases 1 to 4026)
  AUTHORS   Floyd,J.A., Gold,D.A., Concepcion,D., Poon,T.H., Wang,X.,
            Keithley,E., Chen,D., Ward,E.J., Chinn,S.B., Friedman,R.A.,
            Yu,H.T., Moriwaki,K., Shiroishi,T. and Hamilton,B.A.
  TITLE     A natural allele of Nxf1 suppresses retrovirus insertional
            mutations
  JOURNAL   Nat Genet 35 (3), 221-228 (2003)
   PUBMED   14517553
REFERENCE   7  (bases 1 to 4026)
  AUTHORS   Sweet,D.H., Bush,K.T. and Nigam,S.K.
  TITLE     The organic anion transporter family: from physiology to ontogeny
            and the clinic
  JOURNAL   Am J Physiol Renal Physiol 281 (2), F197-F205 (2001)
   PUBMED   11457711
  REMARK    Review article
REFERENCE   8  (bases 1 to 4026)
  AUTHORS   Bartnikas,T.B., Waggoner,D.J., Casareno,R.L., Gaedigk,R.,
            White,R.A. and Gitlin,J.D.
  TITLE     Chromosomal localization of CCS, the copper chaperone for Cu/Zn
            superoxide dismutase
  JOURNAL   Mamm Genome 11 (5), 409-411 (2000)
   PUBMED   10790544
REFERENCE   9  (bases 1 to 4026)
  AUTHORS   Pavlova,A., Sakurai,H., Leclercq,B., Beier,D.R., Yu,A.S. and
            Nigam,S.K.
  TITLE     Developmentally regulated expression of organic ion transporters
            NKT (OAT1), OCT1, NLT (OAT2), and Roct
  JOURNAL   Am J Physiol Renal Physiol 278 (4), F635-F643 (2000)
   PUBMED   10751225
REFERENCE   10 (bases 1 to 4026)
  AUTHORS   Lopez-Nieto,C.E., You,G., Bush,K.T., Barros,E.J., Beier,D.R. and
            Nigam,S.K.
  TITLE     Molecular cloning and characterization of NKT, a gene product
            related to the organic cation transporter family that is almost
            exclusively expressed in the kidney
  JOURNAL   J Biol Chem 272 (10), 6471-6478 (1997)
   PUBMED   9045672
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC025794.9 and AK035971.1.
            
            On Aug 11, 2009 this sequence version replaced NM_008766.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035971.1, BC021647.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC025794.9         80767-80949
            184-2924            AK035971.1         2-2742
            2925-4026           AC025794.9         89969-91070
FEATURES             Location/Qualifiers
     source          1..4026
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.44 cM"
     gene            1..4026
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /note="solute carrier family 22 (organic anion
                     transporter), member 6"
                     /db_xref="GeneID:18399"
                     /db_xref="MGI:MGI:892001"
     exon            1..651
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            652..755
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            756..910
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            911..1079
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1203
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1204..1319
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1534
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1535..1643
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1644..1847
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     exon            1848..4026
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2231..2236
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /note="hexamer: AATAAA"
     polyA_site      2250
                     /gene="Slc22a6"
                     /gene_synonym="mOat1; NKT; Oat1; Orctl1"
                     /note="major polyA site"
ORIGIN      
        1 aaacgctgcc tgcgtaagag tcagggctcc agcagaccct gaaagctgag ctgtccagac
       61 ccccgaagtg aagaaaagag gcgagggcaa gggagggcca gaaccagggg agagagaaag
      121 gaggggcagc ccaccagccc gctgtctcgc cacagaaccg gctcagctcc aactccagga
      181 gtcactcagc tgcagaggca gtggcagccc tactcctcag gcaaagggca gcagacagac
      241 agacagaggt cctaggactg gaggtcctca ggcattgacc actcagcctg gcccagcccc
      301 atggccttca atgacctcct gaaacaggtg gggggtgtcg gacgcttcca gctgatccag
      361 gtcaccatgg tggttgctcc cctactgctg atggcttccc acaacaccct gcagaacttc
      421 actgctgcta tccccgctca ccactgccgc ccacctgcta atgccaacct cagcaaagat
      481 ggaggtctgg aggcctggct gcccctggac aagcaaggac gacccgaatc ttgcctccgc
      541 tttcctttcc cgcacaatgg cacagaggcc aatggcaccg gagtcacaga gccctgcctt
      601 gatggctggg tctatgacaa cagcaccttc ccttcaacca tcgtgactga gtggaacctt
      661 gtgtgctctc atcgggcctt ccgccagctg gcccagtccc tgttcatggt gggagtgtta
      721 ctgggagcca tgatgtttgg ctacctggcg gacaggctgg gccgtcggaa ggtgctgatc
      781 ttgaactacc tgcaaacagc tgtgtcggga acctgtgcag cctatgcacc caactatact
      841 gtctactgca ttttccggct cctctcgggc atgtctttgg ctagcattgc aatcaactgc
      901 atgacactaa acatggagtg gatgcctatt cacacccgtg cctatgtggg caccttgatt
      961 ggctatgtct acagcttggg ccagttcctc ctggctggta tcgcctatgc tgtgccccac
     1021 tggcgccacc tgcagcttgc ggtctctgtg ccttttttcg ttgccttcat ctactcttgg
     1081 ttcttcattg agtcagcccg ctggtactcc tcctctggaa ggctggacct caccctccga
     1141 gccctgcaga gagtggcccg catcaacggg aaacaagaag agggggctaa gctgagtata
     1201 gaggtgctcc agaccagcct gcagaaggaa ctgactctaa acaaaggcca ggcctccgcc
     1261 atggagctgc tgcgctgccc cacgcttcgg cgcctcttcc tctgcctctc tatgctgtgg
     1321 tttgccacta gctttgccta ctacgggctg gtcatggacc tgcagggctt tggggtcagc
     1381 atgtacctta tccaggtgat tttcggcgct gtggacctgc ctgccaagtt tgtgtgcttc
     1441 ctagtcatca attccatggg ccgccggcct gcacagttgg cctccctgct gctggcaggc
     1501 atctgtatcc tagtgaatgg cataataccg aggggccata caatcattcg cacatccctg
     1561 gctgtactag ggaaaggctg tctggcttcc tctttcaact gcatcttcct gtacaccgga
     1621 gagctgtacc ccacaatgat tcggcagacg ggcctgggca tgggcagcac catggcccgg
     1681 gtgggcagca tagtgagccc actgataagc atgactgccg agttctaccc ctccatacct
     1741 ctcttcatct tcggcgctgt ccccgtggcc gccagcgctg tcactgccct gctgccagag
     1801 accttgggcc agccgctgcc tgatacagtg caggacctga agagcaggag cagaggaaag
     1861 cagaagcaac agcagctgga acagcagaag cagatgatac cactccaggt ctcaacacaa
     1921 gagaagaacg gactctgaaa atggagaggg cgtcacacag cactaaaggg agtggggttc
     1981 tgcaggtccc accatctatg aggaggggga gtgagtggag ggactgggcc atctaaatgc
     2041 ggagcctgcc attcagagaa atgcctcccc aaaggtcact tcaatagacc tactaggaac
     2101 aaaagctcta actgtgtgca gcttcttaag cagaatgagc tcttcctcag ccatcttcca
     2161 gctcagtggt cactcctcca gctcctgtcc cttccacctc caggacattg caaagaatcc
     2221 cagacaatta aataaatttc ttctaccttg gtccctctct cttcttctct acctctccta
     2281 tccaaccatt tctgttttaa ctacatgttt tctgtctctt ccctttgcag aaatcagaat
     2341 ttaatgagaa actgaagtga aatcagcagt cagaggctct gccctgggct cttctcctgc
     2401 tgtaagagca gacagaaact tctagcagca aaagagatag atgcttatag gcgtgatgtc
     2461 aggatcctgt cccctgcaag ttcagaccac tagccaacct aatctttcct gtgtttgatg
     2521 ggttttcaac gttgctctgc ttcctgtagg ttcaggggct ggtggaggag tgagacgagg
     2581 accagacagt atttaacagc cagggagacc aaacactgag tgttaattat atgccaggtg
     2641 gtagcttcag caatttaaat gtattaattc agtttatcct ctttggtttc attttcttag
     2701 ttttcctgat aaggggtctt atctagctag ttattttgtt aacttgacac aggctagagt
     2761 catttgaaag gaaagaacct caactgaaaa aaaatgtctc tataagtggc ctgaaggcaa
     2821 gcctgtgcag ggcagattct taattaatga tcgatgtagg aggattcaga ccactgttga
     2881 caacactgcc cctgggatga tggtcctgtt tgctataaca aagcaagctg agcaagccag
     2941 tgagcagtgt tcttccacag cctctgctac agtctctgcc ccgacttccc accatgtcag
     3001 agtgtgacct gagagctgta agatgaaaca aaccctttcc tctctaagta gcttttggtc
     3061 atggtatttt gtcacagcaa tggaaatact aagacagggt ctcatcccta gctggccttg
     3121 acctgactaa gtagctgagg gtgactttga accttgagcc ttctgcctcc acctcccaaa
     3181 tgcaagcatt ccaggcgtgt gccgcaatgc tcaaatctga aaatagtacc ctttgattcc
     3241 tatcttggtc tcttttcagt cagtgtgtca gggaccttgt agcatcttct gtgacttgac
     3301 caagatggaa cactctgaat tctcaacttc ctggtcctgg tagagttctc ctcctgctca
     3361 gggcttcacc tcatcattcc aggttccaca caggctttta gtccaaagcc cttccttaca
     3421 ggatttttcc tccttcaaag atgtttcccg accccagaga gatttagagg acagagtctc
     3481 taccagctaa gcttcctgcc ctagatcagg ctgtgcagag gaaccctaga cgaggtctac
     3541 acaaactcct tggaactttc aattgtgtgg cctaaaacat aaatgacatg cagatataat
     3601 taaattaatg atttcgaagt gaagaaacta tcttaaatta tttgggttag cccaatatga
     3661 ttacaaaggc agttagacag atcagtggac agcagatata acagaagaat caagagggtg
     3721 gagtgactca agaaggaatg aaaaataaaa atcagttcaa gacagagaca ataagcttca
     3781 attagttgtt agcaaattaa agtaacttct gatcattttc aatcaaatag atacatttag
     3841 cattatcaaa tgaataaata tgtggtatgg gcctccaggc caaggaatga aacttccggg
     3901 agcttaaata ggaaggaaat ggattcttct ttgaaaccac caaaaggaac acatccctgt
     3961 tgacatagca accttcaata tccagcctct aactatacaa gaataaactg gactgtttta
     4021 agcctc
//
