LOCUS       NM_011396               3119 bp    mRNA    linear   ROD 27-DEC-2022
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 5 (Slc22a5), transcript variant 1, mRNA.
ACCESSION   NM_011396
VERSION     NM_011396.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3119)
  AUTHORS   Novakova K, Torok M, Panajatovic M, Bouitbir J, Duong FHT,
            Handschin C and Krahenbuhl S.
  TITLE     PGC-1alpha and MEF2 Regulate the Transcription of the Carnitine
            Transporter OCTN2 Gene in C2C12 Cells and in Mouse Skeletal Muscle
  JOURNAL   Int J Mol Sci 23 (20), 12304 (2022)
   PUBMED   36293168
  REMARK    GeneRIF: PGC-1alpha and MEF2 Regulate the Transcription of the
            Carnitine Transporter OCTN2 Gene in C2C12 Cells and in Mouse
            Skeletal Muscle.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3119)
  AUTHORS   Ghnaimawi S, Zhang S, Baum JI and Huang Y.
  TITLE     The Effects of Maternal Intake of EPA and DHA Enriched Diet During
            Pregnancy and Lactation on Offspring's Muscle Development and
            Energy Homeostasis
  JOURNAL   Front Physiol 13, 881624 (2022)
   PUBMED   35733999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3119)
  AUTHORS   Lamhonwah AM and Tein I.
  TITLE     Expression of the organic cation/carnitine transporter family
            (Octn1,-2 and-3) in mdx muscle and heart: Implications for early
            carnitine therapy in Duchenne muscular dystrophy to improve
            cellular carnitine homeostasis
  JOURNAL   Clin Chim Acta 505, 92-97 (2020)
   PUBMED   32070725
  REMARK    GeneRIF: Dystrophin deficiency likely disrupts Octn2 expression
            decreasing muscle carnitine uptake thus contributing to
            membranotoxic long-chain acyl-CoAs with sarcolemmal and organellar
            membrane oxidative injury
REFERENCE   4  (bases 1 to 3119)
  AUTHORS   Ranea-Robles P, Yu C, van Vlies N, Vaz FM and Houten SM.
  TITLE     Slc22a5 haploinsufficiency does not aggravate the phenotype of the
            long-chain acyl-CoA dehydrogenase KO mouse
  JOURNAL   J Inherit Metab Dis 43 (3), 486-495 (2020)
   PUBMED   31845336
  REMARK    GeneRIF: Slc22a5 haploinsufficiency does not aggravate the
            phenotype of the long-chain acyl-CoA dehydrogenase KO mouse.
REFERENCE   5  (bases 1 to 3119)
  AUTHORS   Wang W, Bai M, Jiang T, Li C, Li P, Zhou H, Wang Z, Li L and Jiang
            H.
  TITLE     Clozapine-induced reduction of l-carnitine reabsorption via
            inhibition/down-regulation of renal carnitine/organic cation
            transporter 2 contributes to liver lipid metabolic disorder in mice
  JOURNAL   Toxicol Appl Pharmacol 363, 47-56 (2019)
   PUBMED   30465787
  REMARK    GeneRIF: Acute and chronic administration of clozapine to mice
            resulted in 2-3-fold greater renal excretion of L-carnitine (L-Car)
            than in the vehicle group. Concomitantly, mRNA and protein levels
            of mOctn2 in the kidney were markedly down regulated. These results
            indicate that clozapine-induced reduction of L-Car reabsorption via
            inhibition/down-regulation of renal Octn2 contributes to liver
            lipid metabolic disorder.
REFERENCE   6  (bases 1 to 3119)
  AUTHORS   Nikaido H, Horiuchi M, Hashimoto N, Saheki T and Hayakawa J.
  TITLE     Mapping of jvs (juvenile visceral steatosis) gene, which causes
            systemic carnitine deficiency in mice, on chromosome 11
  JOURNAL   Mamm Genome 6 (5), 369-370 (1995)
   PUBMED   7626891
REFERENCE   7  (bases 1 to 3119)
  AUTHORS   Tomomura M, Nakagawa K and Saheki T.
  TITLE     Proto-oncogene c-jun and c-fos messenger RNAs increase in the liver
            of carnitine-deficient juvenile visceral steatosis (jvs) mice
  JOURNAL   FEBS Lett 311 (1), 63-66 (1992)
   PUBMED   1383034
REFERENCE   8  (bases 1 to 3119)
  AUTHORS   Tomomura M, Imamura Y, Horiuchi M, Koizumi T, Nikaido H, Hayakawa J
            and Saheki T.
  TITLE     Abnormal expression of urea cycle enzyme genes in juvenile visceral
            steatosis (jvs) mice
  JOURNAL   Biochim Biophys Acta 1138 (2), 167-171 (1992)
   PUBMED   1540663
REFERENCE   9  (bases 1 to 3119)
  AUTHORS   Kuwajima M, Kono N, Horiuchi M, Imamura Y, Ono A, Inui Y, Kawata S,
            Koizumi T, Hayakawa J, Saheki T et al.
  TITLE     Animal model of systemic carnitine deficiency: analysis in C3H-H-2
            degrees strain of mouse associated with juvenile visceral steatosis
  JOURNAL   Biochem Biophys Res Commun 174 (3), 1090-1094 (1991)
   PUBMED   1996978
REFERENCE   10 (bases 1 to 3119)
  AUTHORS   Koizumi T, Nikaido H, Hayakawa J, Nonomura A and Yoneda T.
  TITLE     Infantile disease with microvesicular fatty infiltration of viscera
            spontaneously occurring in the C3H-H-2(0) strain of mouse with
            similarities to Reye's syndrome
  JOURNAL   Lab Anim 22 (1), 83-87 (1988)
   PUBMED   3352223
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY017275.1, AK167451.1 and AI428340.1.
            
            [WARNING] On Nov 15, 2023 this sequence was replaced by
            NM_011396.4.
            
            On Apr 18, 2009 this sequence version replaced NM_011396.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031118.1, AK140640.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                BY017275.1         2-26
            26-2999             AK167451.1         2-2975
            3000-3119           AI428340.1         1-120               c
FEATURES             Location/Qualifiers
     source          1..3119
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.02 cM"
     gene            1..3119
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 5"
                     /db_xref="GeneID:20520"
                     /db_xref="MGI:MGI:1329012"
     exon            1..557
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     CDS             165..1838
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 22 member 5; organic
                     cation/carnitine transporter 2; high-affinity
                     sodium-dependent carnitine cotransporter; juvenile
                     visceral steatosis"
                     /codon_start=1
                     /product="organic cation/carnitine transporter 2 isoform
                     1"
                     /protein_id="NP_035526.1"
                     /db_xref="CCDS:CCDS24687.1"
                     /db_xref="GeneID:20520"
                     /db_xref="MGI:MGI:1329012"
                     /translation="MRDYDEVTAFLGEWGPFQRLIFFLLSASIIPNGFNGMSIVFLAG
                     TPEHRCLVPHTVNLSSAWRNHSIPLETKDGRQVPQKCRRYRLATIANFSELGLEPGRD
                     VDLEQLEQESCLDGWEYDKDVFLSTIVTEWDLVCKDDWKAPLTTSLFFVGVLMGSFIS
                     GQLSDRFGRKNVLFLTMGMQTGFSFLQVFSVNFEMFTVLFVLVGMGQISNYVAAFVLG
                     TEILSKSIRIIFATLGVCIFYAFGFMVLPLFAYFIRDWRMLLLALTVPGVLCGALWWF
                     IPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSELQDLNSTKPQLHHIYDL
                     IRTRNIRVITIMSIILWLTISVGYFGLSLDTPNLHGDIYVNCFLLAAVEVPAYVLAWL
                     LLQYLPRRYSISAALFLGGSVLLFMQLVPSELFYLSTALVMVGKFGITSAYSMVYVYT
                     AELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLF
                     FPESFGVPLPDTIDQMLRVKGIKQWQIQSQTRMQKDGEESPTVLKSTAF"
     exon            558..661
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..816
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            817..988
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            989..1115
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1216
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1431
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1614
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1615..1750
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
     exon            1751..3105
                     /gene="Slc22a5"
                     /gene_synonym="jvs; Lstpl; Octn2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agagcccgcc ccgccctcag gccctatgta aagttggcgg tggccgagtc ggaggcgtcg
       61 gtgggaactc acgagccttg cacgcagagg ctctcagcgc cccgtctccc gcgccacggt
      121 gtccccttat tcccatacgg gcgctgtggg aggctgagga cggcatgcgg gactacgacg
      181 aggtgaccgc cttcctaggc gagtgggggc ccttccagcg cctcatcttc ttcctgctca
      241 gcgccagcat catccccaat ggcttcaatg gtatgtccat cgtgttcctg gcggggaccc
      301 cggagcaccg ttgccttgtg cctcacaccg tgaacctgag cagcgcgtgg cgcaaccaca
      361 gtatcccgtt ggagacgaag gacggacgac aggtgcctca gaaatgccgc cgctaccgac
      421 tggccaccat cgccaacttc tctgagctag ggctggagcc ggggcgggac gtggacctgg
      481 agcagctgga gcaggagagc tgcctggatg gctgggagta cgacaaggac gtcttcctgt
      541 ccaccatcgt gacagagtgg gacctggtgt gtaaggatga ctggaaagcc ccactcacca
      601 cctccttgtt tttcgtgggt gtgctgatgg gctccttcat ttcaggacag ctctcagaca
      661 ggtttggtcg caagaatgtg ctgtttttga ccatgggcat gcagactggc ttcagcttcc
      721 tgcaggtctt ctctgtgaac ttcgagatgt ttacagtgct ttttgtcctt gttggcatgg
      781 gtcagatctc caactacgtg gcagcatttg tcctgggaac agaaattctt tccaagtcaa
      841 ttcgaattat attcgccacc ttaggagttt gcatatttta tgcgtttggc ttcatggtgc
      901 tgccactgtt tgcatacttc atcagagact ggaggatgct gctgctggcg ctcactgtgc
      961 caggggtgct atgtggggct ctctggtggt tcatccctga gtccccacga tggctcatct
     1021 ctcaaggccg aattaaagag gcagaggtga tcatccgcaa agctgccaaa atcaatggga
     1081 ttgttgcacc ttccactatc ttcgatccaa gtgagttaca agacttaaat tctacgaagc
     1141 ctcagttgca ccacatttat gatctgatcc gaacacggaa tatcagggtc atcaccatca
     1201 tgtctataat cctgtggctg accatatcag tgggctattt tggactatct cttgacactc
     1261 ctaacttgca tggggacatc tatgtgaact gcttcctact ggcggctgtt gaagtcccag
     1321 cctatgtgct ggcctggctg ttgttgcagt acttgccccg gcgatattct atctcggctg
     1381 cccttttcct gggtggcagt gtccttctct tcatgcagct ggtgccttca gaattgtttt
     1441 acttgtccac tgccctggtg atggtgggga agtttggaat cacctctgcc tactccatgg
     1501 tctatgtgta cacagctgag ctgtacccca ctgtggtcag aaacatgggt gtgggggtca
     1561 gctccacagc atcccgcctt ggcagcatcc tgtctcccta ctttgtttac ctaggtgcct
     1621 atgatcgctt cctgccttat attctcatgg gaagtctgac catcctgaca gctatcctca
     1681 ccttgttctt ccctgagagc tttggtgtcc ctctcccaga taccattgac cagatgctaa
     1741 gggtcaaagg aataaaacag tggcaaatcc aaagccagac aagaatgcaa aaagatggtg
     1801 aagaaagccc aacagtccta aagagcacag ccttctaaca ccctgtccag aaggcaaaaa
     1861 actgattgga aaccttcatg ttgtcagaaa tgctctccat gactgagggc ttttctgttc
     1921 tgttaacctt gtgtctaaca tgctcatgga ttggggcatc tgtcctggag agtcaccttc
     1981 ctctagggcc accaaggcta accaaacagc ttgcacgtcc catcacagtg gtggatgtgg
     2041 gccttccaaa gaaatgaatg agtctcttga acaagcagga cttggaagac tatgagaaac
     2101 atctgctaga catgctttgt tattttttaa gacctgataa gggtgcacat agaacagcag
     2161 gtctttttcc ctctcctttc cctaactgca gaacttacag gaaaggaata agtgtccctc
     2221 aggggcagtg tgcttgtcta ggatgcacca gaaggaaaca aaaatttctt ttcagaaaat
     2281 aagtgattcc attgatagtt tgatttctcg tcttttctca gttaaaaagt tttaactgca
     2341 acactcttaa ctcgtgacat aacaaagact gagggagccc aaaggagact aaggtggagg
     2401 ctggtccata aagcagacaa tgtgttgact gtgactgctc agtcccacag ccaggtactg
     2461 tgtgtgtggt cagggtcctg ggcttgtcca ggccctgtga gaaatctact gttgaggcca
     2521 aggcttgtct tccactgctg tgtaaatcaa aattctggct gccagccact tatctgtgtc
     2581 ttgaaggaaa tgtatggata acagagtgtc ccttccctct cccagcactg tcatggggag
     2641 tttgtttgtt tgtcatctgc tgtttatgtc tcaagctatt tgtcccttag cagaagcttg
     2701 ggaactgcct gtgttcccca gcccagggtc accctggctg gtgtgcagtt accaccatac
     2761 aaggccttcc caatcttagc cactagagct gctctgagtg ccaaaaataa taacactatg
     2821 cttcttcctt ttacgatgta taatcatgag gaaaattaca agaaagaaat gtaaattgtg
     2881 tcacagtctc tcagagtagc tggctgcagt cgtgtcacat cggtgggtgt tttgtgttca
     2941 gtgtgattgt cttctcttct gattatgttg ccatggtgct ccgaaagcac atgcttcacc
     3001 cacttacaat acaaaacaaa caccaaacct gtattttgtg aaggctactg aagtgccttg
     3061 ggcaatgaaa tggttttaat aaacaatgat ttttttttaa taataaaaaa aaaaaaaaa
//
