LOCUS       NM_019687               2301 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 4 (Slc22a4), transcript variant 1, mRNA.
ACCESSION   NM_019687
VERSION     NM_019687.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2301)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2301)
  AUTHORS   Lu,D., Cai,H., Li,Y., Chang,W., Liu,X., Dai,Q., Yu,W., Chen,W.,
            Qiao,G., Xie,H., Xiao,X. and Li,Z.
  TITLE     Investigating the ID3/SLC22A4 as immune-related signatures in
            ischemic stroke
  JOURNAL   Aging (Albany NY) 15 (24), 14803-14829 (2023)
   PUBMED   38112574
  REMARK    GeneRIF: Investigating the ID3/SLC22A4 as immune-related signatures
            in ischemic stroke.
REFERENCE   3  (bases 1 to 2301)
  AUTHORS   Mayayo-Vallverdu,C., Lopez de Heredia,M., Prat,E., Gonzalez,L.,
            Espino Guarch,M., Vilches,C., Munoz,L., Asensi,M.A., Serra,C.,
            Llebaria,A., Casado,M., Artuch,R., Garrabou,G., Garcia-Roves,P.M.,
            Pallardo,F.V. and Nunes,V.
  TITLE     The antioxidant l-Ergothioneine prevents cystine lithiasis in the
            Slc7a9-/- mouse model of cystinuria
  JOURNAL   Redox Biol 64, 102801 (2023)
   PUBMED   37418888
REFERENCE   4  (bases 1 to 2301)
  AUTHORS   Ben Said,M., Grati,M., Ishimoto,T., Zou,B., Chakchouk,I., Ma,Q.,
            Yao,Q., Hammami,B., Yan,D., Mittal,R., Nakamichi,N., Ghorbel,A.,
            Neng,L., Tekin,M., Shi,X.R., Kato,Y., Masmoudi,S., Lu,Z., Hmani,M.
            and Liu,X.
  TITLE     A mutation in SLC22A4 encoding an organic cation transporter
            expressed in the cochlea strial endothelium causes human recessive
            non-syndromic hearing loss DFNB60
  JOURNAL   Hum Genet 135 (5), 513-524 (2016)
   PUBMED   27023905
REFERENCE   5  (bases 1 to 2301)
  AUTHORS   Zhu,C., Nigam,K.B., Date,R.C., Bush,K.T., Springer,S.A., Saier,M.H.
            Jr., Wu,W. and Nigam,S.K.
  TITLE     Evolutionary Analysis and Classification of OATs, OCTs, OCTNs, and
            Other SLC22 Transporters: Structure-Function Implications and
            Analysis of Sequence Motifs
  JOURNAL   PLoS One 10 (11), e0140569 (2015)
   PUBMED   26536134
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2301)
  AUTHORS   Pochini,L., Scalise,M., Galluccio,M. and Indiveri,C.
  TITLE     OCTN cation transporters in health and disease: role as drug
            targets and assay development
  JOURNAL   J Biomol Screen 18 (8), 851-867 (2013)
   PUBMED   23771822
  REMARK    Review article
REFERENCE   7  (bases 1 to 2301)
  AUTHORS   Lamhonwah,A.M., Skaug,J., Scherer,S.W. and Tein,I.
  TITLE     A third human carnitine/organic cation transporter (OCTN3) as a
            candidate for the 5q31 Crohn's disease locus (IBD5)
  JOURNAL   Biochem Biophys Res Commun 301 (1), 98-101 (2003)
   PUBMED   12535646
REFERENCE   8  (bases 1 to 2301)
  AUTHORS   Tamai,I., Ohashi,R., Nezu,J.I., Sai,Y., Kobayashi,D., Oku,A.,
            Shimane,M. and Tsuji,A.
  TITLE     Molecular and functional characterization of organic
            cation/carnitine transporter family in mice
  JOURNAL   J Biol Chem 275 (51), 40064-40072 (2000)
   PUBMED   11010964
REFERENCE   9  (bases 1 to 2301)
  AUTHORS   Wenderfer,S.E., Slack,J.P., McCluskey,T.S. and Monaco,J.J.
  TITLE     Identification of 40 genes on a 1-Mb contig around the IL-4
            cytokine family gene cluster on mouse chromosome 11
  JOURNAL   Genomics 63 (3), 354-373 (2000)
   PUBMED   10704283
REFERENCE   10 (bases 1 to 2301)
  AUTHORS   Zhu,Y., Jong,M.C., Frazer,K.A., Gong,E., Krauss,R.M., Cheng,J.F.,
            Boffelli,D. and Rubin,E.M.
  TITLE     Genomic interval engineering of mice identifies a novel modulator
            of triglyceride production
  JOURNAL   Proc Natl Acad Sci U S A 97 (3), 1137-1142 (2000)
   PUBMED   10655497
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143595.1, AB016257.1, CD773920.1 and AL596444.10.
            
            On Aug 23, 2016 this sequence version replaced NM_019687.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010590.1, AB016257.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-82                AK143595.1         1-82
            83-2090             AB016257.1         76-2083
            2091-2114           CD773920.1         188-211             c
            2115-2115           AL596444.10        114297-114297
            2116-2278           CD773920.1         24-186              c
            2279-2279           AL596444.10        114461-114461
            2280-2301           CD773920.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..2301
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.07 cM"
     gene            1..2301
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 4"
                     /db_xref="GeneID:30805"
                     /db_xref="MGI:MGI:1353479"
     exon            1..521
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            522..625
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            626..780
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            781..952
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            953..1079
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1080..1180
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1395
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1396..1578
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1714
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..2285
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2256..2261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /note="hexamer: AATAAA"
     polyA_site      2285
                     /gene="Slc22a4"
                     /gene_synonym="Octn1"
                     /note="major polyA site"
ORIGIN      
        1 gagttttgca gcacccacgg cgtgtttgca cgcagccacc taggaagatc ccctcagcgc
       61 gccgcaatcg ctgaatcctt tctctccacc cacctccctc acgcaagctg aggaggagag
      121 gtggaaacat gcgggactac gacgaggtga tcgccttcct gggcgagtgg gggcccttcc
      181 agcgcctcat cttctttctg ctcagcgcca gcatcatccc caatggcttc aatggtatgt
      241 cagtcgtgtt cctggcgggg acccccgagc accgttgcct ggttcctgac actgtgaacc
      301 tgagcagctc ctggcgcaac cacagcatcc ccttggagac gaaggacgga cgacaggtgc
      361 ctcagagctg ccgccgctac cgactggcca ccatcgccaa cttctctgcg atggggctgg
      421 agccaggaca ggacgtggat ctggagcagc tggagcagga gagctgcctg gatggctggg
      481 agtacgacaa ggacatcttc ctgtccacca tcgtgacaga gtggaatctg gtgtgtgagg
      541 atgactggaa gacacccctc accacctccc tgttcttcgt aggcgttctc tgcggctcct
      601 tcgtgtctgg gcagctgtca gacaggtttg gcaggaagaa agtcctcttt gcaaccatgg
      661 ctgtgcagac tggattcagc ttcgtgcaga ttttctcaac caactgggag atgttcactg
      721 tgttgtttgc cattgtgggc atgggccaga tctccaacta cgtggtggcc ttcatactag
      781 gaactgaaat cctgagcaag tcggttcgca tcatcttctc cacattagga gtctgtacat
      841 tttttgcaat cggctacatg gtcctgccgc tgtttgcata cttcatcaga gactggagga
      901 tgctgctgct ggccctgaca ctgcctggcc tgttctgtgt tcccctgtgg tggtttattc
      961 cagaatctcc ccggtggctg atatcccaga ggagatttgc agaggccgaa cagatcatcc
     1021 agaaagccgc aaagatgaac agcatcgtgg cgccagcagg gatattcgat cctctagagc
     1081 tacaggagct aaactccttg aagcagcaga aagtcataat cctggacctg ttcaggactc
     1141 ggaacattgc caccataacc gtgatggctg tgatgctgtg gatgctaacc tcagtgggtt
     1201 actttgctct gtctctcaat gttcctaatt tacatggaga tgtctacctg aactgcttcc
     1261 tctctggcct gattgaagtt ccagcttact tcacagcctg gctgctactg cgaaccctgc
     1321 cacggagata tattatagct ggggtgctat tctggggagg aggtgtgctt ctcttgatcc
     1381 aagtggtacc tgaagattat aactttgtgt ccattggact ggtgatgctg gggaaatttg
     1441 ggatcacctc tgccttctcc atgttgtatg tcttcactgc ggagctctac ccaaccctgg
     1501 tcaggaacat ggctgtgggc atcacctcca tggcctctcg ggtgggcagc atcattgccc
     1561 cctatttcgt ttacctgggc gcctataaca gactcctacc ctacatcctc atgggcagtc
     1621 tgactgtcct cattggaatc atcacgcttt ttttccctga aagttttgga gtgactctac
     1681 cagagaactt ggagcagatg cagaaagtga gagggttcag atgtgggaaa aaatcaacag
     1741 tctcagtgga cagagaagaa agccccaagg ttctaataac tgcattctaa cgaggtttcc
     1801 aaggcacttg gcaaactgaa aagcagatgt atacaatgag cagggtgtga tagagcaagc
     1861 ctgcaatccc agcgctcttg gggtggagac agaagatcag gagttcaagg tcatccttgg
     1921 ctacagcagg agtgtaagac cagcctgtct taccacaagc aaccctgtct caacagaaca
     1981 aatcaaaagc cttttctgct gaaagggatt aacagaaaca atgagcacca aactggactt
     2041 gtggagaaat gcacactatc tcatgaattc tgggccactc ttccagatgg ccttgttttc
     2101 aagaacaaac atttctaaat agtcttgact actaactatt caatgaaatt gatttgtaag
     2161 attttttttt ttttttttgg aaaatgtgtt agtcaaggac tggcaaaatc catatgaaga
     2221 ttaacacaca tttctaaacg tataaatgct atccaaataa aattatcaca actattagat
     2281 ggtaaaaaaa aaaaaaaaaa a
//
