LOCUS       NM_011395               3501 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 3 (Slc22a3), mRNA.
ACCESSION   NM_011395 XM_977528
VERSION     NM_011395.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3501)
  AUTHORS   Chan,J.C., Alenina,N., Cunningham,A.M., Ramakrishnan,A., Shen,L.,
            Bader,M. and Maze,I.
  TITLE     Serotonin Transporter-dependent Histone Serotonylation in Placenta
            Contributes to the Neurodevelopmental Transcriptome
  JOURNAL   J Mol Biol 436 (7), 168454 (2024)
   PUBMED   38266980
REFERENCE   2  (bases 1 to 3501)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3501)
  AUTHORS   Sardar,D., Cheng,Y.T., Woo,J., Choi,D.J., Lee,Z.F., Kwon,W.,
            Chen,H.C., Lozzi,B., Cervantes,A., Rajendran,K., Huang,T.W.,
            Jain,A., Arenkiel,B.R., Maze,I. and Deneen,B.
  TITLE     Induction of astrocytic Slc22a3 regulates sensory processing
            through histone serotonylation
  JOURNAL   Science 380 (6650), eade0027 (2023)
   PUBMED   37319217
  REMARK    GeneRIF: Induction of astrocytic Slc22a3 regulates sensory
            processing through histone serotonylation.
REFERENCE   4  (bases 1 to 3501)
  AUTHORS   Zengeler,K.E., Shapiro,D.A., Bruch,K.R., Lammert,C.R., Ennerfelt,H.
            and Lukens,J.R.
  TITLE     SSRI treatment modifies the effects of maternal inflammation on in
            utero physiology and offspring neurobiology
  JOURNAL   Brain Behav Immun 108, 80-97 (2023)
   PUBMED   36343752
REFERENCE   5  (bases 1 to 3501)
  AUTHORS   Pittolo,S., Yokoyama,S., Willoughby,D.D., Taylor,C.R.,
            Reitman,M.E., Tse,V., Wu,Z., Etchenique,R., Li,Y. and
            Poskanzer,K.E.
  TITLE     Dopamine activates astrocytes in prefrontal cortex via
            alpha1-adrenergic receptors
  JOURNAL   Cell Rep 40 (13), 111426 (2022)
   PUBMED   36170823
REFERENCE   6  (bases 1 to 3501)
  AUTHORS   Sleutels,F., Zwart,R. and Barlow,D.P.
  TITLE     The non-coding Air RNA is required for silencing autosomal
            imprinted genes
  JOURNAL   Nature 415 (6873), 810-813 (2002)
   PUBMED   11845212
  REMARK    GeneRIF: Slc22a3 is one of three imprinted genes on chromosome 17
            that is expressed from the maternal allele. A non-coding Air RNA is
            required for repression of all three genes on the paternal allele.
REFERENCE   7  (bases 1 to 3501)
  AUTHORS   Verhaagh,S., Barlow,D.P. and Zwart,R.
  TITLE     The extraneuronal monoamine transporter Slc22a3/Orct3 co-localizes
            with the Maoa metabolizing enzyme in mouse placenta
  JOURNAL   Mech Dev 100 (1), 127-130 (2001)
   PUBMED   11118898
REFERENCE   8  (bases 1 to 3501)
  AUTHORS   Wu,X., Huang,W., Ganapathy,M.E., Wang,H., Kekuda,R., Conway,S.J.,
            Leibach,F.H. and Ganapathy,V.
  TITLE     Structure, function, and regional distribution of the organic
            cation transporter OCT3 in the kidney
  JOURNAL   Am J Physiol Renal Physiol 279 (3), F449-F458 (2000)
   PUBMED   10966924
REFERENCE   9  (bases 1 to 3501)
  AUTHORS   Wieland,A., Hayer-Zillgen,M., Bonisch,H. and Bruss,M.
  TITLE     Analysis of the gene structure of the human (SLC22A3) and murine
            (Slc22a3) extraneuronal monoamine transporter
  JOURNAL   J Neural Transm (Vienna) 107 (10), 1149-1157 (2000)
   PUBMED   11129104
REFERENCE   10 (bases 1 to 3501)
  AUTHORS   Verhaagh,S., Schweifer,N., Barlow,D.P. and Zwart,R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC132106.4 and
            AC087901.21.
            
            On Mar 21, 2007 this sequence version replaced NM_011395.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF078750.1, AF082566.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 11845212
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-794               AC132106.4         61026-61819
            795-898             AC132106.4         104170-104273
            899-1053            AC132106.4         108813-108967
            1054-1222           AC132106.4         110124-110292
            1223-1340           AC132106.4         111068-111185
            1341-1438           AC132106.4         134835-134932
            1439-1653           AC132106.4         135053-135267
            1654-1762           AC087901.21        806-914
            1763-1875           AC087901.21        1871-1983
            1876-1975           AC087901.21        3752-3851
            1976-3501           AC087901.21        6088-7613
FEATURES             Location/Qualifiers
     source          1..3501
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.52 cM"
     gene            1..3501
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 3"
                     /db_xref="GeneID:20519"
                     /db_xref="MGI:MGI:1333817"
     exon            1..794
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     CDS             381..2036
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /note="solute carrier family 22, member 3; organic cation
                     transporter 3"
                     /codon_start=1
                     /product="solute carrier family 22 member 3"
                     /protein_id="NP_035525.1"
                     /db_xref="CCDS:CCDS28391.1"
                     /db_xref="GeneID:20519"
                     /db_xref="MGI:MGI:1333817"
                     /translation="MPTFDQALRKAGEFGRFQRRVFLLLCLTGVTFAFLFVGVVFLGS
                     QPDYYWCRGPRATALAERCAWSPEEEWNLTTPELHVPAERRGQGHCHRYLLEATNTSS
                     ELSCDPLTAFPNRSAPLVSCSGDWRYVETHSTIVSQFDLVCSNAWMLDLTQAILNLGF
                     LAGAFTLGYAADRYGRLIIYLISCFGVGITGVVVAFAPNFSVFVIFRFLQGVFGKGAW
                     MTCFVIVTEIVGSKQRRIVGIVIQMFFTLGIIILPGIAYFTPSWQGIQLAISLPSFLF
                     LLYYWVVPESPRWLITRKQGEKALQILRRVAKCNGKHLSSNYSEITVTDEEVSNPSCL
                     DLVRTPQMRKCTLILMFAWFTSAVVYQGLVMRLGLIGGNLYIDFFISGLVELPGALLI
                     LLTIERLGRRLPFAASNIVAGVSCLVTAFLPEGIPWLRTTVATLGRLGITMAFEIVYL
                     VNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAIWLELPLIIFGILASVCGGL
                     VMLLPETKGIALPETVEDVEKLGSSQLHQCGRKKKTQVSTSDV"
     exon            795..898
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1053
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1222
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1340
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1341..1438
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1653
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1762
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1875
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1876..1975
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..3501
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3473..3478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /note="hexamer: AATAAA"
     polyA_site      3494
                     /gene="Slc22a3"
                     /gene_synonym="EMT; Oct3; Orct3; Slca22a3"
                     /note="major polyA site"
ORIGIN      
        1 ttgggcccct gcagcctaag agtactggag gctattcctg gagtcttcag agtcctgagt
       61 ccagcgagtc tgggtgatcc tggaactcag tgaactctga cttggggtgt ccctttaggg
      121 caggctacag gtcagggccc ttggtgcaca gtgacactac tgtgaaacca ccccaatccg
      181 ctctccgggt ttactccggt cccgggcgcg cacgggcagg aggccgggag cttggaacgg
      241 gaggagcagc ccggggcggg ctgccagggc gagcaagcga gcgaggcggg ggcggcgggt
      301 gcagagctac gggcggcggc gcccgcgggt cactctcagg ccgggcagca gcgacagggc
      361 gcagggtagc agggcgcacc atgcccacgt tcgaccaggc actgaggaag gcgggcgagt
      421 tcgggcgctt ccagcggcgc gtgttcctgc tgctgtgcct gacgggtgtc accttcgcct
      481 tcctcttcgt cggtgtggtc ttcctgggca gccagcccga ctactattgg tgtcgcgggc
      541 cgcgcgccac cgcgctggcc gagcgctgcg cctggagccc cgaggaggag tggaacctca
      601 ccacaccgga gctccacgtc ccagctgagc gccgcggcca aggccactgc caccgctacc
      661 tgctggaagc cactaatacc agctcagagc tcagctgcga cccactcact gccttcccca
      721 accgctccgc gcctctggtg tcctgcagcg gtgactggcg ctatgtggag acccactcta
      781 ccatcgtcag ccagtttgac cttgtctgca gcaatgcctg gatgttggac ctcacccaag
      841 ccatcctgaa ccttggcttc ctggctgggg cttttacctt gggctatgca gcggacagat
      901 atggcaggct catcatttac ttaatatcct gtttcggcgt tggcatcaca ggagtcgtgg
      961 tggcatttgc gccaaatttt tctgtgtttg tgattttccg cttcctacaa ggagtgtttg
     1021 gaaagggggc ctggatgact tgcttcgtga tcgtgacaga aatagttggt tcaaaacaaa
     1081 ggaggattgt gggaatcgtg atccagatgt tcttcaccct cgggatcatt attcttcctg
     1141 ggattgccta cttcacgccc agctggcagg gcatccagct agccatctct ctgcccagct
     1201 ttctcttcct cctctattac tgggtggtcc ctgagtctcc ccgctggctg atcacccgga
     1261 agcaaggaga gaaagccttg cagatcctga ggcgcgtggc taagtgcaat ggaaaacacc
     1321 tctcatcaaa ttactcagag atcacagtta cagatgaaga agtcagtaac ccatcctgtt
     1381 tagaccttgt gagaactccc caaatgagga aatgcacgct catccttatg tttgcttggt
     1441 tcacgagcgc cgtggtgtac caaggacttg tcatgcgcct gggacttatc ggaggcaacc
     1501 tctacataga cttctttatc tctgggctcg tggagctgcc cggagctctc ttaatccttc
     1561 tgaccattga gcgccttgga cgacgccttc cctttgcggc aagcaatata gtggcagggg
     1621 tgtcgtgtct ggtcactgca tttttaccag aagggatacc gtggctgagg accacagtcg
     1681 ctaccctggg aagactagga ataaccatgg ccttcgaaat tgtttatttg gtaaattcag
     1741 agttgtaccc aacgacatta cggaactttg gggtttcact ctgctcaggc ttgtgtgact
     1801 ttggggggat tatagccccg tttctgctct ttcggctggc agctatatgg ttagaactgc
     1861 ctctgatcat ctttgggatc ctggcgtctg tctgtggtgg cctcgtgatg cttttgcctg
     1921 aaacgaaggg cattgccttg ccggagacgg tggaagacgt agaaaagctt ggcagttcac
     1981 agttgcatca gtgtggcaga aaaaagaaaa cccaggtttc tacttctgat gtctgaggcc
     2041 cctgtgttgc ctggaggacc agagaagact ggaatatgcc tgtgcagtgt gcttcgcctc
     2101 ctctaggtgg cgcccttcca aggaaccgta aagatttcgg agtattttat aaggtataag
     2161 atgaagattt atcatgctgc ccaagcttcg gggaacacat aatcttggac ctgtttcatg
     2221 aagacccagt aggtacccgg attctggcta ggttctcatt cagcaagtct ctcacccatt
     2281 aggtaaggag agatgaaaag gccccaacca gttctccagt tctcaggaca agacagtacc
     2341 atccaggaag caggatgaac aaaccaaggc ctggcacgtg tccagaagtg cgctcagctg
     2401 atctgatcaa cacaccgcag tgaagagtgt tctgaagagt ctgagaactg ctatttcttc
     2461 ccttgagctc cgaatacaag ccttcgcagg gccgacatgt ccggcgctgc tcccctcctg
     2521 tctcctgcag gtgctgaggt cccagatccc aggttaggca cagctcctta aatgcaacac
     2581 aacagaggac ctggctgtgg tattgtgaag tcatgctgca gtccccaggc cccagatatt
     2641 tcaccacctc cttcagagga ccactgtaat cacaggctct ttattgagga agaaaacaaa
     2701 gcacggattt ggatttccca ggtcttagaa tttaaaaagt aaagggataa ttatgtcata
     2761 tttgtgaatt ccgttccagg ggtgcctgtg actgagagtc caaagcacag acttttttca
     2821 ttccatcttc gcatttttga cttgtcttgg gaggaaaaac aaaacaaaaa acaaaaccaa
     2881 atacatttgt tgccacttaa tgataaaagt caattgtatt caaacttaaa agaattagca
     2941 gccaatttga cttgtaagtg ttggaggaga tactaatgag gaactggact ttttctttct
     3001 ttcttttttt tttttttaat caagccttct ggagcagaga ctcaaatgta aacacagtat
     3061 tctatatggt gtgcagttct tggtttattt tcaaactcgg tatgtatgtt aggctgactg
     3121 tgtcttaaac ttcaaactca gtgtggacag gcaaaattag catcaaagag aaaccttgcc
     3181 aatgtgtgtg ggggggtggg gggaggaact atttcacttg tggagagcat actatgtttg
     3241 caacactgga gaagatgtgt gtgactgtta gacagatgtt taatcataaa gcacaggaga
     3301 acggagtgtg atgctcagtt ccccaacagc ctttggggta ttcattgcca cacccactgt
     3361 gtacacaggc gtttgtggcc cggctgcctg cgtgtttcgt ggctgtagca cggctcttgt
     3421 ccaccctgct gcctttggat tgcatttcaa gttggtagtt ctgtttcata acaataaacg
     3481 atttttaaac tgtttttaaa a
//
