LOCUS       NM_019723               3473 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 21 (Slc22a21), transcript variant 1, mRNA.
ACCESSION   NM_019723
VERSION     NM_019723.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3473)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3473)
  AUTHORS   Lamhonwah,A.M. and Tein,I.
  TITLE     Expression of the organic cation/carnitine transporter family
            (Octn1,-2 and-3) in mdx muscle and heart: Implications for early
            carnitine therapy in Duchenne muscular dystrophy to improve
            cellular carnitine homeostasis
  JOURNAL   Clin Chim Acta 505, 92-97 (2020)
   PUBMED   32070725
  REMARK    GeneRIF: There was a significant upregulation of mOctn1 and mOctn2
            mRNA by qRT-PCR in mdx quadriceps and of mOctn2 and mOctn3 mRNA in
            mdx heart
REFERENCE   3  (bases 1 to 3473)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3473)
  AUTHORS   Cano,M.M., Calonge,M.L. and Ilundain,A.A.
  TITLE     Expression of OCTN2 and OCTN3 in the apical membrane of rat renal
            cortex and medulla
  JOURNAL   J Cell Physiol 223 (2), 451-459 (2010)
   PUBMED   20112288
  REMARK    GeneRIF: This is the first report showing a functional apical OCTN2
            in the renal medulla and a functional apical OCTN3 in both renal
            cortex and medulla.
REFERENCE   5  (bases 1 to 3473)
  AUTHORS   Lamhonwah,A.M., Wong,J., Tam,C., Mai,L. and Tein,I.
  TITLE     Organic cation/carnitine transporter family expression patterns in
            adult murine heart
  JOURNAL   Pathol Res Pract 205 (6), 395-402 (2009)
   PUBMED   19233567
  REMARK    GeneRIF: Octn1, -2, and -3 are expressed in many regions of murine
            heart
REFERENCE   6  (bases 1 to 3473)
  AUTHORS   Lamhonwah,A.M., Ackerley,C.A., Tilups,A., Edwards,V.D.,
            Wanders,R.J. and Tein,I.
  TITLE     OCTN3 is a mammalian peroxisomal membrane carnitine transporter
  JOURNAL   Biochem Biophys Res Commun 338 (4), 1966-1972 (2005)
   PUBMED   16288981
  REMARK    GeneRIF: demonstration of expression and colocalization of Octn3
            and catalase in liver peroxisomes
REFERENCE   7  (bases 1 to 3473)
  AUTHORS   Duran,J.M., Peral,M.J., Calonge,M.L. and Ilundain,A.A.
  TITLE     OCTN3: A Na+-independent L-carnitine transporter in enterocytes
            basolateral membrane
  JOURNAL   J Cell Physiol 202 (3), 929-935 (2005)
   PUBMED   15389639
  REMARK    GeneRIF: Results demonstrate that mammalian small intestine
            expresses OCTN3 mRNA along the villus and that OCTN3 protein is
            located in the basolateral membrane.
REFERENCE   8  (bases 1 to 3473)
  AUTHORS   Monte,J.C., Nagle,M.A., Eraly,S.A. and Nigam,S.K.
  TITLE     Identification of a novel murine organic anion transporter family
            member, OAT6, expressed in olfactory mucosa
  JOURNAL   Biochem Biophys Res Commun 323 (2), 429-436 (2004)
   PUBMED   15369770
REFERENCE   9  (bases 1 to 3473)
  AUTHORS   Lamhonwah,A.M., Skaug,J., Scherer,S.W. and Tein,I.
  TITLE     A third human carnitine/organic cation transporter (OCTN3) as a
            candidate for the 5q31 Crohn's disease locus (IBD5)
  JOURNAL   Biochem Biophys Res Commun 301 (1), 98-101 (2003)
   PUBMED   12535646
REFERENCE   10 (bases 1 to 3473)
  AUTHORS   Tamai,I., Ohashi,R., Nezu,J.I., Sai,Y., Kobayashi,D., Oku,A.,
            Shimane,M. and Tsuji,A.
  TITLE     Molecular and functional characterization of organic
            cation/carnitine transporter family in mice
  JOURNAL   J Biol Chem 275 (51), 40064-40072 (2000)
   PUBMED   11010964
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL596444.10.
            
            On Apr 7, 2018 this sequence version replaced NM_019723.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB018436.1, AK133431.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-869               AL596444.10        117249-118117
            870-973             AL596444.10        127979-128082
            974-1128            AL596444.10        137145-137299
            1129-1300           AL596444.10        138207-138378
            1301-1427           AL596444.10        139482-139608
            1428-1537           AL596444.10        141488-141597
            1538-1752           AL596444.10        142680-142894
            1753-1935           AL596444.10        144399-144581
            1936-2071           AL596444.10        145740-145875
            2072-3473           AL596444.10        146227-147628
FEATURES             Location/Qualifiers
     source          1..3473
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 32.05 cM"
     gene            1..3473
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 21"
                     /db_xref="GeneID:56517"
                     /db_xref="MGI:MGI:1929481"
     exon            1..869
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             477..2171
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 22 (organic cation transporter),
                     member 9; solute carrier family 22 member 21; organic
                     cation/carnitine transporter 3"
                     /codon_start=1
                     /product="solute carrier family 22 member 21 isoform 1"
                     /protein_id="NP_062697.1"
                     /db_xref="CCDS:CCDS24688.1"
                     /db_xref="GeneID:56517"
                     /db_xref="MGI:MGI:1929481"
                     /translation="MLDYDEVTAFLGEWGTFQRLIFFLLSASIIPNGFTGLSAVFLTA
                     IPEHRCRIPDTVNLSSAWRNHSIPMETKDGPEVPQKCRRYRLATIANFSELGLEPGRD
                     VDLEQLEQENCLDGWEYDKDIFLSTIVTEWDLVCKDDWKAPLTTSFFYVGVLLGSFIS
                     GQLSDRFGRKNILFLTMAMHTGFSFIQVFSVNFEMFTLLYTLVGMGHISNYVAAFVLG
                     TEMLSKSVRIIFATLGVCIFFAFGFMVLPLFAYFIREWRRLLLAITLPGVLCGALWWF
                     IPESPRWLISQGRIKEAEVIIRKAAKINGIVAPSTIFDPSETNKLQDDSSKKPQSHHI
                     YDLVRTPNIRILTIMSIILWLTISVGYFGLSLDTPNLNGNIYVNCFLLAAVEVPAYVL
                     AWLLLQHVSRRYSMAGSLFLGGSVLLLVQLVPSDLHYLSTTLVMVGKFGITSAYSMVY
                     VYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRRLPYILMGSLTILTAII
                     TLFFPESSGVSLPETIDEMQKVKKLKQRQSLSKKGSPKESKGNVSRTSRTSEPKGF"
     exon            870..973
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            974..1128
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1300
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1301..1427
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1428..1537
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1538..1752
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1753..1935
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2071
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            2072..3473
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3439..3444
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /note="hexamer: AATAAA"
     polyA_site      3462
                     /gene="Slc22a21"
                     /gene_synonym="Octn3; Slc22a9"
                     /note="major polyA site"
ORIGIN      
        1 gggcgttcct cagcgaacag ctcagagtag taggcaaggg actcctaggc tccctcacac
       61 ccgcgcagtt ctgaagccag gctccatccc gcttccgcac tgtccagcca gctcggagac
      121 cgggaccaga cccgcctcac gtacaggcgc gtccagtgcc cactacggat cactcagact
      181 cctgccgcgc ccaccccacg gttcgcctca ggactgcacg gccggccttg cagtctaggc
      241 cagactccgc gcggagtcca tcatggcctc acgtcctcgg tgtctctggc gctggcgggg
      301 tctgaggcgg cgggaggaac tcacgagctt ctccgtgtgg aaaacgtctc ccgacgcttt
      361 ctcgaactcc tcttcgacga gtgactggtg ctccgcgtgc acggacaaac cgtgcgccgc
      421 ccactgcgcc cgagtatcct cggattcccg gcgggacgcc gtgggctgcc gactctatgc
      481 ttgactacga cgaggtgacc gccttcctgg gcgagtgggg gaccttccag cgcctcatct
      541 tcttcctgct cagcgccagc atcatcccca atggctttac tgggttgtca gccgtgttcc
      601 tgacggcgat cccggagcac cgttgccgga taccagacac cgtgaacctg agcagcgcgt
      661 ggcgcaacca cagtatcccg atggagacga aggacggacc agaggtgcct cagaaatgcc
      721 gccgctaccg actggccacc atcgccaact tctctgagct agggctggag ccgggacggg
      781 acgtggacct ggagcagctg gagcaggaga actgcctgga tggctgggag tacgacaagg
      841 acatcttcct gtccaccatc gtgacagagt gggacctggt gtgtaaggat gactggaaag
      901 ccccactcac cacctccttc ttttacgtgg gtgtgctctt aggctccttc atttcgggac
      961 agctctcaga caggtttggt cgcaagaata tcttgttttt gaccatggcc atgcacaccg
     1021 gattcagctt catacaagtc ttctctgtga acttcgagat gtttactctg ctctataccc
     1081 ttgttggaat gggacatata tccaactacg tggcagcatt tgtcctggga acagaaatgc
     1141 tttccaagtc agttagaatt atattcgcca ccttaggagt ttgcatattt tttgcgtttg
     1201 gcttcatggt gctgcctctg tttgcatact tcatcagaga gtggaggagg ctgctgctgg
     1261 caattacttt accaggcgtg ctgtgtgggg ctctctggtg gttcatccct gagtccccac
     1321 gatggctcat ctctcaaggc cgaattaaag aggcagaggt gatcatccgc aaagctgcca
     1381 aaatcaatgg gattgttgca ccttccacta tcttcgatcc aagcgagacc aataaattac
     1441 aagacgatag ttccaagaag ccccagtcgc accacattta tgatctggtc cgaacaccaa
     1501 atatcaggat cctcaccatc atgtctataa tcctgtggct gaccatatca gtgggctatt
     1561 ttggactatc tcttgacact cctaacttga atgggaacat ctatgtgaac tgcttcctac
     1621 tggcggctgt tgaagtccca gcctatgtgc tggcctggct gttgttgcag catgtgtccc
     1681 ggcgttattc tatggctggt tccctcttcc tgggtggcag tgtccttctc ttagtacaac
     1741 tggtgccttc agacctacat tacttgtcta ctaccctggt gatggtgggg aagtttggaa
     1801 tcacctctgc ctactccatg gtctatgtgt acacagctga gctgtacccc actgtggtca
     1861 gaaacatggg tgtgggggtc agctccacag catcccgcct tggcagcatc ctgtctccct
     1921 actttgttta tctaggtgcc tatgaccgcc gcctacctta tatcctcatg ggaagtctaa
     1981 ccatcctgac agctatcatc actttattct tcccagagag ttctggggtt tctctcccag
     2041 aaaccattga cgagatgcaa aaagtcaaaa aactaaaaca aaggcaatcc ctaagcaaga
     2101 aagggtcccc gaaggagtct aaaggaaatg tatcccgaac ctcccgaacc tccgaaccta
     2161 aaggctttta acacctggtc cagaagctga ttgaactgaa tggaaaacct gcatgttgtc
     2221 agaaacactg tcagtgaccg acaacagtgc tttctgttgt gttggcattg tgtctaacaa
     2281 gcatctgtcc tggagagtca ccttcctcta gggccgccaa ggcgaactac acacagcttg
     2341 cacatcccat cacagtggtg gacatgggcc ttccaaagaa atgaattgag tctcttgaac
     2401 aagcaggact tggaagacta tgagaaacat ctgctagaca tgctttgtta ttttgtaaga
     2461 cctgataagg gtgcacatag aacagcaggt ccgtttttcc ctcctttccc taactgcaga
     2521 acttatagga aaggaataat tgtggctcag gggcagtgtc cttgtctagg ttacacaggg
     2581 ccctgggttt gatcaagtgc accaaaagga aacaaaaaaa aaaaatcttt tcagaaaata
     2641 aatgattcca tggatagttt gatttctcgt cttttctcag ttaaaaagtt ttaactgcaa
     2701 cactcttaac tcgtgatata acacaagacc aagggagccc aaaggaaact aaggtggagg
     2761 ctggtccata aagcagacag tgtgttgact gtgactgctc agtcccacag ccaggtactg
     2821 tgtgtgtggt cagggtcctg ggcttgtcca ggccctgtga gaaatctact gttgaggcca
     2881 aggcttgtct tccactgctg tgtaaatcag aattctggct gccagccact tatctgtgtc
     2941 ttgaaggaaa tgtatggata acagagtgtc ccttccctct cccagcactg tcatggggag
     3001 tttgtttgtt tgtcatctgc tgtttgtgtc tcaagctatt tgtcccttag cagaagcttg
     3061 ggaactgcct gtgttcccca gcccagggtc accctggctg gtgtgcagtt accaccatac
     3121 aaggccttcc caatcttagc cactagagct gctctgagtg ccaaaaataa taacactatg
     3181 cttcttcctt ttacgatgta taatcatgag gaaaattaca agaaagaaat gtaaattgtg
     3241 tcacagtctc tcagagtagc tggctgcagt cgtgtcacat cggtgggtgt tttgtgttca
     3301 gtgtgattgt cttctcttct gattatgttg ccatggtgct ccgaaagcac atgcttcacc
     3361 cacttacaat acaaaacaaa caccaaaacc tgtattttgt gaaggctact gaagtgcctt
     3421 gggcaatgaa atggttttaa taaactattt ttaaaaaata aataaataat agc
//
