LOCUS       NM_198650               1897 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus solute carrier family 22 (organic anion transporter),
            member 20 (Slc22a20), mRNA.
ACCESSION   NM_198650 XM_355136
VERSION     NM_198650.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1897)
  AUTHORS   Schnabolk,G.W., Gupta,B., Mulgaonkar,A., Kulkarni,M. and Sweet,D.H.
  TITLE     Organic anion transporter 6 (Slc22a20) specificity and Sertoli
            cell-specific expression provide new insight on potential
            endogenous roles
  JOURNAL   J Pharmacol Exp Ther 334 (3), 927-935 (2010)
   PUBMED   20519554
  REMARK    GeneRIF: expression in Sertoli cells suggests Oat6 may be an
            important determinant of blood-testis barrier function
REFERENCE   2  (bases 1 to 1897)
  AUTHORS   Ahn,S.Y., Eraly,S.A., Tsigelny,I. and Nigam,S.K.
  TITLE     Interaction of organic cations with organic anion transporters
  JOURNAL   J Biol Chem 284 (45), 31422-31430 (2009)
   PUBMED   19737926
  REMARK    GeneRIF: Oat1, Oat3, and Oat6 function largely in organic anion
            transport but also bind and transport organic cations.
REFERENCE   3  (bases 1 to 1897)
  AUTHORS   Truong,D.M., Kaler,G., Khandelwal,A., Swaan,P.W. and Nigam,S.K.
  TITLE     Multi-level analysis of organic anion transporters 1, 3, and 6
            reveals major differences in structural determinants of antiviral
            discrimination
  JOURNAL   J Biol Chem 283 (13), 8654-8663 (2008)
   PUBMED   18174163
  REMARK    GeneRIF: despite sharing close overall sequence homology, Oat1,
            Oat3, and Oat6 have signficantly different binding pockets
REFERENCE   4  (bases 1 to 1897)
  AUTHORS   Kaler,G., Truong,D.M., Khandelwal,A., Nagle,M., Eraly,S.A.,
            Swaan,P.W. and Nigam,S.K.
  TITLE     Structural variation governs substrate specificity for organic
            anion transporter (OAT) homologs. Potential remote sensing by OAT
            family members
  JOURNAL   J Biol Chem 282 (33), 23841-23853 (2007)
   PUBMED   17553798
  REMARK    GeneRIF: the substrate binding preferences and transport function
            of olfactory organic anion transporter, Oat6, in comparison with
            the more broadly expressed transporter, Oat1
REFERENCE   5  (bases 1 to 1897)
  AUTHORS   Kaler,G., Truong,D.M., Sweeney,D.E., Logan,D.W., Nagle,M., Wu,W.,
            Eraly,S.A. and Nigam,S.K.
  TITLE     Olfactory mucosa-expressed organic anion transporter, Oat6,
            manifests high affinity interactions with odorant organic anions
  JOURNAL   Biochem Biophys Res Commun 351 (4), 872-876 (2006)
   PUBMED   17094945
  REMARK    GeneRIF: Oat6 might play a direct or indirect role in olfaction,
            such as modulation of the availability of odorant organic anions at
            the mucosal surface.
REFERENCE   6  (bases 1 to 1897)
  AUTHORS   Schnabolk,G.W., Youngblood,G.L. and Sweet,D.H.
  TITLE     Transport of estrone sulfate by the novel organic anion transporter
            Oat6 (Slc22a20)
  JOURNAL   Am J Physiol Renal Physiol 291 (2), F314-F321 (2006)
   PUBMED   16478971
  REMARK    GeneRIF: These data demonstrate for the first time that the novel
            murine gene Oat6 (Slc22a20) encodes a functional organic anion
            transporter and mOat6 is indeed the newest member of the OAT gene
            family.
REFERENCE   7  (bases 1 to 1897)
  AUTHORS   Monte,J.C., Nagle,M.A., Eraly,S.A. and Nigam,S.K.
  TITLE     Identification of a novel murine organic anion transporter family
            member, OAT6, expressed in olfactory mucosa
  JOURNAL   Biochem Biophys Res Commun 323 (2), 429-436 (2004)
   PUBMED   15369770
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC131692.5.
            
            On Nov 17, 2006 this sequence version replaced NM_198650.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC046588.1, AY194118.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849377,
                                           SAMN00849383 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-378               AC131692.5         167694-168071
            379-482             AC131692.5         168154-168257
            483-637             AC131692.5         168885-169039
            638-806             AC131692.5         170836-171004
            807-930             AC131692.5         172084-172207
            931-1046            AC131692.5         173362-173477
            1047-1261           AC131692.5         180767-180981
            1262-1370           AC131692.5         182010-182118
            1371-1577           AC131692.5         182232-182438
            1578-1897           AC131692.5         183284-183603
FEATURES             Location/Qualifiers
     source          1..1897
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 4.34 cM"
     gene            1..1897
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /note="solute carrier family 22 (organic anion
                     transporter), member 20"
                     /db_xref="GeneID:381203"
                     /db_xref="MGI:MGI:2685809"
     exon            1..378
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     CDS             4..1674
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /note="SLC22 organic anion transporter; OAT1-like organic
                     anion transporter; organic anion transporter 6"
                     /codon_start=1
                     /product="solute carrier family 22 member 20"
                     /protein_id="NP_941052.1"
                     /db_xref="CCDS:CCDS29486.1"
                     /db_xref="GeneID:381203"
                     /db_xref="MGI:MGI:2685809"
                     /translation="MAFTDLLDALGGVGRFQLVYTALLLLPCGLLACHTFLQNFTAAA
                     PPHHCQHPANYTEPTTNVSGVWLRAAIPLNQHGDPEPCRRYVEPQWALLKPNASSHGV
                     ATEGCKDGWVYDRSIFPSTIVMEWDLVCEARTLRDLAQSIYMSGVLVGAALFGGLADR
                     LGRKAPLVWSYLQLAVSGAATAYVGSFSAYCVFRFLMGMTFSGIILNSLSLVVEWMPT
                     RGRTVAGILLGFSFTLGQLILAGVAYLIRPWRWLQFAVSAPFLVFFLYSWWLPESSRW
                     LLLHGKAQQAVQNLQKVAMMNGRKAEGERLTTEVVSSYIQDEFASVRTSNSILDLFRT
                     PAIRRVTCCLMGVWFSNSVAYYGLAMDLQKFGLSIYLVQALFGIIDIPAMLVATTTMI
                     YVGRRATVSSFLILAGLMVIANMFMPEDLQTLRTVQAALGKGCLASSFICVYLFTGEL
                     YPTEIRQMGMGFASVNARLGGLVAPLITTLGEISPVLPPVSFGATSVLAGMAVACFLT
                     ETRNVPLVETIAAMERRVKQGRSKRDTEQKSEEISLQQLGASPLKETI"
     exon            379..482
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            483..637
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            638..806
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            807..930
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1046
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1047..1261
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1262..1370
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1577
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
     exon            1578..1897
                     /gene="Slc22a20"
                     /gene_synonym="Gm963; mOAT6; OAT1-L"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gccatggcct tcacagacct gctggatgcc ctgggaggcg tgggtcgctt ccagcttgtc
       61 tatacagcct tgctgctgct gccctgtggg ctgctggctt gccatacctt cctacagaac
      121 ttcacggctg ctgcaccccc tcaccactgc caacatcctg ccaactacac agaacctacc
      181 accaatgtct caggggtctg gctgagggct gccatacccc tgaaccagca tggggacccc
      241 gagccgtgcc ggcgctatgt agaacctcag tgggcccttc tgaaacccaa cgcctcctcc
      301 catggggtgg ccaccgaggg ctgcaaggat ggttgggtct acgaccgaag cattttccca
      361 tctaccattg tgatggagtg ggacctggtg tgtgaggccc gcacccttcg tgacctggct
      421 cagtccatct acatgtccgg ggtgttggtg ggagccgcct tgtttggtgg tcttgctgac
      481 aggttgggtc gcaaggcccc actggtgtgg tcgtacctgc agctggcagt ttcgggggct
      541 gccacagcgt atgtgggctc cttcagtgcc tactgcgtct tccgcttcct gatgggcatg
      601 accttctccg gcatcatcct taactccctc tccctggttg tagaatggat gccaaccaga
      661 ggccgtacag tagcaggcat cttgttgggt ttctccttca ccttgggcca gctcatcctg
      721 gctggcgtgg catacctgat ccggccctgg cggtggctgc agtttgctgt gtctgctcct
      781 tttctggtct ttttcctcta ttcttggtgg cttccagagt catcccgatg gctcctcctt
      841 cacggcaagg cccagcaagc tgtgcagaac cttcagaagg tggccatgat gaatggcagg
      901 aaggcggaag gggagaggct gactacagag gtggtgagct cctacatcca ggatgagttt
      961 gcaagtgtcc gcacctccaa ctccatcttg gacctcttta gaacccctgc catcagaagg
     1021 gtcacgtgct gtctcatggg ggtctggttc tctaattctg tggcttacta cggcctggcc
     1081 atggacctgc agaagtttgg gctcagcatc tacctggtac aggctctgtt tgggatcatc
     1141 gatatcccgg ccatgctggt cgccaccacc acgatgattt atgtgggacg acgggccaca
     1201 gtgtcctcct tcctcatact agctgggctc atggtcattg ccaacatgtt tatgcctgag
     1261 gatctgcaga ccttgcggac agtgcaggca gcgctgggca aaggctgcct ggccagctcc
     1321 ttcatctgcg tgtatctgtt cacgggagaa ctctatccca cagagatcag gcagatgggg
     1381 atgggatttg cttctgtcaa tgcccgcctc ggaggcttgg tggcacccct gatcaccaca
     1441 cttggcgaga tcagtccagt tctgccacct gtatcctttg gtgccacttc agtcttggct
     1501 ggaatggctg tcgcctgctt cctgactgag acccgcaatg tgccactggt agaaactatt
     1561 gctgcaatgg agagacgagt caaacaaggc cgttccaaaa gagacacaga acagaagagt
     1621 gaagaaattt ctcttcagca gctgggggct tcacccctca aagaaaccat ttaagttgtc
     1681 aggaccctga cgctgagctc agcctgtgct aggagggagt gtccaagtcc tgctaggaga
     1741 tcctggtgca gaactccatg caaagccaga gggcatcgtg gactttgctg gggagccaca
     1801 cccaagccca agcagaaagc tcaggaaggg gaagtatcct ccagggaccc aaggagatca
     1861 tgttgtccac tgcaataaaa gcactactgt ccagggc
//
