LOCUS       NM_013667               2139 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 2 (Slc22a2), transcript variant 1, mRNA.
ACCESSION   NM_013667
VERSION     NM_013667.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2139)
  AUTHORS   Orrico-Sanchez,A., Guiard,B.P., Manta,S., Callebert,J.,
            Launay,J.M., Louis,F., Paccard,A., Gruszczynski,C., Betancur,C.,
            Vialou,V. and Gautron,S.
  TITLE     Organic cation transporter 2 contributes to SSRI antidepressant
            efficacy by controlling tryptophan availability in the brain
  JOURNAL   Transl Psychiatry 13 (1), 302 (2023)
   PUBMED   37775532
  REMARK    GeneRIF: Organic cation transporter 2 contributes to SSRI
            antidepressant efficacy by controlling tryptophan availability in
            the brain.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2139)
  AUTHORS   Hucke,A., Schroter,R., Ceresa,C., Chiorazzi,A., Canta,A.,
            Semperboni,S., Marmiroli,P., Cavaletti,G., Gess,B. and
            Ciarimboli,G.
  TITLE     Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin
  JOURNAL   Int J Mol Sci 24 (14), 11486 (2023)
   PUBMED   37511245
  REMARK    GeneRIF: Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2139)
  AUTHORS   La Manno,G., Siletti,K., Furlan,A., Gyllborg,D., Vinsland,E., Mossi
            Albiach,A., Mattsson Langseth,C., Khven,I., Lederer,A.R.,
            Dratva,L.M., Johnsson,A., Nilsson,M., Lonnerberg,P. and
            Linnarsson,S.
  TITLE     Molecular architecture of the developing mouse brain
  JOURNAL   Nature 596 (7870), 92-96 (2021)
   PUBMED   34321664
REFERENCE   4  (bases 1 to 2139)
  AUTHORS   Martinez,M.E. and Hernandez,A.
  TITLE     The Type 3 Deiodinase Is a Critical Modulator of Thyroid Hormone
            Sensitivity in the Fetal Brain
  JOURNAL   Front Neurosci 15, 703730 (2021)
   PUBMED   34248495
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2139)
  AUTHORS   Morse,B.L., Chen,L.H., Catlow,J.T., Fallon,J.K., Smith,P.C. and
            Hillgren,K.M.
  TITLE     Expansion of Knowledge on OCT1 Variant Activity In Vitro and In
            Vivo Using Oct1/2-/- Mice
  JOURNAL   Front Pharmacol 12, 631793 (2021)
   PUBMED   33658943
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2139)
  AUTHORS   Sleutels,F., Zwart,R. and Barlow,D.P.
  TITLE     The non-coding Air RNA is required for silencing autosomal
            imprinted genes
  JOURNAL   Nature 415 (6873), 810-813 (2002)
   PUBMED   11845212
  REMARK    GeneRIF: Slc22a2 is one of three imprinted genes on chromosome 17
            that is expressed from the maternal allele. A non-coding Air RNA is
            required for repression of all three genes on the paternal allele.
REFERENCE   7  (bases 1 to 2139)
  AUTHORS   Vallette-Kasic,S., Pellegrini-Bouiller,I., Sampieri,F., Gunz,G.,
            Diaz,A., Radovick,S., Enjalbert,A. and Brue,T.
  TITLE     Combined pituitary hormone deficiency due to the F135C human Pit-1
            (pituitary-specific factor 1) gene mutation: functional and
            structural correlates
  JOURNAL   Mol Endocrinol 15 (3), 411-420 (2001)
   PUBMED   11222742
REFERENCE   8  (bases 1 to 2139)
  AUTHORS   Mooslehner,K.A. and Allen,N.D.
  TITLE     Cloning of the mouse organic cation transporter 2 gene, Slc22a2,
            from an enhancer-trap transgene integration locus
  JOURNAL   Mamm Genome 10 (3), 218-224 (1999)
   PUBMED   10051314
REFERENCE   9  (bases 1 to 2139)
  AUTHORS   Verhaagh,S., Schweifer,N., Barlow,D.P. and Zwart,R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
REFERENCE   10 (bases 1 to 2139)
  AUTHORS   Koehler,M.R., Wissinger,B., Gorboulev,V., Koepsell,H. and Schmid,M.
  TITLE     The two human organic cation transporter genes SLC22A1 and SLC22A2
            are located on chromosome 6q26
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 198-200 (1997)
   PUBMED   9605850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC167817.4, AK143892.1, AK052658.1 and BB739804.1.
            
            On Sep 27, 2017 this sequence version replaced NM_013667.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC069911.1, AK143892.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 11845212
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC167817.4         57491-57491
            2-4                 AK143892.1         1-3
            5-894               AK052658.1         2-891
            895-2074            AK143892.1         896-2075
            2075-2136           BB739804.1         325-386
            2137-2139           AC167817.4         101789-101791
FEATURES             Location/Qualifiers
     source          1..2139
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.61 cM"
     gene            1..2139
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 2"
                     /db_xref="GeneID:20518"
                     /db_xref="MGI:MGI:1335072"
     exon            1..506
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1754
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     organic cation transporter 2; solute carrier family 22
                     member 2"
                     /codon_start=1
                     /product="solute carrier family 22 member 2 isoform 1"
                     /protein_id="NP_038695.1"
                     /db_xref="CCDS:CCDS28392.1"
                     /db_xref="GeneID:20518"
                     /db_xref="MGI:MGI:1335072"
                     /translation="MPTVDDILEHIGEFHLFQKQTFFLLALLSGAFTPIYVGIVFLGF
                     TPNHHCRSPGVAELSQRCGWSPAEELNYTVPGLGSAGEVSFLSQCMRYEVDWNQSTLD
                     CVDPLSSLAANRSHLPLSPCEHGWVYDTPGSSIVTEFNLVCAHSWMLDLFQSLVNVGF
                     FIGAVGIGYLADRFGRKFCLLVTILINAISGVLMAISPNYAWMLVFRFLQGLVSKAGW
                     LIGYILITEFVGLGYRRTVGICYQIAFTVGLLILAGVAYALPNWRWLQFAVTLPNFCF
                     LLYFWCIPESPRWLISQNKNAKAMKIIKHIAKKNGKSVPVSLQSLTADEDTGMKLNPS
                     FLDLVRTPQIRKHTLILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAF
                     IIILTIDRIGRRYPWAVSNMVAGAACLASVFIPDDLQWLKITVACLGRMGITIAYEMV
                     CLVNAELYPTYIRNLAVLVCSSMCDIGGIVTPFLVYRLTDIWLEFPLVVFAVVGLVAG
                     GLVLLLPETKGKALPETIEDAEKMQRPRKKKEKRIYLQVKKAELS"
     exon            507..610
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..765
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            766..934
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            935..1049
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1156
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1157..1371
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1372..1480
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1481..1593
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1693
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     exon            1694..2139
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2113..2118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /note="hexamer: ATTAAA"
     polyA_site      2138
                     /gene="Slc22a2"
                     /gene_synonym="mOCT2; Oct2; Orct2"
                     /note="major polyA site"
ORIGIN      
        1 ggtcaagagt cgtcctgagc tgaccgcagc tgccttcagc agcatttgca accctgtagg
       61 tgaagcctca ggatcagctg cctccaggaa ccatgccgac cgtggatgat attctagaac
      121 atatagggga attccacctt ttccagaaac aaacattttt cctcttagct ctgctctccg
      181 gtgccttcac ccccatctat gtgggcatcg ttttcctggg cttcaccccc aaccaccact
      241 gccggagtcc tggagtggcc gagctgagcc agcgatgtgg ctggagccca gcagaggagc
      301 tgaactacac cgtgccgggc ctggggtctg cgggtgaggt ctccttcctc agccagtgca
      361 tgaggtatga ggtggactgg aaccagagca cccttgactg tgtggaccca ctgtccagcc
      421 tggctgccaa caggagccac ttgccactga gcccctgcga gcatggctgg gtgtacgaca
      481 ctcccggctc ctccatcgtc actgagttta acctagtgtg tgctcactcc tggatgctgg
      541 acctgtttca gtcattagtg aacgtggggt ttttcatcgg tgctgtgggc attggttacc
      601 tagcagacag gtttgggcgg aagttctgcc tcttggtcac catcctcatc aatgctatct
      661 ctggggttct catggcgatt tcacccaact atgcctggat gttggtgttt cgatttctac
      721 agggactggt cagcaaagcg ggctggttaa ttggctatat cctgattaca gaatttgttg
      781 ggctgggcta tcgcagaaca gtagggattt gttaccaaat cgcctttact gttgggctcc
      841 tgatcctggc tggagtggcc tatgcccttc ccaactggag gtggctgcaa tttgccgtga
      901 ctctgcccaa cttctgcttc ctgctctatt tctggtgcat accggagtct ccaagatggt
      961 tgatctccca gaacaaaaat gcaaaagcca tgaaaatcat taagcatatt gctaagaaaa
     1021 atggaaaatc ggtgccagtc tctcttcaga gcctgacggc agatgaggat actggcatga
     1081 aattgaaccc ttcgttcctg gacttggtca gaacccctca gataaggaaa catacgttga
     1141 tcttgatgta caattggttc acgagctctg ttctctacca gggcctcatc atgcacatgg
     1201 gcctcgcagg ggacaacatc tacttggatt tcttctactc tgccctggtg gaattcccag
     1261 ctgccttcat catcattctc accatagacc ggattggtcg ccgctatccc tgggctgtgt
     1321 caaatatggt ggcaggagca gcctgcctag cttcggtttt tatccctgat gatctacagt
     1381 ggctgaaaat taccgtggcg tgcttgggta gaatgggcat caccatagcc tacgaaatgg
     1441 tctgcctggt caacgctgag ctgtacccca catacatcag gaatcttgct gtccttgtct
     1501 gctcctctat gtgtgacatt ggtggcatcg tcacaccttt cctggtctac cgtctcactg
     1561 acatctggct ggagttcccg ctggtcgtat ttgctgtggt tggccttgtt gctgggggac
     1621 ttgtgctatt gctacctgag accaaaggga aggctctgcc tgagaccatc gaggatgctg
     1681 agaagatgca gaggccaaga aaaaagaaag aaaagagaat ttacctccaa gttaagaaag
     1741 cagaactaag ctaaagagaa agagcatcat tgctgctgga gatgactttg ctctctctga
     1801 gaccagaggc agagcttctc ttcccctccc gcgaaagcca cacaacccaa cctcacttac
     1861 ccctgaattc ctgaactcca tcagcagtga gctgtcgccc gcccagtttg ttgcactgat
     1921 gtgtccagct cttcctctca accaggacct cactccacct cactccactc tcaacagtcc
     1981 tggggaatgc ccattgcttt gctggatttg ttggggtttt tttcatctgt acatttcttt
     2041 acttggtttc tttctccaag catgacatca aaccaaaata tacaagggag ctgtgggtca
     2101 ggacaactaa ctattaaaaa aaaatctgaa aaattatag
//
