LOCUS       NM_144785               1984 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 22 (organic anion transporter),
            member 19 (Slc22a19), mRNA.
ACCESSION   NM_144785
VERSION     NM_144785.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Breljak,D., Ljubojevic,M., Balen,D., Zlender,V., Brzica,H.,
            Micek,V., Kusan,M., Anzai,N. and Sabolic,I.
  TITLE     Renal expression of organic anion transporter Oat5 in rats and mice
            exhibits the female-dominant sex differences
  JOURNAL   Histol Histopathol 25 (11), 1385-1402 (2010)
   PUBMED   20865662
  REMARK    GeneRIF: renal expression of Oat5 in rats (and mice) exhibits zonal
            and sex differences
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Cheng,X. and Klaassen,C.D.
  TITLE     Tissue distribution, ontogeny, and hormonal regulation of
            xenobiotic transporters in mouse kidneys
  JOURNAL   Drug Metab Dispos 37 (11), 2178-2185 (2009)
   PUBMED   19679677
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Jung,S.M., Lee,W.K., Kwak,J.O., Jung,S.Y., Park,J., Kim,W.Y.,
            Kim,J. and Cha,S.H.
  TITLE     Identification of a novel murine organic anion transporter like
            protein 1 (OATLP1) expressed in the kidney
  JOURNAL   Exp Mol Med 38 (5), 485-493 (2006)
   PUBMED   17079864
  REMARK    GeneRIF: mOATLP1 appears to be a novel candidate for an organic
            anion transporter isoform identified in the kidney.
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Sekine,T., Miyazaki,H. and Endou,H.
  TITLE     Molecular physiology of renal organic anion transporters
  JOURNAL   Am J Physiol Renal Physiol 290 (2), F251-F261 (2006)
   PUBMED   16403838
  REMARK    Review article
REFERENCE   6  (bases 1 to 1984)
  AUTHORS   Kwak,J.O., Kim,H.W., Oh,K.J., Ko,C.B., Park,H. and Cha,S.H.
  TITLE     Characterization of mouse organic anion transporter 5 as a renal
            steroid sulfate transporter
  JOURNAL   J Steroid Biochem Mol Biol 97 (4), 369-375 (2005)
   PUBMED   16150593
  REMARK    GeneRIF: mOAT5 has a role in excretion or reabsorption of steroid
            sulfates in the kidney
REFERENCE   7  (bases 1 to 1984)
  AUTHORS   Monte,J.C., Nagle,M.A., Eraly,S.A. and Nigam,S.K.
  TITLE     Identification of a novel murine organic anion transporter family
            member, OAT6, expressed in olfactory mucosa
  JOURNAL   Biochem Biophys Res Commun 323 (2), 429-436 (2004)
   PUBMED   15369770
REFERENCE   8  (bases 1 to 1984)
  AUTHORS   Youngblood,G.L. and Sweet,D.H.
  TITLE     Identification and functional assessment of the novel murine
            organic anion transporter Oat5 (Slc22a19) expressed in kidney
  JOURNAL   Am J Physiol Renal Physiol 287 (2), F236-F244 (2004)
   PUBMED   15068970
  REMARK    GeneRIF: Highly expressed in kidney. Motive forces behind Oat5
            function, which provide insight into its membrane localization,
            need to be further resolved.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130693.15 and AC109225.14.
            
            On Aug 26, 2009 this sequence version replaced NM_144785.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021384.2, AF529221.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               AC130693.15        66818-67336         c
            520-623             AC130693.15        65659-65762         c
            624-778             AC109225.14        2313-2467
            779-947             AC109225.14        3327-3495
            948-1071            AC109225.14        4967-5090
            1072-1187           AC109225.14        12300-12415
            1188-1402           AC109225.14        13180-13394
            1403-1511           AC109225.14        14190-14298
            1512-1715           AC109225.14        21707-21910
            1716-1984           AC109225.14        22810-23078
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.34 cM"
     gene            1..1984
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /note="solute carrier family 22 (organic anion
                     transporter), member 19"
                     /db_xref="GeneID:207151"
                     /db_xref="MGI:MGI:2442751"
     exon            1..519
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     CDS             118..1773
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 19; solute carrier family 22 (organic
                     anion transporter), member 9; organic anion transporter 5"
                     /codon_start=1
                     /product="solute carrier family 22 member 19"
                     /protein_id="NP_659034.1"
                     /db_xref="CCDS:CCDS29532.1"
                     /db_xref="GeneID:207151"
                     /db_xref="MGI:MGI:2442751"
                     /translation="MAFQDLIIQIGSLGRFQILHMIFVLICHALSAPHTLLENFTAAI
                     PSHRCWVPILDNDTASDNGSRILSQDDLLRISIPLDSNLRPDKCRRYIQPQWHLLHLN
                     GTFPTVTEPDTEPCVDGWVYDQSTFLSTTVTQWDLVCGSQALNSVAKFIYMTGIFIGY
                     IMGGHLSDKFGRKLIFTCSLLKMAITETCVAFAPSFLIYCSLRFLSGIFSSTLRTNSA
                     LLILEWTSPKFQALVMALIFIASGVGQTLLGGLAFAFRNWHHLQLALSVPMFLLLIPT
                     RWLSESARWLIMANKPQKSLKELKKAACVNRIKNSGDALTLEVVKTIMKEELEAAQTK
                     PSPLDLFRTPNLRKRICLLSFVRFVSVMSLLGLLINIQYLSNNVFLLQCLYGVVCIPA
                     NVLGNFSMNYMGRRMTQLIFMSVLGISILAVVFLPQEMQILRVFLSTLGGAISSASIT
                     STLVHANELVPTIIRATALGVVGIAGSAGGALSPLLMILTTYSASLPWIIYGILPFLG
                     GLVALLLPETKNQPLPDSIQDIENKRKSSKEAKKDVVAKVTPL"
     exon            520..623
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            624..778
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            779..947
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1071
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1187
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1188..1402
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1403..1511
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1715
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     exon            1716..1984
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1959..1964
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /note="hexamer: AATAAA"
     polyA_site      1984
                     /gene="Slc22a19"
                     /gene_synonym="D630043A20Rik; OAT-5; Oat5; Slc22a9"
                     /note="major polyA site"
ORIGIN      
        1 ggtatctcta aggcagtcag ctccttacct aacacctact tagaagaggg acccattaag
       61 aacagctctg tatctattta gtgtgtctta gtgaaaaaaa aatagagatt gccctagatg
      121 gcctttcagg accttataat tcaaattggc agcttgggga ggttccagat tcttcacatg
      181 atatttgtgt taatctgcca tgccctgtcg gctcctcaca ctcttttgga gaacttcact
      241 gcagccattc ctagtcatcg ctgctgggtc cccatccttg acaatgacac tgcctctgat
      301 aatggcagta ggatcctgag ccaagatgac ctcctgagga tctccatccc cctggactcc
      361 aacctgagac cggataaatg ccgtcgctat attcaaccac agtggcatct ccttcatctg
      421 aatggcacct tccccactgt aacagagcca gacacagagc cctgtgtgga tggctgggtg
      481 tatgaccaaa gcaccttcct ctccaccaca gtgacccagt gggacctggt gtgtggatct
      541 caggcactga attcagtggc taaatttata tacatgactg gtatctttat aggatatatc
      601 atgggtggcc acttatcaga caagtttggg aggaagctca ttttcacgtg ctctttactg
      661 aaaatggcca tcactgaaac ttgtgtagct tttgctccct ccttcctcat ctactgctca
      721 cttcgattcc tgtcagggat tttttcctca accctgagga caaacagtgc tttgctcata
      781 ttagaatgga caagtcctaa gtttcaagct ctggtaatgg cactgatatt tattgcctca
      841 ggagttggac agacactgtt gggaggcctg gcttttgctt ttcgaaactg gcaccatctc
      901 cagctggctc tttctgttcc aatgttctta ctccttattc ccacaaggtg gttgtcagag
      961 tcagctcgat ggctgattat ggccaacaaa ccccagaaga gcttaaagga acttaaaaaa
     1021 gctgcatgcg taaatagaat aaagaattct ggagatgccc taaccttgga ggttgtgaaa
     1081 actatcatga aggaggagtt ggaggcagca cagacaaaac cctccccact ggacttgttc
     1141 cgtacaccta accttcgcaa gcggatctgt ctcctatcct ttgtgagatt tgtgtcagtg
     1201 atgtctttat tgggcctgct tatcaacatc caatacctaa gcaataatgt gttcctactg
     1261 cagtgtctct atggtgtggt gtgcatccca gccaatgttc ttggaaattt ttcaatgaac
     1321 tacatgggcc gcagaatgac gcaactgatt ttcatgtctg tgttgggaat ctccattctg
     1381 gctgttgtat ttttgcctca agaaatgcag atcctgcgtg tatttttgtc aacattagga
     1441 ggagcaattt cttctgcctc tataacgagt actcttgtac atgcaaatga gctagtcccc
     1501 accataatca gggcaactgc tttaggagtc gttggaattg ctggcagtgc tggaggagcg
     1561 ctgtctcctc tacttatgat cctcacgaca tactctgctt ccttgccctg gatcatctat
     1621 gggattcttc ccttccttgg tggcctcgtt gcccttcttc ttcctgagac caagaatcag
     1681 cctctgcctg actcaatcca agatatagaa aataagagga aaagctcaaa agaggcaaag
     1741 aaagatgtgg ttgccaaagt gacaccatta taaagaattc caaccggcct ctgatcaagg
     1801 agaaagatga aaaaatatat atcattcagc atatcgtggt ccagaattat acctatatgt
     1861 tagcaagatt tttccatata agtcactgta taaataatga gttaaattaa aattatacta
     1921 gtttgtcatg tataaaataa ctataataaa gaaatttgaa taaaatcaca atatattgaa
     1981 gaaa
//
