LOCUS       NM_008767               1472 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 18 (Slc22a18), transcript variant 1, mRNA.
ACCESSION   NM_008767
VERSION     NM_008767.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1472)
  AUTHORS   Yamamoto,T., Iizuka,Y., Izumi-Yamamoto,K., Shirota,M., Mori,N.,
            Tahara,Y., Fujita,T. and Gotoda,T.
  TITLE     Overexpression of Slc22a18 facilitates fat accumulation in mice
  JOURNAL   Biochem Biophys Res Commun 712-713, 149922 (2024)
   PUBMED   38626531
  REMARK    GeneRIF: Overexpression of Slc22a18 facilitates fat accumulation in
            mice.
REFERENCE   2  (bases 1 to 1472)
  AUTHORS   Singh,V.B., Sribenja,S., Wilson,K.E., Attwood,K.M., Hillman,J.C.,
            Pathak,S. and Higgins,M.J.
  TITLE     Blocked transcription through KvDMR1 results in absence of
            methylation and gene silencing resembling Beckwith-Wiedemann
            syndrome
  JOURNAL   Development 144 (10), 1820-1830 (2017)
   PUBMED   28428215
REFERENCE   3  (bases 1 to 1472)
  AUTHORS   Korostowski,L., Sedlak,N. and Engel,N.
  TITLE     The Kcnq1ot1 long non-coding RNA affects chromatin conformation and
            expression of Kcnq1, but does not regulate its imprinting in the
            developing heart
  JOURNAL   PLoS Genet 8 (9), e1002956 (2012)
   PUBMED   23028363
REFERENCE   4  (bases 1 to 1472)
  AUTHORS   Mohammad,F., Mondal,T., Guseva,N., Pandey,G.K. and Kanduri,C.
  TITLE     Kcnq1ot1 noncoding RNA mediates transcriptional gene silencing by
            interacting with Dnmt1
  JOURNAL   Development 137 (15), 2493-2499 (2010)
   PUBMED   20573698
REFERENCE   5  (bases 1 to 1472)
  AUTHORS   Tunster,S.J., Tycko,B. and John,R.M.
  TITLE     The imprinted Phlda2 gene regulates extraembryonic energy stores
  JOURNAL   Mol Cell Biol 30 (1), 295-306 (2010)
   PUBMED   19884348
REFERENCE   6  (bases 1 to 1472)
  AUTHORS   Day,C.D., Smilinich,N.J., Fitzpatrick,G.V., deJong,P.J., Shows,T.B.
            and Higgins,M.J.
  TITLE     The imprinted domain in mouse distal Chromosome 7: reagents for
            mutagenesis and sequencing
  JOURNAL   Mamm Genome 10 (2), 182-185 (1999)
   PUBMED   9922400
REFERENCE   7  (bases 1 to 1472)
  AUTHORS   Morisaki,H., Hatada,I., Morisaki,T. and Mukai,T.
  TITLE     A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in
            mice
  JOURNAL   DNA Res 5 (4), 235-240 (1998)
   PUBMED   9802569
  REMARK    GeneRIF: Slc22a18/Itm gene is imprinted, with preferential
            expression from the maternal allele in fetal, newborn and most
            adult tissues, but biallelic expression in adult kidney and liver.
REFERENCE   8  (bases 1 to 1472)
  AUTHORS   Cooper,P.R., Smilinich,N.J., Day,C.D., Nowak,N.J., Reid,L.H.,
            Pearsall,R.S., Reece,M., Prawitt,D., Landers,J., Housman,D.E.,
            Winterpacht,A., Zabel,B.U., Pelletier,J., Weissman,B.E., Shows,T.B.
            and Higgins,M.J.
  TITLE     Divergently transcribed overlapping genes expressed in liver and
            kidney and located in the 11p15.5 imprinted domain
  JOURNAL   Genomics 49 (1), 38-51 (1998)
   PUBMED   9570947
REFERENCE   9  (bases 1 to 1472)
  AUTHORS   Dao,D., Frank,D., Qian,N., O'Keefe,D., Vosatka,R.J., Walsh,C.P. and
            Tycko,B.
  TITLE     IMPT1, an imprinted gene similar to polyspecific transporter and
            multi-drug resistance genes
  JOURNAL   Hum Mol Genet 7 (4), 597-608 (1998)
   PUBMED   9499412
REFERENCE   10 (bases 1 to 1472)
  AUTHORS   Bastian,H. and Gruss,P.
  TITLE     A murine even-skipped homologue, Evx 1, is expressed during early
            embryogenesis and neurogenesis in a biphasic manner
  JOURNAL   EMBO J 9 (6), 1839-1852 (1990)
   PUBMED   1971786
  REMARK    Erratum:[EMBO J 1991 Dec;10(12):3978]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869719.1, AK002460.1, BE865039.1 and BU758157.1.
            
            On May 29, 2019 this sequence version replaced NM_008767.2.
            
            Transcript Variant: This variant (1) represents the predominant
            transcript. Variants 1 and 2 encode the same isoform (b).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC003734.1, AF028739.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            imprinted gene         :: PMID: 9802569
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               BB869719.1         35-348
            315-680             AK002460.1         330-695
            681-1035            BE865039.1         222-576
            1036-1468           AK002460.1         1052-1484
            1469-1472           BU758157.1         15-18               c
FEATURES             Location/Qualifiers
     source          1..1472
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 88.22 cM"
     gene            1..1472
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 18"
                     /db_xref="GeneID:18400"
                     /db_xref="MGI:MGI:1336884"
     exon            1..49
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            50..285
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     CDS             178..1410
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /note="isoform b is encoded by transcript variant 1;
                     solute carrier family 22 member 18; tumor suppressing
                     subtransferable candidate 5; ORCTL-2; imprinted
                     multi-membrane spanning polyspecific transporter-related
                     protein 1; organic cationic transporter-like 2"
                     /codon_start=1
                     /product="solute carrier family 22 member 18 isoform b"
                     /protein_id="NP_032793.2"
                     /db_xref="CCDS:CCDS22041.1"
                     /db_xref="GeneID:18400"
                     /db_xref="MGI:MGI:1336884"
                     /translation="MSGSMAALPRQGIIILTYVLAALELTCLFMQFSILPYLSRTLGL
                     DSVSFGYLQTTFGVLQLLGGPVFGRFADQCGARAALSLSFLAASALYLLLVASCSPAL
                     PGVFLLFASRIPSALMHTLPAAQMVITDLTAPTERPAALGRLGLCFGIGIIFGSLLGG
                     TLNTAYGIQCPAILAFVVTLLGAVLSFTCVPATTKEASVQSAPQGGTKASVFDLKAIT
                     RLLLLPRVLPVFLVKVISGLPSGLFLVMFSIISMDFFQLEAAQAGYLMSFFGILQMMI
                     QGLVIGRLSTHFPEEALLRSSVLVFAVVGLGMALMSSVLHFCFLMPGLVFSLCTLNVV
                     TDSMLTKAVSASDTGTMLGLSASVQPLTRTLGPTLGGLLYRSYGVPIFGHVQLMVNLL
                     VLLVLWKKPLSQKGEKAR"
     exon            286..383
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            384..544
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            545..677
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            678..790
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            791..898
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            899..999
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1101
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1102..1222
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1472
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1443..1448
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /note="hexamer: AATAAA"
     polyA_site      1472
                     /gene="Slc22a18"
                     /gene_synonym="BWR1A; BWSCR1A; HET; Impt1; ITM; Orctl2;
                     p45-BWR1A; Slc22a1l; TSSC5"
                     /note="major polyA site"
ORIGIN      
        1 attcggcctg gcctgccggt tcccccacaa ctgcaagctc tgcttgtggg ccaccccttc
       61 caccctggtg agtcagcacc cggccagaat caacaggact tttgcccctt gcccgcggca
      121 aggcttgccc tgctctggtt caggtccctc caggactctg gatactgtct gcctgggatg
      181 tctggcagca tggctgctct gccccggcag gggatcatca tactcaccta tgtgctggca
      241 gccctggagc taacgtgtct cttcatgcag ttctccatcc taccatatct gtctcggaca
      301 ctgggcctag attctgtctc ctttggctac ctacagacaa cctttggggt gcttcagctg
      361 ttgggtgggc ctgtgttcgg caggttcgca gaccagtgcg gggcaagagc ggcactctca
      421 ctctccttcc tggcggcctc tgctctgtac ctgctcctgg tggcctcctg tagcccagcc
      481 ctgcctggtg tcttcctgct cttcgcctca cgcataccct ctgccctcat gcacacactt
      541 ccagccgccc agatggtcat cactgatctg acagcgccca cagagcggcc cgcagcactg
      601 ggccggctgg gcctctgctt tggcattgga attatcttcg gctccctact tggcgggacc
      661 cttaacaccg catacgggat ccagtgtcct gccatcctgg cttttgtggt caccctccta
      721 ggagctgtcc tcagctttac ctgtgtccct gctaccacca aggaggccag tgtccagtca
      781 gctcctcagg gtggaaccaa ggccagtgta tttgacctga aggccatcac ccgcctgcta
      841 ctgctgccta gagtgctgcc tgtattcctg gtcaaggtaa tctctggcct cccttcagga
      901 ctcttcttgg tgatgttttc catcatctct atggacttct tccagctgga ggctgcacag
      961 gctggctacc tcatgtcctt cttcgggatc ctccagatga tgatccaagg cctggtcatt
     1021 gggaggctga gcacccattt tccagaggaa gccttgctgc gatccagtgt gctggtcttt
     1081 gctgttgtgg gactgggcat ggcgctgatg tccagtgtgc tccatttctg ttttctgatg
     1141 cctgggctgg tattcagtct ctgtactctc aacgtagtca cagacagcat gctgaccaag
     1201 gctgtgtccg cttcagacac agggaccatg ctgggcctct ctgcatctgt gcaaccattg
     1261 acccgaactc taggacccac cctaggtggc ctgctgtacc gtagctatgg tgtccccatc
     1321 tttggccatg tgcagctcat ggtgaacttg cttgtcctat tggtcctttg gaagaagcca
     1381 ttgtcccaga agggagaaaa agcccggtga ccacaaagcc cagtgacttg gcccagtccg
     1441 gcaataaact taagaacctc ttcctcttaa aa
//
