LOCUS       NM_001360406            2399 bp    mRNA    linear   ROD 10-JUN-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 17 (Slc22a17), transcript variant 1, mRNA.
ACCESSION   NM_001360406 XM_006519337
VERSION     NM_001360406.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2399)
  AUTHORS   Li,W., Shi,J., Yu,Z., Garcia-Gabilondo,M., Held,A., Huang,L.,
            Deng,W., Ning,M., Ji,X., Rosell,A., Wainger,B.J. and Lo,E.H.
  TITLE     SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in
            Cerebral Ischemia
  JOURNAL   Stroke 55 (6), 1650-1659 (2024)
   PUBMED   38738428
  REMARK    GeneRIF: SLC22A17 as a Cell Death-Linked Regulator of Tight
            Junctions in Cerebral Ischemia.
REFERENCE   2  (bases 1 to 2399)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 2399)
  AUTHORS   Betten,R., Scharner,B., Probst,S., Edemir,B., Wolff,N.A.,
            Langelueddecke,C., Lee,W.K. and Thevenod,F.
  TITLE     Tonicity inversely modulates lipocalin-2 (Lcn2/24p3/NGAL) receptor
            (SLC22A17) and Lcn2 expression via Wnt/beta-catenin signaling in
            renal inner medullary collecting duct cells: implications for cell
            fate and bacterial infection
  JOURNAL   Cell Commun Signal 16 (1), 74 (2018)
   PUBMED   30404645
  REMARK    GeneRIF: Lcn2-R upregulation and Lcn2 downregulation via
            Wnt/beta-catenin may promote adaptive osmotolerant survival of IMCD
            cells
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2399)
  AUTHORS   Gurdziel,K., Vogt,K.R., Walton,K.D., Schneider,G.K. and
            Gumucio,D.L.
  TITLE     Transcriptome of the inner circular smooth muscle of the developing
            mouse intestine: Evidence for regulation of visceral smooth muscle
            genes by the hedgehog target gene, cJun
  JOURNAL   Dev Dyn 245 (5), 614-626 (2016)
   PUBMED   26930384
REFERENCE   5  (bases 1 to 2399)
  AUTHORS   Langelueddecke,C., Roussa,E., Fenton,R.A., Wolff,N.A., Lee,W.K. and
            Thevenod,F.
  TITLE     Lipocalin-2 (24p3/neutrophil gelatinase-associated lipocalin
            (NGAL)) receptor is expressed in distal nephron and mediates
            protein endocytosis
  JOURNAL   J Biol Chem 287 (1), 159-169 (2012)
   PUBMED   22084236
  REMARK    GeneRIF: 24p3R binds proteins filtered by the kidney with high
            affinity and may contribute to receptor-mediated endocy of proteins
REFERENCE   6  (bases 1 to 2399)
  AUTHORS   Devireddy,L.R., Gazin,C., Zhu,X. and Green,M.R.
  TITLE     A cell-surface receptor for lipocalin 24p3 selectively mediates
            apoptosis and iron uptake
  JOURNAL   Cell 123 (7), 1293-1305 (2005)
   PUBMED   16377569
  REMARK    GeneRIF: cloning of the lipocalin 24p3 receptor (24p3R). Ectopic
            24p3R expression confers on cells the ability to undergo either
            iron uptake or apoptosis, dependent upon the iron content of the
            ligand.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY291454.1, AK007059.1, CX206695.1 and AA271560.1.
            
            [WARNING] On Jan 22, 2025 this sequence was replaced by
            NM_001360406.2.
            
            On Feb 3, 2018 this sequence version replaced XM_006519337.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.95046.1,
                                           SRR1660815.188948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-199               BY291454.1         2-200
            200-511             AK007059.1         145-456
            512-975             CX206695.1         1-464
            976-2384            AK007059.1         817-2225
            2385-2399           AA271560.1         314-328
FEATURES             Location/Qualifiers
     source          1..2399
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 27.99 cM"
     gene            1..2399
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 17"
                     /db_xref="GeneID:59049"
                     /db_xref="MGI:MGI:1926225"
     exon            1..266
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            267..758
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            759..862
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1017
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1018..1183
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1329
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1330..1435
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1653
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1654..1765
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     exon            1766..2394
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2353..2358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /note="hexamer: AATAAA"
     polyA_site      2394
                     /gene="Slc22a17"
                     /gene_synonym="1700094C23Rik; 24p3R; Boct; BOIT"
                     /note="major polyA site"
ORIGIN      
        1 aggggagggg aaagcagcgc agagaccgta gagacggagg aggcgcccgc ggctgcagag
       61 ctgcagagcg gggtctcccg gccctctgcg tcctagctct ccgcacctag cccagccaga
      121 cagcagctca ttctctcggc gcggcccata gggccccagc ggtcggcaag ctggctcccc
      181 gagtagccac cgggaccccc gagcccaatg gcgggggcgg caacaaaatc gacagcgccg
      241 tggagatcgc ccccggctcc aatggacagg tcgggagcct cggagatgcg gtcccccccg
      301 agcagctgca gggtgagcgg gagcgccggc gggaggggga gggcgacgcg ctgggcagca
      361 gcctgtcgct ggccgcgccc ccgggacccc tcagcttcga ggctctgctc gcccaggtgg
      421 gggccctggg tggcggccag cagctgcagc tcggcctgtg ctgcctgccc gtgcttttcg
      481 tggcgctggg catggcctca gaccccatct tcacgctggc gcccccgctg cactgccact
      541 acggcgcctt gccccccaac gcttcgggct gggagcagcc ccccaactcc agcggcgtca
      601 gtgtcgccgg cgcggcccta gcagccagcg ccgccagcgg agtcgtcacc agtacggacc
      661 cctcgtgcag tggcttcgcc ccaccagact tcaaccactg cctgaaggac tgggactata
      721 acggactgcc cgtgctcacc accaatgcca tcggccagtg ggatctggtg tgtgacctgg
      781 gctggcaggt gatcctggag cagatcctct tcatcttggg ctttgcctcc ggctacctgt
      841 tcctcggtta ccccgcggac aggtttggcc gtcgtgggat tgtgctgctg accttggggc
      901 ttgtgggtcc ctgtggagtg ggaggagctg ctgcaggctc ctctacaggc attatggctc
      961 ttcggtttct cctgggcttc ctgctagctg gtgttgacct tggtgtctac ctgatgcgcc
     1021 tggagctgtg cgacccaacc cagaggcttc gggtggccct ggcaggggag ttggtagggg
     1081 tgggagggca cttcctgttc ctgggcctgg cccttgtctc taaggactgg cgatttctac
     1141 agcgaatgat caccgctccc tgcatcctct tcctgtttta tggctggcct ggtctgtttc
     1201 tggagtctgc acggtggctg atagtgaagc ggcagattga ggaagcccag tctgtgctga
     1261 ggatcctggc tgagcgaaac cggccccatg ggcagatgct gggagaagag gcccaggaag
     1321 ctttgcagga actggagaat acctgtcctc tccctgcaac gtccaccttt tcctttgcgt
     1381 ccctcctcaa ctaccgcaac atctggaaaa atctgcttat cctgggcttc accaacttta
     1441 ttgcccatgc cattcgccac tgctaccagc ctgtgggagg aggaggcagc ccatcagact
     1501 tctacttgtg ctctctgctg gccagtggca cagccgccct ggcctgtgtc ttcctggggg
     1561 tgactgtgga ccgttttggc cgtcggggca tcctgcttct ctcaatgact ctcacgggga
     1621 ttgcatccct ggtcctgctg gggctgtggg attatctgaa cgatgctgcc atcacaacct
     1681 tctctgtcct tggcctcttc tcctcccaag cttctgctat cctcagtacc ctccttgctt
     1741 ctgaagtcat ccccaccact gtccgcggcc gtggcctggg ccttatcatg gcacttgggg
     1801 cgctcggggg gctgagctgt ccagctcagc gcctccacat gggccatgga gccttcctgc
     1861 agcatgtggt actggcggcc tgtgccctcc tctgtatcct cagcatcatg ctgttgccag
     1921 agaccaagcg caagcttctg ccagaggtac tccgggatgg ggaactgtgc cgccggcctt
     1981 ccctgctgag gcagccacct cctaaccgct gtgaccatgt cccgctgcta gccactccta
     2041 accctgccct ctaagcagcc tttgagccta gtgggaggcc agccatccag aaaagtagca
     2101 gagggctaga aagatagaca ggaaggcaag gctaccccat acaaaaggct caaaggcgcc
     2161 tcatgccaac cgtctaggag agctcagagg gccgttccca accccatctc ctccctgctg
     2221 ctttctgttc actccgtcag caagagtcag gccaggggag agcatcacgc tataaccatt
     2281 aggtctgggc tccatcctat gcccaaagac atttcccaga cctcgctctt tctcgctctt
     2341 tcattctgtt tcaataaaag acattttgaa taaatgagca tatcatagcc tggaaaaaa
//
