LOCUS       NM_001037749            2200 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 14 (Slc22a14), transcript variant 1, mRNA.
ACCESSION   NM_001037749 XM_356200 XM_902944 XM_916563 XM_924321
VERSION     NM_001037749.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2200)
  AUTHORS   Ito,M., Unou,M., Higuchi,T., So,S., Ito,M. and Yogo,K.
  TITLE     Dysregulation of intracellular pH is a cause of impaired
            capacitation in Slc22a14-deficient mice
  JOURNAL   Reproduction 163 (1), 23-32 (2021)
   PUBMED   34704967
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2200)
  AUTHORS   Kuang,W., Zhang,J., Lan,Z., Deepak,R.N.V.K., Liu,C., Ma,Z.,
            Cheng,L., Zhao,X., Meng,X., Wang,W., Wang,X., Xu,L., Jiao,Y.,
            Luo,Q., Meng,Z., Kee,K., Liu,X., Deng,H., Li,W., Fan,H. and Chen,L.
  TITLE     SLC22A14 is a mitochondrial riboflavin transporter required for
            sperm oxidative phosphorylation and male fertility
  JOURNAL   Cell Rep 35 (3), 109025 (2021)
   PUBMED   33882315
REFERENCE   3  (bases 1 to 2200)
  AUTHORS   Man,J.C.K., Mohan,R.A., Boogaard,M.V.D., Hilvering,C.R.E.,
            Jenkins,C., Wakker,V., Bianchi,V., Laat,W., Barnett,P.,
            Boukens,B.J. and Christoffels,V.M.
  TITLE     An enhancer cluster controls gene activity and topology of the
            SCN5A-SCN10A locus in vivo
  JOURNAL   Nat Commun 10 (1), 4943 (2019)
   PUBMED   31666509
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2200)
  AUTHORS   Maruyama,S.Y., Ito,M., Ikami,Y., Okitsu,Y., Ito,C., Toshimori,K.,
            Fujii,W. and Yogo,K.
  TITLE     A critical role of solute carrier 22a14 in sperm motility and male
            fertility in mice
  JOURNAL   Sci Rep 6, 36468 (2016)
   PUBMED   27811987
  REMARK    GeneRIF: The role of Slc22a14 found that Slc22a14-deficient male
            mice showed severe infertility. Although the differentiation
            process in testis appeared to be normal, cauda epididymal
            spermatozoa in Slc22a14-/- mice showed impaired motility with
            abnormal tails.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC055818.9 and AEKQ02157215.1.
            
            On Aug 21, 2018 this sequence version replaced NM_001037749.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC100471.1, AK133291.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-31                AC055818.9         39604-39634
            32-123              AEKQ02157215.1     23229-23320         c
            124-636             AEKQ02157215.1     19712-20224         c
            637-740             AEKQ02157215.1     18981-19084         c
            741-895             AEKQ02157215.1     18626-18780         c
            896-1064            AEKQ02157215.1     17598-17766         c
            1065-1185           AEKQ02157215.1     13481-13601         c
            1186-1283           AEKQ02157215.1     13152-13249         c
            1284-1498           AEKQ02157215.1     12642-12856         c
            1499-1607           AEKQ02157215.1     11240-11348         c
            1608-1802           AEKQ02157215.1     9642-9836           c
            1803-2200           AEKQ02157215.1     8655-9052           c
FEATURES             Location/Qualifiers
     source          1..2200
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 71.33 cM"
     gene            1..2200
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 14"
                     /db_xref="GeneID:382113"
                     /db_xref="MGI:MGI:2685974"
     exon            1..31
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            32..123
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2013
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /note="organic cation transporter like 4"
                     /codon_start=1
                     /product="solute carrier family 22 member 14"
                     /protein_id="NP_001032838.1"
                     /db_xref="CCDS:CCDS23609.1"
                     /db_xref="GeneID:382113"
                     /db_xref="MGI:MGI:2685974"
                     /translation="MKEDQNYKTAFGSQNSRDTHRHEISFPSQNWSLEMLLRRLKAID
                     ARRDDKFASVMDAIGEFGTFQWRLVVLTFIPSILSTFFIFSHHFLLTAQRPYCNTSWI
                     LEVGPNLTEDEQLNLTLPRAPNGSFLTCLMYIPVPWDLDSIIHFGLNYTETCKFGWIY
                     PFAHTRSLINEFDLVCGNEPNKENGLTVFLSGVLTGSLLFGFLSDKLGRYPIILLSLL
                     GFLIFGFGTAFVSSFYQYLFFRFFVAQASVGYAICSVSLVMEWLVGEHRAQAVILQHS
                     FLTIGVILLTGLAYKVVHWRLLCLLGGMPMFPLICNIWVLRESPRWLMVRGKVEEAKK
                     VLCYAAEVNKKTIPLNLLNELQISGKKVAKASILDFCTNQHLFKVVLAIGCVWFTVSY
                     ISFTLNLKMNDFGLDVYFVQMVRSIVAVPARLCCIILLEYFGRKWALNLTLFLVTSMC
                     LFLLFLPQEPKSTIILTLMLAEFSMAGTLSIFFIYTAELLPTVLRSTGLGMVSLAWVA
                     GAISSVAIFKQTKTQLPIFFCCLCCVLALCFSSLVPETGSQSLRDSIEYNIRDSIEPK
                     DRNKDVPMVIAEESMSDIVADSEVTNTTLNAVTFKPEENSLLNMTLEVPKMDLPVQSL
                     KAQPP"
     exon            124..636
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            637..740
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            741..895
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            896..1064
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1185
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            1186..1283
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1498
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1607
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            1608..1802
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..2200
                     /gene="Slc22a14"
                     /gene_synonym="Gm1128"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaggatatgg ttgggtctgg acaccagtca gggtgaccaa attgtcatcc atttcaagac
       61 actttcgaga agaggagagg accaaggttg agtccctaca ccagctcaga agacacaaac
      121 aagatgaagg aagaccagaa ctacaagaca gcattcggat cccagaattc cagggacaca
      181 caccggcatg agatttcctt tccctcacag aactggtcct tggagatgct gctacgcaga
      241 ttgaaggcca tagatgccag gagggatgac aagtttgcca gtgttatgga tgccattggg
      301 gaatttggca cattccagtg gaggctggtg gtcctcacct tcatccccag catcctgtca
      361 accttcttca tattctctca tcacttcttg ctcacagctc agaggcccta ctgtaacacc
      421 agctggatcc tggaagtggg ccccaatctc acagaggatg agcagctgaa cctgaccctg
      481 ccccgagcac ccaatggcag ctttctgacg tgcctcatgt atatacctgt gccatgggac
      541 ctagactcta tcatccactt cggcctcaat tatacagaaa catgcaaatt cgggtggatc
      601 tacccttttg ctcacacccg ttctctgatc aatgagtttg acctggtatg tggcaacgaa
      661 ccaaacaagg aaaacgggct gactgtgttc ctgtcaggcg tcttgacagg gtctcttctc
      721 ttcgggttct taagtgacaa gttgggccgc tatccaatca tcctgctgtc gctgctgggg
      781 ttcctcatct ttggcttcgg aacagccttt gtgagcagct tttatcaata tctgttcttc
      841 cgcttttttg tggcccaggc ctccgtgggc tatgccatct gcagtgtatc tttagtcatg
      901 gagtggctgg tgggcgagca ccgcgctcaa gccgtcatcc tgcagcacag cttcctcacc
      961 ataggggtca tactcctgac ggggctggct tacaaagtcg tccactggag actgctgtgc
     1021 ctgctgggcg gcatgcccat gtttcccctt atctgcaata tctgggttct ccgagagtcc
     1081 ccacgatggc tgatggtgag aggcaaggtg gaagaagcta agaaggtcct gtgctatgca
     1141 gctgaggtga acaagaagac catcccttta aatctactca atgagctaca gatttcagga
     1201 aagaaagtgg caaaggcttc tatcttggac ttctgtacca atcagcacct cttcaaggtg
     1261 gtcttggcca ttggctgtgt gtggtttacc gtcagttaca tcagttttac actgaacctc
     1321 aagatgaacg actttgggct ggacgtctac ttcgtacaaa tggtccggag catagtggca
     1381 gtgccagccc ggctgtgttg tatcattctc ctggagtatt ttgggaggaa gtgggcctta
     1441 aacctgactc tcttcctagt tacctccatg tgtttgtttc tccttttcct cccccaagag
     1501 ccgaagtcga caataatcct gacgctcatg cttgcagagt tcagcatggc tggcactctc
     1561 tctatattct ttatctacac tgcagagctt ctccccacag tcctcaggtc tacaggtctg
     1621 ggaatggtgt ctctagcctg ggtggctgga gccatctcat ctgtggccat cttcaaacag
     1681 accaaaacac agctgcccat cttcttctgt tgtctgtgct gcgtattggc cttgtgcttc
     1741 tcctccctgg taccagaaac gggaagccag tctctccgtg acagcataga gtacaatata
     1801 agagattcta ttgagcccaa ggatagaaat aaggatgttc ccatggtgat agctgaggag
     1861 tcgatgtctg acattgtggc tgattctgaa gtgacaaata ccacgctcaa tgccgtgact
     1921 ttcaagccag aagaaaatag cctcctcaac atgaccttgg aggtacccaa gatggactta
     1981 ccagtccagt cccttaaggc ccagcctccc tagagcattt tggatcggag gctggtatgg
     2041 gtatggggcc atggattcat ggcctcaagt tctagaccca gtctggcatg tgggatgagt
     2101 ctgtcctcct ccaaggtcag ccctcgggat cccaaaatag tcccttctga agggggtgct
     2161 gacttgtgat tcactccaat aaaatatcat gttggtcttg
//
