LOCUS       NM_009203               2255 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus solute carrier family 22 (organic anion/cation
            transporter), member 12 (Slc22a12), mRNA.
ACCESSION   NM_009203
VERSION     NM_009203.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2255)
  AUTHORS   Toyoda,Y., Miyata,H., Uchida,N., Morimoto,K., Shigesawa,R.,
            Kassai,H., Nakao,K., Tomioka,N.H., Matsuo,H., Ichida,K.,
            Hosoyamada,M., Aiba,A., Suzuki,H. and Takada,T.
  TITLE     Vitamin C transporter SVCT1 serves a physiological role as a urate
            importer: functional analyses and in vivo investigations
  JOURNAL   Pflugers Arch 475 (4), 489-504 (2023)
   PUBMED   36749388
REFERENCE   2  (bases 1 to 2255)
  AUTHORS   Hosoya,T., Uchida,S., Shibata,S., Tomioka,N.H., Matsumoto,K. and
            Hosoyamada,M.
  TITLE     Xanthine Oxidoreductase Inhibitors Suppress the Onset of
            Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double
            Knockout Mice
  JOURNAL   J Am Soc Nephrol 33 (2), 326-341 (2022)
   PUBMED   34799437
REFERENCE   3  (bases 1 to 2255)
  AUTHORS   Tanaka,Y., Nagoshi,T., Takahashi,H., Oi,Y., Yoshii,A., Kimura,H.,
            Ito,K., Kashiwagi,Y., Tanaka,T.D. and Yoshimura,M.
  TITLE     URAT1-selective inhibition ameliorates insulin resistance by
            attenuating diet-induced hepatic steatosis and brown adipose tissue
            whitening in mice
  JOURNAL   Mol Metab 55, 101411 (2022)
   PUBMED   34863940
  REMARK    GeneRIF: URAT1-selective inhibition ameliorates insulin resistance
            by attenuating diet-induced hepatic steatosis and brown adipose
            tissue whitening in mice.
REFERENCE   4  (bases 1 to 2255)
  AUTHORS   Matsubayashi,M., Sakaguchi,Y.M., Sahara,Y., Nanaura,H., Kikuchi,S.,
            Asghari,A., Bui,L., Kobashigawa,S., Nakanishi,M., Nagata,R.,
            Matsui,T.K., Kashino,G., Hasegawa,M., Takasawa,S., Eriguchi,M.,
            Tsuruya,K., Nagamori,S., Sugie,K., Nakagawa,T., Takasato,M.,
            Umetani,M. and Mori,E.
  TITLE     27-Hydroxycholesterol regulates human SLC22A12 gene expression
            through estrogen receptor action
  JOURNAL   FASEB J 35 (1), e21262 (2021)
   PUBMED   33368618
REFERENCE   5  (bases 1 to 2255)
  AUTHORS   Li,X., Yan,Z., Tian,J., Zhang,X., Han,H. and Ye,F.
  TITLE     Urate Transporter URAT1 in Hyperuricemia: New Insights from
            Hyperuricemic Models
  JOURNAL   Ann Clin Lab Sci 49 (6), 756-762 (2019)
   PUBMED   31882426
  REMARK    GeneRIF: Extracellular uric acid levels in the proximal tubule
            epithelial cells positively regulated URAT1 expression.Renal URAT1
            expression increased in hyperuricemic mice.
REFERENCE   6  (bases 1 to 2255)
  AUTHORS   Monte,J.C., Nagle,M.A., Eraly,S.A. and Nigam,S.K.
  TITLE     Identification of a novel murine organic anion transporter family
            member, OAT6, expressed in olfactory mucosa
  JOURNAL   Biochem Biophys Res Commun 323 (2), 429-436 (2004)
   PUBMED   15369770
REFERENCE   7  (bases 1 to 2255)
  AUTHORS   Imaoka,T., Kusuhara,H., Adachi-Akahane,S., Hasegawa,M., Morita,N.,
            Endou,H. and Sugiyama,Y.
  TITLE     The renal-specific transporter mediates facilitative transport of
            organic anions at the brush border membrane of mouse renal tubules
  JOURNAL   J Am Soc Nephrol 15 (8), 2012-2022 (2004)
   PUBMED   15284287
  REMARK    GeneRIF: mouse RST mediates the efflux of organic anions including
            urate and works as exit for organic anions in the proximal tubules
REFERENCE   8  (bases 1 to 2255)
  AUTHORS   Hosoyamada,M., Ichida,K., Enomoto,A., Hosoya,T. and Endou,H.
  TITLE     Function and localization of urate transporter 1 in mouse kidney
  JOURNAL   J Am Soc Nephrol 15 (2), 261-268 (2004)
   PUBMED   14747372
REFERENCE   9  (bases 1 to 2255)
  AUTHORS   Gisler,S.M., Pribanic,S., Bacic,D., Forrer,P., Gantenbein,A.,
            Sabourin,L.A., Tsuji,A., Zhao,Z.S., Manser,E., Biber,J. and
            Murer,H.
  TITLE     PDZK1: I. a major scaffolder in brush borders of proximal tubular
            cells
  JOURNAL   Kidney Int 64 (5), 1733-1745 (2003)
   PUBMED   14531806
REFERENCE   10 (bases 1 to 2255)
  AUTHORS   Mori,K., Ogawa,Y., Ebihara,K., Aoki,T., Tamura,N., Sugawara,A.,
            Kuwahara,T., Ozaki,S., Mukoyama,M., Tashiro,K., Tanaka,I. and
            Nakao,K.
  TITLE     Kidney-specific expression of a novel mouse organic cation
            transporter-like protein
  JOURNAL   FEBS Lett 417 (3), 371-374 (1997)
   PUBMED   9409754
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD241755.1, AB005451.1, AK142580.1, AI314749.1 and BX631781.1.
            
            On Jan 16, 2008 this sequence version replaced NM_009203.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC035927.1, AB005451.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-219               CD241755.1         3-221
            220-746             AB005451.1         1-527
            747-979             AK142580.1         65-297
            980-1998            AB005451.1         761-1779
            1999-2230           AI314749.1         1-232               c
            2231-2255           BX631781.1         7-31                c
FEATURES             Location/Qualifiers
     source          1..2255
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 5.05 cM"
     gene            1..2255
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /note="solute carrier family 22 (organic anion/cation
                     transporter), member 12"
                     /db_xref="GeneID:20521"
                     /db_xref="MGI:MGI:1195269"
     exon            1..720
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             319..1980
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /note="solute carrier family 22 (organic cation
                     transporter)-like 2; urate anion exchanger 1;
                     renal-specific transporter; urate:anion antiporter
                     SLC22A12"
                     /codon_start=1
                     /product="solute carrier family 22 member 12"
                     /protein_id="NP_033229.3"
                     /db_xref="CCDS:CCDS29505.1"
                     /db_xref="GeneID:20521"
                     /db_xref="MGI:MGI:1195269"
                     /translation="MAFPELLDRVGGLGRFQLFQTVALVTPILWVTTQNMLENFSAAV
                     PHHRCWVPLLDNSTSQASIPGDLGPDVLLAVSIPPGPDQQPHQCLRFRQPQWQLTESN
                     ATATNWSDAATEPCEDGWVYDHSTFRSTIVTTWDLVCNSQALRPMAQSIFLAGILVGA
                     AVCGHASDRFGRRRVLTWSYLLVSVSGTAAAFMPTFPLYCLFRFLLASAVAGVMMNTA
                     SLLMEWTSAQGSPLVMTLNALGFSFGQVLTGSVAYGVRSWRMLQLAVSAPFFLFFVYS
                     WWLPESARWLITVGKLDQGLQELQRVAAVNRRKAEGDTLTMEVLRSAMEEEPSRDKAG
                     ASLGTLLHTPGLRHRTIISMLCWFAFGFTFYGLALDLQALGSNIFLLQALIGIVDFPV
                     KTGSLLLISRLGRRLCQVSFLVLPGLCILSNILVPHGMGVLRSALAVLGLGCLGGAFT
                     CITIFSSELFPTVIRMTAVGLCQVAARGGAMLGPLVRLLGVYGSWMPLLVYGVVPVLS
                     GLAALLLPETKNLPLPDTIQDIQKQSVKKVTHDTPDGSILMSTRL"
     exon            721..824
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            825..979
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1148
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1272
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1273..1388
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1603
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1604..1712
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1916
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..2255
                     /gene="Slc22a12"
                     /gene_synonym="OAT4L; Rst; Slc22al2; URAT1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccagagtg acttctctct ccaccctcct tgcttctcaa atttggtttt tcctgagagc
       61 cagactctgc tgtgtcgctg agaggttccc atggcctcca gattaccaca gagggttcca
      121 ggtctcatgg tgacagccag caggcagata cacaagagcc ttgactggct gtgactcagc
      181 aacatggctg tgtgacatgc atatgaagag actggtgtgg tcagagccaa ggggaaagca
      241 ggctcatcac aaagacccca tggtcctggg ccagcctctg tgaagtggaa gctgcgtggt
      301 ggtacccagg agaaacccat ggcctttcct gaactcctgg accgagtggg ggggctgggc
      361 aggttccagc tcttccagac ggtggctctg gtgaccccca ttttgtgggt caccacccag
      421 aacatgctgg agaacttctc agccgcagtt ccccaccacc gctgttgggt gcctctcctg
      481 gacaatagca cctcccaggc gagtatccct ggggaccttg gacccgatgt tcttctggcc
      541 gtctccatcc cacctggtcc tgaccagcaa ccccaccagt gcctccgctt ccgacaacct
      601 caatggcagc ttacagagtc caacgccacg gccaccaact ggagtgacgc tgccactgag
      661 ccatgcgagg atggctgggt ttacgaccac agcaccttca ggtccacaat cgtgaccacg
      721 tgggacctgg tatgtaactc ccaggccctg agacccatgg cccagtccat cttcctggct
      781 ggaatcctgg taggagccgc agtgtgtggc catgcctcag ataggtttgg gcgcagaagg
      841 gtgctgacct ggagctatct tctggtgtcc gtgtccggca cagcagctgc cttcatgccc
      901 accttccccc tctactgcct gtttcgtttc ctgctggcct ctgcagtggc aggtgtcatg
      961 atgaacacag ccagtctctt gatggagtgg acatcagccc agggtagccc tttggtgatg
     1021 accttgaacg ccttgggctt cagctttggg caggtcctga caggttctgt ggcctatggt
     1081 gtgcgcagct ggaggatgct acagctggct gtctctgccc ccttcttcct cttctttgtt
     1141 tattcatggt ggctaccaga atcggcacgc tggctcatca cggtaggcaa gctggaccag
     1201 ggcctgcagg aactacagag ggtagctgct gtcaacagga ggaaggcaga gggagacacg
     1261 ttgaccatgg aggtgctgcg gtcagctatg gaggaggaac caagcaggga caaagctggt
     1321 gccagtctgg gcactctact ccacacacct gggctgcgcc accgaaccat catctccatg
     1381 ctgtgctggt ttgcctttgg cttcaccttc tacggcctgg cccttgacct gcaagcccta
     1441 ggaagcaata tcttcctgct ccaggcactc atcgggattg tggacttccc ggtgaagaca
     1501 ggcagcctgc tgctgatcag ccgcttgggc cggcgcctct gccaggtcag cttcctggtg
     1561 ctccccggac tctgcatcct gtccaacata ctggtgcccc atgggatggg ggtccttcgc
     1621 tcggccctgg ctgtgctggg gctgggctgc ctggggggcg ccttcacctg catcaccatc
     1681 ttctccagtg agctcttccc cactgtgatc aggatgactg cagtgggcct ctgccaggtg
     1741 gcagcccgag ggggagccat gctagggcct ttggtacggc tgctgggtgt ctatggctcc
     1801 tggatgcccc tgctggtgta tggagtggtg ccagtgttaa gtggcctagc tgcactgctg
     1861 ctgcctgaga ccaagaactt accactgcct gacaccatcc aagacatcca gaaacagtca
     1921 gtgaagaagg taacacatga cacaccagat ggctccatcc tgatgtctac ccggctgtag
     1981 ttgcctggag aaggaacaca gccacaataa gaggaggagg aagaagagga ggaggaggaa
     2041 gaggagaaga gagagagaga gagaaggagg aggaggagga ggaggaggag gaggaggagt
     2101 aaagggcagg gctggcgacg gcgggtaaag acacctgcct ccgggcctaa atttctgaaa
     2161 ctcatgtgac aacagacttc acaaagttgt cctctgagct ccgcatggac acatacccgc
     2221 ccccggtgat acacacaaat aaataatttt taaaa
//
