LOCUS       NM_009202               1994 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus solute carrier family 22 (organic cation transporter),
            member 1 (Slc22a1), mRNA.
ACCESSION   NM_009202
VERSION     NM_009202.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1994)
  AUTHORS   Hucke,A., Schroter,R., Ceresa,C., Chiorazzi,A., Canta,A.,
            Semperboni,S., Marmiroli,P., Cavaletti,G., Gess,B. and
            Ciarimboli,G.
  TITLE     Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin
  JOURNAL   Int J Mol Sci 24 (14), 11486 (2023)
   PUBMED   37511245
  REMARK    GeneRIF: Role of Mouse Organic Cation Transporter 2 for Nephro- and
            Peripheral Neurotoxicity Induced by Chemotherapeutic Treatment with
            Cisplatin.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1994)
  AUTHORS   Goodyer,W.R., Beyersdorf,B.M., Duan,L., van den Berg,N.S.,
            Mantri,S., Galdos,F.X., Puluca,N., Buikema,J.W., Lee,S., Salmi,D.,
            Robinson,E.R., Rogalla,S., Cogan,D.P., Khosla,C., Rosenthal,E.L.
            and Wu,S.M.
  TITLE     In vivo visualization and molecular targeting of the cardiac
            conduction system
  JOURNAL   J Clin Invest 132 (20), e156955 (2022)
   PUBMED   35951416
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1994)
  AUTHORS   Meyer,M.J., Schreier,P.C.F., Basaran,M., Vlasova,S., Seitz,T.,
            Brockmoller,J., Zdrazil,B. and Tzvetkov,M.V.
  TITLE     Amino acids in transmembrane helix 1 confer major functional
            differences between human and mouse orthologs of the polyspecific
            membrane transporter OCT1
  JOURNAL   J Biol Chem 298 (6), 101974 (2022)
   PUBMED   35469921
  REMARK    GeneRIF: Amino acids in transmembrane helix 1 confer major
            functional differences between human and mouse orthologs of the
            polyspecific membrane transporter OCT1.
REFERENCE   4  (bases 1 to 1994)
  AUTHORS   Jensen,O., Matthaei,J., Klemp,H.G., Meyer,M.J., Brockmoller,J. and
            Tzvetkov,M.V.
  TITLE     Isobutyrylcarnitine as a Biomarker of OCT1 Activity and
            Interspecies Differences in its Membrane Transport
  JOURNAL   Front Pharmacol 12, 674559 (2021)
   PUBMED   34040533
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1994)
  AUTHORS   Morse,B.L., Chen,L.H., Catlow,J.T., Fallon,J.K., Smith,P.C. and
            Hillgren,K.M.
  TITLE     Expansion of Knowledge on OCT1 Variant Activity In Vitro and In
            Vivo Using Oct1/2-/- Mice
  JOURNAL   Front Pharmacol 12, 631793 (2021)
   PUBMED   33658943
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1994)
  AUTHORS   Mooslehner,K.A. and Allen,N.D.
  TITLE     Cloning of the mouse organic cation transporter 2 gene, Slc22a2,
            from an enhancer-trap transgene integration locus
  JOURNAL   Mamm Genome 10 (3), 218-224 (1999)
   PUBMED   10051314
REFERENCE   7  (bases 1 to 1994)
  AUTHORS   Verhaagh,S., Schweifer,N., Barlow,D.P. and Zwart,R.
  TITLE     Cloning of the mouse and human solute carrier 22a3
            (Slc22a3/SLC22A3) identifies a conserved cluster of three organic
            cation transporters on mouse chromosome 17 and human 6q26-q27
  JOURNAL   Genomics 55 (2), 209-218 (1999)
   PUBMED   9933568
REFERENCE   8  (bases 1 to 1994)
  AUTHORS   Schweifer,N., Valk,P.J., Delwel,R., Cox,R., Francis,F.,
            Meier-Ewert,S., Lehrach,H. and Barlow,D.P.
  TITLE     Characterization of the C3 YAC contig from proximal mouse
            chromosome 17 and analysis of allelic expression of genes flanking
            the imprinted Igf2r gene
  JOURNAL   Genomics 43 (3), 285-297 (1997)
   PUBMED   9268631
REFERENCE   9  (bases 1 to 1994)
  AUTHORS   Koehler,M.R., Wissinger,B., Gorboulev,V., Koepsell,H. and Schmid,M.
  TITLE     The two human organic cation transporter genes SLC22A1 and SLC22A2
            are located on chromosome 6q26
  JOURNAL   Cytogenet Cell Genet 79 (3-4), 198-200 (1997)
   PUBMED   9605850
REFERENCE   10 (bases 1 to 1994)
  AUTHORS   Schweifer,N. and Barlow,D.P.
  TITLE     The Lx1 gene maps to mouse chromosome 17 and codes for a protein
            that is homologous to glucose and polyspecific transmembrane
            transporters
  JOURNAL   Mamm Genome 7 (10), 735-740 (1996)
   PUBMED   8854860
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC167817.4.
            
            On Oct 19, 2007 this sequence version replaced NM_009202.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021651.1, AF010259.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849386 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-593               AC167817.4         148548-149140       c
            594-697             AC167817.4         140529-140632       c
            698-852             AC167817.4         139927-140081       c
            853-1021            AC167817.4         137692-137860       c
            1022-1136           AC167817.4         136066-136180       c
            1137-1243           AC167817.4         135839-135945       c
            1244-1458           AC167817.4         132848-133062       c
            1459-1567           AC167817.4         130240-130348       c
            1568-1680           AC167817.4         125674-125786       c
            1681-1783           AC167817.4         124171-124273       c
            1784-1994           AC167817.4         122176-122386       c
FEATURES             Location/Qualifiers
     source          1..1994
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 8.63 cM"
     gene            1..1994
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /note="solute carrier family 22 (organic cation
                     transporter), member 1"
                     /db_xref="GeneID:20517"
                     /db_xref="MGI:MGI:108111"
     exon            1..593
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            594..697
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            698..852
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1021
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1136
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1137..1243
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1244..1458
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1567
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1568..1680
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1681..1783
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1994
                     /gene="Slc22a1"
                     /gene_synonym="Lx1; Oct1; Orct; Orct1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactggtatc gcggggtaaa aggttgtttc tggttggttg ccttccagat gtatcaggct
       61 tgaacagcaa cttgatttca agccaccgca gttccaagaa ctttaaatga gacgctgcac
      121 gaacccccag tggcagtcca gagcaggcct ggctgagttg gtgagggccc tacccagcca
      181 tgcccaccgt ggacgatgtc ctggagcacg ttggagagtt tggctggttc cagaagcaag
      241 ccttcctgtt gctatgcctg atctcagctt ctttagctcc catctacgtg ggcatcgttt
      301 tcctgggctt cacccccgac caccactgcc ggagtcctgg agtggccgag ctgagccagc
      361 ggtgtggctg gagcccggca gaggagctga actacaccgt gccgggcctg gggtctgcgg
      421 gtgaggcctc cttcctcagc caatgcatga agtatgaggt ggactggaac cagagcaccc
      481 ttgactgtgt ggacccactg tccagcctgg ctgccaacag gagccacttg ccactgagcc
      541 cctgcgagca tggctgggtg tacgacactc ccggctcctc catcgtcact gagtttaacc
      601 tggtgtgtgg agacgcctgg aaagtggacc tttttcagtc ctgtgtgaac ttgggcttct
      661 tcctgggctc cctggttgtg ggttacattg cagacaggtt tggccgtaag ctctgcctcc
      721 tggtgaccac tctggtcacc tccctgtctg gcgtgttaac agcggtggcc ccagactata
      781 catccatgtt gctctttcgc cttctgcaag gcatggtcag caaaggcagc tgggtgtctg
      841 gctacacctt gatcacagag tttgtcggct ctggctacag gagaacgaca gccatcttgt
      901 accaggtggc cttcacagtg gggctagtgg ggcttgctgg ggtggcctat gccattccag
      961 actggcgctg gctccagctg gcggtgtccc tgcccacctt cctcttcctg ctgtattact
     1021 ggtttgtccc agaatccccc cggtggctgt tgtctcagaa gagaaccact caagcggtaa
     1081 ggataatgga gcaaattgca cagaagaaca ggaaggtgcc ccctgctgac ctgaagatga
     1141 tgtgccttga ggaagatgcc tcagagaggc ggagtccttc gtttgcagac ctgttccgca
     1201 cccccagcct gaggaagcac accctcatcc tgatgtatct atggttctct tgtgctgtgc
     1261 tgtaccaggg cctcatcatg catgtgggag ccacaggggc caacctctac ctggacttct
     1321 tttattcttc tctagtggaa ttccctgcgg cctttatcat ccttgtcacc attgaccgca
     1381 ttggccgcat ctacccaata gcggcatcaa atctggtggc gggggcagcc tgcctcctca
     1441 tgatctttat cccacatgag ctgcattggt tgaatgtgac cctcgcttgt cttggccgta
     1501 tgggagccac cattgtgttg cagatggtct gcctagtgaa cgctgagctg taccctacat
     1561 tcatcaggaa tctcgggatg atggtgtgct ctgccctgtg tgacctaggt gggatcttca
     1621 cccccttcat ggtgttcagg ctgatggaag tttggcaagc cctgcccctc attttgtttg
     1681 gggttttggg cctgagtgct ggggctgtga cccttctact tccggagacc aagggcgtgg
     1741 ctctgcctga gactattgaa gaagcggaga acctgggaag gaggaaatca aaggccaaag
     1801 aaaacacgat ttaccttcag gtccaaacag gcaaatcccc acatacctga cagggatgcc
     1861 gtgtcaggag ctgagtggag agaggaagga ggactggcca cttggaagat tcctagaagc
     1921 ctttgccttc ccagacactt ctatatattc accaggttcc aaatgaattc ccaaccttaa
     1981 agacttttct gaaa
//
