LOCUS       NM_015747               3316 bp    mRNA    linear   ROD 18-DEC-2022
DEFINITION  Mus musculus solute carrier family 20, member 1 (Slc20a1),
            transcript variant 1, mRNA.
ACCESSION   NM_015747
VERSION     NM_015747.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3316)
  AUTHORS   Du C, Wang X, Wu Y, Liao W, Xiong J, Zhu Y, Liu C, Han W, Wang Y,
            Han S, Chen S, Xu Y, Wang S, Wang F, Yang K, Zhao J and Wang J.
  TITLE     Renal Klotho and inorganic phosphate are extrinsic factors that
            antagonistically regulate hematopoietic stem cell maintenance
  JOURNAL   Cell Rep 38 (7), 110392 (2022)
   PUBMED   35172146
REFERENCE   2  (bases 1 to 3316)
  AUTHORS   Chande S, Caballero D, Ho BB, Fetene J, Serna J, Pesta D, Nasiri A,
            Jurczak M, Chavkin NW, Hernando N, Giachelli CM, Wagner CA, Zeiss
            C, Shulman GI and Bergwitz C.
  TITLE     Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal
            myofiber function and survival
  JOURNAL   Sci Rep 10 (1), 3069 (2020)
   PUBMED   32080237
  REMARK    GeneRIF: Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal
            skeletal myofiber function and survival.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3316)
  AUTHORS   Koumakis E, Millet-Botti J, Benna JE, Leroy C, Boitez V, Codogno P,
            Friedlander G and Forand A.
  TITLE     Novel function of PiT1/SLC20A1 in LPS-related inflammation and
            wound healing
  JOURNAL   Sci Rep 9 (1), 1808 (2019)
   PUBMED   30755642
  REMARK    GeneRIF: Novel function of PiT1/SLC20A1 in LPS-related inflammation
            and wound healing.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3316)
  AUTHORS   Couasnay G, Bon N, Devignes CS, Sourice S, Bianchi A, Veziers J,
            Weiss P, Elefteriou F, Provot S, Guicheux J, Beck-Cormier S and
            Beck L.
  TITLE     PiT1/Slc20a1 Is Required for Endoplasmic Reticulum Homeostasis,
            Chondrocyte Survival, and Skeletal Development
  JOURNAL   J Bone Miner Res 34 (2), 387-398 (2019)
   PUBMED   30347511
  REMARK    GeneRIF: data thus reveal a novel, Pi-transport independent
            function of PiT1, as a critical modulator of ER homeostasis and
            chondrocyte survival during endochondral ossification.
REFERENCE   5  (bases 1 to 3316)
  AUTHORS   Bon N, Frangi G, Sourice S, Guicheux J, Beck-Cormier S and Beck L.
  TITLE     Phosphate-dependent FGF23 secretion is modulated by PiT2/Slc20a2
  JOURNAL   Mol Metab 11, 197-204 (2018)
   PUBMED   29551636
REFERENCE   6  (bases 1 to 3316)
  AUTHORS   Kozak CA, Adamson MC, Buckler CE, Segovia L, Paralkar V and Wistow
            G.
  TITLE     Genomic cloning of mouse MIF (macrophage inhibitory factor) and
            genetic mapping of the human and mouse expressed gene and nine
            mouse pseudogenes
  JOURNAL   Genomics 27 (3), 405-411 (1995)
   PUBMED   7558020
REFERENCE   7  (bases 1 to 3316)
  AUTHORS   Johann SV, Gibbons JJ and O'Hara B.
  TITLE     GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a
            phosphate permease of Neurospora crassa and is expressed at high
            levels in the brain and thymus
  JOURNAL   J Virol 66 (3), 1635-1640 (1992)
   PUBMED   1531369
REFERENCE   8  (bases 1 to 3316)
  AUTHORS   Takeuchi Y, Vile RG, Simpson G, O'Hara B, Collins MK and Weiss RA.
  TITLE     Feline leukemia virus subgroup B uses the same cell surface
            receptor as gibbon ape leukemia virus
  JOURNAL   J Virol 66 (2), 1219-1222 (1992)
   PUBMED   1309898
REFERENCE   9  (bases 1 to 3316)
  AUTHORS   Adamson MC, Silver J and Kozak CA.
  TITLE     The mouse homolog of the Gibbon ape leukemia virus receptor:
            genetic mapping and a possible receptor function in rodents
  JOURNAL   Virology 183 (2), 778-781 (1991)
   PUBMED   1649508
REFERENCE   10 (bases 1 to 3316)
  AUTHORS   Kaelbling M, Eddy R, Shows TB, Copeland NG, Gilbert DJ, Jenkins NA,
            Klinger HP and O'Hara B.
  TITLE     Localization of the human gene allowing infection by gibbon ape
            leukemia virus to human chromosome region 2q11-q14 and to the
            homologous region on mouse chromosome 2
  JOURNAL   J Virol 65 (4), 1743-1747 (1991)
   PUBMED   1672162
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CD545381.1, M73696.1, BQ179432.1 and AI840202.1.
            
            [WARNING] On May 9, 2023 this sequence was replaced by NM_015747.3.
            
            On Apr 23, 2009 this sequence version replaced NM_015747.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC015085.1, AK155506.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               CD545381.1         1-220
            221-2872            M73696.1           140-2791
            2873-3301           BQ179432.1         40-468              c
            3302-3316           AI840202.1         1-15                c
FEATURES             Location/Qualifiers
     source          1..3316
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 62.79 cM"
     gene            1..3316
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /note="solute carrier family 20, member 1"
                     /db_xref="GeneID:20515"
                     /db_xref="MGI:MGI:108392"
     exon            1..220
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            221..836
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     CDS             491..2536
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     sodium-dependent phosphate transporter 1; piT-1; leukemia
                     virus receptor 1 homolog; gibbon ape leukemia virus
                     receptor 1"
                     /codon_start=1
                     /product="sodium-dependent phosphate transporter 1 isoform
                     1"
                     /protein_id="NP_056562.1"
                     /db_xref="CCDS:CCDS16722.1"
                     /db_xref="GeneID:20515"
                     /db_xref="MGI:MGI:108392"
                     /translation="MESTVATITSTLAAVTASAPPKYDNLWMLILGFIIAFVLAFSVG
                     ANDVANSFGTAVGSGVVTLKQACILASIFETVGSALLGAKVSETIRNGLIDVELYNET
                     QDLLMAGSVSAMFGSAVWQLVASFLKLPISGTHCIVGATIGFSLVANGQKGVKWSELI
                     KIVMSWFVSPLLSGIMSGILFFLVRAFILRKADPVPNGLRALPIFYACTIGINLFSIM
                     YTGAPLLGFDKLPLWGTILISVGCAVFCALIVWFFVCPRMKRKIEREVKSSPSESPLM
                     EKKSNLKEDHEETKMAPGDVEHRNPVSEVVCATGPLRAVVEERTVSFKLGDLEEAPER
                     ERLPMDLKEETSIDSTINGAVQLPNGNLVQFSQTVSNQINSSGHYQYHTVHKDSGLYK
                     ELLHKLHLAKVGDCMGDSGDKPLRRNNSYTSYTMAICGMPLDSFRAKEGEQKGDEMET
                     LTWPNADTKKRIRMDSYTSYCNAVSDLHSESEMDMSVKAEMGLGDRKGSSGSLEEWYD
                     QDKPEVSLLFQFLQILTACFGSFAHGGNDVSNAIGPLVALYLVYKQEASTKAATPIWL
                     LLYGGVGICMGLWVWGRRVIQTMGKDLTPITPSSGFSIELASALTVVIASNIGLPIST
                     THCKVGSVVSVGWLRSKKAVDWRLFRNIFMAWFVTVPISGVISAAIMAVFKYIILPV"
     exon            837..977
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1063
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1160
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1161..1280
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1281..1547
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..2106
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2107..2289
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..2374
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
     exon            2375..3306
                     /gene="Slc20a1"
                     /gene_synonym="Glvr-1; Glvr1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ataaatagga gccggcggca tgctctctat atgatggccg ccggcgcgcg ttgcgtgttt
       61 tcacctctcg cctgctgagg cgcccgcggc tgcttcacga gtgggtagag agtccctccg
      121 tgctgtgccc ggtgttgccg tcctgggttg tgcgaccgtg gctcgagcct gcctcagtct
      181 cgttcttctg gtctctctgt tcggccctca gtttcctttg gatgaacttg cgtcctttct
      241 ctaatccgcc atggaattct gctccgtgct tttagccctc cagagccaaa gaaaccccag
      301 acaacagacg cccagacgca gcagcgtata gcagtaactc cccagctcgg tttccgtgcc
      361 gtagtttaca gtatttaatt ttatataata tatactattt attatagcat tttgatacct
      421 cattccgttt acacatctca aaagccgctt agtaattctc ttattattta aagaaccact
      481 acactagaga atggaatcta ctgtggcaac gattactagt accctagctg ctgttactgc
      541 ttccgctcca ccgaagtatg acaatctatg gatgctcatc ctgggcttca tcattgcatt
      601 tgtcttggca ttctccgtgg gagccaatga tgtagcaaat tcgttcggta cagctgtagg
      661 ctcaggtgta gtgaccctga agcaagcctg catcttagct agcatcttcg aaactgtggg
      721 ctccgccttg ctgggggcca aagtgagcga aaccatccgg aacggcttga tagatgtgga
      781 gctgtacaac gaaactcaag atctgctcat ggctggctcc gtcagtgcta tgtttggttc
      841 tgctgtgtgg cagctcgtgg cttcgttttt gaagcttccg atttctggga cccattgtat
      901 tgtcggtgca accattggtt tctcccttgt ggcaaatggg cagaagggtg tcaagtggtc
      961 tgaactgata aaaattgtga tgtcgtggtt cgtctctccg ctgctttctg gtattatgtc
     1021 tggaatttta ttcttccttg ttcgtgcgtt catcctccgt aaggcagatc cggttcctaa
     1081 tggcttacga gctttaccaa ttttttatgc ctgcacaatc ggaatcaacc tcttttccat
     1141 tatgtatact ggagcaccgt tgctgggctt tgacaaactt cctctgtggg gtaccatcct
     1201 catctcggtg ggatgtgcag ttttctgtgc ccttatcgtc tggttctttg tatgtcccag
     1261 gatgaagaga aaaattgaac gagaagtaaa gtctagtccg tctgaaagtc ccttaatgga
     1321 aaagaagagc aacttaaaag aagaccatga agaaacaaag atggctcctg gagacgttga
     1381 gcataggaat cctgtgtctg aggtagtgtg tgccactggg ccactccggg ctgtggtgga
     1441 ggagaggacg gtgtcattca aacttggtga cctggaggag gctccggagc gagagcggct
     1501 tcccatggac ctgaaggagg agaccagcat agacagcacc atcaatggtg cagtgcagtt
     1561 gcctaatggg aaccttgttc agttcagtca aactgtcagc aaccagatca actccagtgg
     1621 ccactatcag tatcacaccg tgcacaagga ttctggcttg tacaaggagc tgctccataa
     1681 gttacatctg gccaaggtgg gagactgcat gggagattct ggggacaagc ccttgagacg
     1741 caacaacagc tacacttcct acactatggc aatatgtggc atgcccctgg attcattccg
     1801 tgccaaagaa ggtgaacaaa agggagatga aatggagacg ctgacatggc ctaatgcaga
     1861 taccaagaag cggattcgaa tggacagtta caccagttac tgcaatgccg tgtctgacct
     1921 tcactccgag tctgagatgg acatgagtgt gaaggctgag atgggcctgg gtgacagaaa
     1981 aggaagcagt ggctctcttg aagaatggta tgaccaggat aagcctgaag tgtcccttct
     2041 cttccagttc ctgcagatcc ttacagcctg ctttgggtca tttgcccatg gtggcaatga
     2101 cgtcagcaat gccatcggcc ctctggttgc tttgtatctt gtttataaac aagaagcctc
     2161 tacaaaagcg gcaacaccca tatggcttct gctttatggt ggtgttggca tttgcatggg
     2221 cctgtgggtt tggggaagaa gagttatcca gaccatgggg aaggacctga ccccaatcac
     2281 accctccagt ggtttcagta ttgaactggc gtctgcctta actgtggtca tcgcatcaaa
     2341 cattggcctt cccatcagca caacacattg caaagtgggc tctgttgtgt ctgttggctg
     2401 gctccgatca aagaaggctg ttgactggcg actgtttcga aacattttta tggcctggtt
     2461 tgtcacggtc cccatctctg gggttatcag tgccgctatc atggcagtat tcaagtacat
     2521 catcctgcca gtgtgacgct ggggttgaaa gctgtgtcag tgtctgggac cattgtacac
     2581 attcctgttc ctaggagaac gctcacagtg ttgctgaaga caggcaaggg tcttaaagga
     2641 gccgtgggaa ggaagtgtaa tttacactat aattgctttt gtgctaaata tgacttatct
     2701 caaaattagc tatgtaaaat agccaggttt ccattgattc attccaaggt cccttttctc
     2761 ctgggctatg aattcctgta catatttctc tacttttgta tcaggcctca attccagtat
     2821 gttttaatgt tgtctgtgag ataacttagg tgggttcttt ttaaacagcc aggcagagcc
     2881 atttgatggc atgtactgct ttgtcggcct caccagcttc ttccccaaca tgcacaggga
     2941 tttaacaaca tgtaactgaa gcttccctcc ctcatagtct ctcatagaaa tagtcacggc
     3001 actctgctcc ctgtcactag tggcaggttc tgttgatgtg tgacaacttc ttagagggcc
     3061 gagaatcttt ggcacagtgg aaatataagt ttgtagtaac ctctttgcaa acagttcacg
     3121 gacatgttgc taagaagcag ggagacaaag ccccctggcg gttgtggtta ttcttctgag
     3181 atttctggca gtgtgggatg ggtgaatgaa gtggaatgtg aactttgggc aaattcaatg
     3241 ggacagcctt ccatgttcat ctgtctacct cttaactgaa taaaaagcct acagttttta
     3301 gaaaaaaaaa aaaaaa
//
