LOCUS       NM_146255               2930 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 1 (glutamate transporter),
            member 7 (Slc1a7), mRNA.
ACCESSION   NM_146255
VERSION     NM_146255.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2930)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2930)
  AUTHORS   Tang,F.S., Yuan,H.L., Liu,J.B., Zhang,G., Chen,S.Y. and Ke,J.B.
  TITLE     Glutamate Transporters EAAT2 and EAAT5 Differentially Shape
            Synaptic Transmission from Rod Bipolar Cell Terminals
  JOURNAL   eNeuro 9 (3) (2022)
   PUBMED   35523583
  REMARK    GeneRIF: Glutamate Transporters EAAT2 and EAAT5 Differentially
            Shape Synaptic Transmission from Rod Bipolar Cell Terminals.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2930)
  AUTHORS   Gehlen,J., Aretzweiler,C., Mataruga,A., Fahlke,C. and Muller,F.
  TITLE     Excitatory Amino Acid Transporter EAAT5 Improves Temporal
            Resolution in the Retina
  JOURNAL   eNeuro 8 (6) (2021)
   PUBMED   34772693
  REMARK    GeneRIF: Excitatory Amino Acid Transporter EAAT5 Improves Temporal
            Resolution in the Retina.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2930)
  AUTHORS   Bligard,G.W., DeBrecht,J., Smith,R.G. and Lukasiewicz,P.D.
  TITLE     Light-evoked glutamate transporter EAAT5 activation coordinates
            with conventional feedback inhibition to control rod bipolar cell
            output
  JOURNAL   J Neurophysiol 123 (5), 1828-1837 (2020)
   PUBMED   32233906
REFERENCE   5  (bases 1 to 2930)
  AUTHORS   Reichhart,N., Schoberl,S., Keckeis,S., Alfaar,A.S., Roubeix,C.,
            Cordes,M., Crespo-Garcia,S., Haeckel,A., Kociok,N., Fockler,R.,
            Fels,G., Mataruga,A., Rauh,R., Milenkovic,V.M., Zuhlke,K.,
            Klussmann,E., Schellenberger,E. and Strauss,O.
  TITLE     Anoctamin-4 is a bona fide Ca2+-dependent non-selective cation
            channel
  JOURNAL   Sci Rep 9 (1), 2257 (2019)
   PUBMED   30783137
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2930)
  AUTHORS   Valerius,M.T. and McMahon,A.P.
  TITLE     Transcriptional profiling of Wnt4 mutant mouse kidneys identifies
            genes expressed during nephron formation
  JOURNAL   Gene Expr Patterns 8 (5), 297-306 (2008)
   PUBMED   18346943
REFERENCE   7  (bases 1 to 2930)
  AUTHORS   Wersinger,E., Schwab,Y., Sahel,J.A., Rendon,A., Pow,D.V., Picaud,S.
            and Roux,M.J.
  TITLE     The glutamate transporter EAAT5 works as a presynaptic receptor in
            mouse rod bipolar cells
  JOURNAL   J Physiol 577 (Pt 1), 221-234 (2006)
   PUBMED   16973698
  REMARK    GeneRIF: These results indicate that EAAT5 acts as a major
            inhibitory presynaptic receptor at mammalian rod bipolar cell axon
            terminals.
REFERENCE   8  (bases 1 to 2930)
  AUTHORS   Hasegawa,J., Obara,T., Tanaka,K. and Tachibana,M.
  TITLE     High-density presynaptic transporters are required for glutamate
            removal from the first visual synapse
  JOURNAL   Neuron 50 (1), 63-74 (2006)
   PUBMED   16600856
REFERENCE   9  (bases 1 to 2930)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   10 (bases 1 to 2930)
  AUTHORS   Cooper,T.G., Wagenfeld,A., Cornwall,G.A., Hsia,N., Chu,S.T.,
            Orgebin-Crist,M.C., Drevet,J., Vernet,P., Avram,C., Nieschlag,E.
            and Yeung,C.H.
  TITLE     Gene and protein expression in the epididymis of infertile c-ros
            receptor tyrosine kinase-deficient mice
  JOURNAL   Biol Reprod 69 (5), 1750-1762 (2003)
   PUBMED   12890734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC030400.1.
            
            On Mar 22, 2019 this sequence version replaced NM_146255.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC030400.1, AK044671.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: lack of evidence for use of
                                                upstream AUG
            RefSeq Select criteria           :: based on conservation,
                                                expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2930              BC030400.1         84-3013
FEATURES             Location/Qualifiers
     source          1..2930
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..2930
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /note="solute carrier family 1 (glutamate transporter),
                     member 7"
                     /db_xref="GeneID:242607"
                     /db_xref="MGI:MGI:2444087"
     exon            1..305
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     CDS             171..1850
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /note="solute carrier family 1 member 7"
                     /codon_start=1
                     /product="excitatory amino acid transporter 5"
                     /protein_id="NP_666367.3"
                     /db_xref="CCDS:CCDS18444.3"
                     /db_xref="GeneID:242607"
                     /db_xref="MGI:MGI:2444087"
                     /translation="MVLDAVLARGRTVCKHNGLLILSVLSVIVGCLLGFFLRTQRLSP
                     QEISYFQFPGELLMRMLKMLILPLVVSSLMSGLASLDAKTSSRLGILTVAYYLWTTFL
                     AVVVGIIMVSIIHPGGAAQKETTEQSGKPVMSSADALLDLVRNMFPANLVEATFKQYR
                     TKTTPVIKSPRGAAEEAPRRIVIYGVQEDNGSRVQNFALDLTPPPEIVYKSEPGTSDG
                     MNVLGIVIFSATMGIMLGRMGDSGTPLVSFCQCLNESVMKIVAVAGWYFPFGIVFLIA
                     GKILEMDDPKAVGKKLGFYAVTVVCGLVVHGLLILPLLYFLITKKNPIVFIRGVLQAL
                     LIALATSSSSATLPITFKCLLENNHIDRRIARFVLPVGATINMDGTALYEAVAAIFIA
                     QVNNYELDFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDINLIIAVD
                     WALDRFRTMINVLGDALAAGIMAHICRKDFAQDMGTEKLLPCETKPVTLQEIVAAQQN
                     GCVKSVAEASELTLGPTCPHHIPVQVEQDEDPAAASLDHCTIEISELETNV"
     exon            306..385
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            386..601
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            602..644
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            645..864
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            865..964
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            965..1198
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1199..1393
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1394..1528
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1529..1631
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..2930
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2901..2906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="Slc1a7"
                     /gene_synonym="A930031E15Rik; Eaat5"
                     /note="major polyA site"
ORIGIN      
        1 ggtaatagga ttgtggcttc cctctggacg gctgcacaga ccatggctgc aaggctgctg
       61 ataggtgcct aggactctgt tcacctgtaa gcagagaggc ttgtgcctcc agcccagccc
      121 tgggcctcat ctgacagtgc atggaatggt gccaacaggc tgggctcagc atggtgctcg
      181 acgctgtcct ggctcgaggg cgcacagtgt gtaagcacaa cgggctgctc atcctgtctg
      241 tgctctctgt catcgtgggc tgcctccttg gcttcttcct caggacccag cgcctctcac
      301 cacaggagat tagttacttc cagttccctg gagaactctt gatgcggatg ctgaagatgc
      361 tgatcctacc actggtggtc tccagcttga tgtccggcct tgcctccctg gatgccaaga
      421 cctccagccg cttggggatc ctcaccgtgg catactacct gtggactacc tttctggctg
      481 ttgttgtggg catcatcatg gtctccatca tccaccctgg tggtgcagca cagaaggaga
      541 caactgaaca gagtggaaag ccggtcatga gctcagctga tgccctcctg gatcttgtcc
      601 ggaacatgtt cccagccaac ctggtagaag ccacgttcaa acagtaccgc accaagacca
      661 ccccagttat caagtctccc aggggagcag cggaggaggc tccccggcgg atcgtcatct
      721 atggggtcca ggaagacaat ggctcacgtg tgcagaactt tgccctggat ctgacgcccc
      781 cacctgagat tgtctacaag tcagagcctg gtaccagtga tggcatgaac gtgctaggca
      841 ttgtcatctt ctcagccacg atgggtatca tgctgggccg catgggtgac agcgggacgc
      901 ccctggtcag cttctgtcag tgccttaatg agtctgtcat gaagatcgtg gcagtggcag
      961 ggtggtactt tccctttggc attgtcttcc tgatcgctgg caagatcttg gagatggatg
     1021 accccaaggc agtggggaaa aagctgggct tctacgccgt gactgtggtt tgtgggctgg
     1081 tggtccacgg tctcctcatc ctgcccctac tgtacttcct catcaccaag aagaacccca
     1141 tcgtcttcat ccgaggcgtc ctccaggctc tgctcattgc gttggccacc tcctccagct
     1201 cagccacact gcccatcacc ttcaagtgcc tgctggagaa caaccatatc gaccgccgca
     1261 tcgctcgctt cgtgctgcct gtgggcgcca ccatcaacat ggatggcacc gcgctctacg
     1321 aggccgtggc tgccatcttt atcgcccagg tcaacaacta tgagctagac tttggacaga
     1381 tcatcactat cagcatcacg gccacggcag ccagcattgg ggcggctggc atcccccagg
     1441 cggggctcgt caccatggtc atcgtgctca cctctgtggg actgccgacc gatgacatca
     1501 acctcatcat agctgtagac tgggcactgg atcgcttccg aaccatgatt aatgtgctgg
     1561 gtgatgcact ggcggcaggg atcatggccc acatctgccg gaaggatttt gctcaggaca
     1621 tgggcactga gaaattgcta ccctgtgaga ccaagccagt gacactgcag gagatcgtgg
     1681 ctgcccagca gaatggctgt gtgaagagtg tggctgaggc ctcagagcta accctgggcc
     1741 ccacgtgccc ccaccacatc ccagtccagg tagagcagga tgaggatcca gccgctgcca
     1801 gcctagacca ctgtactatt gagatcagtg agctagagac caacgtgtga acctgcaggg
     1861 ccgcagcaga gccaagccag accctggggt ttgggctaag gggtaggagc taaactcaaa
     1921 acacacctgg cgcaggctgg cacattccac cctgacaggc tagtcagtca ctgatgagaa
     1981 agagtgtcaa aaaagagaca actatgtgca gagacccatc agcaactatg gctcttgtgg
     2041 cccagaacct agctgtgaca gtttctacta catgagcaca caaaggtacc tggtaggggt
     2101 ctttgtctat actttgtgga aaaatagttt gggagcccga gagctaaaac cactccctga
     2161 aagaacagtc atagccagga tgctaattca agtctttgga gtctccgcca ctctgttcta
     2221 ataaacaagg cagcctgcag ggaacagtga aagaggctct gccttctcca ggtccccacg
     2281 gccacaacag cttccaactc atgaagatag aacaacagtg tccctgttgc tgccccagct
     2341 gtgtccaggc caggtcaacc ctgccccacc ccacagcatg tgtgttggtt tttttaaaga
     2401 tttatttatt tattttatgt atgtgagtac actgtagcta tcttcagaca caccagaaga
     2461 ggggggtcag attccattac agatggtttg tgagtcacca tgtggttgct gggatttgaa
     2521 cacaggacct ctggaagagc agtcagtgct cttaaccact gagccatctc tccagcccac
     2581 agcatgtggt tttaactcag taaagtctgg tccatcccag gtctgagacc ttctgccttc
     2641 acacgttaca agcctgtccg tttctgtcca ccagacctct catctaatat ggagactgat
     2701 gtccactagg gctgggaagc cgagcaggta cagcccagtc agccttccat gagatgggtg
     2761 ggcaaggtcg gccataaaga gaaagaccca gcttgggatg ctccggccaa gggactagca
     2821 gtaccttggg gtcagaactc tttgtgtggc aaaatggaac aagagtccct agtcccttcc
     2881 atgtttgcga taatgtgata aataaaagtc tgtttttttt tcaagactta
//
