LOCUS       NM_009201               2758 bp    mRNA    linear   ROD 16-OCT-2024
DEFINITION  Mus musculus solute carrier family 1 (neutral amino acid
            transporter), member 5 (Slc1a5), mRNA.
ACCESSION   NM_009201
VERSION     NM_009201.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2758)
  AUTHORS   Li,W., Zeng,Q., Wang,B., Lv,C., He,H., Yang,X., Cheng,B. and Tao,X.
  TITLE     Oxidative stress promotes oral carcinogenesis via Thbs1-mediated
            M1-like tumor-associated macrophages polarization
  JOURNAL   Redox Biol 76, 103335 (2024)
   PUBMED   39255693
REFERENCE   2  (bases 1 to 2758)
  AUTHORS   Liu,X.W., Xu,H.W., Yi,Y.Y., Zhang,S.B., Chang,S.J., Pan,W. and
            Wang,S.J.
  TITLE     Inhibition of Mettl3 ameliorates osteoblastic senescence by
            mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent
            mechanisms
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (7), 167273 (2024)
   PUBMED   38844111
  REMARK    GeneRIF: Inhibition of Mettl3 ameliorates osteoblastic senescence
            by mitigating m6A modifications on Slc1a5 via Igf2bp2-dependent
            mechanisms.
REFERENCE   3  (bases 1 to 2758)
  AUTHORS   Huang,S., Reed,C., Ilsley,M., Magor,G., Tallack,M., Landsberg,M.,
            Mitchell,H., Gillinder,K. and Perkins,A.
  TITLE     Mutations in linker-2 of KLF1 impair expression of membrane
            transporters and cytoskeletal proteins causing hemolysis
  JOURNAL   Nat Commun 15 (1), 7019 (2024)
   PUBMED   39147774
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2758)
  AUTHORS   Awad,S., Skipper,W., Vostrejs,W., Ozorowski,K., Min,K., Pfuhler,L.,
            Mehta,D. and Cooke,A.
  TITLE     The YBX3 RNA-binding protein posttranscriptionally controls SLC1A5
            mRNA in proliferating and differentiating skeletal muscle cells
  JOURNAL   J Biol Chem 300 (2), 105602 (2024)
   PUBMED   38159852
  REMARK    GeneRIF: The YBX3 RNA-binding protein posttranscriptionally
            controls SLC1A5 mRNA in proliferating and differentiating skeletal
            muscle cells.
REFERENCE   5  (bases 1 to 2758)
  AUTHORS   Jiang,J., Dong,W., Zhang,W., Wang,Q., Wang,R., Wang,J., Wu,H.,
            Dong,H., Zhao,R.C., Wang,J. and Li,Z.
  TITLE     LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant
            Progression of Hepatocellular Carcinoma
  JOURNAL   Discov Med 35 (179), 995-1014 (2023)
   PUBMED   38058065
  REMARK    GeneRIF: LncRNA SLC1A5-AS/MZF1/ASCT2 Axis Contributes to Malignant
            Progression of Hepatocellular Carcinoma.
REFERENCE   6  (bases 1 to 2758)
  AUTHORS   Komatsu,Y., Yukutake,Y. and Yoshida,M.
  TITLE     Four different clones of mouse anti-acetyllysine monoclonal
            antibodies having different recognition properties share a common
            immunoglobulin framework structure
  JOURNAL   J Immunol Methods 272 (1-2), 161-175 (2003)
   PUBMED   12505721
REFERENCE   7  (bases 1 to 2758)
  AUTHORS   Lavillette,D., Marin,M., Ruggieri,A., Mallet,F., Cosset,F.L. and
            Kabat,D.
  TITLE     The envelope glycoprotein of human endogenous retrovirus type W
            uses a divergent family of amino acid transporters/cell surface
            receptors
  JOURNAL   J Virol 76 (13), 6442-6452 (2002)
   PUBMED   12050356
  REMARK    GeneRIF: used as receptor by HERV-W Env glycoproteins when their
            sites for N-linked glycosylation are eliminated by mutagenesis
REFERENCE   8  (bases 1 to 2758)
  AUTHORS   Marin,M., Tailor,C.S., Nouri,A. and Kabat,D.
  TITLE     Sodium-dependent neutral amino acid transporter type 1 is an
            auxiliary receptor for baboon endogenous retrovirus
  JOURNAL   J Virol 74 (17), 8085-8093 (2000)
   PUBMED   10933718
REFERENCE   9  (bases 1 to 2758)
  AUTHORS   Utsunomiya-Tate,N., Endou,H. and Kanai,Y.
  TITLE     Cloning and functional characterization of a system ASC-like
            Na+-dependent neutral amino acid transporter
  JOURNAL   J Biol Chem 271 (25), 14883-14890 (1996)
   PUBMED   8662767
REFERENCE   10 (bases 1 to 2758)
  AUTHORS   Liao,K. and Lane,M.D.
  TITLE     Expression of a novel insulin-activated amino acid transporter gene
            during differentiation of 3T3-L1 preadipocytes into adipocytes
  JOURNAL   Biochem Biophys Res Commun 208 (3), 1008-1015 (1995)
   PUBMED   7702599
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK148346.1 and AK157838.1.
            
            On Sep 14, 2006 this sequence version replaced NM_009201.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148346.1, L42115.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1759              AK148346.1         1-1759
            1760-1850           AK157838.1         1739-1829
            1851-2595           AK148346.1         1851-2595
            2596-2758           AK157838.1         2646-2808
FEATURES             Location/Qualifiers
     source          1..2758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.15 cM"
     gene            1..2758
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /note="solute carrier family 1 (neutral amino acid
                     transporter), member 5"
                     /db_xref="GeneID:20514"
                     /db_xref="MGI:MGI:105305"
     exon            1..1130
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     CDS             556..2223
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /note="solute carrier family 1, member 7; ATB(0); solute
                     carrier family 1 member 5; insulin-activated amino acid
                     transporter; sodium-dependent neutral amino acid
                     transporter type 2; ASC-like Na(+)-dependent neutral amino
                     acid transporter ASCT2"
                     /codon_start=1
                     /product="neutral amino acid transporter B(0)"
                     /protein_id="NP_033227.2"
                     /db_xref="CCDS:CCDS39785.1"
                     /db_xref="GeneID:20514"
                     /db_xref="MGI:MGI:105305"
                     /translation="MAVDPPKADPKGVVAVDSTANGGPALGSREDQSAKAGGCCGSRD
                     RVRRCIRANLLVLLTVAAVVAGVGLGLGVSAAGGADALGPARLTAFAFPGELLLRLLK
                     MIILPLVVCSLIGGAASLDPSALGRVGAWALLFFLVTTLLASALGVGLALALKPGAAV
                     TAITSINDSVVDPCARSAPTKEVLDSFLDLVRNIFPSNLVSAAFRSFATSYEPKDNSC
                     KIPQSCIQREINSTMVQLLCEVEGMNILGLVVFAIVFGVALRKLGPEGELLIRFFNSF
                     NDATMVLVSWIMWYAPVGILFLVASKIVEMKDVRQLFISLGKYILCCLLGHAIHGLLV
                     LPLIYFLFTRKNPYRFLWGIMTPLATAFGTSSSSATLPLMMKCVEEKNGVAKHISRFI
                     LPIGATVNMDGAALFQCVAAVFIAQLNGVSLDFVKIITILVTATASSVGAAGIPAGGV
                     LTLAIILEAVSLPVKDISLILAVDWLVDRSCTVLNVEGDAFGAGLLQSYVDRTKMPSS
                     EPELIQVKNEVSLNPLPLATEEGNPLLKQYQGPTGDSSATFEKESVM"
     exon            1131..1173
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1218
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1260
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1261..1421
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1422..1655
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1656..1850
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1851..1985
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     exon            1986..2758
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2707..2712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /note="hexamer: AATAAA"
     polyA_site      2727
                     /gene="Slc1a5"
                     /gene_synonym="AAAT; ASCT2; ATBO; M7V1; M7VS1; R16; RDRC;
                     Slc1a7"
                     /note="major polyA site"
ORIGIN      
        1 ggtcgcttcc gtctagcagc ctcagagaca cgcggcgcgg cctgggaggt ttctccttgg
       61 cgccactttc catatccccc gggctgcttc ctatttgcat ctggaaattt gatttttctc
      121 tccagagccc gaaacgctcg gtccactcct tctagggctc cagtacccaa gagtccgaga
      181 gccaggcgtc ctaatcctgg gatctcggtc tcccggagca aggcatcccg gatctatgcc
      241 acttgggttg agcttcctga agacctcagc tacctgagtt tccttactcc ttcagggagt
      301 caaagaaccc tctgaagagc tgttccctac tccaacaagg cgctctcaac tcccagtttt
      361 cggggattcg acatcaccag gaaaaataaa gggatctccg catacagctc agggagccta
      421 ggaccctcca gtttccgaga tccggtggac gcataacttc aaggaccgct gcaaagtttc
      481 agcctccatt ctcggtccta aggacgtcac acctagtctc caggctcaca aggaacctcc
      541 ctgttacggc tcagcatggc agtggatccc cctaaggctg accccaaagg ggtagtagcg
      601 gtggattcca ccgcgaacgg tggccccgcg ctgggatcca gagaggacca gagtgcgaaa
      661 gcaggtggtt gctgcggttc ccgtgaccgg gtgcgccgct gcattcgcgc caacctgctg
      721 gtgctgctca cggtggctgc ggtggtggct ggcgtggggc tggggctggg ggtctcggcg
      781 gcgggcggtg ctgacgcgct gggtcccgcg cgcttgaccg ctttcgcctt cccgggagag
      841 ctgctgctgc gtctgctgaa gatgatcatc ctgccgctcg tggtgtgcag cctgatcgga
      901 ggtgcagcca gcttggaccc tagcgcgctc ggtcgtgtgg gcgcctgggc gctgctcttt
      961 ttcctggtca ccacactgct cgcgtcggcg ctcggcgtgg gtttggccct ggcgctgaag
     1021 ccgggcgccg ccgttaccgc catcacctcc atcaacgact ctgttgtaga cccctgtgcc
     1081 cgcagtgcac caaccaaaga ggtgctggat tcctttctag atctcgtgag gaatattttc
     1141 ccctccaatc tggtgtctgc tgccttccgc tcttttgcta cctcatatga acccaaagac
     1201 aactcatgta aaataccgca atcctgtatc cagcgggaga tcaattcaac catggtccag
     1261 cttctctgtg aggtggaggg aatgaacatc ctgggcctgg tggtcttcgc tatcgtcttt
     1321 ggtgtggctc tgcggaagct ggggcccgag ggtgagctgc tcattcgttt cttcaactcc
     1381 ttcaatgatg ccaccatggt cctggtctcc tggattatgt ggtacgcacc cgttggaatc
     1441 ctgttcctgg tggccagcaa gattgtggag atgaaagacg tccgccagct cttcatcagc
     1501 ctcggcaaat acattctgtg ctgcctgctg ggccacgcca tccacgggct cctggttctg
     1561 cctctcatct acttcctctt cacccgcaaa aatccctatc gattcctgtg gggcatcatg
     1621 acacccctgg ccactgcttt cgggacctct tctagctctg ccaccttgcc tctgatgatg
     1681 aagtgtgtag aggagaagaa tggtgtggcc aaacacatca gccggttcat cctacccatc
     1741 ggcgccacgg tcaacatgga cggggcggcg ctgttccagt gtgtggcggc agtgttcatc
     1801 gcacaactaa acggggtgtc cctggacttc gtgaagatca tcaccatcct ggtcacagcc
     1861 acagcatcca gtgtcggtgc ggcagggatc cctgcagggg gcgtcctcac cctcgccatc
     1921 atcctggaag cagtcagcct gcctgtgaag gacatctcct tgatcttggc cgtggactgg
     1981 ctagtggaca ggtcctgtac tgtcctcaac gtggaaggtg atgcttttgg ggctggactg
     2041 cttcagagtt acgtggatcg aaccaagatg ccgagctcag agcccgaatt gatccaggtg
     2101 aagaacgagg tgtctctgaa tccactgccc ctcgccacag aggaggggaa tcccctcctg
     2161 aaacagtacc agggacccac cggggactcc agtgccacgt tcgaaaagga atctgtcatg
     2221 tgaatatcag gagggacttt ctacgccctg gtgacttcac gttggaagcc gggtcttgcg
     2281 agctggagaa atggactgga tgagggctct aggggtgggc tgtttacaca ctccaggaat
     2341 ctaggggtcg gtgtctcctt cctggagagg ctattaggag ccttgttgct ggggtgcata
     2401 tgcttatatg tgaatgtgtc cacaaatccc accccctctc cgttctgtcc cccattcaag
     2461 gaatgacatt ctcagtcacc cagagccatc tggcctaccc tctcaggaaa tgggttgtcc
     2521 tgtagagttc tctacccttt taaaggcaaa agtattggga tgcaatacta tcttaatgtc
     2581 cctatctgtg gtgtgtgtgc acttgctgtg accttcccag tagtccctcc atgacagaaa
     2641 acactcccat gagtctcgag ggaaagccaa gaataaatgt cactccagaa cacatttttt
     2701 tttagcaata aaatggtgtc aaatgtattg accatggccc tagagtctga gtaatacc
//
