LOCUS       NM_018861               3926 bp    mRNA    linear   ROD 23-JAN-2024
DEFINITION  Mus musculus solute carrier family 1 (glutamate/neutral amino acid
            transporter), member 4 (Slc1a4), mRNA.
ACCESSION   NM_018861
VERSION     NM_018861.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3926)
  AUTHORS   Ratz-Mitchem,M.L., Leary,G., Grindeland,A., Silvius,D., Guter,J.,
            Kavanaugh,M.P. and Gunn,T.M.
  TITLE     Generation and characterization of a knock-in mouse model for
            spastic tetraplegia, thin corpus callosum, and progressive
            microcephaly (SPATCCM)
  JOURNAL   Mamm Genome 34 (4), 572-585 (2023)
   PUBMED   37642681
REFERENCE   2  (bases 1 to 3926)
  AUTHORS   Puris,E., Saveleva,L., de Sousa Maciel,I., Kanninen,K.M.,
            Auriola,S. and Fricker,G.
  TITLE     Protein Expression of Amino Acid Transporters Is Altered in
            Isolated Cerebral Microvessels of 5xFAD Mouse Model of Alzheimer's
            Disease
  JOURNAL   Mol Neurobiol 60 (2), 732-748 (2023)
   PUBMED   36367657
  REMARK    GeneRIF: Protein Expression of Amino Acid Transporters Is Altered
            in Isolated Cerebral Microvessels of 5xFAD Mouse Model of
            Alzheimer's Disease.
REFERENCE   3  (bases 1 to 3926)
  AUTHORS   Puris,E., Saveleva,L., Gorova,V., Vartiainen,P., Kortelainen,M.,
            Lamberg,H., Sippula,O., Malm,T., Jalava,P.I., Auriola,S.,
            Fricker,G. and Kanninen,K.M.
  TITLE     Air pollution exposure increases ABCB1 and ASCT1 transporter levels
            in mouse cortex
  JOURNAL   Environ Toxicol Pharmacol 96, 104003 (2022)
   PUBMED   36283621
  REMARK    GeneRIF: Air pollution exposure increases ABCB1 and ASCT1
            transporter levels in mouse cortex.
REFERENCE   4  (bases 1 to 3926)
  AUTHORS   Tapanes,S.A., Arizanovska,D., Diaz,M.M., Folorunso,O.O., Harvey,T.,
            Brown,S.E., Radzishevsky,I., Close,L.N., Jagid,J.R., Graciolli
            Cordeiro,J., Wolosker,H., Balu,D.T. and Liebl,D.J.
  TITLE     Inhibition of glial D-serine release rescues synaptic damage after
            brain injury
  JOURNAL   Glia 70 (6), 1133-1152 (2022)
   PUBMED   35195906
REFERENCE   5  (bases 1 to 3926)
  AUTHORS   Pereira,M., Ko,J.H., Logan,J., Protheroe,H., Kim,K.B., Tan,A.L.M.,
            Croucher,P.I., Park,K.S., Rotival,M., Petretto,E., Bassett,J.D.,
            Williams,G.R. and Behmoaras,J.
  TITLE     A trans-eQTL network regulates osteoclast multinucleation and bone
            mass
  JOURNAL   Elife 9, e55549 (2020)
   PUBMED   32553114
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3926)
  AUTHORS   Fuchs,S., Resch,K., Thiel,C., Ulbrich,M., Platzer,M., Jockusch,H.
            and Schmitt-John,T.
  TITLE     Comparative transcription map of the wobbler critical region on
            mouse chromosome 11 and the homologous region on human chromosome
            2p13-14
  JOURNAL   BMC Genet 3, 14 (2002)
   PUBMED   12174196
REFERENCE   7  (bases 1 to 3926)
  AUTHORS   Lavillette,D., Marin,M., Ruggieri,A., Mallet,F., Cosset,F.L. and
            Kabat,D.
  TITLE     The envelope glycoprotein of human endogenous retrovirus type W
            uses a divergent family of amino acid transporters/cell surface
            receptors
  JOURNAL   J Virol 76 (13), 6442-6452 (2002)
   PUBMED   12050356
  REMARK    GeneRIF: used as receptor by HERV-W Env glycoprotein when their
            sites for N-glycosylation are eliminated by mutagenesis
REFERENCE   8  (bases 1 to 3926)
  AUTHORS   Marin,M., Tailor,C.S., Nouri,A. and Kabat,D.
  TITLE     Sodium-dependent neutral amino acid transporter type 1 is an
            auxiliary receptor for baboon endogenous retrovirus
  JOURNAL   J Virol 74 (17), 8085-8093 (2000)
   PUBMED   10933718
REFERENCE   9  (bases 1 to 3926)
  AUTHORS   Li,J., Fei,J., Huang,F., Guo,L.H. and Schwarz,W.
  TITLE     Functional significance of N- and C-terminus of the amino acid
            transporters EAAC1 and ASCT1: characterization of chimeric
            transporters
  JOURNAL   Biochim Biophys Acta 1467 (2), 338-346 (2000)
   PUBMED   11030592
REFERENCE   10 (bases 1 to 3926)
  AUTHORS   Vannucci,S.J., Rutherford,T., Wilkie,M.B., Simpson,I.A. and
            Lauder,J.M.
  TITLE     Prenatal expression of the GLUT4 glucose transporter in the mouse
  JOURNAL   Dev Neurosci 22 (4), 274-282 (2000)
   PUBMED   10965149
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK140866.1 and BC052733.1.
            
            [WARNING] On Mar 27, 2024 this sequence was replaced by
            NM_018861.4.
            
            On Jul 18, 2009 this sequence version replaced NM_018861.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK140866.1, AK139248.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-878               AK140866.1         2-879
            879-3535            BC052733.1         753-3409
            3536-3926           AK140866.1         3537-3927
FEATURES             Location/Qualifiers
     source          1..3926
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 12.97 cM"
     gene            1..3926
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /note="solute carrier family 1 (glutamate/neutral amino
                     acid transporter), member 4"
                     /db_xref="GeneID:55963"
                     /db_xref="MGI:MGI:2135601"
     exon            1..768
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     CDS             242..1840
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /note="solute carrier family 1 member 4;
                     alanine/serine/cysteine/threonine transporter 1"
                     /codon_start=1
                     /product="neutral amino acid transporter A"
                     /protein_id="NP_061349.3"
                     /db_xref="CCDS:CCDS24457.1"
                     /db_xref="GeneID:55963"
                     /db_xref="MGI:MGI:2135601"
                     /translation="MEKSGETNGYLDGTQAEPAAGPRTPETAMGKSQRCASFFRRHAL
                     VLLTVSGVLVGAGMGAALRGLQLTRTQITYLAFPGEMLLRMLRMIILPLVVCSLVSGA
                     ASLDASSLGRLGGIAVAYFGLTTLSASALAVALAFIIKPGAGAQTLQSSSLGLENSGP
                     PPVSKETVDSFLDLLRNLFPSNLVVAAFTTSATDYTVVTHNTSSGNVTKEKIPVVTDV
                     EGMNILGLVLFALVLGVALKKLGPEGEDLIRFFNSFNEATMVLVSWIMWYVPIGIMFL
                     IGSKIVEMKDIVMLVTSLGKYIFASMLGHVIHGGIVLPLVYFAFTRKNPFTFLLGLLT
                     PFATAFATCSSSATLPSMMKCIEENNGVDKRISRFILPIGATVNMDGAAIFQCVAAVF
                     IAQLNNVDLNAGQIFTILVTATASSVGAAGVPAGGVLTIAIILEAIGLPTHDLSLILA
                     VDWIVDRTTTVVNVEGDALGAGILNHLNQKVVKKGEQELQEVKVEAIPNSKSEEETSP
                     LVTHQNPAGPVAIAPELESKESVL"
     exon            769..811
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     exon            812..874
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1041
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1275
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1470
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     exon            1471..1605
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
     exon            1606..3926
                     /gene="Slc1a4"
                     /gene_synonym="ASCT-1; ASCT1; SATT"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atcatctcca gcctgcagcg gctctgaaag aaggctgggc gcggcgcggt ctgctctgcc
       61 tgggctccaa cccacaaccc acgtctctct tttatctttc tgaaaagtgt tcctgtaggg
      121 actcacagag ctcggaagcc gcagctggca caggccactg tctccgcctg atccattcat
      181 tcgaaaccgg tcttttctcc aagttccttg agtgttaccg cttagagcgg tgggcaacga
      241 catggagaag agcggcgaga ccaacggcta cctcgacggc acccaggcag agcctgcggc
      301 cgggccccga acgcccgaga cggcgatggg caaatcgcag cgctgtgcta gcttttttcg
      361 gcgccacgcg ctggtgctgc tcaccgtgtc gggagtgttg gtgggtgccg gcatgggcgc
      421 ggcgctgagg gggctgcagc tcacccgcac ccagatcact tacctggcct tcccgggcga
      481 gatgctgctc cgcatgctgc gcatgatcat cctgccgctg gtggtttgca gcctggtgtc
      541 gggagccgcc tccctggatg ccagctccct cgggcgtctg ggtggcatcg ctgttgctta
      601 cttcggcctc accacgctga gcgcctcggc tctcgccgtt gctctggcgt tcatcatcaa
      661 gccaggggcg ggcgcgcaga ccctccagtc cagcagcctg gggctggaga actcagggcc
      721 tcctccggtc tccaaagaga cagtggactc tttcctcgat ttactcagaa acctgttccc
      781 ttccaatctt gtggttgccg cattcactac gtctgcaacc gattacacag tggtgaccca
      841 taacaccagc tcggggaacg tgaccaaaga gaagatcccc gttgtaacag atgtggaagg
      901 gatgaacatt ttaggtctcg tcctttttgc cctggtgtta ggagtggctc taaagaagct
      961 aggccccgag ggagaagacc tcatccgatt cttcaattcc ttcaatgagg ccacaatggt
     1021 gctggtgtca tggatcatgt ggtatgttcc tataggcatc atgttcctga tcggaagcaa
     1081 gattgtagaa atgaaggaca tcgtcatgct ggtgaccagt ctcgggaaat acatcttcgc
     1141 atctatgctg ggccatgtca tccacggagg aattgtcctg cctcttgtgt attttgcttt
     1201 cacaaggaaa aacccgttca cgttcctcct gggcctcctc accccatttg cgacagcttt
     1261 tgcgacctgt tccagctcag caacccttcc gtctatgatg aagtgcattg aggagaacaa
     1321 tggtgtagac aagaggatca gcaggttcat cctccccatt ggggccacgg tcaacatgga
     1381 cggagcagcc atcttccagt gtgtggccgc agtgttcatt gcccagctca acaacgtaga
     1441 cctgaacgca ggacagattt tcaccattct agtgactgcc acggcatcca gtgttggagc
     1501 agcaggtgtg ccggctgggg gtgtcctcac aattgccatc atcttggagg ccattggatt
     1561 gcccacacat gacctctctc tgatcctggc tgtggactgg attgtggacc ggaccaccac
     1621 tgtggtgaat gtggaagggg atgccctggg agcggggatc ctcaaccacc tgaatcagaa
     1681 ggtagtgaag aaaggtgagc aggagctaca agaagtgaag gtggaagcca ttcccaattc
     1741 caagtctgag gaggagacgt cgcctctggt gacacaccag aacccagcag gccctgtggc
     1801 cattgctcct gaacttgaat ccaaggagtc agtgctgtga ttgggctggg tctgggccag
     1861 cctgccagta ccagcaaccc accctggtag cctgccccat tgatgtgggc atggccctca
     1921 tacacttttc atctcccaag gaatgctttg cccaatcacc agtttgagag tggcctctca
     1981 gcactggcat gaatgcctcc tgagctagaa cactctgccg tttgtcttga tccatgtctc
     2041 catggagctc tggatacacc ttgagtctat accccttgag ctgccaggcc tgagggattc
     2101 caagttcatg gaggcctggg gaccaaggtt ggggggcgat gcagatggat tcttcacttt
     2161 cccctgggag cgttgcatct ggtgctttct gggccaacca gaagggttga tagttgtctg
     2221 tcacgttgtc tctgcagcag cagacactga agagcttccc agagtcttag actgagctgg
     2281 aatctgctgg gctgccgctg ggttaaagga ttatgctcca cttgtgtggg aggcttctaa
     2341 ggggccagag gtaaaacagg tttagagaga ccccctgtga cggttagcac agctaggggc
     2401 tcagtttgag taaaccataa actctgaggt caggaacaga ctggggagca ccctaaagaa
     2461 gatgagacag aattgttccc actctagact gaggctcctg ccaacttccc ctccatttcc
     2521 atttggactt agccgcagac cataggacct cctcctctgg gaagggtgat gtggtcactg
     2581 cactgtggac ttgtattggt tggtcagtct attactacag tttgactagg tccttcctaa
     2641 aatgctgctg agctacaaag tcatatactc ccccaataaa ctcacgcgct ggcgcagctc
     2701 tgccccaggc ccctgtctgg tttccacagt atactactcg cttgtgtgag acctatggtt
     2761 agtcctgggt ctgatgtaac ttgcctcttg cctacttcac tggaatctga taaggccaag
     2821 gatacgtctg tggaaattat cgttttgctc cttggaagtc aagttctaac acccgtaagt
     2881 gcccagctta tctgagagac agcttttttc gtgaagggtg cctactggcg tgagcaactc
     2941 tcctgaactg ttaccctcac acttccgaag ctaagctctg aagagttgtg aagacattca
     3001 acgcagcctt ttcttaatga gctacccaac ttctaccaca ttcctgggta cccaactgtg
     3061 ttgttactct gaacccacag tttctgccaa taccacccta acaggagatt aagtccctaa
     3121 gtcattggct tcatgctttc gaaaccttgc tttctctgct gtgttgtcac cagacccaca
     3181 catacttggg acagagtccg ttttaaaatg gggcctgtgc ctgagtgaag gggtgggcaa
     3241 ggagcagagc ccacagccag ggtaaaggac agctctctga accagctgtg ccactgcact
     3301 ctcctgtggg gccaggaact aagcggagag cggtaaacct tattcccagc actgtttttt
     3361 aaaggggaat caatcacatt gtttgattat gagtgagcat ttggtatttt ttcagtttca
     3421 gtgtatcttt tcctctgtat ttacatatac tttatgtatc aagtgtgtgt gtgtatgtgt
     3481 gtgcttttag ctccaagcaa acctgagttt ggataaaggg gaactaaact acaaattatg
     3541 tctatggtat cctgatattc ccatttctac agaatcttat tatgtaggaa ctggagctgg
     3601 acagtgaaac cccctggctg gcactcaggt ctcagcctgg acccacagta acaaatgctg
     3661 ctgtggacag agggagatgt ttctgtgtga catgcgtggg atctccctct tggaggccaa
     3721 aagagaaggt ggccccgcac ttccctgagt tctggctctc agagaagttg atggagtttc
     3781 ggaacaggga agacaccacc acaactgact gaaatatctc ctggctattt ttctaacatg
     3841 ttcatgtatt gatgttttgt gtatgtgtga catttgcctt aaaacgtagc acagccatca
     3901 agcctgagta acgtgttttt cctggc
//
