LOCUS       NM_148938               4214 bp    mRNA    linear   ROD 01-AUG-2024
DEFINITION  Mus musculus solute carrier family 1 (glial high affinity glutamate
            transporter), member 3 (Slc1a3), mRNA.
ACCESSION   NM_148938
VERSION     NM_148938.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4214)
  AUTHORS   Muhamad,N.A., Masutani,K., Furukawa,S., Yuri,S., Toriyama,M.,
            Matsumoto,C., Itoh,S., Shinagawa,Y., Isotani,A., Toriyama,M. and
            Itoh,H.
  TITLE     Astrocyte-Specific Inhibition of the Primary Cilium Suppresses C3
            Expression in Reactive Astrocyte
  JOURNAL   Cell Mol Neurobiol 44 (1), 48 (2024)
   PUBMED   38822888
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4214)
  AUTHORS   Hu,L., Liu,X.Y., Zhao,L., Hu,Z.B., Li,Z.X., Liu,W.T., Song,N.N.,
            Hu,Y.Q., Jiang,L.P., Zhang,L., Tao,Y.C., Zhang,Q., Chen,J.Y.,
            Lang,B., Wang,Y.B., Yue,L. and Ding,Y.Q.
  TITLE     Ventricular Netrin-1 deficiency leads to defective pyramidal
            decussation and mirror movement in mice
  JOURNAL   Cell Death Dis 15 (5), 343 (2024)
   PUBMED   38760361
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4214)
  AUTHORS   Xing,L., Gkini,V., Nieminen,A.I., Zhou,H.C., Aquilino,M.,
            Naumann,R., Reppe,K., Tanaka,K., Carmeliet,P., Heikinheimo,O.,
            Paabo,S., Huttner,W.B. and Namba,T.
  TITLE     Functional synergy of a human-specific and an ape-specific
            metabolic regulator in human neocortex development
  JOURNAL   Nat Commun 15 (1), 3468 (2024)
   PUBMED   38658571
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4214)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 4214)
  AUTHORS   Wang,Y., Wang,W., Su,L., Ji,F., Zhang,M., Xie,Y., Zhang,T. and
            Jiao,J.
  TITLE     BACH1 changes microglial metabolism and affects astrogenesis during
            mouse brain development
  JOURNAL   Dev Cell 59 (1), 108-124 (2024)
   PUBMED   38101413
REFERENCE   6  (bases 1 to 4214)
  AUTHORS   Sutherland,M.L., Delaney,T.A. and Noebels,J.L.
  TITLE     Glutamate transporter mRNA expression in proliferative zones of the
            developing and adult murine CNS
  JOURNAL   J Neurosci 16 (7), 2191-2207 (1996)
   PUBMED   8601800
REFERENCE   7  (bases 1 to 4214)
  AUTHORS   Inoue,K., Sakaitani,M., Shimada,S. and Tohyama,M.
  TITLE     Cloning and expression of a bovine glutamate transporter
  JOURNAL   Brain Res Mol Brain Res 28 (2), 343-348 (1995)
   PUBMED   7723632
REFERENCE   8  (bases 1 to 4214)
  AUTHORS   Kirschner,M.A., Arriza,J.L., Copeland,N.G., Gilbert,D.J.,
            Jenkins,N.A., Magenis,E. and Amara,S.G.
  TITLE     The mouse and human excitatory amino acid transporter gene (EAAT1)
            maps to mouse chromosome 15 and a region of syntenic homology on
            human chromosome 5
  JOURNAL   Genomics 22 (3), 631-633 (1994)
   PUBMED   8001975
REFERENCE   9  (bases 1 to 4214)
  AUTHORS   Ramachandran,B., Houben,K., Rozenberg,Y.Y., Haigh,J.R.,
            Varpetian,A. and Howard,B.D.
  TITLE     Differential expression of transporters for norepinephrine and
            glutamate in wild type, variant, and WNT1-expressing PC12 cells
  JOURNAL   J Biol Chem 268 (32), 23891-23897 (1993)
   PUBMED   8226929
REFERENCE   10 (bases 1 to 4214)
  AUTHORS   Tanaka,K.
  TITLE     Cloning and expression of a glutamate transporter from mouse brain
  JOURNAL   Neurosci Lett 159 (1-2), 183-186 (1993)
   PUBMED   7903437
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY281420.1, AK040798.1, AK031831.1 and BC058711.1.
            
            On Oct 23, 2009 this sequence version replaced NM_148938.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058711.1, AK080879.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-341               BY281420.1         2-342
            342-3418            AK040798.1         2-3078
            3419-4159           AK031831.1         3082-3822
            4160-4214           BC058711.1         4085-4139
FEATURES             Location/Qualifiers
     source          1..4214
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 3.82 cM"
     gene            1..4214
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /note="solute carrier family 1 (glial high affinity
                     glutamate transporter), member 3"
                     /db_xref="GeneID:20512"
                     /db_xref="MGI:MGI:99917"
     exon            1..469
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            470..747
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             567..2198
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /note="solute carrier family 1, member 3;
                     glutamate/aspartate transporter; high-affinity neuronal
                     glutamate transporter; sodium-dependent
                     glutamate/aspartate transporter 1; glial high affinity
                     glutamate transporter"
                     /codon_start=1
                     /product="excitatory amino acid transporter 1"
                     /protein_id="NP_683740.1"
                     /db_xref="CCDS:CCDS27373.1"
                     /db_xref="GeneID:20512"
                     /db_xref="MGI:MGI:99917"
                     /translation="MTKSNGEEPRMGGRMERLQQGVRKRTLLAKKKVQSLTKEDVKSY
                     LFRNAFVLLTVTAVIVGTILGFALRPYKMSYREVKYFSFPGELLMRMLQMLVLPLIIS
                     SLVTGMAALDSKASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGTKENMYREGK
                     IVQVTAADAFLDLIRNMFPPNLVEACFKQFKTSYEKRSFKVPIQSNETLLGAVINNVS
                     EAMETLTRIREEMVPVPGSVNGVNALGLVVFSMCFGFVIGNMKEQGQALREFFDSLNE
                     AIMRLVAVIMWYAPLGILFLIAGKIVEMEDMGVIGGQLAMYTVTVIVGLLIHAVIVLP
                     LLYFLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRITRFVLP
                     VGATINMDGTALYEALAAIFIAQVNNFDLNFGQIITISITATAASIGAAGIPQAGLVT
                     MVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHLSRHELKNRDVE
                     MGNSVIEENEMKKPYQLIAQDNEPEKPVADSETKM"
     exon            748..885
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1090
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1133
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1426
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1660
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1661..1855
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1856..1990
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     exon            1991..4206
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4184..4189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /note="hexamer: AAGAAA"
     polyA_site      4206
                     /gene="Slc1a3"
                     /gene_synonym="B430115D02Rik; Eaat1; GLAST; GLAST-1;
                     GLU-T; GluT-1; Gmt1; MGluT1"
                     /note="major polyA site"
ORIGIN      
        1 aggggaggca acctgaaatg aggtaattaa acgtggcctt ggagaagtct cccagacgtt
       61 ctaatccgga cttccagcgt ccatgtgtgt gagcgcttta gttttcgatt ctctcaggtc
      121 ctgattttgc gtttctaata taagtgaact aacaaggcgt gaacgtggtc tacggagcaa
      181 aacaaagcca taaagcgtgc ttctgtggtg ccaagattaa tcaatattcc ggggagctcg
      241 ggctcccccc tcctcctgct gttttcattt tcccactccc cctttcccca gtacaggctc
      301 ctcctctttt cttaagttgc ctgatagtaa gtggcggttt cagagcacat gcatgttgtc
      361 agggccagcc tgctccgccg ctcgctaagc tgttactccg agctacctgc tggggaattc
      421 acctccacgt agcccggggt gtcttcctcc catcccagag tcagaaaagt tgtcctctct
      481 aacaccaaag aggagaattc actttctggg aacaagtgca agacactgac acgcaaggac
      541 gtgataaatt cctagaaaga taaaatatga ccaaaagcaa cggagaagag cctaggatgg
      601 ggggcaggat ggagagattg cagcaagggg tccgcaagcg gacacttctg gccaagaaga
      661 aagttcagag cctcaccaag gaagatgtta agagttacct gtttcggaat gccttcgttc
      721 tgctcacggt cactgctgtc attgtgggta caatccttgg atttgccctc cgaccgtata
      781 aaatgagcta ccgggaggtg aagtactttt cgttccctgg ggagcttctc atgaggatgc
      841 tgcagatgct ggtcttgccc ctgatcatct ccagtctcgt cacaggaatg gcggccctag
      901 atagtaaggc atccgggaag atggggatgc gcgctgtagt ctattacatg actactacca
      961 tcattgctgt ggtgattggc ataatcattg tcatcatcat ccaccccgga aagggcacaa
     1021 aggaaaacat gtacagagaa ggtaaaatcg tgcaggtcac tgcagcagat gccttcctgg
     1081 atttgatcag gaacatgttc cctcccaatc tggtagaagc ctgctttaaa cagtttaaaa
     1141 ccagctacga gaaaagaagc tttaaagtgc ctatccagtc caacgaaaca cttctgggcg
     1201 ccgtgatcaa caacgtgtca gaggccatgg agactctgac ccggatccgg gaggagatgg
     1261 tgcccgtgcc tggatctgtg aatggggtca atgccctggg cctagttgtc ttctccatgt
     1321 gcttcggttt cgtgatcgga aacatgaagg agcaggggca agcgctgaga gagttctttg
     1381 attctcttaa cgaagccatc atgcgattgg tcgcggtgat aatgtggtat gcgcctctgg
     1441 gcatcctctt cttgatcgca gggaagattg ttgagatgga agacatgggt gtgattgggg
     1501 gacagcttgc catgtacacc gtgacagtca ttgtcggcct cctcattcac gccgtcatcg
     1561 tcctgcctct cctctacttc ctggtaaccc ggaagaaccc ctgggttttc attggagggt
     1621 tgctgcaagc gctcatcaca gcccttggga cctcctcaag ttctgccacc ctacccatca
     1681 ctttcaagtg cctggaagag aacaatggtg tggacaaacg catcaccaga tttgtgctcc
     1741 ccgtgggggc caccattaac atggatggga ccgccctcta cgaggctttg gctgccattt
     1801 tcatcgctca agtgaacaac tttgacctga actttggaca gattataaca ataagcatca
     1861 cagccacggc cgcaagcatc ggggcagccg ggattcctca ggccggtctg gtcaccatgg
     1921 tcatcgtgct gacatctgtg ggcctgccca cagatgacat cacactcatc attgcagtgg
     1981 actggtttct ggaccgcctc cgaaccacca ccaacgtact gggtgactcc ctcggagcag
     2041 ggattgtcga gcacttgtcc cgacatgaac tgaagaaccg agatgttgaa atggggaact
     2101 cggtgattga ggagaacgaa atgaagaagc cgtatcagct gattgcccag gacaatgaac
     2161 cggagaaacc cgtggcagac agcgaaacca agatgtagac ggacagagaa gtgctttctt
     2221 aagcaccaag tgttggaaac tgttctacaa tgtatccatc tccctgggct cactttccca
     2281 gtgagctcct ctttcctccc tactctgata ggattggaaa acggccaaac acaaaggagg
     2341 gctctgcagc agcccaaacc tatcggtttt agcctacatt tgaaaatttt aagtcatttc
     2401 atattattct taccaagtaa gctactacaa tcaaacacag tttcgatatt accaatttag
     2461 gtggcaaacg atcctgtgcc attgctctgt aagtaaaaga attaagcaaa tgataggcta
     2521 ccgaaaaaaa aagttttaaa atcaactttc aagatgtaaa aatccttcag aatgcaactg
     2581 agttttaatc ttaaaacatt acaacttgat gagcaattat cagttaccca ttgagtagct
     2641 gagaggttcc catttcttct gactcctgcc ctgactttgt cagcatcagg gcaatcccca
     2701 catgcacaca gcacagctgt gaggaggagc ggagagtgag gctcccaaat ggtctagagt
     2761 gagccttgtc tcatccattg gcctcagtgt tctcatccgg aaaatgagtg actcctagac
     2821 aggcctctct agcccaaact tctggaacat caggaaggac cctgcccctg tacaccatga
     2881 ggatctcaga caggacactt attgggaatg gacatttctc tctaggggca ggctgtgtgt
     2941 ggctcactag atcctgggtt caaaatgttc gttctatcag tagacaggtg gaaggccatc
     3001 ctagaaggcc tattgtcctg ttttgttttc caatactaga ggccctccct tctggggtac
     3061 acttcccaaa tccaagggaa gacagtctct tcaattagat gtctaggaaa taaagagaag
     3121 actagcaagt gtgctcaagt cttagtgtgg aacactaaag agtggagaaa gaatagagta
     3181 tggccaacat tacaaaaggg aggattcttt gaaagatcag gaaaagttgg ttttctttaa
     3241 agactaaaat ggagagctat atctcaaccc tttttctgtt agcctaaaca cttcctcttc
     3301 agtccctaat cagcccccaa agaaacgacg tcataacacc acttcctcct catctcccag
     3361 tccaaccaac cacatctctg ggacagatcc atacgctggg tggatggtct catttctgaa
     3421 aaagattttt tttttttggt ttttttattt gttttgtttt tactatttta accaggcgtt
     3481 cttaggatga caaaaacaac atactctttt ttgtatagag atgtctcttg acaaatcatt
     3541 caaaagtctc atctagagtg gagtgtgctt gtttatgtcc ctaccaaaaa aaaaaaaaaa
     3601 aaaagacaga tgaatcagca tgaggataac atcactgagg atggaagaaa acacagcagg
     3661 agaattcttt tcaggcgagg cagctcccag gtttaaaaga gattatattc actcccttag
     3721 gaatatccaa tcaaagatac tcagtgagag ccatctgaca gtaccagctg cttcagactt
     3781 tctgagcgaa aatgatgaat ggacataatt atgctaacag actgagcatc tagaatggca
     3841 tctcccagtc tacagttaga gataatttct agagatcctg agcatcccat gtatagaaag
     3901 gttaacacta ggctgcgggg gagtaatcat ttaatggcaa gctctatttg ggaaatacac
     3961 tacagaggtt aatctatgtg gcagtcattt ttcgacacta gttgaacaga ccttaatcgc
     4021 atcaaattaa tgctgtttac ccggtgtgat attttttata ctaaccattt cttacagaaa
     4081 cagattcaca agggtgatcc ttttgctggt ccatcccggg ctctgcctat gtgtgtaccc
     4141 actgtggact gggaaacttc actttgtaga tgtattttca ataaagaaaa aatagtttta
     4201 cattaaaaaa aaaa
//
