LOCUS       NM_009199               3739 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus solute carrier family 1 (neuronal/epithelial high
            affinity glutamate transporter, system Xag), member 1 (Slc1a1),
            mRNA.
ACCESSION   NM_009199 XM_001002136 XM_001002144 XM_001002151 XM_001002163
            XM_001002173 XM_001002184 XM_001002198 XM_001002207
VERSION     NM_009199.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3739)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3739)
  AUTHORS   Zhang,Y., Ya,D., Yang,J., Jiang,Y., Li,X., Wang,J., Tian,N.,
            Deng,J., Yang,B., Li,Q. and Liao,R.
  TITLE     EAAT3 impedes oligodendrocyte remyelination in chronic cerebral
            hypoperfusion-induced white matter injury
  JOURNAL   CNS Neurosci Ther 30 (1), e14487 (2024)
   PUBMED   37803915
  REMARK    GeneRIF: EAAT3 impedes oligodendrocyte remyelination in chronic
            cerebral hypoperfusion-induced white matter injury.
REFERENCE   3  (bases 1 to 3739)
  AUTHORS   Yang,Z., Su,W., Wei,X., Qu,S., Zhao,D., Zhou,J., Wang,Y., Guan,Q.,
            Qin,C., Xiang,J., Zen,K. and Yao,B.
  TITLE     HIF-1alpha drives resistance to ferroptosis in solid tumors by
            promoting lactate production and activating SLC1A1
  JOURNAL   Cell Rep 42 (8), 112945 (2023)
   PUBMED   37542723
  REMARK    GeneRIF: HIF-1alpha drives resistance to ferroptosis in solid
            tumors by promoting lactate production and activating SLC1A1.
REFERENCE   4  (bases 1 to 3739)
  AUTHORS   Petroccione,M.A., D'Brant,L.Y., Affinnih,N., Wehrle,P.H.,
            Todd,G.C., Zahid,S., Chesbro,H.E., Tschang,I.L. and Scimemi,A.
  TITLE     Neuronal glutamate transporters control reciprocal inhibition and
            gain modulation in D1 medium spiny neurons
  JOURNAL   Elife 12, e81830 (2023)
   PUBMED   37435808
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3739)
  AUTHORS   Wang,X., Chen,Z., Xu,J., Tang,S., An,N., Jiang,L., Zhang,Y.,
            Zhang,S., Zhang,Q., Shen,Y., Chen,S., Lan,X., Wang,T., Zhai,L.,
            Cao,S., Guo,S., Liu,Y., Bi,A., Chen,Y., Gai,X., Duan,Y., Zheng,Y.,
            Fu,Y., Li,Y., Yuan,L., Tong,L., Mo,K., Wang,M., Lin,S.H., Tan,M.,
            Luo,C., Chen,Y., Liu,J., Zhang,Q., Li,L. and Huang,M.
  TITLE     SLC1A1-mediated cellular and mitochondrial influx of
            R-2-hydroxyglutarate in vascular endothelial cells promotes tumor
            angiogenesis in IDH1-mutant solid tumors
  JOURNAL   Cell Res 32 (7), 638-658 (2022)
   PUBMED   35459936
  REMARK    GeneRIF: SLC1A1-mediated cellular and mitochondrial influx of
            R-2-hydroxyglutarate in vascular endothelial cells promotes tumor
            angiogenesis in IDH1-mutant solid tumors.
REFERENCE   6  (bases 1 to 3739)
  AUTHORS   Shibata,T., Watanabe,M., Tanaka,K., Wada,K. and Inoue,Y.
  TITLE     Dynamic changes in expression of glutamate transporter mRNAs in
            developing brain
  JOURNAL   Neuroreport 7 (3), 705-709 (1996)
   PUBMED   8733726
REFERENCE   7  (bases 1 to 3739)
  AUTHORS   Mukainaka,Y., Tanaka,K., Hagiwara,T. and Wada,K.
  TITLE     Molecular cloning of two glutamate transporter subtypes from mouse
            brain
  JOURNAL   Biochim Biophys Acta 1244 (1), 233-237 (1995)
   PUBMED   7766664
REFERENCE   8  (bases 1 to 3739)
  AUTHORS   Tanaka,K.
  TITLE     Cloning and expression of a glutamate transporter from mouse brain
  JOURNAL   Neurosci Lett 159 (1-2), 183-186 (1993)
   PUBMED   7903437
REFERENCE   9  (bases 1 to 3739)
  AUTHORS   Rothstein,J.D., Martin,L.J. and Kuncl,R.W.
  TITLE     Decreased glutamate transport by the brain and spinal cord in
            amyotrophic lateral sclerosis
  JOURNAL   N Engl J Med 326 (22), 1464-1468 (1992)
   PUBMED   1349424
REFERENCE   10 (bases 1 to 3739)
  AUTHORS   Swarna,M., Rao,D.N. and Reddy,P.P.
  TITLE     Dicarboxylic aminoaciduria associated with mental retardation
  JOURNAL   Hum Genet 82 (3), 299-300 (1989)
   PUBMED   2567279
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163993.3 and AC113961.14.
            
            On Jul 24, 2018 this sequence version replaced NM_009199.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC065099.1, AK018188.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-198               AC163993.3         109598-109795
            199-339             AC163993.3         153476-153616
            340-432             AC163993.3         167298-167390
            433-547             AC163993.3         168917-169031
            548-590             AC163993.3         170547-170589
            591-686             AC163993.3         171970-172065
            687-871             AC163993.3         175905-176089
            872-979             AC163993.3         177149-177256
            980-1102            AC113961.14        169725-169847       c
            1103-1297           AC113961.14        168932-169126       c
            1298-1432           AC113961.14        164894-165028       c
            1433-3739           AC113961.14        160499-162805       c
FEATURES             Location/Qualifiers
     source          1..3739
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 23.5 cM"
     gene            1..3739
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /note="solute carrier family 1 (neuronal/epithelial high
                     affinity glutamate transporter, system Xag), member 1"
                     /db_xref="GeneID:20510"
                     /db_xref="MGI:MGI:105083"
     exon            1..198
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..339
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            340..432
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            433..547
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            548..590
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            591..686
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            687..871
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            872..979
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            980..1102
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1297
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1298..1432
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..3739
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2398..2403
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /note="hexamer: AATGAA"
     polyA_site      2417
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /note="major polyA site"
     regulatory      3708..3713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /note="hexamer: AATAAA"
     polyA_site      3739
                     /gene="Slc1a1"
                     /gene_synonym="D130048G10Rik; EAAC1; EAAC2; EAAT3; MEAAC1"
                     /note="major polyA site"
ORIGIN      
        1 agtggcagcg ctgacagcgg ccggtgcgcg ttgtctccac tgtgccctgc atcccgcatc
       61 tcgcatcggc caggctaccc gactcatcgc aaacgtcagt gctcaccatg gggaagccca
      121 cgagctcggg atgtgactgg cgccgcttcc tacggaatca ctggctgctg ctctccaccg
      181 tggccgccgt ggtactagga attgtcttag gagtcgtggt tcgaggacac agtgagctct
      241 caaatctgga taaattctac tttgcttttc ctggggaaat tctgatgagg atgctgaagc
      301 tggtcatttt gccgctgatc gtatccagca tgatcacagg tgtcgctgca ctggattcca
      361 atgtgtctgg gaagattggt ctgcgcgctg tagtatatta tttctccacc accgtcattg
      421 ctgtaatcct aggtattgtg ttagttgtga gtatcaagcc tggtgtcact cagaaagtga
      481 atgacatcaa caggacgggt aaaacccctg aagtcagcac catggatgcc atgttggacc
      541 tgatcaggaa catgttccct gagaatctgg tccaagcctg ttttcagcag tacaaaacca
      601 agcgggaaga ggtgaagcct gtgggcgatc ctggggggaa cgcaacggag gtgtctgtca
      661 ccacagccat gacaacaatg tctgagaaca agacaaagga atacaagatc gtgggcctgt
      721 actcagacgg catcaatgtc ctgggcttga ttatcttctg cctcgtcttt ggccttgtca
      781 ttgggaaaat gggagaaaag gggcagattc tggtggactt cttcaatgcc ttgagtgacg
      841 ccaccatgaa aatcgtccag atcatcatgt gctacatgcc gattggcatt ttgttcctaa
      901 ttgctgggaa gatcatagaa gttgaagact gggaaatatt ccgcaagctg ggcctttaca
      961 tggccactgt cctgagcggg cttgcaatcc actccctcat agttctgccc ctgctctatt
     1021 tcatagttgt gcggaagaac cctttccgct ttgccttggg tatggcgcag gctctcctga
     1081 cagctctcat gatctcgtcc agttcggcaa ccctgccagt tacattccgc tgtgcggaag
     1141 aaaagaacca ggtagacaag aggatcacga gatttgtgct gcctgttggt gccaccatca
     1201 acatggacgg cactgcgctc tacgaagctg tggcagccgt gtttattgcg caactgaatg
     1261 gcttggacct aagcattggg cagatcgtca ccatcagcat tacagccacc gctgccagca
     1321 ttggagctgc tggggtgccc caggctggcc tggtgaccat ggtgatcgtg ctgagtgctg
     1381 tggggctgcc tgccgaggac gtcaccctga tcattgctgt tgactggctc ctggaccggt
     1441 tcaggaccat ggtgaacgtc ctgggtgatg cgtttgggac gggcatcgta gagaagctct
     1501 cgaagaagga gctggagcag atggatgttt cgtctgaagt caacatcgtg aacccctttg
     1561 ccttggaacc cacaaccctc gataacgaag actcagatac caagaagtct tatgtcaatg
     1621 ggggcttcgc ggtagacaaa tctgacacca tctcgttcac tcagacctca cagttctaga
     1681 tgcctgacct cagattgagg cctgggattg tgaagggcgt ctccacagga gccatctcct
     1741 agcaaactcc gacattaagg aacgagaagg acactaagag tcaactgtac atttagtttg
     1801 ataaacagac ctccagatta ttttctatat ttgactttat agccttggtt ctctgggttt
     1861 agggatttgg ggtgagatga actgaaagga aattaagaaa gttgtgttat ctggattttc
     1921 taattctata caacagagtt tggaagtata tgaagtagta actgttagga ttaggtcata
     1981 gatatggaag agaaattggt ttctcatgca tagaccagtg tttggggttt ttaaacaata
     2041 ttattggcta caaattttta ctcaggcttt ctattggcag gacttccttt gcctttttac
     2101 ttttatagat tataatgcat ctcaaaagcc ctacccagtt aatgtgccaa attttccatt
     2161 ttgacctcat ctccagccac tctcaaacta ccctggggcg gggggagcaa aaaagatcag
     2221 catagttctg caataacagt ttaaagatag ttgtggggtt taggggaagg gaaagggttt
     2281 tttattcaat gtactgtatt gagacactgg tagctgacag ccagtgttcg gtatagaact
     2341 atatgtatat gtgtgtatat ttattatttt catgtaattt gcaagacaga gatcagtaat
     2401 gaactatcaa tgtgaaatac gcagcttccc ttgtacttga atcaaaacga tagctccagc
     2461 ctaggtgtga gctcaccaga acactgtcag gcactctggg atgagaaatc aagttgctgg
     2521 cttactgtga ttcaagccct aaagcagaaa catattatgg tgaaactcta agatgacaca
     2581 gccattcacg tacaacatct agggtcaggc tcccgggagg gggaggctcc ctgcgagcat
     2641 ggaataagta catttacaaa ggcactgtag aggcaggaag tgctcccata gcaacaaaag
     2701 gcttcgatct tcaagtagac ttcaagaccc acttcacaag gctgtcactt ttctgttctt
     2761 ggttttctct gcctgcgccc cccaccccca gggccaaacc agcagtgaca agccactgct
     2821 gtttcaaaac ggggtggcct aaattgaata agcctcattg caaggtgacc aagctatcct
     2881 tatactgtcg tctttttatt ttatcttctg gtttttttat tttttagttt ttgagacagc
     2941 gcctctctac atagccctgg atatcctgga actcactatg tagactagac tggcctcaaa
     3001 ctcacagaga tcctcctgcc tctgcctctt tagtgctggc ctgaaaggta ggtaccacca
     3061 tgcccagctc tacactgtat ttttacagaa gaaaagccag gccataagcg actggtacca
     3121 gcggttcagg gacaatactt cagtccttcc ctggagagga ttgttctggg aatctcagcc
     3181 ttgtggctta gaatcctctg cctgtctttc tcctgctaat tcccgaagat ggcttataaa
     3241 agtctacact tctgtcctca tcctgtaaat aaaactcaac aaaaacttgt tcttaacttg
     3301 gagacaggtt cataacagcc gtgtttctgt agtgccctta agtcatctta aacccgtgct
     3361 tttatattta agaagccaga aatcgtgcca aagatagcag gaaggtaacc gaatgctcag
     3421 agttggccac gcccacctga aagctaccga ctgaccgtca cggtgaccct tgactccgaa
     3481 ctttgaagta caaatatctg tattctttat aggaagtaaa tctaaatcta aatgaggttg
     3541 aatggatatt ttatttagga gtggatggtt ctgtcccctt atcaggtggt tctccttagt
     3601 ggcagtgaat tggcagagcc gttcacaaga tcattggggt catcttgtaa ccagccactt
     3661 cacacactgt gctgttaact caagatgata tgttccactt ccttctcaat aaacatctcc
     3721 cccactcttt ctcccctta
//
