LOCUS       NM_054087               3571 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus solute carrier family 19 (thiamine transporter),
            member 2 (Slc19a2), transcript variant 1, mRNA.
ACCESSION   NM_054087 XM_917473 XM_924965 XM_924966
VERSION     NM_054087.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3571)
  AUTHORS   Miyake,K., Yasujima,T., Takahashi,S., Yamashiro,T. and Yuasa,H.
  TITLE     Identification of the amino acid residues involved in the
            species-dependent differences in the pyridoxine transport function
            of SLC19A3
  JOURNAL   J Biol Chem 298 (8), 102161 (2022)
   PUBMED   35724964
REFERENCE   2  (bases 1 to 3571)
  AUTHORS   Yamashiro,T., Yasujima,T. and Yuasa,H.
  TITLE     Animal species differences in the pyridoxine transport function of
            SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat
            small intestine
  JOURNAL   Drug Metab Pharmacokinet 44, 100456 (2022)
   PUBMED   35512554
REFERENCE   3  (bases 1 to 3571)
  AUTHORS   Chen,L., Shu,Y., Liang,X., Chen,E.C., Yee,S.W., Zur,A.A., Li,S.,
            Xu,L., Keshari,K.R., Lin,M.J., Chien,H.C., Zhang,Y.,
            Morrissey,K.M., Liu,J., Ostrem,J., Younger,N.S., Kurhanewicz,J.,
            Shokat,K.M., Ashrafi,K. and Giacomini,K.M.
  TITLE     OCT1 is a high-capacity thiamine transporter that regulates hepatic
            steatosis and is a target of metformin
  JOURNAL   Proc Natl Acad Sci U S A 111 (27), 9983-9988 (2014)
   PUBMED   24961373
REFERENCE   4  (bases 1 to 3571)
  AUTHORS   Subramanian,V.S., Subramanya,S.B. and Said,H.M.
  TITLE     Relative contribution of THTR-1 and THTR-2 in thiamin uptake by
            pancreatic acinar cells: studies utilizing Slc19a2 and Slc19a3
            knockout mouse models
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 302 (5), G572-G578 (2012)
   PUBMED   22194418
  REMARK    GeneRIF: both mTHTR-1 and mTHTR-2 are involved in carrier-mediated
            thiamin uptake by pancreatic acinar cells.
REFERENCE   5  (bases 1 to 3571)
  AUTHORS   Zilberstein,Y., Liberman,M.C. and Corfas,G.
  TITLE     Inner hair cells are not required for survival of spiral ganglion
            neurons in the adult cochlea
  JOURNAL   J Neurosci 32 (2), 405-410 (2012)
   PUBMED   22238076
  REMARK    Erratum:[J Neurosci. 2012 Apr 4;32(14):5016]
REFERENCE   6  (bases 1 to 3571)
  AUTHORS   Lo,P.K. and Wang,F.F.
  TITLE     Identification of transcriptional start sites and splicing of mouse
            thiamine transporter gene THTR-1 (Slc19a2)
  JOURNAL   Biochim Biophys Acta 1576 (1-2), 209-213 (2002)
   PUBMED   12031504
REFERENCE   7  (bases 1 to 3571)
  AUTHORS   Lo,P.K., Chen,J.Y., Tang,P.P., Lin,J., Lin,C.H., Su,L.T., Wu,C.H.,
            Chen,T.L., Yang,Y. and Wang,F.F.
  TITLE     Identification of a mouse thiamine transporter gene as a direct
            transcriptional target for p53
  JOURNAL   J Biol Chem 276 (40), 37186-37193 (2001)
   PUBMED   11481326
REFERENCE   8  (bases 1 to 3571)
  AUTHORS   Fleming,J.C., Steinkamp,M.P., Kawatsuji,R., Tartaglini,E.,
            Pinkus,J.L., Pinkus,G.S., Fleming,M.D. and Neufeld,E.J.
  TITLE     Characterization of a murine high-affinity thiamine transporter,
            Slc19a2
  JOURNAL   Mol Genet Metab 74 (1-2), 273-280 (2001)
   PUBMED   11592824
REFERENCE   9  (bases 1 to 3571)
  AUTHORS   Oishi,K., Hirai,T., Gelb,B.D. and Diaz,G.A.
  TITLE     Slc19a2: cloning and characterization of the murine thiamin
            transporter cDNA and genomic sequence, the orthologue of the human
            TRMA gene
  JOURNAL   Mol Genet Metab 73 (2), 149-159 (2001)
   PUBMED   11386850
REFERENCE   10 (bases 1 to 3571)
  AUTHORS   Bettendorff,L.
  TITLE     The compartmentation of phosphorylated thiamine derivatives in
            cultured neuroblastoma cells
  JOURNAL   Biochim Biophys Acta 1222 (1), 7-14 (1994)
   PUBMED   8186267
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK044825.1 and BC034659.1.
            
            On Feb 14, 2013 this sequence version replaced NM_054087.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK044825.1, SRR1660815.270789.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1387              AK044825.1         2-1388
            1388-3555           BC034659.1         1369-3536
            3556-3571           AK044825.1         3557-3572
FEATURES             Location/Qualifiers
     source          1..3571
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.56 cM"
     gene            1..3571
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /note="solute carrier family 19 (thiamine transporter),
                     member 2"
                     /db_xref="GeneID:116914"
                     /db_xref="MGI:MGI:1928761"
     exon            1..411
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /inference="alignment:Splign:2.1.0"
     CDS             208..1704
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /note="isoform a is encoded by transcript variant 1;
                     solute carrier family 19 member 2; thiamine transporter 1"
                     /codon_start=1
                     /product="thiamine transporter 1 isoform a"
                     /protein_id="NP_473428.1"
                     /db_xref="CCDS:CCDS15433.1"
                     /db_xref="GeneID:116914"
                     /db_xref="MGI:MGI:1928761"
                     /translation="MDVPARVSRRAAAAAARMLLRTARVPRECWFLPTALLCAYGFFA
                     NLRPSEPFLTPYLLGPDKNLTERQVYNEIYPVWTYSYLLLLFPVFLATDYLRYKPVIL
                     LQGLSLIVTWFMLLYAQGLLAIQFLEFFYGIATATEIAYYSYIYTVVDLGMYQKVTSY
                     CRSATLVGFTVGSVLGQILVSVVGWSLFSLNVISLTCVSVAFAVAWFLPMPQKSLFFH
                     HIPSSCHGVNGLKVQNGGIVTDTPAANHLPGWEDIESKIPLNLDEPPVEEPEEPKPDR
                     LRVFRVLWNDFLMCYSSRPLLCWSVWWALSTCGYFQVVNYAQGLWEKVMPSQNADIYN
                     GGVEAVSTLLGASAVFAVGYIKLSWSTWGEMTLFLCSLLIAAAVYVMDTVQSIWVCYA
                     SYVVFRIIYMVLITIATFQIAANLSMERYALVFGVNTFIALALQTLLTLIVVDARGLG
                     LCITTQFLIYASYFAAISVVFLANGIVSIIKKCRKQEDPSSSPQASTS"
     exon            412..1014
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1015..1240
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1241..1433
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1575
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..3571
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3536..3541
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /note="hexamer: AATAAA"
     polyA_site      3555
                     /gene="Slc19a2"
                     /gene_synonym="DDA1; ThTr-1; THTR1; TRMA"
                     /note="major polyA site"
ORIGIN      
        1 agacccggag gcggacttag ggaaagggcg ttcggctagc gagctgtggc cgccggcggg
       61 cggtggggac tccaagcacc ttgaccctgg cgcgaggcgg cgtcgcgcac gcttacaggt
      121 gcccgcgcgg gctcgcggct cgggcgccct cccgttggcc gagaaggagg agggggccgt
      181 gtcggcgtcc agcccctcgc gcccaggatg gacgtgccag ccagggtgtc cagacgagcg
      241 gcggcggcgg cggccaggat gcttctgcgt actgcccgcg tccctcgcga gtgctggttc
      301 ctgccgaccg cgctgctctg cgcctacggc ttcttcgcaa acctccggcc gtcggagccg
      361 ttcctcacgc cctaccttct gggacccgac aagaacttga ccgagagaca ggtctacaat
      421 gaaatttatc cggtgtggac gtactcttac ctgctgctgc tgtttcccgt gttccttgcc
      481 acagactacc tccggtacaa gcctgtcatc ctgctgcagg gactcagcct gattgtgacg
      541 tggttcatgc tgctctatgc ccagggactg ctggccattc agttcttgga attcttctac
      601 ggcatcgcca cagccaccga aatcgcctac tactcctata tctatactgt ggtggacctg
      661 ggcatgtacc agaaagtcac aagctactgt agaagtgcca ccttggtggg ctttacagtg
      721 ggctccgtcc tagggcagat cctcgtctcc gtggtgggct ggtcactgtt cagcttgaac
      781 gtcatctccc tcacctgtgt ttctgtggct tttgctgtgg cctggtttct gcctatgcca
      841 cagaagagcc tcttctttca ccacattcct tcctcctgtc atggagtgaa cggcctcaag
      901 gtacaaaacg gtggcatcgt tactgatacc ccagcagcta accatcttcc tggatgggag
      961 gacattgagt caaaaatccc tctaaattta gatgagcctc cggtggaaga accggaggag
     1021 cccaagccag accggctgcg ggtgttcaga gtcctgtgga atgacttcct gatgtgttat
     1081 tcctcccgcc ctctgctctg ctggtccgtg tggtgggccc tgtccacctg cggctatttc
     1141 caagtggtga actacgcgca gggattgtgg gagaaggtga tgccttctca gaatgctgac
     1201 atctacaatg gcggtgtgga ggccgtttca accttgctgg gtgctagtgc tgtgtttgca
     1261 gttggctata taaagctatc ttggtcaact tggggagaaa tgacgttgtt cctgtgttct
     1321 ctcctgattg ctgctgcagt gtatgtcatg gacactgtgc agagcatctg ggtgtgctat
     1381 gcatcctatg ttgtcttcag aatcatctac atggtactca tcaccatagc aactttccag
     1441 attgctgcga acctcagcat ggaacgttac gcccttgtgt tcggcgtgaa caccttcatt
     1501 gccctggcat tgcagactct gctcactctg attgtcgtgg atgccagggg ccttggctta
     1561 tgtatcacca ctcagttcct gatttacgcc agttacttcg cagccatctc tgtggttttc
     1621 ctggcgaatg gcatagtcag tattataaag aaatgcagaa agcaggaaga tcccagctcc
     1681 agcccccaag cctccacgtc ctaacgggct cccgaagtgc tgctgcttcc aagcaaggat
     1741 tttgcaccgc agctgcttgg atgtatttaa actcctcatg gttcagatag ctatttctga
     1801 atgtatattt catggcttca aagcagctac tcaactaaca ccttgcagtc ttggagttag
     1861 tataatactg ctaagagaag ccggaagctt ttttttcttg gattgcttat gagcagtaat
     1921 ttaagaaaac ccacaaaact tgattgtgaa aaaccgaata accaagcagc gcgtctgctc
     1981 tttccctgat tcgcatgtga ctgtgatgct ttccagtcac attcatcacg cactcagacc
     2041 tgtggcctgg tgggaccagg gcttcaggag ccacaggatg gtacaagcct cgacagacac
     2101 gttctgtcag cacttgcccc ggccacctca ttctggtttc agtgttactt gtgcgcatgt
     2161 gtgtgtgtgt ctgcagatgg aaatcattcc ccactggcag tatctgctcg ggttcaacgc
     2221 tctgtcctct gaggagtgtt gtgtctgatt ttattttaaa agttcacggt atgagagtta
     2281 gtgcttcttc ccaatttgac cgttgtatat ttttggaaac gttctttaga atacatttct
     2341 gcattatttg tatgcttccc agagaagctc atttcattac aaaaggcaca ttttaaagcc
     2401 tgctgataac tgaggagggc taatgagata ggtttgctcg tctgtaatag ttatgtatga
     2461 aggactctta attgcaactg aaaaggtcgt gtataggtta gagatacagg gagcccattt
     2521 tatatttgca taccctttta tttccaaaac aaaatgagct cttttccctt gagacaatat
     2581 cattcccata tacctctcat tgtcttggct ttcttatcca agacgagaag atatcagtcg
     2641 gaactggatt attccacagc ctttttataa actgagcctc ttcttaatga ttgttctggg
     2701 cttggcagta ggatagactt gatgcctgcg ttttggacct tagacctgcc cgccttcgtt
     2761 cctacagtta gatcatcttg agagatactt aaaagtatct cctccttact tgaaagaatg
     2821 atgttctaca tgctaatatt tgtgagacat gaaaactatt tcaaagccaa ctttgttgtc
     2881 ttgttgtata agaaatctag gtaggtgctt tcaactagag tgttgacctt gttaagacgg
     2941 acgtagctgc acggtattct caatactgag attgcaaaac tgaagcttga caagtgtgtg
     3001 gaagaccctg gctcaagttc cagcactgga aagaccaaag tgcaaacgtg catgggagga
     3061 gtgagggtaa cagaggccat ggcgtacgtc ttcctttgca gctagggaaa gagaagaaca
     3121 ctaaggagat ggagaactaa ggtcagagta gcagtctcca gtcttacatt ttggtctctt
     3181 tcctcctata cttccttgtt gctctataag aagttggttg cccagaaaca agaagaaaca
     3241 ttgtgattgc gaagtgtcat tttgtttttt ttttaaataa catgtattat ggtacaatca
     3301 aattgttcac attaccaaag caatatttct ttgggattca gttcagtgtt tgtggcatct
     3361 aatctgatcc ttctttacgt gtctaaatca agactgtatc cacattttac cacgcggcca
     3421 tacttgcaga atgcagaccc tagtgggctg tactgtatgc actttgatga agacgtgaaa
     3481 agaatctgtt gtacttttta ttcaatctgt atagactata aaactatttt tattaaataa
     3541 atattttaca gtaaattttc ccttttcact c
//
