LOCUS       NM_031196               2354 bp    mRNA    linear   ROD 01-FEB-2024
DEFINITION  Mus musculus solute carrier family 19 (folate transporter), member
            1 (Slc19a1), transcript variant 1, mRNA.
ACCESSION   NM_031196
VERSION     NM_031196.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2354)
  AUTHORS   Gurler,G., Belder,N., Beker,M.C., Sever-Bahcekapili,M., Uruk,G.,
            Kilic,E. and Yemisci,M.
  TITLE     Reduced folate carrier 1 is present in retinal microvessels and
            crucial for the inner blood retinal barrier integrity
  JOURNAL   Fluids Barriers CNS 20 (1), 47 (2023)
   PUBMED   37328777
  REMARK    GeneRIF: Reduced folate carrier 1 is present in retinal
            microvessels and crucial for the inner blood retinal barrier
            integrity.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2354)
  AUTHORS   Liu,M., Ge,Y., Cabelof,D.C., Aboukameel,A., Heydari,A.R.,
            Mohammad,R. and Matherly,L.H.
  TITLE     Structure and regulation of the murine reduced folate carrier gene:
            identification of four noncoding exons and promoters and regulation
            by dietary folates
  JOURNAL   J Biol Chem 280 (7), 5588-5597 (2005)
   PUBMED   15579899
  REMARK    GeneRIF: existence of four unique noncoding exons and promoters for
            mRFC and demonstrate a facile induction of mRNAs for mRFC and
            multidrug resistance-associated proteins 1 and 3 in intestine in
            response to changes in dietary folate intake
REFERENCE   3  (bases 1 to 2354)
  AUTHORS   Zhao,R., Wang,Y., Gao,F. and Goldman,I.D.
  TITLE     Residues 45 and 404 in the murine reduced folate carrier may
            interact to alter carrier binding and mobility
  JOURNAL   Biochim Biophys Acta 1613 (1-2), 49-56 (2003)
   PUBMED   12832086
  REMARK    GeneRIF: interaction between the E45 and K404 residues in the first
            and 11th transmembrane domains; the E45 residue appears to be the
            more dominant determinant of binding and anion sensitivity
REFERENCE   4  (bases 1 to 2354)
  AUTHORS   Tse,A., Brigle,K., Taylor,S.M. and Moran,R.G.
  TITLE     Mutations in the reduced folate carrier gene which confer dominant
            resistance to 5,10-dideazatetrahydrofolate
  JOURNAL   J Biol Chem 273 (40), 25953-25960 (1998)
   PUBMED   9748272
REFERENCE   5  (bases 1 to 2354)
  AUTHORS   Roy,K., Chiao,J.H., Spengler,B.A., Tolner,B., Yang,C.H.,
            Biedler,J.L. and Sirotnak,F.M.
  TITLE     Chromosomal localization of the murine RFC-1 gene encoding a folate
            transporter and its amplification in an antifolate resistant
            variant overproducing the transporter
  JOURNAL   Cancer Genet Cytogenet 105 (1), 29-38 (1998)
   PUBMED   9689927
REFERENCE   6  (bases 1 to 2354)
  AUTHORS   Orlowski,J. and Grinstein,S.
  TITLE     Na+/H+ exchangers of mammalian cells
  JOURNAL   J Biol Chem 272 (36), 22373-22376 (1997)
   PUBMED   9278382
  REMARK    Review article
REFERENCE   7  (bases 1 to 2354)
  AUTHORS   Brigle,K.E., Spinella,M.J., Sierra,E.E. and Goldman,I.D.
  TITLE     Organization of the murine reduced folate carrier gene and
            identification of variant splice forms
  JOURNAL   Biochim Biophys Acta 1353 (2), 191-198 (1997)
   PUBMED   9294013
REFERENCE   8  (bases 1 to 2354)
  AUTHORS   Tolner,B., Roy,K. and Sirotnak,F.M.
  TITLE     Organization, structure and alternate splicing of the murine RFC-1
            gene encoding a folate transporter
  JOURNAL   Gene 189 (1), 1-7 (1997)
   PUBMED   9161403
REFERENCE   9  (bases 1 to 2354)
  AUTHORS   Wakabayashi,S., Shigekawa,M. and Pouyssegur,J.
  TITLE     Molecular physiology of vertebrate Na+/H+ exchangers
  JOURNAL   Physiol Rev 77 (1), 51-74 (1997)
   PUBMED   9016300
  REMARK    Review article
REFERENCE   10 (bases 1 to 2354)
  AUTHORS   Said,H.M., Nguyen,T.T., Dyer,D.L., Cowan,K.H. and Rubin,S.A.
  TITLE     Intestinal folate transport: identification of a cDNA involved in
            folate transport and the functional expression and distribution of
            its mRNA
  JOURNAL   Biochim Biophys Acta 1281 (2), 164-172 (1996)
   PUBMED   8664315
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY791593.1, AK079592.1 and AI323572.1.
            
            [WARNING] On Mar 25, 2024 this sequence was replaced by
            NM_031196.4.
            
            On Nov 30, 2010 this sequence version replaced NM_031196.2.
            
            Transcript Variant: This variant (1) represents the longer and more
            frequently occurring transcript. Variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088803.1, AK079592.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-40                BY791593.1         2-41
            41-2340             AK079592.1         2-2301
            2341-2354           AI323572.1         1-14                c
FEATURES             Location/Qualifiers
     source          1..2354
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..2354
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /note="solute carrier family 19 (folate transporter),
                     member 1"
                     /db_xref="GeneID:20509"
                     /db_xref="MGI:MGI:103182"
     exon            1..136
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /inference="alignment:Splign:2.1.0"
     exon            137..366
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..1722
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /note="folate transporter 1; IFC-1; reduced folate carrier
                     1; intestinal folate carrier protein; solute carrier
                     family 19 member 1; intestinal folate carrier 1; solute
                     carrier family 19 (sodium/hydrogen exchanger), member 1;
                     plasma membrane folate antiporter SLC19A1"
                     /codon_start=1
                     /product="reduced folate transporter"
                     /protein_id="NP_112473.1"
                     /db_xref="CCDS:CCDS35947.1"
                     /db_xref="GeneID:20509"
                     /db_xref="MGI:MGI:103182"
                     /translation="MVPTGQVAEKQAYEEPRQDHELKSWRCLVFYLCFFGFMAQLRPG
                     ESFITPFLLERKFTKEQVTNEIIPMLPYSHLAVLVPVFLLTDYLRYKPVLVLQCLSFV
                     CVWLLLLLGTSVVHMQLMEVFYSVTMAARIAYSSYIFSLVHPSRYQRMASYSRAAVLL
                     GVFISSVLGQALVTVGHISTYTLNCVSLGFILFSLVLSLFLKRPKRSLFFNRSTLARG
                     ALPCELDQMHPGPDRPETRKLDRMLGTCRDSFLVRMLSELVENARQPQLRLWCLWWVF
                     NSSGYYLITYYVHVLWRSTDSSLSYNGAVDAASTLLSAITSFSAGFLSIRWTLWSKLV
                     IAGVIAIQASLVFCMFQIRDIWVCYVTFVLFRGAYQFLVPIATFQIASSLSKELCALV
                     FGINTFLATALKTCITLVVSDKRGLGLQVRDQFRIYFIYFLMLSITCFAWAGLDGLRY
                     CQRGRHQPLAQAQELRSPLETSVQAISLQDGDLRGPQPSAPQLLSEDGMEDDRGDLRV
                     EAKA"
     exon            367..1120
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1121..1313
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1455
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..2348
                     /gene="Slc19a1"
                     /gene_synonym="RFC; RFC-1; RFC1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 atgcggccct tgagcctacg cgcgggtttt tgggtgttgt agtctgcgtg tgcgcgttga
       61 atcagccaca ggcctgtggg acgcagagct aggaatccat tctatgcgtg cctggggagc
      121 cacggggtag tgcaaggtgg agtgtcatct tggcccgcca gttcccatga ggacctgggc
      181 aacatggtgc ccactggcca ggtggcagaa aagcaggcat acgaagagcc caggcaggac
      241 cacgaactga aatcctggcg atgcctggtg ttctatctct gcttcttcgg cttcatggcc
      301 cagttgcgtc ctggggaaag cttcatcaca cccttcctcc tggaacgtaa attcaccaag
      361 gagcaggtga ctaacgagat cattccgatg ctgccctact cccacctggc tgtgctggtc
      421 ccggtcttcc tgctcaccga ctacctgcga tacaagccag tcttggtcct gcagtgcctg
      481 agcttcgtgt gcgtgtggct gttgctgctg ctgggcacat ctgtcgtgca catgcaactc
      541 atggaagtct tctacagcgt caccatggcg gcccgcatcg cctactcctc ctacatattc
      601 tccctggtgc acccctcccg ctaccagcgc atggccagct actcacgggc ggcagtactg
      661 ctgggagtct tcatcagctc tgtgttgggc caggcgctgg tcaccgtagg acatataagc
      721 acctatacac tcaactgtgt ctccctgggc ttcatcctct tcagcctggt cctctccctc
      781 tttctaaagc gccctaagcg gagcctcttt ttcaaccgca gtacgcttgc gcgtggagcc
      841 ttgccctgtg agctggatca gatgcacccg gggcctgacc ggccagaaac caggaaacta
      901 gatcgcatgc tgggcacttg cagggactcc ttcctggtgc gcatgctaag tgaactggtg
      961 gaaaatgctc ggcaaccaca gctgcgtctc tggtgcctct ggtgggtctt caactcttca
     1021 ggctactacc tgatcaccta ctatgtgcat gtcctgtgga gaagcactga cagcagcctc
     1081 agctacaatg gcgccgtaga tgccgcctcc acactgctga gcgccatcac gtccttctcc
     1141 gccggcttcc tgagcatccg ctggactctg tggtccaagc tggtcatcgc aggtgtgatc
     1201 gccatccagg ccagcctggt tttctgtatg ttccagatcc gggacatctg ggtgtgctac
     1261 gtgacctttg tgcttttccg tggggcctac cagttccttg tgcccattgc cacttttcag
     1321 attgcgtctt ccctgtctaa agagctctgt gcattggtct ttgggatcaa cactttccta
     1381 gctactgcgc ttaagacctg tatcacactt gtggtctctg acaagcgggg tctgggtctc
     1441 caagtccgtg atcagttccg tatctacttc atatacttcc tgatgctgtc tatcacctgc
     1501 tttgcctggg cggggctgga tggcttaagg tactgccagc gtggtcgcca ccagcccctg
     1561 gcccaggccc aggagctgag gagtcccttg gagacttctg tgcaagcgat aagcctacag
     1621 gatggagacc taaggggacc gcagccctca gcgccacagc tgctctcaga ggatggcatg
     1681 gaggacgaca ggggagactt aagagtcgaa gccaaggctt gaccttccta gcttcatccc
     1741 agttcagcgg cgggattcct gactcagagg cagcccctcc tgtttgcact ccacctgaac
     1801 cagcctgggc ctgatgctac acacagtgct cccagtcgat gttgccttga gtccaagaca
     1861 tacagggggc ccccgctgtt gccttttagg agcctttagg ttaggccaca gaaccctcct
     1921 taaggggcca cctgttagct tatccttctg aggaccctaa acccagccta cttcatgctt
     1981 tagcaatggc tgtagcctgc taccgacact caagggcagc tccctggctt tgtgaaccac
     2041 gtgccaggcc actgcgagtc tgggttgtct attgcttgcc aagaagaacc tgtgtcgggc
     2101 tcaactatgc ccaccaggcc attctgcctt ttttgctctg ggaagctctg ggcaaatcat
     2161 gtctgcccct tagggctagt gaggtagccc agatgccagc caaggtccgc tgagcctgca
     2221 gggtgccagt tgcctgccct aggctcctgg ctatgctgcc atacatcctt ccactatcgg
     2281 aggtgcttgt ttaaatggtt ttctgatttc ttttttaact tgacattaaa atggagaact
     2341 accttgggaa aaaa
//
