LOCUS       NM_172523               3803 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 18 (vesicular monoamine), member
            2 (Slc18a2), mRNA.
ACCESSION   NM_172523
VERSION     NM_172523.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3803)
  AUTHORS   Frolova,V.S., Nikishina,Y.O., Shmukler,Y.B. and Nikishin,D.A.
  TITLE     Serotonin Signaling in Mouse Preimplantation Development: Insights
            from Transcriptomic and Structural-Functional Analyses
  JOURNAL   Int J Mol Sci 25 (23), 12954 (2024)
   PUBMED   39684667
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3803)
  AUTHORS   Pulcrano,S., De Gregorio,R., De Sanctis,C., Volpicelli,F.,
            Piscitelli,R.M., Speranza,L., Perrone-Capano,C., di Porzio,U.,
            Caiazzo,M., Martini,A., Giacomet,C., Medina,D., Awatramani,R.,
            Viggiano,D., Federici,M., Mercuri,N.B., Guatteo,E. and
            Bellenchi,G.C.
  TITLE     miR-218 Promotes Dopaminergic Differentiation and Controls Neuron
            Excitability and Neurotransmitter Release through the Regulation of
            a Synaptic-Related Genes Network
  JOURNAL   J Neurosci 43 (48), 8104-8125 (2023)
   PUBMED   37816598
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3803)
  AUTHORS   Kim,H.Y., Lee,J., Kim,H.J., Lee,B.E., Jeong,J., Cho,E.J.,
            Jang,H.J., Shin,K.J., Kim,M.J., Chae,Y.C., Lee,S.E., Myung,K.,
            Baik,J.H., Suh,P.G. and Kim,J.I.
  TITLE     PLCgamma1 in dopamine neurons critically regulates striatal
            dopamine release via VMAT2 and synapsin III
  JOURNAL   Exp Mol Med 55 (11), 2357-2375 (2023)
   PUBMED   37907739
  REMARK    GeneRIF: PLCgamma1 in dopamine neurons critically regulates
            striatal dopamine release via VMAT2 and synapsin III.
REFERENCE   4  (bases 1 to 3803)
  AUTHORS   Xu,Y., Jiang,Z., Li,H., Cai,J., Jiang,Y., Otiz-Guzman,J., Xu,Y.,
            Arenkiel,B.R. and Tong,Q.
  TITLE     Lateral septum as a melanocortin downstream site in obesity
            development
  JOURNAL   Cell Rep 42 (5), 112502 (2023)
   PUBMED   37171957
  REMARK    Erratum:[Cell Rep. 2023 Jun 27;42(6):112626. doi:
            10.1016/j.celrep.2023.112626.. PMID: 37285271]
REFERENCE   5  (bases 1 to 3803)
  AUTHORS   Isingrini,E., Guinaudie,C., Perret,L., Guma,E., Gorgievski,V.,
            Blum,I.D., Colby-Milley,J., Bairachnaya,M., Mella,S.,
            Adamantidis,A., Storch,K.F. and Giros,B.
  TITLE     Behavioral and Transcriptomic Changes Following Brain-Specific Loss
            of Noradrenergic Transmission
  JOURNAL   Biomolecules 13 (3), 511 (2023)
   PUBMED   36979445
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3803)
  AUTHORS   Fon,E.A., Pothos,E.N., Sun,B.C., Killeen,N., Sulzer,D. and
            Edwards,R.H.
  TITLE     Vesicular transport regulates monoamine storage and release but is
            not essential for amphetamine action
  JOURNAL   Neuron 19 (6), 1271-1283 (1997)
   PUBMED   9427250
REFERENCE   7  (bases 1 to 3803)
  AUTHORS   Takahashi,N. and Uhl,G.
  TITLE     Murine vesicular monoamine transporter 2: molecular cloning and
            genomic structure
  JOURNAL   Brain Res Mol Brain Res 49 (1-2), 7-14 (1997)
   PUBMED   9387858
REFERENCE   8  (bases 1 to 3803)
  AUTHORS   Sang,Q. and Young,H.M.
  TITLE     Development of nicotinic receptor clusters and innervation
            accompanying the change in muscle phenotype in the mouse esophagus
  JOURNAL   J Comp Neurol 386 (1), 119-136 (1997)
   PUBMED   9303529
REFERENCE   9  (bases 1 to 3803)
  AUTHORS   Takahashi,N., Miner,L.L., Sora,I., Ujike,H., Revay,R.S., Kostic,V.,
            Jackson-Lewis,V., Przedborski,S. and Uhl,G.R.
  TITLE     VMAT2 knockout mice: heterozygotes display reduced
            amphetamine-conditioned reward, enhanced amphetamine locomotion,
            and enhanced MPTP toxicity
  JOURNAL   Proc Natl Acad Sci U S A 94 (18), 9938-9943 (1997)
   PUBMED   9275230
REFERENCE   10 (bases 1 to 3803)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC139040.8, AK035644.1, AK033871.1 and AV328655.2.
            
            On Dec 10, 2009 this sequence version replaced NM_172523.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035644.1, AK041274.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC139040.8         120117-120134       c
            19-1125             AK035644.1         2-1108
            1126-2595           AK033871.1         1082-2551
            2596-3170           AC139040.8         85633-86207         c
            3171-3803           AV328655.2         25-657
FEATURES             Location/Qualifiers
     source          1..3803
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="19"
                     /map="19 54.64 cM"
     gene            1..3803
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /note="solute carrier family 18 (vesicular monoamine),
                     member 2"
                     /db_xref="GeneID:214084"
                     /db_xref="MGI:MGI:106677"
     exon            1..141
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            142..274
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     CDS             154..1707
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /note="vesicular monoamine transporter 2; VAT2; vesicular
                     amine transporter 2; solute carrier family 18 member 2"
                     /codon_start=1
                     /product="synaptic vesicular amine transporter"
                     /protein_id="NP_766111.1"
                     /db_xref="CCDS:CCDS29935.1"
                     /db_xref="GeneID:214084"
                     /db_xref="MGI:MGI:106677"
                     /translation="MALSDLVLLRWLRDSRHSRKLILFIVFLALLLDNMLLTVVVPII
                     PSYLYSIKHEKNTTEIQTARPALTASTSESFHSIFSYYNNSTVFTGNATGGLPGGESP
                     KATTTQHTVTNTTVPPDCPSEDKDLLNENVQVGLLFASKATVQLLTNPFIGLLTNRIG
                     YPIPMFAGFCIMFISTVMFAFSSSYAFLLIARSLQGIGSSCSSVAGMGMLASVYTDDE
                     ERGNAMGIALGGLAMGVLVGPPFGSVLYEFVGKTAPFLVLAALVLLDGAIQLFVLQPS
                     RVQPESQKGTPLTTLLKDPYILIAAGSICFANMGIAMLEPALPIWMMETMCSRKWQLG
                     VAFLPASISYLIGTNIFGILAHKMGRWLCALLGMIVVGISILCIPFAKNIYGLIAPNF
                     GVGFAIGMVDSSMMPIMGYLVDLRHVSVYGSVYAIADVAFCMGYAIGPSAGGAIAKAI
                     GFPWLMTIIGIIDIVFAPLCFFLRSPPAKEEKMAILMDHNCPIKTKMYTQNNVQPYPV
                     GDDEESESD"
     exon            275..626
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            627..685
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            686..769
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            770..862
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            863..952
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            953..996
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1057
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1058..1153
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1154..1232
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1233..1284
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1348
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1468
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1469..1602
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..3803
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3783..3788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /note="hexamer: AATAAA"
     polyA_site      3803
                     /gene="Slc18a2"
                     /gene_synonym="1110037L13Rik; 9330105E13; Vmat2"
                     /note="major polyA site"
ORIGIN      
        1 gtcagagccg gactgggtaa actgagcagg gctctggggc gctggagcat aggagacctg
       61 gagcagcggg gacggacgca cggactggga cccgggcagt gtggagatat aaccctgcag
      121 gcagtcgcag gcgagccgaa gcgaagcaaa gctatggccc tgagcgatct ggtgctgctg
      181 cgatggctgc gggacagccg ccactcgcgc aagctgatcc tgttcatcgt gttcctcgcg
      241 ctgctgctag acaacatgct gctcaccgtc gtagttccca tcattcccag ctacctgtac
      301 agcattaagc acgagaaaaa tactacggaa atccagactg ccaggccagc gctcacagcc
      361 tccacttccg aaagcttcca cagcatcttc tcttactata acaactctac tgtgttcacg
      421 gggaatgcca cggggggcct cccaggaggg gagtcaccca aggctaccac cacacagcac
      481 actgtgacca acacgactgt ccctcccgac tgccccagtg aagacaaaga ccttctaaat
      541 gagaatgtgc aagttgggct gctgtttgcc tccaaagcca ctgtccagct cctcaccaac
      601 ccattcatag gacttctaac caacagaatt ggctatccaa ttcccatgtt tgctggattc
      661 tgcattatgt ttatctcaac agttatgttt gccttctcca gcagctatgc cttcctgctg
      721 atcgccaggt ccctgcaggg aatcggctcc tcttgctcat ctgtggctgg gatgggcatg
      781 ctggccagcg tgtacacaga tgatgaagag aggggtaacg ccatggggat tgctctgggg
      841 ggcctggcca tgggggtctt agtgggaccc ccctttggaa gtgtgctcta tgagtttgtg
      901 gggaagacag ctcctttcct ggtgcttgct gccttggtgc tcttggatgg agctattcag
      961 ctctttgtgc tccagccatc ccgagtgcag ccagaaagtc agaaggggac acctcttacg
     1021 accttgctga aggacccata cattctcatc gctgcaggct ccatctgctt tgcaaacatg
     1081 gggatagcca tgctggagcc cgccctgccc atctggatga tggagaccat gtgttcccga
     1141 aagtggcagc tgggcgttgc cttcctgcca gcgagcatct cttatctcat tggaaccaat
     1201 atttttggga tacttgcaca caaaatggga aggtggctgt gtgctcttct gggaatgata
     1261 gttgttggga tcagcatttt atgtattcct tttgcaaaaa atatctacgg actcatcgct
     1321 cccaactttg gagttggttt tgccattggg atggtggact cctccatgat gcctatcatg
     1381 ggctacctgg tggacctgcg gcacgtgtct gtctatggga gtgtgtatgc cattgcagat
     1441 gtagccttct gcatggggta tgctatcggt ccctctgctg gtggtgctat tgcaaaggca
     1501 attggctttc cttggctcat gacaattatt gggataattg atattgtttt tgctccactc
     1561 tgcttttttc ttcgaagtcc acctgctaag gaagaaaaaa tggctatcct catggaccac
     1621 aactgcccca ttaagacaaa gatgtacact cagaataatg tccagccgta ccccgtcggt
     1681 gatgatgaag aatctgagag tgactgagcc cctctaacgt tgcccaatgt ttaactgtgt
     1741 acatgtgtct ccagtgagat gacttaagag ctgtcttagt cacgccatcc attgctggca
     1801 tagagtaaaa caaccaaagg tgatactttc tttttcatgg ttatgatcga ctgccaacag
     1861 ccttataaag aaaaagcaac ttttctaggg gtttgtataa atagtgttga aaactttatt
     1921 ttatgtattt gattttatta atattataca atatattttg acgaaatagg tatactgtaa
     1981 atgtataaat atttgaatcc aaattaaata taatttttta acttacattc atcaacactt
     2041 ggacaaaaaa aatcttattt ttttttttct gaatactggt aatgagtgtt taaagcacac
     2101 attatctgag attctccaac aaaaaactag cagtctgaga aacagaatcg tgtaagacaa
     2161 tgcattgtat accaacactg aatgtgttgt tatttaactt gaaactaata ccaatgtatt
     2221 tatgagttaa aagctagtca tcttaaatac aaaggacaag aaactttatc agccatcttt
     2281 cagacttatt cataaacctt tgctggcatt agttttctgt tataaccact cacctggaaa
     2341 gaggtggttg taaatggttt tctgtgtcat atcattggca gcagtaatta aagccaacaa
     2401 ggggtaaaaa gtgaatgttc tgaaagcaga ggaaagaacc caaatgctgc tttcttttat
     2461 atattcttga tggtcttact gggtgaaaat aaaactctgc actttaaaca gtcaaggttg
     2521 aatatgttaa ggtttatcaa tccagttcat gttctggaac agtaaacaag gctatcatca
     2581 agctgttata atgtgaaaaa aaaatcacat ctctcacctg cttgcaggtc atccaagtgt
     2641 ttttctagag atgttaattt tgagttgctg ttatttttta gactcctaaa agttgtttat
     2701 atcaatgtag aaatgaattt caagcaaaga tgaagaaata aaattgttca cggctaacac
     2761 gattatgtta agaaagataa tagagtggtt aggacacctc ccctttctga agcaggaaaa
     2821 aaacaatcta caaatgatat gtgttattgt atcatcttgt gtgctgggta gaataacttt
     2881 tctaagcatg acaacactga tatgtctttt cagtgtgcca gttaatgctg ttagtgaact
     2941 ctatctacaa ttgctttgta tgagactaca atcttccgga atgcaaacac agtatagaat
     3001 ttgtctcaaa tagtatctgt caaaaaactg ttttaaaaaa actgtcagtt ttgttaagct
     3061 taattgtttg tgtgaccttg gacattgaga actttaggat gacaacccct caaatcttat
     3121 tggctatcca cattcttcag aaaagtggca aatatttctt ttgttttatg aagctttctg
     3181 tgggaccctg gtgatgtgaa gtctggtgtg tttaagggac aattgggttc ccactcttaa
     3241 gccattggac agtcatgggt ctgcaactct gaaagatggc tgctcttaca tggctaaaag
     3301 ggcagggctt aaccttctcc aggatgcctt gtgatgtgat gtgagagagg ccttgtagtt
     3361 gtccttaccc acaataccat atacaataac tgattcctgt catttctgct tttgaggctt
     3421 cagtttcagt aaaaacgatc agcaaaggca tgcctgttac tgctctccaa agaaaaaaga
     3481 aaaattgcag aactatttgg agaggaaagg ataagttgtt tatgagggga aaggaaagac
     3541 atttatatga ctaatctcct gggtacacaa gaccgaaaat agcgtttaaa agagactgtg
     3601 catgtaccag aacaaagaac ttacagctct ctgaagattt atttttattt ttaaagtaga
     3661 gatggctttt gtttgtactt ggtaattcag acacaaaaat cttagtgagg tagtaatgaa
     3721 tactcaactt ccttttgact gctaactgta tctgtgctgg ttgcacttta gttagattac
     3781 ttaataaatc ttcttgaaca ctg
//
