LOCUS       NM_153054               3118 bp    mRNA    linear   ROD 03-APR-2024
DEFINITION  Mus musculus solute carrier family 18 (vesicular monoamine), member
            1 (Slc18a1), mRNA.
ACCESSION   NM_153054
VERSION     NM_153054.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3118)
  AUTHORS   Sato,D.X., Inoue,Y.U., Kuga,N., Hattori,S., Nomoto,K., Morimoto,Y.,
            Sala,G., Hagihara,H., Kikusui,T., Sasaki,T., Ikegaya,Y.,
            Miyakawa,T., Inoue,T. and Kawata,M.
  TITLE     Humanized substitutions of Vmat1 in mice alter amygdala-dependent
            behaviors associated with the evolution of anxiety
  JOURNAL   iScience 25 (8), 104800 (2022)
   PUBMED   35992083
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3118)
  AUTHORS   Dumas,S. and Wallen-Mackenzie,A.
  TITLE     Developmental Co-expression of Vglut2 and Nurr1 in a
            Mes-Di-Encephalic Continuum Preceeds Dopamine and Glutamate Neuron
            Specification
  JOURNAL   Front Cell Dev Biol 7, 307 (2019)
   PUBMED   31850343
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3118)
  AUTHORS   Lohoff,F.W., Carr,G.V., Brookshire,B., Ferraro,T.N. and Lucki,I.
  TITLE     Deletion of the vesicular monoamine transporter 1 (vmat1/slc18a1)
            gene affects dopamine signaling
  JOURNAL   Brain Res 1712, 151-157 (2019)
   PUBMED   30685272
  REMARK    GeneRIF: Deletion of the vesicular monoamine transporter 1
            (vmat1/slc18a1) gene affects dopamine signaling.
REFERENCE   4  (bases 1 to 3118)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   5  (bases 1 to 3118)
  AUTHORS   Veenvliet,J.V., Dos Santos,M.T., Kouwenhoven,W.M., von Oerthel,L.,
            Lim,J.L., van der Linden,A.J., Koerkamp,M.J., Holstege,F.C. and
            Smidt,M.P.
  TITLE     Specification of dopaminergic subsets involves interplay of En1 and
            Pitx3
  JOURNAL   Development 140 (16), 3373-3384 (2013)
   PUBMED   23863478
  REMARK    Erratum:[Development. 2013 Oct;140(19):4116]
REFERENCE   6  (bases 1 to 3118)
  AUTHORS   Boldogkoi,Z., Schutz,B., Sallach,J. and Zimmer,A.
  TITLE     P2X(3) receptor expression at early stage of mouse embryogenesis
  JOURNAL   Mech Dev 118 (1-2), 255-260 (2002)
   PUBMED   12351197
REFERENCE   7  (bases 1 to 3118)
  AUTHORS   Finotto,S., Krieglstein,K., Schober,A., Deimling,F., Lindner,K.,
            Bruhl,B., Beier,K., Metz,J., Garcia-Arraras,J.E., Roig-Lopez,J.L.,
            Monaghan,P., Schmid,W., Cole,T.J., Kellendonk,C., Tronche,F.,
            Schutz,G. and Unsicker,K.
  TITLE     Analysis of mice carrying targeted mutations of the glucocorticoid
            receptor gene argues against an essential role of glucocorticoid
            signalling for generating adrenal chromaffin cells
  JOURNAL   Development 126 (13), 2935-2944 (1999)
   PUBMED   10357937
REFERENCE   8  (bases 1 to 3118)
  AUTHORS   Rooke,K., Briquet-Laugier,V., Xia,Y.R., Lusis,A.J. and
            Doolittle,M.H.
  TITLE     Mapping of the gene for calreticulin (Calr) to mouse chromosome 8
  JOURNAL   Mamm Genome 8 (11), 870-871 (1997)
   PUBMED   9337407
REFERENCE   9  (bases 1 to 3118)
  AUTHORS   Roghani,A., Welch,C., Xia,Y., Liu,Y., Peter,D., Finn,J.P.,
            Edwards,R.H. and Lusis,A.J.
  TITLE     Assignment of the mouse vesicular monoamine transporter genes,
            Slc18a1 and Slc18a2, to chromosomes 8 and 19 by linkage analysis
  JOURNAL   Mamm Genome 7 (5), 393-394 (1996)
   PUBMED   8661734
REFERENCE   10 (bases 1 to 3118)
  AUTHORS   Peter,D., Finn,J.P., Klisak,I., Liu,Y., Kojis,T., Heinzmann,C.,
            Roghani,A., Sparkes,R.S. and Edwards,R.H.
  TITLE     Chromosomal localization of the human vesicular amine transporter
            genes
  JOURNAL   Genomics 18 (3), 720-723 (1993)
   PUBMED   7905859
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CN663918.1, AK076433.1 and AC114995.7.
            
            On Nov 4, 2005 this sequence version replaced NM_153054.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031146.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-503               CN663918.1         1-503
            504-1498            AK076433.1         228-1222
            1499-1872           AK076433.1         1224-1597
            1873-1920           AC114995.7         178269-178316
            1921-2714           AK076433.1         1646-2439
            2715-3118           AC114995.7         180446-180849
FEATURES             Location/Qualifiers
     source          1..3118
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 33.88 cM"
     gene            1..3118
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /note="solute carrier family 18 (vesicular monoamine),
                     member 1"
                     /db_xref="GeneID:110877"
                     /db_xref="MGI:MGI:106684"
     exon            1..242
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            243..317
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            318..589
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     CDS             466..2031
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /note="vesicular amine transporter 1; solute carrier
                     family 18 member 1"
                     /codon_start=1
                     /product="chromaffin granule amine transporter"
                     /protein_id="NP_694694.1"
                     /db_xref="CCDS:CCDS22344.1"
                     /db_xref="GeneID:110877"
                     /db_xref="MGI:MGI:106684"
                     /translation="MFQVVLGAPQRLLKEGRQSRKLVLVVVFVALLLDNMLLTVVVPI
                     VPTFLYATEFKDINSSLLRGPSVSSQQALTSPAFSTTFSFFDNTTMTVEEHVPFRVAW
                     INGTIPPPVTEAGSVPKNNCLQGIEFLEEENVRIGILFASKALMQLLVNPFVGPLTNR
                     IGYHIPMFVGFMIMFLSTLMFAFSGTYALLFVARTLQGIGSSFSSVAGLGMLASVYTD
                     NYERGRAMGIALGGLALGLLVGAPFGSVMYEFVGKSSPFLILAFLALLDGALQFCILW
                     PSKVSPESAMGTPLLTLLKDPYILVAAGSICLANMGVAILEPTLPIWMMQTMCSPEWQ
                     LGLAFLPASVAYLIGTNLFGVLANKMGRWLCSLVGMVAVGISLLCVPLAHNIFGLIGP
                     NAGLGFAIGMVDSSLMPIMGYLVDLRHTSVYGSVYAIADVAFCVGFAIGPSTGGVIVP
                     VIGFPWLMVIIGTINIIYAPLCCFLQNPPAKEEELAILNQECPTETQMYTIQRPTKEF
                     PLGENSDDPGSEE"
     exon            590..944
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            945..1003
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1004..1087
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1180
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1270
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1314
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1375
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1376..1471
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1550
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1551..1602
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1603..1666
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1667..1786
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1920
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
     exon            1921..3118
                     /gene="Slc18a1"
                     /gene_synonym="4832416I10Rik; Vat1; Vmat1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agcagatgaa gacagtgaca agaagtggcc ctcagagaca gaccagtgtc tgacaatacc
       61 cagagaactc ggagcgggta gggcaatcat caggagccca cttagcccat gggaaggttc
      121 cagtcggtgc tctcacgctc ggcccaccga agtcacggaa aagctcacgc aaagctggag
      181 aggtgcttgt gaactgagcg atgggggaaa tgaatcccat tccctccccg ctggctgaac
      241 agagaacaga gtttccgctg ccttgccaac agctgccagt tcctctcgga gtgcctcaca
      301 tcaagacgag ctgtaagtga gcttcactag accagacaga ctgccctttc tcctgtaaag
      361 gtgacagaag accacatcta tcaaggggcc ttcctaagca cccggaggag aaggcctccc
      421 cgccatccca ctccctaccc agcccagcct cctgcagccc ttgccatgtt ccaggttgtt
      481 ctgggtgctc ctcagcgact gctgaaggaa gggaggcagt cccggaagct ggtgttggtg
      541 gtggtgtttg tggctctact cctggacaat atgctgctca ctgtggtggt gcccattgtg
      601 cccaccttcc tgtatgcgac agagttcaaa gacatcaact cttctctgct taggggtcct
      661 tctgtaagct cccagcaagc tctcacctct cctgccttct ctaccacctt ctccttcttt
      721 gacaacacca ccatgactgt agaagaacat gtaccttttc gtgtagcatg gataaatggt
      781 accatccctc ctccagtcac cgaagctggc tcagtaccta aaaacaactg cttgcaaggg
      841 atagagttct tggaagaaga aaatgtccgg attgggattc tatttgcttc aaaggctttg
      901 atgcaacttc tggttaaccc atttgtagga cctcttacta acaggattgg ctatcacatc
      961 cccatgtttg ttggctttat gatcatgttt ctctccacac taatgtttgc tttctctggc
     1021 acctatgccc tgctgtttgt ggcccgaact ctccaaggca ttggatcttc attttcatct
     1081 gttgcagggc ttgggatgct ggccagtgtc tatacggata actacgagag aggaagagcc
     1141 atgggaattg ctttgggggg cctggctttg ggacttctgg tgggagcacc ttttggaagt
     1201 gtgatgtatg aatttgtggg caagtcctca ccattcctca tcttggcctt cctggcactt
     1261 ctggatggag ctctccagtt ttgcatccta tggccttcga aagtgtctcc tgagagtgcc
     1321 atggggactc cacttttgac acttctcaaa gatccttaca ttctggtagc agcaggttcc
     1381 atctgcctgg ccaacatggg agtcgccata ttagagccca cgctacccat ctggatgatg
     1441 cagaccatgt gttccccgga gtggcagcta ggtctggctt ttttacctgc cagtgtggcc
     1501 tacctcattg gcacgaacct ttttggtgtg ttggccaaca agatgggtcg gtggctgtgc
     1561 tcccttgttg gaatggtagc tgtaggtatc agcttgctct gtgtacctct ggctcacaat
     1621 atttttggtc ttattggacc caatgcaggc cttggctttg ccataggcat ggtggattcc
     1681 tctctgatgc ccatcatggg atacctggtg gacttacgcc atacctctgt gtatgggagt
     1741 gtctatgcca tcgctgatgt ggctttttgt gtgggctttg ctattggccc atctaccggg
     1801 ggtgttattg taccggtcat cggcttccct tggctcatgg tcatcattgg aactatcaac
     1861 atcatctatg cccctctctg ctgcttcctg cagaacccac cagctaagga ggaggagctt
     1921 gcaattctga accaggaatg ccccacagag acccagatgt acacaatcca gaggcccacg
     1981 aaggagtttc cactgggaga gaacagcgat gatcctggca gtgaggagta gctgtagagg
     2041 gtgatatctg ggcctcattc caggtgaccc catgaggcgt gaatctcagt gtcccagggg
     2101 accagatcat cacagattca atgggtctca ctttcctctc ctctgggcaa ctcccttcct
     2161 tccttcttat tgatagcttg ttcttactca cctgtaagta caacccacca ctctcccaat
     2221 gtgctttgac accaccagtg gcccattttt tgtgggagga cagtgctact tcctgccagg
     2281 ccaaagcgaa gctgattaaa gctgagttga gacaagttct gcaaggggtg actcacttcc
     2341 tgcaggcagt gctgaacaac gtgcctgtga aaccagggct acaaatggca agccttcctt
     2401 tcttctctga ttttgtctaa catattacca atatgtctta aaatttgacc tgtctcctgt
     2461 gatatatttt ccccttattt tttccaggtg agcttccata tgtaggttgt tgtttttttt
     2521 tttctttctt attttatgtg ctaaaattac tttaacttca tcaaatgaag ccttctggct
     2581 ttcctcatca tccaatcaaa gggaaataag cacttttcct aggtctgtgt tatgtctgct
     2641 ctgatgattt ctcatgtatg tttctagctt tccccaacct cttaaactct tataaataaa
     2701 agtggttgaa gtacagaaaa acaaacaaac aaacaaacaa acaagccaat gaaacaacaa
     2761 cagaaacccc aaataaacaa cattgcatta gactcaaggg ttccctgcat gaagcaaaaa
     2821 gaaacttgaa atttccccca aacgtgtatt tcctagtaga agaagcagaa caaggcgttc
     2881 attgttcaca cgtgtcaatg agtaagtcaa ttagccaatt cagacatgaa gaaccagatg
     2941 gttttgtagc aggagagaga gtgtgggaaa atacagtggg tgttgtacat catgtgacat
     3001 ttggctacat ttttgaaatg gttattggat gatagagtct ccaatttggg aaatatggca
     3061 ttcattctaa gtagcttctc atttttctca gcaaacaata aaatttatga acaactca
//
