LOCUS       NM_183161               2197 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus solute carrier family 17, member 9 (Slc17a9), mRNA.
ACCESSION   NM_183161
VERSION     NM_183161.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2197)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2197)
  AUTHORS   Higashikuni,Y., Liu,W., Numata,G., Tanaka,K., Fukuda,D., Tanaka,Y.,
            Hirata,Y., Imamura,T., Takimoto,E., Komuro,I. and Sata,M.
  TITLE     NLRP3 Inflammasome Activation Through Heart-Brain Interaction
            Initiates Cardiac Inflammation and Hypertrophy During Pressure
            Overload
  JOURNAL   Circulation 147 (4), 338-355 (2023)
   PUBMED   36440584
REFERENCE   3  (bases 1 to 2197)
  AUTHORS   Kato,Y., Ohsugi,K., Fukuno,Y., Iwatsuki,K., Harada,Y. and Miyaji,T.
  TITLE     Vesicular nucleotide transporter is a molecular target of
            eicosapentaenoic acid for neuropathic and inflammatory pain
            treatment
  JOURNAL   Proc Natl Acad Sci U S A 119 (30), e2122158119 (2022)
   PUBMED   35858418
REFERENCE   4  (bases 1 to 2197)
  AUTHORS   Alcada-Morais,S., Goncalves,N., Moreno-Juan,V., Andres,B.,
            Ferreira,S., Marques,J.M., Magalhaes,J., Rocha,J.M.M., Xu,X.,
            Partidario,M., Cunha,R.A., Lopez-Bendito,G. and Rodrigues,R.J.
  TITLE     Adenosine A2A Receptors Contribute to the Radial Migration of
            Cortical Projection Neurons through the Regulation of Neuronal
            Polarization and Axon Formation
  JOURNAL   Cereb Cortex 31 (12), 5652-5663 (2021)
   PUBMED   34184030
REFERENCE   5  (bases 1 to 2197)
  AUTHORS   Hasuzawa,N., Tatsushima,K., Wang,L., Kabashima,M., Tokubuchi,R.,
            Nagayama,A., Ashida,K., Ogawa,Y., Moriyama,Y. and Nomura,M.
  TITLE     Clodronate, an inhibitor of the vesicular nucleotide transporter,
            ameliorates steatohepatitis and acute liver injury
  JOURNAL   Sci Rep 11 (1), 5192 (2021)
   PUBMED   33664289
  REMARK    GeneRIF: Clodronate, an inhibitor of the vesicular nucleotide
            transporter, ameliorates steatohepatitis and acute liver injury.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2197)
  AUTHORS   Larsson,M., Sawada,K., Morland,C., Hiasa,M., Ormel,L., Moriyama,Y.
            and Gundersen,V.
  TITLE     Functional and anatomical identification of a vesicular transporter
            mediating neuronal ATP release
  JOURNAL   Cereb Cortex 22 (5), 1203-1214 (2012)
   PUBMED   21810784
  REMARK    GeneRIF: VNUT mediates transport of ATP into synaptic vesicles of
            hippocampal neurons.
REFERENCE   7  (bases 1 to 2197)
  AUTHORS   Sathe,M.N., Woo,K., Kresge,C., Bugde,A., Luby-Phelps,K., Lewis,M.A.
            and Feranchak,A.P.
  TITLE     Regulation of purinergic signaling in biliary epithelial cells by
            exocytosis of SLC17A9-dependent ATP-enriched vesicles
  JOURNAL   J Biol Chem 286 (28), 25363-25376 (2011)
   PUBMED   21613220
  REMARK    GeneRIF: the existence of an SLC17A9-dependent ATP-enriched
            vesicular pool in biliary epithelium that undergoes regulated
            exocytosis to initiate purinergic signaling.
REFERENCE   8  (bases 1 to 2197)
  AUTHORS   Tokunaga,A., Tsukimoto,M., Harada,H., Moriyama,Y. and Kojima,S.
  TITLE     Involvement of SLC17A9-dependent vesicular exocytosis in the
            mechanism of ATP release during T cell activation
  JOURNAL   J Biol Chem 285 (23), 17406-17416 (2010)
   PUBMED   20382737
  REMARK    GeneRIF: analysis of involvement of SLC17A9-dependent vesicular
            exocytosis in the mechanism of ATP release during T cell activation
REFERENCE   9  (bases 1 to 2197)
  AUTHORS   Sawada,K., Echigo,N., Juge,N., Miyaji,T., Otsuka,M., Omote,H.,
            Yamamoto,A. and Moriyama,Y.
  TITLE     Identification of a vesicular nucleotide transporter
  JOURNAL   Proc Natl Acad Sci U S A 105 (15), 5683-5686 (2008)
   PUBMED   18375752
  REMARK    GeneRIF: SLC17A9 protein acts as a vesicular nucleotide transporter
            (VNUT) and plays an essential role in vesicular storage of ATP in
            the ATP-secreting cells
REFERENCE   10 (bases 1 to 2197)
  AUTHORS   Piao,Y., Ko,N.T., Lim,M.K. and Ko,M.S.
  TITLE     Construction of long-transcript enriched cDNA libraries from
            submicrogram amounts of total RNAs by a universal PCR amplification
            method
  JOURNAL   Genome Res 11 (9), 1553-1558 (2001)
   PUBMED   11544199
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG087579.2, CF165170.1, BE850231.1, AK006122.1 and AW554829.2.
            
            On Feb 8, 2007 this sequence version replaced NM_183161.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN00849374,
                              SAMN00849375 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-551               BG087579.2         1-551
            552-876             CF165170.1         38-362
            877-1115            BE850231.1         6-244
            1116-2066           AK006122.1         481-1431
            2067-2197           AW554829.2         1-131               c
FEATURES             Location/Qualifiers
     source          1..2197
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 103.28 cM"
     gene            1..2197
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /note="solute carrier family 17, member 9"
                     /db_xref="GeneID:228993"
                     /db_xref="MGI:MGI:1919107"
     exon            1..113
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     CDS             22..1365
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /note="vesicular nucleotide transporter"
                     /codon_start=1
                     /product="voltage-gated purine nucleotide uniporter
                     SLC17A9"
                     /protein_id="NP_898984.3"
                     /db_xref="CCDS:CCDS38378.1"
                     /db_xref="GeneID:228993"
                     /db_xref="MGI:MGI:1919107"
                     /translation="MPSQRSSLMQPIPEETRKTPSAAAEDTRWSRPECQAWTGILLLG
                     TCLLYCARVTMPVCTVAMSQDFGWNKKEAGIVLSSFFWGYCLTQVVGGHLGDRIGGEK
                     VILLSASAWGFITVTTPLLAHLGSGHLAFLTFSRILTGLLQGVYFPALTSLLSQKVQE
                     SERAFTYSTVGAGSQVGTLVTGGVGSVLLDQCGWQSVFYFSGGLTLLWAYYVYRYLLN
                     EKDLVLALGFLAQGLPVTKPSKVPWRQLFRKASVWAAICSQLCSACSFFILLSWLPTF
                     FKETFPNSKGWVFNVVPWMLAIPASLFSGFISDRLISQGYRVITVRKFMQVMGLGLSS
                     IFALCLGHTTSFLKAMIFASASIGFQTFNHSGISVNIQDLAPSCAGFLFGVANTAGAL
                     AGVVGVCLSGYLIETTGSWTCVFHLVAIISNLGLGTFLVFGKAQRVDLVPTHEDL"
     exon            114..311
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            312..451
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            452..551
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            552..682
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            683..779
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            780..876
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            877..964
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            965..999
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1115
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1171
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..1201
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
     exon            1202..2197
                     /gene="Slc17a9"
                     /gene_synonym="1700019H03Rik; Vnut"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcacggtaca cagcggtgcc catgccatcc cagcgctcta gcctgatgca gccaatccca
       61 gaggagaccc gcaagacccc ttctgcggca gcagaggata cacggtggtc caggcctgaa
      121 tgccaggcct ggacaggaat cctgctcctg ggcacctgcc tgctgtactg cgcccgagtc
      181 accatgcccg tctgtactgt tgccatgagc caggactttg gctggaacaa gaaggaggct
      241 ggtatcgtgc tcagcagctt cttctggggc tactgcctga ctcaggtggt gggcggccac
      301 cttggggatc gcatcggagg agagaaggtc atcttgctgt cagcctccgc ctggggcttc
      361 attactgtca ccacaccact gcttgcgcac ctcggcagcg gccacctggc cttcctgaca
      421 ttctctcgaa tcctcaccgg tctgctccaa ggtgtctact ttccagccct gaccagtctg
      481 ctgtcccaga aagtacagga gagcgagaga gcctttacct acagcactgt gggtgctggc
      541 tcccaggtcg ggaccctggt gactgggggc gtaggctccg tgctcctgga ccagtgtggc
      601 tggcagagtg tcttctactt ctcaggtggc ctcaccttgc tctgggcgta ctatgtgtac
      661 aggtacctgc tgaatgagaa agaccttgtc ctggccctgg gattccttgc tcaaggccta
      721 cctgtgacca agccctccaa agtgccctgg agacaactat tccggaaggc ctctgtctgg
      781 gcggcaatct gctcccagtt gtgctctgct tgctccttct tcattctact ctcctggctg
      841 cccaccttct tcaaggagac cttccccaac tccaagggct gggtcttcaa tgtagtcccc
      901 tggatgctgg caattcctgc tagtctattc agtgggttca tctccgaccg ccttatcagt
      961 cagggttaca gagtcatcac ggtgcgtaag ttcatgcagg tcatgggcct tggtctgtca
     1021 agcatttttg ccctgtgtct gggtcatacc acaagcttcc tcaaggctat gatctttgca
     1081 tcagcttcca ttggcttcca gaccttcaac cacagtggta tttcagtcaa cattcaggac
     1141 ctggccccat cctgtgctgg cttcctgttt ggtgtagcca acactgcagg ggccttagca
     1201 ggtgtggtag gcgtgtgtct gagtggctac ctgatcgaga ccactggttc ctggacctgt
     1261 gtgttccacc tggtagccat catcagcaac ctggggctgg gcaccttcct ggtgttcggg
     1321 aaggcgcaga gggtggacct ggtccccact catgaggacc tctaactccc tgacgatcca
     1381 gtcacccagg acctgatgtc agcagcctga ggataacaac cctgtcagtg aaacggaatc
     1441 tccaccccag acgtatgagc atacagcaag accacagttt cctggggagg cctgagtaca
     1501 cacaggcctg tgtcaggagg agggtcatgg ctccaaatcc gcttgccagt cccgccctct
     1561 ctcaggttca gtgggactgc cactgttaag gaagccacgt tgctgatggg aggtctcacc
     1621 ggccacagtg agggttgttt cctgacaaga cttttgtgtt aaggatgtgt tgtgtgctgg
     1681 tagatgttca ggagtggctc tgacccccaa cctactctgg gcaccttcct acccccatct
     1741 ctccagcaac aataacctaa gatgtctata gacattagac catgtctcca taagacaggc
     1801 ccactagaaa caccgttcag aaccatagag aagccatggt ttctgcttct ctccaggagt
     1861 caggcttgcc actccagctg ggccggtgtg cagtgggcca gggtcctcac ctgccttgca
     1921 gaccctggtt cccgccctgt ggatctctca gcactactga tgtgtcctgg gttggcaggt
     1981 gcctggcagt ccagacatca cagaccccag aacaaggtga aacccccccc ccccatttct
     2041 ggccttgttt ttctacctcc cgcacttatt tcttgtagag cttgtggttt catgagctga
     2101 taatgaattc tccaagatgc ctattagatt ttctttatag atgtggtgag tcttgccaga
     2161 gccttattta agtgaaaact attaaactat ttaaagt
//
