LOCUS       NM_182959               4452 bp    mRNA    linear   ROD 18-FEB-2025
DEFINITION  Mus musculus solute carrier family 17 (sodium-dependent inorganic
            phosphate cotransporter), member 8 (Slc17a8), transcript variant 1,
            mRNA.
ACCESSION   NM_182959
VERSION     NM_182959.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4452)
  AUTHORS   Sun,Y., Ren,M., Zhang,Y., Li,S., Luo,Z., Sun,S., He,S., Wang,G.,
            Zhang,D., Mansour,S.L., Song,L. and Liu,Z.
  TITLE     Casz1 is required for both inner hair cell fate stabilization and
            outer hair cell survival
  JOURNAL   Science, eado4930 (2025) In press
   PUBMED   39883789
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4452)
  AUTHORS   O'Connor,A.P., Amariutei,A.E., Zanella,A., Hool,S.A., Carlton,A.J.,
            Kong,F., Saenz-Roldan,M., Jeng,J.Y., Lecomte,M.J., Johnson,S.L.,
            Safieddine,S. and Marcotti,W.
  TITLE     In vivo AAV9-Myo7a gene rescue restores hearing and cholinergic
            efferent innervation in inner hair cells
  JOURNAL   JCI Insight 9 (23), e182138 (2024)
   PUBMED   39641274
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4452)
  AUTHORS   Regalado Nunez,K., Bronson,D., Chang,R. and Kalluri,R.
  TITLE     Vestibular afferent neurons develop normally in the absence of
            quantal/glutamatergic input
  JOURNAL   Front Neurol 15, 1441964 (2024)
   PUBMED   39655160
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4452)
  AUTHORS   de Haan,S., Corbat,A.A., Cederroth,C.R., Autrum,L.G., Hankeova,S.,
            Driver,E.C., Canlon,B., Kelley,M.W. and Andersson,E.R.
  TITLE     Jag1 represses Notch activation in lateral supporting cells and
            inhibits an outer hair cell fate in the medial cochlea
  JOURNAL   Development 151 (21) (2024)
   PUBMED   39373109
REFERENCE   5  (bases 1 to 4452)
  AUTHORS   Stinson,H.E. and Ninan,I.
  TITLE     Median raphe glutamatergic neuron-mediated enhancement of GABAergic
            transmission and suppression of long-term potentiation in the
            hippocampus
  JOURNAL   Heliyon 10 (19), e38192 (2024)
   PUBMED   39386853
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4452)
  AUTHORS   Ruel,J., Emery,S., Nouvian,R., Bersot,T., Amilhon,B., Van
            Rybroek,J.M., Rebillard,G., Lenoir,M., Eybalin,M., Delprat,B.,
            Sivakumaran,T.A., Giros,B., El Mestikawy,S., Moser,T., Smith,R.J.,
            Lesperance,M.M. and Puel,J.L.
  TITLE     Impairment of SLC17A8 encoding vesicular glutamate transporter-3,
            VGLUT3, underlies nonsyndromic deafness DFNA25 and inner hair cell
            dysfunction in null mice
  JOURNAL   Am J Hum Genet 83 (2), 278-292 (2008)
   PUBMED   18674745
  REMARK    GeneRIF: SLC17A8 encodes vesicular glutamate transporter-3, VGLUT3
            and its impairment has a role in nonsyndromic deafness DFNA25 and
            inner hair cell dysfunction
REFERENCE   7  (bases 1 to 4452)
  AUTHORS   Gras,C., Amilhon,B., Lepicard,E.M., Poirel,O., Vinatier,J.,
            Herbin,M., Dumas,S., Tzavara,E.T., Wade,M.R., Nomikos,G.G.,
            Hanoun,N., Saurini,F., Kemel,M.L., Gasnier,B., Giros,B. and El
            Mestikawy,S.
  TITLE     The vesicular glutamate transporter VGLUT3 synergizes striatal
            acetylcholine tone
  JOURNAL   Nat Neurosci 11 (3), 292-300 (2008)
   PUBMED   18278042
  REMARK    GeneRIF: Loss of Vglut3 caused a hypocholinergic striatal
            phenotype. In Vglut3(-/-) mice, acetylcholine release was decreased
            in striatum slices lacking VGLUT3.
REFERENCE   8  (bases 1 to 4452)
  AUTHORS   Mackenzie,B., Illing,A.C., Morris,M.E., Varoqui,H. and
            Erickson,J.D.
  TITLE     Analysis of a vesicular glutamate transporter (VGLUT2) supports a
            cell-leakage mode in addition to vesicular packaging
  JOURNAL   Neurochem Res 33 (2), 238-247 (2008)
   PUBMED   18080752
REFERENCE   9  (bases 1 to 4452)
  AUTHORS   Seal,R.P., Akil,O., Yi,E., Weber,C.M., Grant,L., Yoo,J., Clause,A.,
            Kandler,K., Noebels,J.L., Glowatzki,E., Lustig,L.R. and
            Edwards,R.H.
  TITLE     Sensorineural deafness and seizures in mice lacking vesicular
            glutamate transporter 3
  JOURNAL   Neuron 57 (2), 263-275 (2008)
   PUBMED   18215623
  REMARK    GeneRIF: Sensorineural deafness and seizures in mice lacking
            vesicular glutamate transporter 3.
REFERENCE   10 (bases 1 to 4452)
  AUTHORS   Schafer,M.K., Varoqui,H., Defamie,N., Weihe,E. and Erickson,J.D.
  TITLE     Molecular cloning and functional identification of mouse vesicular
            glutamate transporter 3 and its expression in subsets of novel
            excitatory neurons
  JOURNAL   J Biol Chem 277 (52), 50734-50748 (2002)
   PUBMED   12384506
  REMARK    GeneRIF: cloning and functionally characterization; expressed on
            synaptic vesicles that identifies a distinct glutamatergic system
            in the brain that is partly and selectively promiscuous with
            cholinergic and serotoninergic transmission (VGLUT3)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC127279.3 and AF510321.1.
            
            On Aug 26, 2009 this sequence version replaced NM_182959.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC042593.1, AF510321.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164135, SAMN01164141
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-329               AC127279.3         71616-71944
            330-826             AF510321.1         1-497
            827-862             AC127279.3         92627-92662
            863-2068            AF510321.1         534-1739
            2069-4452           AC127279.3         116462-118845
FEATURES             Location/Qualifiers
     source          1..4452
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 44.99 cM"
     gene            1..4452
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /note="solute carrier family 17 (sodium-dependent
                     inorganic phosphate cotransporter), member 8"
                     /db_xref="GeneID:216227"
                     /db_xref="MGI:MGI:3039629"
     exon            1..451
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     CDS             351..2156
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /note="isoform 1 is encoded by transcript variant 1;
                     vesicular glutamate transporter 3; solute carrier family
                     17 member 8"
                     /codon_start=1
                     /product="vesicular glutamate transporter 3 isoform 1"
                     /protein_id="NP_892004.1"
                     /db_xref="CCDS:CCDS24117.1"
                     /db_xref="GeneID:216227"
                     /db_xref="MGI:MGI:3039629"
                     /translation="MPFKAFDTFKEKILKPGKEGVKNAVGDSLGILQRKIDGTNEEED
                     AIELNEEGRPVQTSRAHRPVCDCSCCGIPKRYICDCSCCGIPKRYIIAVMSGLGFCIS
                     FGIRCNLGVAIVEMVNNSTVYVDGKPEIQTAQFNWDPETVGLIHGSFFWGYIVTQIPG
                     GFISNKFAASRVFGAAIFLTSTLNMFIPSAARVHYGCVMGVRILQGLVEGVTYPACHG
                     MWSKWAPPLERSRLATTSFCGSYAGAVVAMPLAGVLVQYIGWASVFYIYGMFGIIWYM
                     FWLLQAYECPAAHPTISNAERTYIETSIGEGANLASLSKFNTPWRRFFTSLPVYAIIV
                     ANFCRSWTFYLLLISQPAYFEEVFGFAISKVGLLSAVPHMVMTIVVPIGGQLADYLRS
                     RKILTTTAVRKIMNCGGFGMEATLLLVVGFSHTKGVAISFLVLAVGFSGFAISGFNVN
                     HLDIAPRYASILMGISNGVGTLSGMVCPLIVGAMTKHKTREEWQNVFLIAALVHYSGV
                     IFYGVFASGEKQDWADPENLSEDKCGIIDQDELAEETELNHETFVSPRKKMSYGATTQ
                     NCEVQKTEWRQQRESAFDGEEPLSYQAEGDFSETS"
     exon            452..743
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            744..862
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            863..977
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            978..1065
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1152
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1153..1292
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1293..1442
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1443..1575
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1576..1686
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..1814
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     exon            1815..4452
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      3268
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
     regulatory      4432..4437
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /note="hexamer: ATTAAA"
     polyA_site      4452
                     /gene="Slc17a8"
                     /gene_synonym="Vglut3; Vgt3"
                     /note="major polyA site"
ORIGIN      
        1 ccagggatac aggctgtgct cattctgagc ttggctgccc gagacagcgg ccacaggctg
       61 ctgctcagcc agtagctttt tgcaaggggc tggattcctc cccagcaact cctcactcag
      121 ctttgttgat tctggatcga gaggagaagg gtttgtctct tcttggaacc cctgagctgg
      181 ggtttttacc tcctttctga ttttaagtag ttccctccat gagaactgaa tttcaagtgt
      241 tcctccaggg caagcgcagt gcccgtgggc tggagttgag agaggatgac agcttctgag
      301 gttgcctcct aagggctctg aggtgcctcc tccatcgccc cccgttcaaa atgccattta
      361 aagcatttga taccttcaaa gaaaagattt tgaaacctgg gaaggaagga gtgaagaatg
      421 ccgtgggaga ctcgctgggc atcttacaaa gaaaaatcga tgggaccaat gaagaggaag
      481 atgccattga gctgaatgaa gaaggaaggc ccgtgcagac gtccagagca catcgccctg
      541 tctgtgactg cagctgctgc ggcatcccca agcggtacat ctgtgactgc agctgctgcg
      601 gcatccccaa acggtacatc attgctgtca tgagcggcct cggcttctgc atttcctttg
      661 ggattcggtg caaccttgga gtggccattg tggaaatggt caacaatagc actgtgtatg
      721 tggatgggaa accagaaatt cagacagcgc agtttaactg ggacccagag acggtgggcc
      781 tgatccatgg atcttttttc tggggttata ttgtgacaca aattcccggt ggcttcattt
      841 caaacaagtt tgctgctagc agggtctttg gagccgccat cttcttgaca tcaactctga
      901 acatgtttat cccttctgcg gcgagggtgc attacggctg tgtcatgggt gtgaggattt
      961 tgcagggtct ggtggagggt gtgacctacc ctgcctgcca tgggatgtgg agtaagtggg
     1021 cgcctcccct ggagagaagc cgtctagcca cgacttcctt ctgtggttcc tatgctgggg
     1081 cagttgttgc tatgcctctt gcaggggtat tggtgcagta cattggctgg gcctctgtct
     1141 tttacatcta cggtatgttt gggattattt ggtatatgtt ttggctgctg caggcttatg
     1201 agtgcccggc agctcaccca acaatatcca atgcagaaag gacctacata gagacaagca
     1261 taggagaagg ggccaacttg gccagtctga gcaaattcaa cacaccatgg agaaggtttt
     1321 tcacatcctt gcctgtctat gccatcattg tggcaaactt ctgtagaagc tggaccttct
     1381 atttgctcct gataagtcag ccagcttact ttgaggaggt ctttggattt gcaataagta
     1441 aggtgggtct cttgtcagct gtcccacaca tggtgatgac aatcgtggtg cccatcggag
     1501 gacaactggc tgattattta agaagccgaa agattttgac cacaaccgct gtcagaaaga
     1561 tcatgaattg tggaggcttt ggcatggagg caaccttgct cctggtggtt ggattttccc
     1621 ataccaaagg agtggctatc tccttcctgg tgcttgctgt aggatttagt ggctttgcta
     1681 tttcaggctt caatgtcaac cacctggaca ttgctccacg ctatgccagc atcctcatgg
     1741 ggatctcaaa tggtgtgggg accctctctg gaatggtttg tcccctcatt gttggtgcaa
     1801 tgactaagca caagacccgg gaggagtggc agaatgtgtt cctcatagca gcgctggtac
     1861 actacagcgg agtcatcttc tacggggtct tcgcttctgg ggaaaaacag gactgggctg
     1921 acccagagaa tctctctgag gacaaatgtg gaatcattga ccaagatgag ttagctgagg
     1981 agacagaact caaccacgag actttcgtaa gtcccagaaa gaagatgtct tatggagcca
     2041 ccacccagaa ttgtgaggtc cagaagacgg agtggagaca acagagagaa tctgccttcg
     2101 acggggagga gccattatcc taccaggccg aaggagactt ctcagaaaca tcctaaatgt
     2161 ctggcttcac ctcagcttac aactggaagt atcgcaccca tcgcctttcc catactgcgt
     2221 cttgccaggg ggccaaatcg tgggaaaggg ggagattaaa ttaacaacag agaaaagaaa
     2281 cacgccttct tacaaagatg ggaatatgga ccttggtctc agttgataaa atagttgatc
     2341 atatttgggg ttggggtgtg gattgggcat tggccgttga gccttctctc aaaagaacta
     2401 gttattcagg aattaatggt gagaagaata aggagtagca tgttgctcaa ataaacactg
     2461 gaagaaatcc ctctttgttc tggagaagag tacatggtgg ttgccatcac atctcttagg
     2521 atactcatgt agaggagttt cctaaaccta atgaagggaa tcactcatgg gggcccttgg
     2581 ttgtgccagg tgctttgtga acattattta acactcacac cctaatacag ttatacctgt
     2641 tttacaatag gttggtctac ccaaggtcgt cctctcagga ccaaggctga gaatggcaga
     2701 tgagcgggag ttataggaag gaaggaagga aggaaggaag gaagggaggg agggagggag
     2761 ggagggagga aggaaggaag gaaggaagga aggaaggaag gaaggaagga aggaaggaag
     2821 gaaggagaga aggaagggtt cagctcattg tagagacatt ttcaatgaca aaaactaaaa
     2881 ctgaagtcag ctgttttgta ggtaattcca tgtttggtca agggtgtgtg tgtgtgtgtg
     2941 tgtgtgtttg tatatatgta aatatttaaa ctaatatgga agagggaatt caaacatatg
     3001 aaattctaaa agcaaaaacc cttaagatat tatattaact gttggaccaa acaatttgtt
     3061 aatcaatggc ctttttattt tttaaaaaag tcacagtcta gtaaaatact taaagctaag
     3121 caagagctgg gcatggtggc gcacaccttt aatcccagca ctcgggaggc agaggaaggc
     3181 gatttctgag ttcaaggcca gcctggtcta caaagtgaat tccaggacag ccagggctat
     3241 acagagaaac cctgtctcaa aaaaccaggg ggaaaaaaaa agctaagcaa gatagctcag
     3301 tttccaggaa tggttgaaaa gaagtatata aaggagtggc cattaaattt aaccccccta
     3361 gagtatcagg aattttttta aataatgtct caagttaact atgagcccct aaggcagtta
     3421 atacctaaga agcaggttca ggggagacta ttacgtaaat agtctgttta ctatttacgt
     3481 aatagtatct tgaaaagaat cttgttcaaa caaatgggtg tcattagctt tcttggaaag
     3541 tatggtcaga tgatataaaa ctatgcccaa aagactcaca atgactccat ctggcatgtt
     3601 cacagaaaac gaaagcacag cagtagtttt atagagaaat attgcagtca acatatttga
     3661 gagaaccagg cctataatag gtattgggga atttatctgt gattgtgtag ggcaataaca
     3721 tggatattct ctaaatacat ttaaaatgta atgttaacat gtaagagtat tagaaaataa
     3781 aactattttc ttgctcttca gttttgaaat ttttatttct gttttcagga ggaaagtgta
     3841 atatgatgat aaaatataaa tttacttgca taatatttat tttctagttt ttttccattt
     3901 tatttctgaa cccccccttg ttatacttaa ggagttataa tgcactttat aaaaagacta
     3961 atcatagatt tttaaaactt cccattaaat aatattcttt atatcatttg tagatagttt
     4021 gtgttatcag atgttgttag atctccttat tgtgtgaatc cacgtaagtc ccctagaaca
     4081 gttatgggca taaagaagca ctcaagaaat agctgtcaca ttggcattat ctttaactct
     4141 tgtgtgacca tgtcatctgt gaagagtgtt gtgtcatttc atgcattggc cacagagttt
     4201 attatgaaaa ttatactgtt ttcttagtaa aaaaatagga aaaatgtgtt tatttctttg
     4261 tgtgttaata aaacataact ataagtatga aaaaagcctc atgatgatca tgaaggcaat
     4321 gtagattatg gcacaatctg ttgttagtgt tgacatcatg cagaaatacc acattttgct
     4381 tttaacctgc ttgtatgatc tatttttttt aatggtgggc tggatcgtgg cattaaacac
     4441 aataaagcac ga
//
