LOCUS       NM_080853               4338 bp    mRNA    linear   ROD 18-MAR-2025
DEFINITION  Mus musculus solute carrier family 17 (sodium-dependent inorganic
            phosphate cotransporter), member 6 (Slc17a6), transcript variant 1,
            mRNA.
ACCESSION   NM_080853
VERSION     NM_080853.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4338)
  AUTHORS   Lee,A.S., Arefin,T.M., Gubanova,A., Stephen,D.N., Liu,Y., Lao,Z.,
            Krishnamurthy,A., De Marco Garcia,N.V., Heck,D.H., Zhang,J.,
            Rajadhyaksha,A.M. and Joyner,A.L.
  TITLE     Cerebellar output neurons can impair non-motor behaviors by
            altering development of extracerebellar connectivity
  JOURNAL   Nat Commun 16 (1), 1858 (2025)
   PUBMED   39984491
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4338)
  AUTHORS   Laing,B.T., Anderson,M.S., Jayan,A., Park,A.S., Erbaugh,L.J.,
            Solis,O., Wilson,D.J., Michaelides,M. and Aponte,Y.
  TITLE     Repetitive Grooming Behavior Following Aversive Stimulus Coincides
            with a Decrease in Anterior Hypothalamic Area Activity
  JOURNAL   eNeuro 12 (1) (2025)
   PUBMED   39837667
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4338)
  AUTHORS   Zhang,H., Deska-Gauthier,D., MacKay,C.S., Hari,K., Lucas-Osma,A.M.,
            Borowska-Fielding,J., Letawsky,R.L., Rancic,V., Akay,T.,
            Fenrich,K.K., Bennett,D.J. and Zhang,Y.
  TITLE     Widespread innervation of motoneurons by spinal V3 neurons globally
            amplifies locomotor output in mice
  JOURNAL   Cell Rep 44 (1), 115212 (2025)
   PUBMED   39817902
REFERENCE   4  (bases 1 to 4338)
  AUTHORS   Huey,E.L., Turecek,J., Delisle,M.M., Mazor,O., Romero,G.E., Dua,M.,
            Sarafis,Z.K., Hobble,A., Booth,K.T., Goodrich,L.V., Corey,D.P. and
            Ginty,D.D.
  TITLE     The auditory midbrain mediates tactile vibration sensing
  JOURNAL   Cell 188 (1), 104-120 (2025)
   PUBMED   39701100
REFERENCE   5  (bases 1 to 4338)
  AUTHORS   Korkutata,M., De Luca,R., Fitzgerald,B., Khanday,M.A., Arrigoni,E.
            and Scammell,T.E.
  TITLE     Afferent Projections to the Calca/CGRP-Expressing Parabrachial
            Neurons in Mice
  JOURNAL   J Comp Neurol 533 (1), e70018 (2025)
   PUBMED   39801453
REFERENCE   6  (bases 1 to 4338)
  AUTHORS   Cheng,L., Arata,A., Mizuguchi,R., Qian,Y., Karunaratne,A.,
            Gray,P.A., Arata,S., Shirasawa,S., Bouchard,M., Luo,P., Chen,C.L.,
            Busslinger,M., Goulding,M., Onimaru,H. and Ma,Q.
  TITLE     Tlx3 and Tlx1 are post-mitotic selector genes determining
            glutamatergic over GABAergic cell fates
  JOURNAL   Nat Neurosci 7 (5), 510-517 (2004)
   PUBMED   15064766
REFERENCE   7  (bases 1 to 4338)
  AUTHORS   Miyazaki,T., Fukaya,M., Shimizu,H. and Watanabe,M.
  TITLE     Subtype switching of vesicular glutamate transporters at parallel
            fibre-Purkinje cell synapses in developing mouse cerebellum
  JOURNAL   Eur J Neurosci 17 (12), 2563-2572 (2003)
   PUBMED   12823463
  REMARK    GeneRIF: Subtype switching of vesicular glutamate transporters at
            parallel fibre-Purkinje cell synapses in developing mouse
            cerebellum.
REFERENCE   8  (bases 1 to 4338)
  AUTHORS   Raab,M. and Neuhuber,W.L.
  TITLE     Vesicular glutamate transporter 2 immunoreactivity in putative
            vagal mechanosensor terminals of mouse and rat esophagus:
            indication of a local effector function?
  JOURNAL   Cell Tissue Res 312 (2), 141-148 (2003)
   PUBMED   12698357
  REMARK    GeneRIF: VGLUT2 is found in vagal afferent endings in the
            esophagus, suggesting that glutamate is contained in, and probably
            released from, synaptic vesicles previously described in
            intraganglionic laminar endings
REFERENCE   9  (bases 1 to 4338)
  AUTHORS   Nunzi,M.G., Russo,M. and Mugnaini,E.
  TITLE     Vesicular glutamate transporters VGLUT1 and VGLUT2 define two
            subsets of unipolar brush cells in organotypic cultures of mouse
            vestibulocerebellum
  JOURNAL   Neuroscience 122 (2), 359-371 (2003)
   PUBMED   14614902
  REMARK    GeneRIF: Mossy terminals of unipolar brush cells are immunoreactive
            for VGLUT2; moreover, dendritic brushes are contacted by mossy
            terminals expressing VGLUT2 in organotypic cultures of mouse
            vestibulocerebellum.
REFERENCE   10 (bases 1 to 4338)
  AUTHORS   Bai,L., Xu,H., Collins,J.F. and Ghishan,F.K.
  TITLE     Molecular and functional analysis of a novel neuronal vesicular
            glutamate transporter
  JOURNAL   J Biol Chem 276 (39), 36764-36769 (2001)
   PUBMED   11432869
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB519039.1, AF324864.1, BC038375.1, BB304814.2 and CD578992.1.
            
            On May 15, 2008 this sequence version replaced NM_080853.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK045409.1, SRR1660821.126778.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164132
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-176               CB519039.1         1-176
            177-621             AF324864.1         10-454
            622-3956            BC038375.1         1-3335
            3957-4313           BB304814.2         325-681
            4314-4338           CD578992.1         626-650
FEATURES             Location/Qualifiers
     source          1..4338
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 32.78 cM"
     gene            1..4338
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /note="solute carrier family 17 (sodium-dependent
                     inorganic phosphate cotransporter), member 6"
                     /db_xref="GeneID:140919"
                     /db_xref="MGI:MGI:2156052"
     exon            1..891
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             806..2554
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     solute carrier family 17 (vesicular glutamate
                     transporter), member 6; vesicular glutamate transporter 2;
                     differentiation-associated Na(+)-dependent inorganic
                     phosphate cotransporter; differentiation-associated BNPI;
                     solute carrier family 17 member 6"
                     /codon_start=1
                     /product="vesicular glutamate transporter 2 isoform 1"
                     /protein_id="NP_543129.3"
                     /db_xref="CCDS:CCDS39969.1"
                     /db_xref="GeneID:140919"
                     /db_xref="MGI:MGI:2156052"
                     /translation="MESVKQRILAPGKEGIKNFAGKSLGQIYRVLEKKQDNRETIELT
                     EDGKPLEVPEKKAPLCDCTCFGLPRRYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNS
                     TIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAIL
                     LTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTS
                     FCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITD
                     EERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQP
                     AYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGG
                     FGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISN
                     GVGTLSGMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADP
                     EETSEEKCGFIHEDELDEETGDITQNYINYGTTKSYGATSQENGGWPNGWEKKEEFVQ
                     EGAQDAYTYKDRDDYS"
     exon            892..1144
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1263
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1378
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1379..1466
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1467..1553
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1554..1696
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1846
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..1979
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2090
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2091..2218
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2219..4320
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4287..4292
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /note="hexamer: AATAAA"
     polyA_site      4317
                     /gene="Slc17a6"
                     /gene_synonym="2900073D12Rik; DNPI; VGLUT2"
                     /note="major polyA site"
ORIGIN      
        1 gccaaaagca gcagccaagg ttccttagct tcctctgtcc gtggtcctga aatgctaaac
       61 tgcgccgcgc gcactgacgg gagcggtcag gttttatgga aggtctcccc cggcgctgcc
      121 taaaccacag ctgtgtgtct gttattcact cacgttcgca aagatcagct aacattctca
      181 gtcttaattc cactctgcca ctctgccgca gagcacaatt acgccggcgc gatgggagga
      241 gaccatgtta aggcaggaag ctaacagcag ccgctcacct gaggcctagg aagctcccaa
      301 gggttctgag agctatgagc tctgatcagc aaagtcacca ttttagacag tagggttctt
      361 ttgctttttt ccttacacaa gggttcgatg acgtttctgg tcaatctgat taaaagacag
      421 cggatttgat tgcgataaga cttcaaaacc gggaatttac gttgtttttc ggtgaggtga
      481 cttccagaac agggactcat cagcacccgc ccaaatacca cggcactgcg cgcgccctcg
      541 gccaccggat cctccccttc caatgagact ttgtgactgt gtgtaccaat tctcctatta
      601 ggaaacccgt gggctgcatg cagctattct gttgtactct ctttctcgcc ctccctcccc
      661 tctccaactc acagccttgc tggaaagctc acctctgctg agaagaaaaa gctctacctt
      721 aaccaactaa gactatgcgc agaatccgtc tttcatagcc acaacaattt aaatctggta
      781 aggctggaca ccagtcttta caagaatgga gtcggtaaaa caaaggattt tggccccggg
      841 gaaagagggg ataaagaatt ttgctggaaa atccctcgga cagatctaca gggtgctgga
      901 gaagaagcag gacaaccgag agaccatcga gctgacagag gacggtaagc ccctggaggt
      961 gcctgagaag aaggctccgc tatgcgactg cacgtgcttc ggcctgccgc gccgctacat
     1021 catagccatc atgagcggcc tcggcttctg catatccttc ggcatccgct gtaacctggg
     1081 cgtggccatc gtggacatgg tcaacaacag cactatccac cgcggaggca aagttatcaa
     1141 ggagaaagcc aaatttaact gggaccccga gaccgtgggg atgatccacg gatcgttctt
     1201 ctggggctat atcatcaccc agattccagg aggatatatc gcatcgcggc tggctgctaa
     1261 ccgggtcttt ggggctgcga tactgctcac ctctaccctc aatatgctga tcccatctgc
     1321 agccagagtg cattatggat gtgtcatctt tgttaggata ttgcaaggac ttgtggaggg
     1381 tgtcacctac ccagcctgtc atgggatatg gagcaagtgg gcccctccct tggagaggag
     1441 taggttggct acaacctcct tttgtggttc ctatgctgga gcagtcattg caatgccctt
     1501 agctggtatc cttgtgcagt acactggatg gtcgtcagta ttttatgtgt atggaagctt
     1561 tggcatggtc tggtacatgt tctggcttct ggtgtcttat gagagccctg caaagcatcc
     1621 taccattaca gatgaagaac gtaggtacat agaggagagc attggagaga gcgcaaatct
     1681 gctaggtgca atggaaaaat ttaagacccc atggaggaag tttttcacat ccatgcccgt
     1741 ctacgcgata attgttgcca acttctgcag gagctggact ttttatttac tgctcatcag
     1801 tcagccagct tattttgagg aggtttttgg atttgaaatc agcaaggttg gcatgttgtc
     1861 tgcagtccct caccttgtca tgacaatcat tgtgcctatc ggggggcaaa ttgcagattt
     1921 cctaaggagc aagcaaattc tctcaacaac tacagtgaga aagatcatga attgtggggg
     1981 ttttggcatg gaagccacgc tgcttctggt tgttggctac tctcatacta gaggggtggc
     2041 catctccttc ttggtgcttg cagtaggatt cagtggattt gctatctctg gtttcaatgt
     2101 taatcacttg gatattgctc caagatatgc cagtatctta atgggcattt caaatggcgt
     2161 tggcacgctg tcggggatgg tttgccctat cattgttggt gcaatgacaa agaataagtc
     2221 ccgtgaagaa tggcagtatg tcttcctcat tgctgcactc gtccactatg gtggagtcat
     2281 attttatgca ctatttgcct caggagagaa acaaccttgg gcagaccctg aggaaacaag
     2341 cgaagaaaaa tgtggcttca ttcacgaaga tgaactggat gaagaaacgg gggacatcac
     2401 tcagaattac ataaattacg gtaccaccaa atcttacggt gctacctcac aggagaatgg
     2461 aggctggcct aacggctggg agaaaaagga agaatttgtg caagaaggtg cgcaagacgc
     2521 gtacacctat aaggaccgag atgattattc ataacgatgc tagttgctgg attcatttgt
     2581 agtgtttgtg aatcaattaa ttgtgattgc acaaaaataa ttttaaaaat gtggtgtgaa
     2641 catgtaaaca tatcaaccaa gcaagtcttg ctgttcaaaa acaaaaacaa aaaaatctga
     2701 attcaaaaca gaccatgaga ttcccatcaa gtgcaatctg tggcagttgt cacgttatgc
     2761 cgtcttcatt caggccattt gtcctttcgt ttgtgattta aaggtttcct gtagaaataa
     2821 gtaggtattc gttggaccca tcaccatttt agagagcaca actacaacag ttggcacatg
     2881 tcatcctaca gaagttagga agccaaagct actggatcat gcaaactgca cttatttatt
     2941 acactggact gcaaactatc ccagggaaag cctgtctaga gacatagtgg aacaggaaag
     3001 atggctagat caggtattga ctataatcat tatgtgtcta tcatggagtg gctatatctt
     3061 tcaatgaaga actatattgt gtagctagca aactgtactg aactcttact aggagtgcac
     3121 agtgtgtgat attttgtgat cttccaaaag cttatcttgc agtgttttgt gaaatgcttg
     3181 ggcacaaaca cttattttta tgaatgagag cttgtaaagg gaggggtatg ctccatgctc
     3241 ccccattcac tacctgacag tatcaaaccc ttcacatttc aataaaatcc aactttcatg
     3301 taacatatca cataactttt tttttttgca aaaaaataag aagaaataga cttcaatgta
     3361 ttttttatta caactttgta ctggttgtaa cttgcattag gaaaaaatga ttaatatatg
     3421 tataatcata aagaatctaa taaaaattta ctatgatgat atagccctta aaatgcaata
     3481 ttaacaaaat aaatagaaaa tttagataat cttccttgat aactagagac tatatgaaac
     3541 tcatgccaca aagctatata taatatgaag agataaacaa tagagattct atatgtagac
     3601 aattttatta cctaatgtcc cacataagag atatttgtct tgagtatata gtacaaaata
     3661 tattaaaatt atatctacat ccctgtatat cttatacata tccactcaca cgaacataac
     3721 aaatactttt cacacagaac caaaaacaag catacaccta atgttgggtt tggggattgc
     3781 aatttctact ttcatagagt catagaattt tagatggaaa aaaaaaagca ttttgctcgt
     3841 catttcttaa tataattcaa caggaactgc aacatttgtg taccaagcaa taagtgcaaa
     3901 gcataaaacc tcctgtgtgt aaattatccc catgttgctt gtggtagcag tgatttcttt
     3961 cttttaaaaa agttaacctc agagctcttt ctaatgtttt gcgctgataa gaatgcacat
     4021 cccaatttac tgcaaaatgt cacctggtgt gtttacctgt cagttttggg tatttgatct
     4081 gtctggtgtc ctgtgctctt gactggaggc cctgctactg caaatataca atgtgaagtt
     4141 tgtttctaaa tgcaaaccac tcctgacctt aagaaactga agtccctctc tgctttgtgt
     4201 ctcagagtac tatcatgtga ccataacctt tgctgtgctg agtaaagaga tgtgaactgt
     4261 cattttgttg ctgcaaaaca agtgttaata aaatgttcta tttacccttt tgtaaaatca
     4321 aaaaaaaaaa aaaaaaaa
//
