LOCUS       NM_172773               3241 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus solute carrier family 17 (anion/sugar transporter),
            member 5 (Slc17a5), transcript variant 1, mRNA.
ACCESSION   NM_172773
VERSION     NM_172773.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3241)
  AUTHORS   Cai,R., Scott,O., Ye,G., Le,T., Saran,E., Kwon,W., Inpanathan,S.,
            Sayed,B.A., Botelho,R.J., Saric,A., Uderhardt,S. and Freeman,S.A.
  TITLE     Pressure sensing of lysosomes enables control of TFEB responses in
            macrophages
  JOURNAL   Nat Cell Biol 26 (8), 1247-1260 (2024)
   PUBMED   38997458
REFERENCE   2  (bases 1 to 3241)
  AUTHORS   Stroobants,S., Van Acker,N.G., Verheijen,F.W., Goris,I.,
            Daneels,G.F., Schot,R., Verbeek,E., Knaapen,M.W., De Bondt,A.,
            Gohlmann,H.W., Crauwels,M.L., Mancini,G.M., Andries,L.J.,
            Moechars,D.W. and D'Hooge,R.
  TITLE     Progressive leukoencephalopathy impairs neurobehavioral development
            in sialin-deficient mice
  JOURNAL   Exp Neurol 291, 106-119 (2017)
   PUBMED   28189729
  REMARK    GeneRIF: This study demonstrated that Progressive
            leukoencephalopathy impairs neurobehavioral development in
            sialin-deficient mice.
REFERENCE   3  (bases 1 to 3241)
  AUTHORS   Huang,C., Seino,J., Wang,L., Haga,Y. and Suzuki,T.
  TITLE     Autophagy regulates the stability of sialin, a lysosomal sialic
            acid transporter
  JOURNAL   Biosci Biotechnol Biochem 79 (4), 553-557 (2015)
   PUBMED   25494612
  REMARK    GeneRIF: Autophagy regulates the stability of sialin, a lysosomal
            sialic acid transporter.
REFERENCE   4  (bases 1 to 3241)
  AUTHORS   Lodder-Gadaczek,J., Gieselmann,V. and Eckhardt,M.
  TITLE     Vesicular uptake of N-acetylaspartylglutamate is catalysed by
            sialin (SLC17A5)
  JOURNAL   Biochem J 454 (1), 31-38 (2013)
   PUBMED   23889254
  REMARK    GeneRIF: The uptake of N-acetylaspartylglutamate into synaptic
            vesicles depends on sialic acid transporter sialin, SLC17A5.
REFERENCE   5  (bases 1 to 3241)
  AUTHORS   Morland,C., Nordengen,K., Larsson,M., Prolo,L.M., Farzampour,Z.,
            Reimer,R.J. and Gundersen,V.
  TITLE     Vesicular uptake and exocytosis of L-aspartate is independent of
            sialin
  JOURNAL   FASEB J 27 (3), 1264-1274 (2013)
   PUBMED   23221336
  REMARK    GeneRIF: l-aspartate is exocytotically released from nerve
            terminals after vesicular accumulation by a transporter other than
            sialin.
REFERENCE   6  (bases 1 to 3241)
  AUTHORS   Miyaji,T., Echigo,N., Hiasa,M., Senoh,S., Omote,H. and Moriyama,Y.
  TITLE     Identification of a vesicular aspartate transporter
  JOURNAL   Proc Natl Acad Sci U S A 105 (33), 11720-11724 (2008)
   PUBMED   18695252
  REMARK    GeneRIF: sialin possesses dual physiological functions and acts as
            a vesicular aspartate/glutamate transporter
REFERENCE   7  (bases 1 to 3241)
  AUTHORS   Van Dyck,F., Braem,C.V., Chen,Z., Declercq,J., Deckers,R.,
            Kim,B.M., Ito,S., Wu,M.K., Cohen,D.E., Dewerchin,M., Derua,R.,
            Waelkens,E., Fiette,L., Roebroek,A., Schuit,F., Van de Ven,W.J. and
            Shivdasani,R.A.
  TITLE     Loss of the PlagL2 transcription factor affects lacteal uptake of
            chylomicrons
  JOURNAL   Cell Metab 6 (5), 406-413 (2007)
   PUBMED   17983586
REFERENCE   8  (bases 1 to 3241)
  AUTHORS   Yarovaya,N., Schot,R., Fodero,L., McMahon,M., Mahoney,A.,
            Williams,R., Verbeek,E., de Bondt,A., Hampson,M., van der Spek,P.,
            Stubbs,A., Masters,C.L., Verheijen,F.W., Mancini,G.M. and
            Venter,D.J.
  TITLE     Sialin, an anion transporter defective in sialic acid storage
            diseases, shows highly variable expression in adult mouse brain,
            and is developmentally regulated
  JOURNAL   Neurobiol Dis 19 (3), 351-365 (2005)
   PUBMED   16023578
REFERENCE   9  (bases 1 to 3241)
  AUTHORS   Aula,N., Kopra,O., Jalanko,A. and Peltonen,L.
  TITLE     Sialin expression in the CNS implicates extralysosomal function in
            neurons
  JOURNAL   Neurobiol Dis 15 (2), 251-261 (2004)
   PUBMED   15006695
REFERENCE   10 (bases 1 to 3241)
  AUTHORS   Verheijen,F.W., Verbeek,E., Aula,N., Beerens,C.E., Havelaar,A.C.,
            Joosse,M., Peltonen,L., Aula,P., Galjaard,H., van der Spek,P.J. and
            Mancini,G.M.
  TITLE     A new gene, encoding an anion transporter, is mutated in sialic
            acid storage diseases
  JOURNAL   Nat Genet 23 (4), 462-465 (1999)
   PUBMED   10581036
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159883.2, AK029102.1 and BE630039.1.
            
            On Feb 14, 2013 this sequence version replaced NM_172773.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK029102.1, AK169868.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC159883.2         86265-86282
            19-3219             AK029102.1         2-3202
            3220-3241           BE630039.1         1-22                c
FEATURES             Location/Qualifiers
     source          1..3241
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.65 cM"
     gene            1..3241
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /note="solute carrier family 17 (anion/sugar transporter),
                     member 5"
                     /db_xref="GeneID:235504"
                     /db_xref="MGI:MGI:1924105"
     exon            1..172
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     CDS             79..1566
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /note="isoform a is encoded by transcript variant 1;
                     sodium/sialic acid cotransporter; H(+)/nitrate
                     cotransporter; vesicular H(+)/Aspartate-glutamate
                     cotransporter; vesicular excitatory amino acid
                     transporter"
                     /codon_start=1
                     /product="sialin isoform a"
                     /protein_id="NP_766361.1"
                     /db_xref="CCDS:CCDS23364.1"
                     /db_xref="GeneID:235504"
                     /db_xref="MGI:MGI:1924105"
                     /translation="MRPLLRGPAGNDDEESSDSTPLLPGARQTEAAPVCCSARYNLAI
                     LAFCGFFVLYALRVNLSVALVDMVDSNTTLTDNRTSKECAEHSAPIKVHHNHTGKKYK
                     WDAETQGWILGSFFYGYIVTQIPGGYIASRVGGKLLLGLGILGTSVFTLFTPLAADLG
                     VVTLVVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLTISYAGAQLGTVISLPLSG
                     IICYYMNWTYVFYLFGIVGIVWFILWMWIVSDTPETHKTISHYEKEYIVSSLKNQLSS
                     QKVVPWGSILKSLPLWAIVVAHFSYNWSFYTLLTLLPTYMKEILRFNVQENGFLSALP
                     YFGCWLCMILCGQAADYLRVKWNFSTISVRRIFSLVGMVGPAVFLVAAGFIGCDYSLA
                     VAFLTISTTLGGFASSGFSINHLDIAPSYAGILLGITNTFATIPGMTGPIIAKSLTPD
                     NTIREWQTVFCIAAAINVFGAIFFTLFAKGEVQSWALSDHHGHRN"
     exon            173..369
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            370..603
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            604..691
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            692..778
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            779..897
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            898..1056
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1189
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1337
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1338..1428
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..3241
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3217..3222
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /note="hexamer: ATTAAA"
     polyA_site      3241
                     /gene="Slc17a5"
                     /gene_synonym="4631416G20Rik; 4732491M05; AST; ISSD; NSD;
                     SD; SIALIN; SIASD; SLD; VEAT"
                     /note="major polyA site"
ORIGIN      
        1 ccagcacggc gaagggctgt cctgccgaga gctaggttgg ccaagcaacg acgccggcac
       61 atctgctctc caggcgttat gaggcccctg cttcggggtc cggcgggaaa cgacgatgag
      121 gagagctcgg acagcacccc gctcctgccg ggcgcccggc agaccgaagc ggctccagtg
      181 tgctgctctg ctcggtacaa cttagcgatt ttggcgttct gtggtttctt cgttctctat
      241 gccttacggg tgaacctgag tgttgcgtta gtggacatgg tagattcaaa tacaactctg
      301 actgataata gaacgtctaa ggagtgtgcg gaacattctg cccccataaa agttcaccac
      361 aatcacacag gtaaaaagta caagtgggat gcagaaactc aagggtggat tctcggctct
      421 tttttttacg gctacatcgt cacccagatt cccggtgggt acattgccag cagggtcgga
      481 gggaagctgc tgctgggcct gggcatctta ggcacctccg tcttcaccct gttcacaccg
      541 ctggccgcag acttaggcgt ggtgactctc gttgtgctta gagcgctgga aggactggga
      601 gagggtgtta cgtttccagc tatgcacgcc atgtggtctt cctgggctcc ccctctggaa
      661 agaagcaagc ttcttaccat ttcctatgcg ggagcacagc ttgggacagt gatctcactt
      721 cctctttccg gaataatatg ctactatatg aactggactt acgtcttcta tctttttggt
      781 atagttggaa ttgtctggtt tattttatgg atgtggatag tcagtgatac accagaaact
      841 cacaagacaa tctcccatta tgaaaaagaa tacattgttt catcattaaa aaatcagctt
      901 tcttcgcaga aggtggtgcc gtgggggtcc atcttgaagt cactgccact ttgggcaatt
      961 gtggtagcac atttctccta caactggtct ttttacacct tattgacgct actgccaact
     1021 tatatgaagg aaatcctaag gttcaatgtt caagagaacg ggtttttatc tgcattgcct
     1081 tattttggct gttggttatg catgatcctc tgtggtcaag ccgctgacta tttaagggtc
     1141 aagtggaact tttcaactat aagcgttcgg agaattttta gcctcgtagg aatggttggc
     1201 cctgcggttt tcctagtcgc ggctggattt ataggctgtg actattcctt ggccgttgcg
     1261 ttcctaacca tatccacgac gctgggaggc ttcgcctctt ctggatttag catcaaccat
     1321 ctggatatcg ctccttcgta tgctggcatc ctcttgggca tcacaaacac gtttgccact
     1381 attcccggga tgacgggacc catcattgct aaaagtctga cccctgataa cactattagg
     1441 gaatggcaga ctgtcttctg tatcgctgct gctattaacg tgtttggggc cattttcttc
     1501 acgctgtttg ccaaagggga agtgcagagc tgggctctca gtgaccacca cggacacaga
     1561 aactgaagac aacaaacaat aattaatgtg tttttattta tcatggaaac tgaaagtgcc
     1621 tttggtattt gaatgtgcaa gcattctatg tgagagaaaa aaagtactta tatttgtatg
     1681 gtaatcatga aatgttacta gttccaagat catataaaat gagctgttgg gctggacaga
     1741 tggctcagtg gttacgagca ctgattgctc ttggagaggt cctgagttca attcccagca
     1801 accacatggt ggctcataac catctgtaat gggatcagat gccctcttct ggtgtgtctg
     1861 aagacagaga cagtgtactc acacacatta aataaataaa taaatcttta aaaaaaaaga
     1921 agaagaagag gctggtcctc ttttaaaaaa ataaataaaa aataaaatga gctgttttta
     1981 attattacta gtatatctgc caggccgtat actgggttca catatcaggc tgcaggaaag
     2041 gcagtatgat ataaggtaag ggcataggaa atgaagctga aatggacaca cacacacaca
     2101 cacacactga taaacttggt taattaaatc agataaatca tttcagatct tattaaaata
     2161 cctgcttttg tctacttccc ttataaaaat gcttgccaac tctccctgac acctagacct
     2221 caataacgtc tccaaagaac tgccagccac agtaagagtc ggcagcctgg cagcggtact
     2281 gggggatccg tgcccaggca gctgtcaagc attccctccc tggctgcagg gcaggaatgc
     2341 ccagcactta ccagggatgg tggcttccaa gtgcagggcc aatgacaagt gtttggctga
     2401 cactctttcc cccatggctg ttaatgtgca gataaagctc taagtggact ggagcagtgg
     2461 gagccatagc tactgtcttg acactgccag cctgcctcgg cagcacccgg gcccgactcc
     2521 tggcaggtga tctacaaagc agaagcgtgg tacccagtca gtcacagaga atagcatcct
     2581 tgattcacat cactggccca tgaattggag aacacatttt cacattcagg tttttctagc
     2641 tacattagaa cttttttaaa tgtcttacat ttcttccctt cagtctgtct tgatttatgc
     2701 ttctggttac agtttaaagg gactttcagg gccaggggtt tggctcagtg gtagagcatt
     2761 tacataggat tgtgctccat tcaacaccaa aatagaggta aaaggcaggg cacccaaagc
     2821 ttgtcagtcc cctttaccct gcttcctgac cagtgtctcc cagtggttag gcacactgta
     2881 agaggtccct agtctgtgtg gtggtacctt taatgccagc acttgggagg cagaagcagg
     2941 cagatctttg cgacttcgag gccagtctgg tctgcaaagg ggcttccagg acagccgggg
     3001 ctataactca aaaacaaaaa caaaaagatt atccaaggat tgaaagcctg ccttatgttt
     3061 tgttgtatct gttcaacact tatctataac attttaacta atgattggtt aatgtactgt
     3121 tgtgtaaata cagttatata aatttgtttt taatttgtaa atataaatta agttgccatg
     3181 tgacatttct tttataaatc atcaaaatcc ttttgcatta aatttttgtg tttttatttt
     3241 a
//
