LOCUS       NM_001164743            4152 bp    mRNA    linear   ROD 06-NOV-2024
DEFINITION  Mus musculus solute carrier family 17 (sodium phosphate), member 3
            (Slc17a3), transcript variant 2, mRNA.
ACCESSION   NM_001164743
VERSION     NM_001164743.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4152)
  AUTHORS   Li,V.L., Xiao,S., Schlosser,P., Scherer,N., Wiggenhorn,A.L.,
            Spaas,J., Tung,A.S., Karoly,E.D., Kottgen,A. and Long,J.Z.
  TITLE     SLC17A1/3 transporters mediate renal excretion of Lac-Phe in mice
            and humans
  JOURNAL   Nat Commun 15 (1), 6895 (2024)
   PUBMED   39134528
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4152)
  AUTHORS   Imamura,R., Sugimoto,M., Horike,S.I., Terakawa,J., Fujita,K.,
            Tamai,I., Daikoku,T., Kato,Y. and Arakawa,H.
  TITLE     Role of Organic Anion Transporter NPT4 in Renal Handling of Uremic
            Toxin 3-indoxyl Sulfate
  JOURNAL   J Pharm Sci 113 (7), 1996-2000 (2024)
   PUBMED   38641061
  REMARK    GeneRIF: Role of Organic Anion Transporter NPT4 in Renal Handling
            of Uremic Toxin 3-indoxyl Sulfate.
REFERENCE   3  (bases 1 to 4152)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 4152)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 4152)
  AUTHORS   Thiagarajan,R.D., Georgas,K.M., Rumballe,B.A., Lesieur,E.,
            Chiu,H.S., Taylor,D., Tang,D.T., Grimmond,S.M. and Little,M.H.
  TITLE     Identification of anchor genes during kidney development defines
            ontological relationships, molecular subcompartments and regulatory
            pathways
  JOURNAL   PLoS One 6 (2), e17286 (2011)
   PUBMED   21386911
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4152)
  AUTHORS   Cheret,C., Doyen,A., Yaniv,M. and Pontoglio,M.
  TITLE     Hepatocyte nuclear factor 1 alpha controls renal expression of the
            Npt1-Npt4 anionic transporter locus
  JOURNAL   J Mol Biol 322 (5), 929-941 (2002)
   PUBMED   12367519
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590388.4, AK143896.1 and AA986956.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region, and initiates translation at a
            downstream start codon, compared to variant 1. The encoded isoform
            (2) is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.77290.1,
                                           ERR2680379.328868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849385, SAMN00849386
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AL590388.4         48916-48944         c
            30-232              AK143896.1         2-204
            233-498             AK143896.1         329-594
            499-499             AA986956.1         150-150
            500-3044            AK143896.1         596-3140
            3045-3045           AL590388.4         28771-28771         c
            3046-4152           AK143896.1         3142-4248
FEATURES             Location/Qualifiers
     source          1..4152
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 9.95 cM"
     gene            1..4152
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /note="solute carrier family 17 (sodium phosphate), member
                     3"
                     /db_xref="GeneID:105355"
                     /db_xref="MGI:MGI:2389216"
     exon            1..232
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            233..444
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     CDS             250..1638
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="sodium-dependent phosphate transport protein 4
                     isoform 2"
                     /protein_id="NP_001158215.1"
                     /db_xref="CCDS:CCDS49220.1"
                     /db_xref="GeneID:105355"
                     /db_xref="MGI:MGI:2389216"
                     /translation="MRYGIAFVTHFCNFTLMAQNSIISITMVAMVNNTDHPPHLNSST
                     EQLPAGLSGDQHEASKHLPIKAPVYNWSPQTQGIIFSSVQYGMILMQGPGGYLAGKIG
                     TKKVVGIALLGSSLLTLCIPLAANLGLVFFLATRAVQGLMQGTGYGGQFALWQKWAPP
                     NERSRLCTIALSGMTLGIFTVLLVGGIISEALGWPFVFYSFGGGGVLCSLLWFILIYD
                     DPVSHPWISGPEREYILSSLNQQFSSEEQPLPIKAMLKSLPLWSMCLCTMTHQWLVNT
                     FIMYTPTYISSVFKVNIRDNGFLSSLPFIVAWVLGILGGWLADFLLSKNFRLITVRKF
                     ITLLGNAPPAALVAALPYIQSSYITTIIFLTISCGLCPLSQAGIYINALDIAPRYASF
                     LMGTSRGLAHSSAVLVPIVAGFFLSQDSEFGWRNFFFVVFAVNLLGLIIYLVFGKADV
                     QEWARERKLTRL"
     exon            445..678
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            679..766
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            767..853
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            854..972
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            973..1134
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1135..1264
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1412
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1503
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1504..1640
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     exon            1641..4152
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1766..1771
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /note="hexamer: AATAAA"
     polyA_site      1790
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /note="major polyA site"
     regulatory      2425..2430
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
                     /note="hexamer: AGTAAA"
     polyA_site      2455
                     /gene="Slc17a3"
                     /gene_synonym="Npt4"
ORIGIN      
        1 aataactgcc tgcaggtgtc agacccagta gatccttctg gggtgctggc aagacactgg
       61 acaaggacga aggctgtgaa gctcacagct gaaagcaggg ggtgcttcag cctgtcatta
      121 atgattaata attggagtca tggagtgaca cagaatactg agtggtctgg taagaggtaa
      181 gagaagcctg tccagaggaa acacaggaag gcctacctca gtcactaagt tgtcccgagt
      241 ttatgttcca tgcgctatgg aatcgccttc gtcacacatt tctgcaattt cacactgatg
      301 gcgcagaatt ctattataag catcaccatg gtagcaatgg tcaacaacac cgaccaccca
      361 ccccacctca atagctctac tgaacagctt cctgcgggtt taagcggtga tcagcatgaa
      421 gcctcaaagc atcttcctat aaaggcccct gtgtataact ggagtcctca aactcaagga
      481 atcatcttca gctctgtcca gtatggcatg atactgatgc aaggtcctgg aggatacttg
      541 gcagggaaaa taggaacaaa gaaagtggtt ggaattgctc tgcttggatc ttcattactc
      601 actctctgca tcccactggc tgccaatctt ggactagttt ttttcctggc aactcgagca
      661 gttcaaggct taatgcaggg cactggatat gggggacagt ttgcactctg gcagaaatgg
      721 gctcctccga atgagcgcag ccgactctgc accattgcct tgtcaggaat gacattggga
      781 atctttactg tcctccttgt gggcggcatc attagtgaag cccttgggtg gccctttgtc
      841 ttctatagtt ttggaggtgg tggtgtgctc tgcagccttc tctggttcat tctgatttat
      901 gatgaccctg tctctcaccc atggataagt ggcccagaaa gagaatatat tttatcctct
      961 ctgaaccaac agttcagctc agaagagcag ccacttccca tcaaagctat gctcaaatct
     1021 ctgcctctct ggtccatgtg tctctgcact atgacccatc agtggcttgt taacaccttt
     1081 ataatgtaca ctccaaccta catcagttct gtattcaaag ttaacatcag agacaatggg
     1141 ttcctgtctt ctcttccctt tattgttgcc tgggtccttg gtatcctggg aggctggctg
     1201 gcagattttc tactgagcaa gaattttagg ctcataactg tgagaaaatt catcacactt
     1261 ttaggaaatg ctcctcctgc agccctcgtt gcggctctgc cctatatcca atccagctat
     1321 attacaacaa ttatatttct gacaatttcc tgtggactgt gccctctatc tcaggcagga
     1381 atctatatta atgcgttaga cattgctcca aggtatgcca gctttctcat gggaacatca
     1441 agaggattgg cacattcatc ggctgtgctg gtacccattg ttgctggctt tttcctcagc
     1501 caggactctg aattcgggtg gaggaatttc ttttttgtag tgtttgcagt taacctactt
     1561 ggcttaatca tctacctcgt gtttgggaaa gcagatgttc aagaatgggc tagagagagg
     1621 aagctcactc gtttgtgaag ctgtcccact tgctgtaaag aagtcattac atacgctggc
     1681 tcctctgtgg gaagactttc atgaaaaatg atgtcagata ttttccccct ttcacccaga
     1741 cttcttttga agaaaatatg agaggaataa aacatcgagt aaaatgataa gaagggacca
     1801 ggttgtcatc tttgaatcaa gaatttggtg ctgacatggt agtttccatt tttttaaggg
     1861 ccaaagttta tggacccttg gtccagagcg gtaatcttta ctagagaaat tatttatttt
     1921 ctatttgtca ggttgaatat tcatttctcg ttatgcctgt ggtactggaa gaagagagag
     1981 cattctttga ctggctttca ctcctagtct gcagtttctg tttcctggct tggcactgac
     2041 acatgttcca cacatggtcc attcttcttc actgtgctca ggctactggc ggatgagttg
     2101 cgtgccttgt ctactggctt cagccagatt tttgatggag aaatgaaaat gtagtctgag
     2161 gaacttagca cagagggtca ctgcagtccc tggccctgag aggcaacccc cttgtgtgtt
     2221 ctggtaactt cttccctcta tttgttattt ttgtcttcgc ttgtgccatc tctgttattc
     2281 tctagaacct gttatggttt tcttgccctt tgcctgatcc tgtgcaaatg atctttccac
     2341 tgtcctgaaa ctgcctagtg tggctgtcat ccctcttctg tgagatatgc ctaatttgtg
     2401 gttaaatcac tcataaggat ggaaagtaaa accgacttag cgttttgtaa agtaatggtt
     2461 tgtaggtgtc tgtgggtcac accaagttca gagacccagg acagcattga gaactgttcc
     2521 ccatgctaac ctttactgtc tatgacagag atcactgccc tcaaatcata tcctacagag
     2581 gtggtgtaat acattctgag tacagattag ggcaagatta gagaggccaa ccatgaacaa
     2641 acacagcaat gactgtgatc ttggtatgag ctctgatctg tctgttggga cactagagta
     2701 agttaaatat ggtttccttc tattgtgcag aatcaggtgt agtagcagag ggacagaaac
     2761 gggacacaga tgaagatttg ccattccata caaaaaaact ctgagaaggt ctcatgtatg
     2821 aagcaattcc aggggtacat attaaatgga caacccttct tctacaaaat cataaaagca
     2881 ggaaacagga tgcattctaa agggagtacc ctgtctgcat attcataaaa aagcacaaag
     2941 cacaaaatta gaggaaggtg tgtggctaat gcatgtagtg ttcctgtgtt atgggagaga
     3001 gtttgagaac attatataag cagtgaagta gggctcatag caatagctac atggacagat
     3061 ctttctagat ggagcatttt cctaaaattt cagaattagg atgacacgtc aaatgatgat
     3121 ctgtatgctg gtctttaaaa cagcagtttt agggactgga ataaggcagg acacattgaa
     3181 atgaagagaa gaggggtggg aaatgcttgt gtggaagaat ttgaagaccc taccatttaa
     3241 ctggatggat ggtagagaag acagacagaa ggtgagaatc ctagggctgg aacctgctag
     3301 acaagataga ctactaaaca gagactgcag aaagatggtc tctgatcaaa gaaaagataa
     3361 tgagctgact gaggtgggct gagatcgtag tgatgctgga aaggtcaagt agccataggc
     3421 tcaaaagact agactccacc gtttgtccca catgcctacc aaagagatca ctgagtggtg
     3481 gtaaaggaca atgaaagaag attaacttga catgactaca ttggaagcag tgtccctaag
     3541 tctgtcttca aggtgccagt ggtctgatgg tcattgtgtc agctctggtc cttgtctcaa
     3601 gttctagaga agttgacagt gctgtcacca cttgagggga gtaatcttga gttccatgga
     3661 gtgatgatac ctgttccaag gtgcagcctt gccacctgag taactgctaa ttcctcactt
     3721 gggagcagga gattcaccct gcaaactgta gtttggctct tttatcatga agatgtttat
     3781 taccaatgct ttaatcccgg agttcaacgc aactgcaaaa gagaatgact gtcataatta
     3841 ggtttctaca gctgtgataa aacaccatgg ccaacacaat gtggggagaa aataatttat
     3901 ttcacccttc aactctcagg ccacacgcca tcaccaagag gagtcagtac aggaacttaa
     3961 ggcagaaacc tcaatgcaga aactgaaaca gaagccatgg gggagtgctg cttacagact
     4021 tgttctctgt gggtttttca tgctgctttc ttatataact cggggccacc tacctgccca
     4081 aggatggaac caccaccagt ggtctaggtc tcccaacata catcatcaat caataaaata
     4141 ttaatcaaga ct
//
