LOCUS       NM_020516               1887 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 8 (Slc16a8), mRNA.
ACCESSION   NM_020516
VERSION     NM_020516.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1887)
  AUTHORS   Liu,Y., Ng,L., Liu,H., Heuer,H. and Forrest,D.
  TITLE     Cone photoreceptor differentiation regulated by thyroid hormone
            transporter MCT8 in the retinal pigment epithelium
  JOURNAL   Proc Natl Acad Sci U S A 121 (30), e2402560121 (2024)
   PUBMED   39018199
REFERENCE   2  (bases 1 to 1887)
  AUTHORS   Ohana,R., Weiman-Kelman,B., Raviv,S., Tamm,E.R., Pasmanik-Chor,M.,
            Rinon,A., Netanely,D., Shamir,R., Solomon,A.S. and Ashery-Padan,R.
  TITLE     MicroRNAs are essential for differentiation of the retinal
            pigmented epithelium and maturation of adjacent photoreceptors
  JOURNAL   Development 142 (14), 2487-2498 (2015)
   PUBMED   26062936
REFERENCE   3  (bases 1 to 1887)
  AUTHORS   Daniele,L.L., Sauer,B., Gallagher,S.M., Pugh,E.N. Jr. and
            Philp,N.J.
  TITLE     Altered visual function in monocarboxylate transporter 3 (Slc16a8)
            knockout mice
  JOURNAL   Am J Physiol Cell Physiol 295 (2), C451-C457 (2008)
   PUBMED   18524945
  REMARK    GeneRIF: Disruption of Mct3 leads to a potentially reversible
            decrease in subretinal space pH, thereby reducing the magnitude of
            the light suppressible photoreceptor current.
REFERENCE   4  (bases 1 to 1887)
  AUTHORS   Trajkovic,M., Visser,T.J., Mittag,J., Horn,S., Lukas,J.,
            Darras,V.M., Raivich,G., Bauer,K. and Heuer,H.
  TITLE     Abnormal thyroid hormone metabolism in mice lacking the
            monocarboxylate transporter 8
  JOURNAL   J Clin Invest 117 (3), 627-635 (2007)
   PUBMED   17318265
  REMARK    GeneRIF: MCT8-null mice developed without overt deficits but also
            exhibited distorted 3,5,3'-triiodothyronine (T3) and thyroxine (T4)
            serum levels, resulting in increased hepatic activity of type 1
            deiodinase (D1).
REFERENCE   5  (bases 1 to 1887)
  AUTHORS   Jansen,S., Esmaeilpour,T., Pantaleon,M. and Kaye,P.L.
  TITLE     Glucose affects monocarboxylate cotransporter (MCT) 1 expression
            during mouse preimplantation development
  JOURNAL   Reproduction 131 (3), 469-479 (2006)
   PUBMED   16514190
REFERENCE   6  (bases 1 to 1887)
  AUTHORS   Philp,N.J., Ochrietor,J.D., Rudoy,C., Muramatsu,T. and Linser,P.J.
  TITLE     Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment
            epithelium and neural retina of the 5A11/basigin-null mouse
  JOURNAL   Invest Ophthalmol Vis Sci 44 (3), 1305-1311 (2003)
   PUBMED   12601063
REFERENCE   7  (bases 1 to 1887)
  AUTHORS   Herubel,F., El Mouatassim,S., Guerin,P., Frydman,R. and Menezo,Y.
  TITLE     Genetic expression of monocarboxylate transporters during human and
            murine oocyte maturation and early embryonic development
  JOURNAL   Zygote 10 (2), 175-181 (2002)
   PUBMED   12056458
REFERENCE   8  (bases 1 to 1887)
  AUTHORS   Philp,N.J., Yoon,H. and Lombardi,L.
  TITLE     Mouse MCT3 gene is expressed preferentially in retinal pigment and
            choroid plexus epithelia
  JOURNAL   Am J Physiol Cell Physiol 280 (5), C1319-C1326 (2001)
   PUBMED   11287345
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC018216.1.
            
            On Jun 19, 2003 this sequence version replaced NM_020516.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC018216.1, AF019111.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164136, SAMN01164138
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1887
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 37.7 cM"
     gene            1..1887
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 8"
                     /db_xref="GeneID:57274"
                     /db_xref="MGI:MGI:1929519"
     exon            1..110
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /inference="alignment:Splign:2.1.0"
     exon            111..189
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /inference="alignment:Splign:2.1.0"
     exon            190..414
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1679
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /note="preferentially expressed in RPE cells and choroid
                     plexus epithelium; MCT 3; solute carrier family 16 member
                     8; proton-coupled monocarboxylate transporter 3"
                     /codon_start=1
                     /product="monocarboxylate transporter 3"
                     /protein_id="NP_065262.1"
                     /db_xref="CCDS:CCDS27636.1"
                     /db_xref="GeneID:57274"
                     /db_xref="MGI:MGI:1929519"
                     /translation="MGAGGPRRGAGPPDGGWGWVVLGACFVVTGFAYGFPKAVSVFFR
                     ELKRDFGAGYSDTAWVSSIMLAMLYGTGPLSSILVTRFGCRPVMLAGGLLASAGMILA
                     SFASRLVELYLTAGVLTGLGLALNFQPSLIMLGLYFERRRPLANGLAAAGSPVFLSML
                     SPLGQLLGERFGWRGGFLLFGGLLLHCCACGAVMRPPPGPPPRRDPSPHGGPARRRRL
                     LDVAVCTDRAFVVYVVTKFLMALGLFVPAILLVNYAKDAGVPDAEAAFLLSIVGFVDI
                     VARPACGALAGLGRLRPHVPYLFSLALLANGLTDLISARARSYGTLVAFCIAFGLSYG
                     MVGALQFEVLMATVGAPRFPSALGLVLLVEAVAVLIGPPSAGRLVDALKNYEIIFYLA
                     GSEVALAGVFMAVTTYCCLRCSKNISSGRSAEGGASDPEDVEAERDSEPMPASTEEPG
                     SLEALEVLSPRAGSPEQEPEEEAVPELDHESIGGHEARGQKA"
     exon            415..558
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..1326
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1791
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1772..1777
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /note="hexamer: AATAAA"
     polyA_site      1791
                     /gene="Slc16a8"
                     /gene_synonym="Mct3"
                     /note="major polyA site"
ORIGIN      
        1 gtgcagccac cattgccaag gctgttggac actctctgga gctagaagct gcccctcccg
       61 caggcctcga gagatgtgag gctcaaccct aaatccagag tcaggtccag gttcccagag
      121 gagaggagcc ctggtgagga aactccgaag tgaagtttcc attcaccctt cacaggcctt
      181 tgcaggaaga agcagaagca atgggtgctg gcggtccgag gcggggtgct ggccctccgg
      241 atggtggctg gggctgggtg gtgctgggcg cctgcttcgt ggtcaccggc ttcgcctatg
      301 gcttccctaa ggctgtgagc gtcttcttcc gagagctcaa gcgcgacttt ggggcaggtt
      361 acagtgacac agcctgggtg tcctccatca tgttggccat gctctacggc acgggcccct
      421 tgtccagcat cctcgtgacg cgctttggct gtcgccccgt gatgctggct ggtggactgc
      481 tggcttcagc aggcatgatt ctggcttcct ttgcctcgcg cctcgtggag ctgtacctga
      541 cggctggggt gctcacaggc ctgggcctag ctctcaactt ccagccgtcg ctcatcatgc
      601 tgggactcta cttcgagcgg cgacggcccc tggccaacgg gctggcagcg gcgggcagtc
      661 ccgtgtttct gtccatgctg tcgccgctcg ggcagctgct gggggagcgc ttcggctggc
      721 gtggcggctt cctgctgttt ggcggcctcc tgctgcactg ttgcgcctgt ggggcagtca
      781 tgcgtccgcc ccctggaccc ccgccgcgca gagacccctc gccccacggt ggcccggctc
      841 gccgccggcg gctgctggac gtggcagtgt gcaccgaccg tgctttcgtg gtgtacgtgg
      901 tcaccaagtt cctgatggca ctcgggctct ttgtgccggc catcctgctg gtgaactacg
      961 ccaaggacgc gggcgtgcct gacgccgagg ccgccttctt gctgtccatc gtgggcttcg
     1021 tggacatcgt ggcacgaccg gcgtgcggtg ctttggcggg tctggggcgc ctgagacccc
     1081 acgtccccta cctcttcagc ctggccctgt tggccaatgg gctcacggac ctgattagcg
     1141 cgcgtgcgcg ctcctacggg accctcgttg ctttctgcat tgccttcggc ctgtcctacg
     1201 gcatggtggg cgcactgcag tttgaggtgc tcatggcaac cgtgggtgca ccccgcttcc
     1261 ctagtgcatt gggcctagtg ctgctcgtgg aggccgtggc tgtgctcata ggaccgccct
     1321 ctgccggccg cctggtggat gctctgaaga actatgaaat catcttctac cttgctggct
     1381 ctgaagtggc cttggcagga gtcttcatgg cagttaccac ctactgctgc ctgcgctgct
     1441 ctaagaacat ctcatcaggt cgatctgctg agggaggagc cagcgaccca gaggatgtgg
     1501 aggctgagag ggactctgag ccaatgcctg ccagcactga ggagccgggc agccttgaag
     1561 ctctggaggt gctgagcccc cgggctgggt ccccagaaca agaaccagag gaggaggcag
     1621 tgcctgagct ggatcacgag tccataggtg gccatgaggc acgaggccag aaggcatgaa
     1681 actgtggctt cctctctgag ggcctggtac atggggagcc agcctggggt ggtctcttgg
     1741 gaacccaata tgttagaccc tgttcacagt gaataaaggg cccctaaaag aaaaaaaaaa
     1801 aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa
     1861 aaaaaaaaaa aaaaaaaaaa aaaaaaa
//
