LOCUS       NM_001363364            3931 bp    mRNA    linear   ROD 14-FEB-2025
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 6 (Slc16a6), transcript variant 3, mRNA.
ACCESSION   NM_001363364 XM_006531946
VERSION     NM_001363364.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3931)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3931)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3931)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   4  (bases 1 to 3931)
  AUTHORS   Jones,R.S., Tu,C., Zhang,M., Qu,J. and Morris,M.E.
  TITLE     Characterization and Proteomic-Transcriptomic Investigation of
            Monocarboxylate Transporter 6 Knockout Mice: Evidence of a
            Potential Role in Glucose and Lipid Metabolism
  JOURNAL   Mol Pharmacol 96 (3), 364-376 (2019)
   PUBMED   31436537
  REMARK    GeneRIF: Results from the knockout (KO) mouse model of Mct6
            deficiency support the importance of MCT6 in regulating a variety
            of glucose and lipid metabolic pathways, which may indicate its
            significance in metabolic diseases.
REFERENCE   5  (bases 1 to 3931)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3931)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL645791.14.
            
            On Dec 21, 2022 this sequence version replaced NM_001363364.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784647.663293.1,
                                           SRR17784646.921486.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-63                AL645791.14        79618-79680         c
            64-302              AL645791.14        70404-70642         c
            303-446             AL645791.14        66893-67036         c
            447-575             AL645791.14        65571-65699         c
            576-1391            AL645791.14        61957-62772         c
            1392-3931           AL645791.14        57949-60488         c
FEATURES             Location/Qualifiers
     source          1..3931
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 71.94 cM"
     gene            1..3931
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 6"
                     /db_xref="GeneID:104681"
                     /db_xref="MGI:MGI:2144585"
     exon            1..63
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1642
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /note="isoform c is encoded by transcript variant 3;
                     monocarboxylate transporter 6; solute carrier family 16
                     member 6; monocarboxylate transporter 7"
                     /codon_start=1
                     /product="monocarboxylate transporter 7 isoform c"
                     /protein_id="NP_001350293.1"
                     /db_xref="GeneID:104681"
                     /db_xref="MGI:MGI:2144585"
                     /translation="MKLPARQQSEMSERSRMTQKNSKLCARANVYTQVPDGGWGWAVA
                     VSFFFVEVFTYGIIKSFGVFFNDLMDSFDESNSKISWIISICVFVLTFTAPLSTVLSN
                     RFGHRLVVMAGGLLISLGMITASFSQRVYHMYISIGVISGLGYCFSFLPTVTILSQYF
                     DKRRSVVTAVASTGECFAVFAFAPAITALKEHIGWRYSLLFVGLLQLNIMVCGALLRP
                     IIIQGPGQSPKAVTLEPRREVQYMLENEKTRTSIDSIDSGVELTTSPKNVPSEAKMEQ
                     ETRAEQQQTLVTAPKHSQMKAPLLDFSVLKEKSFICYALFGLFATLGFFAPSLYIIPL
                     GISLGIDPDRAAFLLSTMAIAEVFGRIGAGFVLNREPIRKIYIELICVILLTASLFAF
                     TFATEFWGLMLCSVFFGSMVGTIGGTHIPMLAEDDVVGIEKMSSAAGVYVFIQSISGL
                     AGPPLAGLLVDQSKIYSRAFYSCAAGMCLAAVCLALVRPCKKGLCQNSHSGENQTDRQ
                     RGKALQDIPEDFLEMDLGKCEHRAHMKMDPV"
     exon            64..302
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            303..446
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            447..575
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            576..1391
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..3931
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3906..3911
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /note="hexamer: AATAAA"
     polyA_site      3931
                     /gene="Slc16a6"
                     /gene_synonym="ESTM12; MCT 6; MCT 7; MCT6"
                     /note="major polyA site"
ORIGIN      
        1 agaccctctc tggattttcc tcatgaagtt gccggcgcgt cagcagagcg aaatgtcaga
       61 gagatcaaga atgacccaaa agaactcgaa gctttgtgcc agagccaatg tgtataccca
      121 agtgcctgat ggaggatggg gctgggcagt agctgtttct tttttcttcg ttgaagtctt
      181 cacctatggc atcattaagt catttggtgt cttcttcaat gacttaatgg acagctttga
      241 tgaatccaat agcaagatct catggataat atcaatatgt gtatttgtat taacatttac
      301 agctcccctc tccacagtcc tgagcaaccg cttcggacat cggctggtgg tgatggcagg
      361 cgggttgctc atcagcttgg gaatgatcac cgcctccttc tcccaaaggg tctaccacat
      421 gtacatctcc ataggggtaa tctcgggttt agggtactgc tttagtttcc tcccaactgt
      481 gaccattctg tcgcagtact ttgacaaaag gcgttcggta gtcaccgcgg tcgcttctac
      541 gggagagtgc ttcgcggtgt ttgctttcgc accagctatc acagctctga aggagcatat
      601 tggctggaga tacagcctcc tcttcgtggg ccttctgcag ctgaacatca tggtctgcgg
      661 cgccttgcta agaccaatta ttatccaagg gccggggcaa tcaccgaaag cagtcactct
      721 ggagccccgc agagaagttc agtacatgct tgaaaacgag aaaacacgga cctcaataga
      781 ctccatcgac tcaggagtag aactaactac ctcaccaaaa aatgtgccta gcgaagcgaa
      841 gatggagcag gaaaccaggg ctgagcaaca gcagaccctg gtgactgccc ccaagcacag
      901 ccagatgaaa gccccgctgt tggacttctc cgtcttgaaa gagaaaagct tcatttgtta
      961 cgctttgttc ggcctcttcg ccaccctggg cttctttgcg ccttccctct acatcattcc
     1021 tttgggtatc agtctaggca ttgaccctga ccgcgctgcg tttttgctgt cgacgatggc
     1081 cattgcggaa gtgttcggaa ggatcggggc tgggtttgtc ctcaacaggg agcccattcg
     1141 caagatctac atcgaactca tctgcgtcat tttactgacg gcgtctctgt tcgccttcac
     1201 tttcgctacc gagttctggg gcctcatgct gtgtagcgtg ttctttggca gcatggttgg
     1261 gaccatagga gggacccaca tcccgatgtt ggcagaggat gacgtcgttg ggatcgagaa
     1321 gatgtcatct gcagctggag tctatgtctt cattcagagc atctcggggc ttgcgggacc
     1381 acccctggca ggtctgctgg ttgaccagag caagatatac agcagggcct tctactcctg
     1441 cgcagccggc atgtgcctgg ctgccgtgtg cctcgccctg gtaagaccct gtaaaaaggg
     1501 cctgtgccag aattctcatt caggtgagaa ccagacagac cggcagcgtg ggaaggcgtt
     1561 acaggacata cccgaagact ttctggaaat ggatcttggg aaatgtgaac acagggctca
     1621 tatgaaaatg gatcccgtgt gacacatttt cacgtcgtgg cttctatgtc gcctgggagc
     1681 ggagcccctg gggatacagg gaggggtagg cgctaaccac tagaccccca ccttcaaact
     1741 tgcatgaagg gaatgcctgt ctgacagcag ggccagcagc tgtctcttcc cctccagtcc
     1801 cttttgcttg ttctttaagc caaaaccaaa acaaccaaac cttttccata caggaatcca
     1861 gccctgttcc gtagcaatac aaagataagc ggaaggacct gggggggtgg aggcacccca
     1921 gcacaaaagc aatgccacga actgacagac tgctgttaca agcactccgt tcctgtgata
     1981 aactactata ttataaagtg acatccagcc caagtcacag aaattaattg gccattccaa
     2041 aacgacaaaa aaaaaaaaaa acccaaaaaa caaaaaaaac cccacaatct tgaaccatta
     2101 aagatgttgc tgattttcag aactacaggt gaattatttt taaacgattt gaaaatgatt
     2161 actaacgttt acattgacga atcatggctt ctgggttttc cgaataccac atgaaaagga
     2221 agctatgctt taaagccaag catttgatta atatgcaaaa aatttaaaca catataacaa
     2281 cttgaacttc ataaacatga agattattgc tatttttttc gtggccagcc atcaccacaa
     2341 gtatttcaat agaaatgata aattgcattc atgtttccta tttttcataa tgcaagaaat
     2401 aaatgactgt tgtgtcttta acttaaacca ctatttatta ttaagttatt ctaggatgat
     2461 taaaacgatc aaaagaaagg gccagcgaga tggctcagta ggtgaagttg cctgccacca
     2521 agtctgacaa tctgagttca attcctagga cccacacggt aggtcaactt ctgtgagttg
     2581 tcctctgacc tccacacatg ctatgacatg catgtgcctg cacacagaca cacacaaaaa
     2641 tatttaaatg taaaaatata atctaataat caaaataaat aaaaggtgat tggaggtata
     2701 caccacatat ttttacctct gttctgtggc tctttaaatg cttcagagag cttttctggt
     2761 ctcataatgt aagttttcca cagcccaagt tgtaacgatt cttcaggtgt tgttaaaggc
     2821 aatgttgtgc tatttaaagg ggagggggat aacagacgac aaatcgcctc agcttttaca
     2881 tatatcagct aagaatactt gaggatcttc tttgatcaga attatatttc attggattgt
     2941 tggaacattt ccagtggttt tttgttgttg ttgttgttgt tgttattcga tctgtaactg
     3001 ttgttgaagc ctttcttcat tcatctgaaa tgggagaaac gcagccgtca ccatcactga
     3061 gttacaagtt gcaatttcca tcttctgtag aacttgattg ccctaagttg ccatgggtac
     3121 cgagtggtac ctggtcactg ctgctggtga gttacactat acagagttct gcattctagc
     3181 agatctctac aaaggggggg gggggggtgc agtgtgaggg tgagggggtc tgcttcctcg
     3241 cctgtgtgat ggcatctccc cgacagggcg gccgatgcct gctgctctac ctttcttcat
     3301 ctttactgtt aaggacaact cagggggaaa cgtagaacaa gcctagtctg gttacaggta
     3361 cacacacaag cttgaatctt tttctctgca ctgagacgaa gggggtgtgg ctcatcaccg
     3421 cctgccacat tcaatacagc atcttatcag ccatagaaat aggacaatct gtcaaacttt
     3481 ggggagggtg agtgacagga cgaaagacaa cgtgtctgtc caaaaaaaag cagactgcac
     3541 ctgaaatggg atggatgtag ccaagctcgg tgggacccct cccccacccc cacccccccg
     3601 agcaatgctt tagtttaggc tcctgggcag gtttacagat gtatgtgact tcggcacttt
     3661 aaaagctatt ttgtactacg aatgttcgag acgatttaat atttgtaact gatttctgag
     3721 ggatcaactc ttaagttcaa tctatatact gcatgagaca gggaaatgta tgccaatttc
     3781 agtgtgtgaa caatccgggg ggggggtggg cggggtgcaa atgttgggaa ggaaaaaaac
     3841 gaaataccac tacaggatca ctgctctgtt ctgtatgagt gacatcctgg tacttaggga
     3901 tttacaataa atttacggct ttttatctaa a
//
