LOCUS       NM_146136               2204 bp    mRNA    linear   ROD 07-DEC-2024
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 4 (Slc16a4), transcript variant 1, mRNA.
ACCESSION   NM_146136
VERSION     NM_146136.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2204)
  AUTHORS   Zhang,Y., Jiang,H., Dong,M., Min,J., He,X., Tan,Y., Liu,F.,
            Chen,M., Chen,X., Yin,Q., Zheng,L., Shao,Y., Li,X. and Chen,H.
  TITLE     Macrophage MCT4 inhibition activates reparative genes and protects
            from atherosclerosis by histone H3 lysine 18 lactylation
  JOURNAL   Cell Rep 43 (5), 114180 (2024)
   PUBMED   38733581
  REMARK    GeneRIF: Macrophage MCT4 inhibition activates reparative genes and
            protects from atherosclerosis by histone H3 lysine 18 lactylation.
            Erratum:[Cell Rep. 2024 Oct 22;43(10):114884. doi:
            10.1016/j.celrep.2024.114884. PMID: 39392757]
REFERENCE   2  (bases 1 to 2204)
  AUTHORS   Buth,J.E., Dyevich,C.E., Rubin,A., Wang,C., Gao,L., Marks,T.,
            Harrison,M.R., Kong,J.H., Ross,M.E., Novitch,B.G. and Pearson,C.A.
  TITLE     Foxp1 suppresses cortical angiogenesis and attenuates HIF-1alpha
            signaling to promote neural progenitor cell maintenance
  JOURNAL   EMBO Rep 25 (5), 2202-2219 (2024)
   PUBMED   38600346
REFERENCE   3  (bases 1 to 2204)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2204)
  AUTHORS   Lee,J.G., Kim,G., Park,S.G., Yon,J.M., Yeom,J., Song,H.E.,
            Cheong,S.A., Lim,J.S., Sung,Y.H., Kim,K., Yoo,H.J., Hong,E.J.,
            Nam,K.H., Seong,J.K., Kim,C.J., Nam,S.Y. and Baek,I.J.
  TITLE     Lipid signatures reflect the function of the murine primary
            placentationdagger
  JOURNAL   Biol Reprod 106 (3), 583-596 (2022)
   PUBMED   34850819
REFERENCE   5  (bases 1 to 2204)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2204)
  AUTHORS   Babu,E., Bhutia,Y.D., Ramachandran,S., Gnanaprakasam,J.P.,
            Prasad,P.D., Thangaraju,M. and Ganapathy,V.
  TITLE     Deletion of the amino acid transporter Slc6a14 suppresses tumour
            growth in spontaneous mouse models of breast cancer
  JOURNAL   Biochem J 469 (1), 17-23 (2015)
   PUBMED   26173258
REFERENCE   7  (bases 1 to 2204)
  AUTHORS   Domenech-Estevez,E., Baloui,H., Repond,C., Rosafio,K., Medard,J.J.,
            Tricaud,N., Pellerin,L. and Chrast,R.
  TITLE     Distribution of monocarboxylate transporters in the peripheral
            nervous system suggests putative roles in lactate shuttling and
            myelination
  JOURNAL   J Neurosci 35 (10), 4151-4156 (2015)
   PUBMED   25762662
  REMARK    GeneRIF: This study showed that mouse MCT1, MCT2, and MCT4 are
            expressed in the PNS. While DRG neurons express MCT1, myelinating
            Schwann cells.
REFERENCE   8  (bases 1 to 2204)
  AUTHORS   Pierre,K., Parent,A., Jayet,P.Y., Halestrap,A.P., Scherrer,U. and
            Pellerin,L.
  TITLE     Enhanced expression of three monocarboxylate transporter isoforms
            in the brain of obese mice
  JOURNAL   J Physiol 583 (Pt 2), 469-486 (2007)
   PUBMED   17599960
  REMARK    GeneRIF: Expression of cerebral MCT isoforms can be modulated by
            alterations of peripheral metabolism, suggesting that the adult
            brain is sensitive and adapts to new metabolic states.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC132405.3.
            
            On Aug 26, 2022 this sequence version replaced NM_146136.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026596.1, AK136837.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849382
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-142               AC132405.3         90506-90647         c
            143-260             AC132405.3         89396-89513         c
            261-393             AC132405.3         83844-83976         c
            394-537             AC132405.3         82942-83085         c
            538-699             AC132405.3         82640-82801         c
            700-1218            AC132405.3         80701-81219         c
            1219-1430           AC132405.3         78649-78860         c
            1431-1524           AC132405.3         77417-77510         c
            1525-2204           AC132405.3         69806-70485         c
FEATURES             Location/Qualifiers
     source          1..2204
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 46.81 cM"
     gene            1..2204
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 4"
                     /db_xref="GeneID:229699"
                     /db_xref="MGI:MGI:2385183"
     exon            1..142
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            143..260
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            261..393
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            394..537
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            538..699
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            700..1218
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1219..1430
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1431..1524
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     exon            1525..2204
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2053..2058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /note="hexamer: AATAAA"
     polyA_site      2081
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /note="major polyA site"
     regulatory      2185..2190
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /note="hexamer: AATAAA"
     polyA_site      2204
                     /gene="Slc16a4"
                     /gene_synonym="MCT 5"
                     /note="major polyA site"
ORIGIN      
        1 agcgctgccc ccgcttgact acagtgcctg gttgtttcca ccaagcagcg gaatgggaag
       61 ccttagaaag agagtaacgt tttagggaaa ataatttttc acctgaaatt ttcttgtctc
      121 tagaggattc atttgcttaa agtgatctcc gcatgtagcc tacaggaagc atcatggtga
      181 agaaggaaaa aacgccctcc ccttacacca aaccccttga tggaggatgg gggtggatgg
      241 tcgtgcttca ttttttcctg gtaaatgtgt ttgtgatggg aatgaccaag acatttgcaa
      301 ttttctttgt ggtttttcaa gaagagtttg aaggcacttc agagcaaatt ggttggattg
      361 gatccattat gtcatcactc cgtttctctg caggtcccct ggctgctatc atctgtgacg
      421 tacttggaga gaaagctacc tccattcttg ggacgttcct tgtctctggt ggctatgtca
      481 tcagcagctg ggccacaggc attccctttc tttgtgtgac catggggctg ctacctggtt
      541 tgggatctgc tttcttgtac caagtagctg ctgtggtaat taccaaatat ttcaaaaaac
      601 gattgggcct ttctacagca attgcccgtt ctggaatggg gctgacattt ttgttggcac
      661 cctttacaaa attcctcata gatctttatg actggacagg cgctcttatt ttatttggag
      721 caattatatt gaacttggtg ccttccagca tgctcttaag acccatccac agccaatcaa
      781 acaacaattc tgacattgaa aacaaaggta gcattttgtc tgcaactgaa ccagaggcat
      841 catacaagac agagacatcg aagtgcaagg agacacagga gcctttcatc aaagacagta
      901 ctatgaagaa atctgaacaa cctaccacaa ccttaactgt cttaggaaat caaagcgaag
      961 agttcagcaa taggcctcac aggaacaggc cgttacttat gagcaatggc aaaagtcaca
     1021 agaaaaagtt tgtttcatgg aactgcaaac aaaaactttt agatatctcg ctctttagaa
     1081 accctttctt ctacattttt acctggtctt ttctcctgag ccaattagca tatttcattc
     1141 ccactttcca cctagtagcc agagcaaaaa cacttgggat tgacgtaatg gatgcctcct
     1201 accttgtgtc tgtagctggt atcactgaga cagtcagtca gctcatttct ggatggattg
     1261 ctgatcaaaa ttggatcaag aagtatcaat accacaagtc ttacctcatt ctgtgtggtg
     1321 tgactaacct gcttgctcct ttagccacca cattcccact ccttatggcc tataccatcc
     1381 tttttgccat ttttgctggt ggctacctgg cactaatact gccagtattg gttgacctat
     1441 ctaagaattc tagagtacac aagtttttgg gatatgccag tttctttgcc gggatagctg
     1501 tactttctgg accaccaata gcaggctgga tatatgatta cacacagact tacacaggct
     1561 ctttctattt ctctggcacc tgctatatcc tctcttcagt ttcccttttt tttgtaccac
     1621 tggctgaaag atggaaacgc aaacagtctg accttctgag gactacaatc aagtaagagc
     1681 ctaacaaaca aaaatctaaa caagctactg taagcaaaag ctcagaagaa aagtctttgt
     1741 taagaaagca agccatagag tttttaagat tccttcctac tttcttagca ctgccaggaa
     1801 tgtcaactgg tggaaggagt aataaatgag taataaagga gcaacaactt aaatgtaatc
     1861 aaacaggcta caaactgaat ccattgaagc agctccttta ctattaaatg aaaatcagaa
     1921 tgtactgtaa taaatcaatc caatttttca tttgtgctat ggtaattctg tcaccaaaat
     1981 atgtaacaat tataaactat ttttttcttt tatttaaata tagtcattgg ttaactagat
     2041 ctctggaatc tgaataaagc cttatttagt gacaagaata ataccctctc caaaaaagtt
     2101 tattgttgtt tattcattat aagtaatctt gttttcttat tactttgtct tttagatttc
     2161 tatagtgtac tgctatctaa taaaaataaa atttgctaaa ataa
//
