LOCUS       NM_001038653            2481 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus solute carrier family 16 (monocarboxylic acid
            transporters), member 3 (Slc16a3), mRNA.
ACCESSION   NM_001038653
VERSION     NM_001038653.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2481)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2481)
  AUTHORS   Ballasy,N., Apantaku,I., Dean,W. and Hemberger,M.
  TITLE     Off to a good start: The importance of the placental exchange
            surface - Lessons from the mouse
  JOURNAL   Dev Biol 517, 248-264 (2025)
   PUBMED   39491740
REFERENCE   3  (bases 1 to 2481)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   4  (bases 1 to 2481)
  AUTHORS   Jeyarajah,M.J., Patterson,V.S., Jaju Bhattad,G., Zhao,L.,
            Whitehead,S.N. and Renaud,S.J.
  TITLE     Placental extracellular vesicles promote cardiomyocyte maturation
            and fetal heart development
  JOURNAL   Commun Biol 7 (1), 1254 (2024)
   PUBMED   39363116
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2481)
  AUTHORS   Braga,A., Chiacchiaretta,M., Pellerin,L., Kong,D. and Haydon,P.G.
  TITLE     Astrocytic metabolic control of orexinergic activity in the lateral
            hypothalamus regulates sleep and wake architecture
  JOURNAL   Nat Commun 15 (1), 5979 (2024)
   PUBMED   39013907
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2481)
  AUTHORS   Nagai,A., Takebe,K., Nio-Kobayashi,J., Takahashi-Iwanaga,H. and
            Iwanaga,T.
  TITLE     Cellular expression of the monocarboxylate transporter (MCT) family
            in the placenta of mice
  JOURNAL   Placenta 31 (2), 126-133 (2010)
   PUBMED   20022372
  REMARK    GeneRIF: In situ hybridization survey of MCT subtypes in placenta
            detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational
            day 11.5 through day 18.5); subcellular localization of MCT1 & MCT4
            in cell membrane is opposite polarity found in human.
REFERENCE   7  (bases 1 to 2481)
  AUTHORS   Jansen,S., Pantaleon,M. and Kaye,P.L.
  TITLE     Characterization and regulation of monocarboxylate cotransporters
            Slc16a7 and Slc16a3 in preimplantation mouse embryos
  JOURNAL   Biol Reprod 79 (1), 84-92 (2008)
   PUBMED   18385447
  REMARK    GeneRIF: Unique roles for slc16a3 in monocarboxylate transport and
            pH regulation during preimplantation development.
REFERENCE   8  (bases 1 to 2481)
  AUTHORS   Otsuka,S., Konno,A., Hashimoto,Y., Sasaki,N., Endoh,D. and Kon,Y.
  TITLE     Oocytes in newborn MRL mouse testes
  JOURNAL   Biol Reprod 79 (1), 9-16 (2008)
   PUBMED   18354036
REFERENCE   9  (bases 1 to 2481)
  AUTHORS   Jansen,S., Esmaeilpour,T., Pantaleon,M. and Kaye,P.L.
  TITLE     Glucose affects monocarboxylate cotransporter (MCT) 1 expression
            during mouse preimplantation development
  JOURNAL   Reproduction 131 (3), 469-479 (2006)
   PUBMED   16514190
REFERENCE   10 (bases 1 to 2481)
  AUTHORS   Herubel,F., El Mouatassim,S., Guerin,P., Frydman,R. and Menezo,Y.
  TITLE     Genetic expression of monocarboxylate transporters during human and
            murine oocyte maturation and early embryonic development
  JOURNAL   Zygote 10 (2), 175-181 (2002)
   PUBMED   12056458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK149707.1 and AK166048.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166048.1, AK149707.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2249              AK149707.1         4-2252
            2250-2481           AK166048.1         2238-2469
FEATURES             Location/Qualifiers
     source          1..2481
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.73 cM"
     gene            1..2481
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /note="solute carrier family 16 (monocarboxylic acid
                     transporters), member 3"
                     /db_xref="GeneID:80879"
                     /db_xref="MGI:MGI:1933438"
     exon            1..84
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /inference="alignment:Splign:2.1.0"
     exon            85..179
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /inference="alignment:Splign:2.1.0"
     exon            180..423
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /inference="alignment:Splign:2.1.0"
     CDS             201..1613
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /note="MCT 4; solute carrier family 16 member 3"
                     /codon_start=1
                     /product="monocarboxylate transporter 4"
                     /protein_id="NP_001033742.1"
                     /db_xref="CCDS:CCDS25761.1"
                     /db_xref="GeneID:80879"
                     /db_xref="MGI:MGI:1933438"
                     /translation="MGGAVVDEGPTGIKAPDGGWGWAVLFGCFIITGFSYAFPKAVSV
                     FFKELMHEFGIGYSDTAWISSILLAMLYGTGPLCSVCVNRFGCRPVMLVGGLFASLGM
                     VAASFCRSIIQIYLTTGVITGLGLALNFQPSLIMLNRYFNKRRPIANGLAAAGSPVFL
                     CALSPLGQLLQDHYGWRGGFLILGGLLLNCCVCAALMRPLVAPQVGGGTEPRGPQRPP
                     QRLLDLSVFRDRGFLIYAVAASIMVLGLFVPPVFVVSYAKDMGVPDTKAAFLLTILGF
                     IDIFARPTAGFITGLKKVRPYSVYLFSFAMFFNGFTDLTGSTATDYGGLVVFCIFFGI
                     SYGMVGALQFEVLMAIVGTQKFSSAIGLVLLLEAVAVLIGPPSGGKLLDATKVYKYVF
                     ILAGAEVLTSSLVLLLGNFFCIGKRKRPEVTEPEEVASEEKLHKPPVDVGVDSREVEH
                     FLKAEPEKNGEVVHTPETSV"
     exon            424..567
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /inference="alignment:Splign:2.1.0"
     exon            568..1335
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /inference="alignment:Splign:2.1.0"
     exon            1336..2481
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2234..2239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /note="hexamer: AACAAA"
     polyA_site      2256
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /note="major polyA site"
ORIGIN      
        1 ggatgagagc acttaaagtc gcccccggcg cggcgccggg cagccaaggc ggacagaggc
       61 agatacagcg gctggcggta acagagtact gtttggcagc acaccatttg tggagagaga
      121 cgagtaggct ggactgaata ctcaggtccg aggccgccct cgctgcagct cagttcttgg
      181 tgaaagcagc cctcctggct atgggagggg ctgtggtgga cgagggtccc accggcatca
      241 aggcccccga tgggggctgg ggctgggccg tcctctttgg ctgttttatc atcacgggtt
      301 tctcctacgc cttccccaag gcggtcagcg tctttttcaa ggagcttatg catgagtttg
      361 ggattggcta cagcgacacg gcttggatct cctccatcct gctggctatg ctctatggca
      421 caggaccgct ctgcagtgtg tgtgtgaacc gctttggctg ccggcctgtc atgcttgtgg
      481 gtggcctctt tgcgtccctg ggaatggtgg ctgcgtcctt ctgcagaagc attatccaga
      541 tctacctcac cacgggggtc atcactggct tgggtctggc tctcaacttc cagccttccc
      601 tcatcatgct caatcgatac ttcaacaagc gtcgccctat tgccaatggg ttggcagcgg
      661 caggcagccc agtgttcctt tgtgcactgt ctccactggg gcagctgctg caggatcact
      721 atggttggcg gggtggcttc ctcatcctgg ggggcctact gctcaactgc tgtgtgtgtg
      781 ctgcgctcat gaggccgctg gtggcaccgc aggtaggcgg agggactgag ccccgcggac
      841 cccagcggcc acctcaacgc ctgctagacc tgagtgtctt ccgagaccgc ggcttcctca
      901 tctatgccgt ggccgcctca atcatggtgc tgggactctt tgtgcctccg gtctttgtgg
      961 tgagctatgc taaggatatg ggtgtacccg acacaaaggc cgccttcctt ctcaccatcc
     1021 tgggcttcat cgacatcttt gccaggccca cggctggttt cataacaggc ctcaagaagg
     1081 tgcggcccta ctctgtctac ctcttcagct ttgccatgtt cttcaatggc ttcactgacc
     1141 tgacaggctc cacagccact gactacggtg gcctggtggt cttttgcatc ttctttggca
     1201 tctcatatgg catggtgggc gcactacagt ttgaggtgct catggctatc gtgggcactc
     1261 agaagttctc cagtgccatt ggtctcgtgc tgctgctgga ggccgtggct gtgctcatcg
     1321 gacccccgtc aggaggcaag ctgctggatg caaccaaagt ttacaagtat gtgttcatcc
     1381 tggcgggggc cgaggtgctc acctcctccc ttgtgctgct gctgggcaac ttcttctgca
     1441 tcgggaagag gaagaggccc gaggtgacag agcctgagga ggtggcctca gaggagaagc
     1501 tccacaagcc ccctgtggac gtgggagtgg actcgaggga ggtggagcac ttcctgaagg
     1561 cagagcctga gaaaaatggg gaggtggttc ataccccgga aaccagcgtg tgagcagcct
     1621 ggccgggcgg gcagggagca gggaagaggt ccagagactg gcaacgctca tatttatttc
     1681 acaaacagga ccagctgagg gcgggcgggg ccatcggctc agctcttggc tgcctggtca
     1741 gccggtcagt gttttgcggg gagaggtggc ggggtgggaa ccgcgtcatt ccaaagtgga
     1801 tctgcggtga agccaaggaa gccccatagt tatcagccac ctaaaccagg gacccagcct
     1861 gctgagccca agcagcctgt ggctcccccg ccccctcccc accctccatc cccactgtgg
     1921 ccaaggacct agaaacccac acttaggaga caacacgact ttaatcagag ggcagggctg
     1981 ggacaggctg gcaggtggac actgcctgca gggtcttccc tgatcccacc atcctaccta
     2041 cgccccccct cccctcagcc ctagtctcct ccattgacag tcatccatct ctgcctaagg
     2101 gacaaagaaa tccttctacc tgagaaggca gaaatagacc tgcccgtggg aggagcatca
     2161 aggggcctgt ctctaggagc tgtgtggttc tgggcagtgg tctgttcacc ctgagtccca
     2221 ccctttgtta aataacaaac tgctgattct taaaaagtgg ttctggccct cattagctct
     2281 tccaggtctg cctgctgtaa cattctctgc tgcccctagg gtttgttcaa tagccacagc
     2341 attcatacag caggaagaaa gggggagagg ggaatagcaa gggagggagc cccatgctag
     2401 agaggggtgc ctgggtggca tttggaggcc atggggaacc cccaagggcg agctgaagta
     2461 tagcataagc tgttcactgt g
//
