LOCUS       NP_001033742             470 aa            linear   ROD 15-MAY-2025
DEFINITION  monocarboxylate transporter 4 [Mus musculus].
ACCESSION   NP_001033742
VERSION     NP_001033742.1
DBSOURCE    REFSEQ: accession NM_001038653.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 470)
  AUTHORS   Di Michele,M., Attina,A., Roux,P.F., Tabet,I., Laguesse,S.,
            Florido,J., Houdeville,M., Choquet,A., Encislai,B., Arena,G., De
            Blasio,C., Wendling,O., Frenois,F.X., Papon,L., Stuani,L.,
            Fuentes,M., Jahannault Talignani,C., Rousseau,M., Guegan,J.,
            Buscail,Y., Dupre,P., Michaud,H.A., Rodier,G., Bellvert,F.,
            Kulyk,H., Ferraro Peyret,C., Mathieu,H., Close,P., Rapino,F.,
            Chaveroux,C., Pirot,N., Rubio,L., Torro,A., Sorg,T., Ango,F.,
            Hirtz,C., Compan,V., Lebigot,E., Legati,A., Ghezzi,D., Nguyen,L.,
            David,A., Sardet,C., Lacroix,M. and Le Cam,L.
  TITLE     E4F1 coordinates pyruvate metabolism and the activity of the
            elongator complex to ensure translation fidelity during brain
            development
  JOURNAL   Nat Commun 16 (1), 67 (2025)
   PUBMED   39747033
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 470)
  AUTHORS   Ballasy,N., Apantaku,I., Dean,W. and Hemberger,M.
  TITLE     Off to a good start: The importance of the placental exchange
            surface - Lessons from the mouse
  JOURNAL   Dev Biol 517, 248-264 (2025)
   PUBMED   39491740
REFERENCE   3  (residues 1 to 470)
  AUTHORS   Fan,W., Li,Z., He,X., Wang,X., Sun,M. and Yang,Z.
  TITLE     SLC25A1 regulates placental development to ensure embryonic heart
            morphogenesis
  JOURNAL   Development 151 (22) (2024)
   PUBMED   39591637
REFERENCE   4  (residues 1 to 470)
  AUTHORS   Jeyarajah,M.J., Patterson,V.S., Jaju Bhattad,G., Zhao,L.,
            Whitehead,S.N. and Renaud,S.J.
  TITLE     Placental extracellular vesicles promote cardiomyocyte maturation
            and fetal heart development
  JOURNAL   Commun Biol 7 (1), 1254 (2024)
   PUBMED   39363116
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 470)
  AUTHORS   Braga,A., Chiacchiaretta,M., Pellerin,L., Kong,D. and Haydon,P.G.
  TITLE     Astrocytic metabolic control of orexinergic activity in the lateral
            hypothalamus regulates sleep and wake architecture
  JOURNAL   Nat Commun 15 (1), 5979 (2024)
   PUBMED   39013907
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 470)
  AUTHORS   Nagai,A., Takebe,K., Nio-Kobayashi,J., Takahashi-Iwanaga,H. and
            Iwanaga,T.
  TITLE     Cellular expression of the monocarboxylate transporter (MCT) family
            in the placenta of mice
  JOURNAL   Placenta 31 (2), 126-133 (2010)
   PUBMED   20022372
  REMARK    GeneRIF: In situ hybridization survey of MCT subtypes in placenta
            detected intense mRNA expression of MCT1, MCT4, & MCT9 (gestational
            day 11.5 through day 18.5); subcellular localization of MCT1 & MCT4
            in cell membrane is opposite polarity found in human.
REFERENCE   7  (residues 1 to 470)
  AUTHORS   Jansen,S., Pantaleon,M. and Kaye,P.L.
  TITLE     Characterization and regulation of monocarboxylate cotransporters
            Slc16a7 and Slc16a3 in preimplantation mouse embryos
  JOURNAL   Biol Reprod 79 (1), 84-92 (2008)
   PUBMED   18385447
  REMARK    GeneRIF: Unique roles for slc16a3 in monocarboxylate transport and
            pH regulation during preimplantation development.
REFERENCE   8  (residues 1 to 470)
  AUTHORS   Otsuka,S., Konno,A., Hashimoto,Y., Sasaki,N., Endoh,D. and Kon,Y.
  TITLE     Oocytes in newborn MRL mouse testes
  JOURNAL   Biol Reprod 79 (1), 9-16 (2008)
   PUBMED   18354036
REFERENCE   9  (residues 1 to 470)
  AUTHORS   Jansen,S., Esmaeilpour,T., Pantaleon,M. and Kaye,P.L.
  TITLE     Glucose affects monocarboxylate cotransporter (MCT) 1 expression
            during mouse preimplantation development
  JOURNAL   Reproduction 131 (3), 469-479 (2006)
   PUBMED   16514190
REFERENCE   10 (residues 1 to 470)
  AUTHORS   Herubel,F., El Mouatassim,S., Guerin,P., Frydman,R. and Menezo,Y.
  TITLE     Genetic expression of monocarboxylate transporters during human and
            murine oocyte maturation and early embryonic development
  JOURNAL   Zygote 10 (2), 175-181 (2002)
   PUBMED   12056458
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL662901.18.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK166048.1, AK149983.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..470
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.73 cM"
     Protein         1..470
                     /product="monocarboxylate transporter 4"
                     /note="MCT 4; solute carrier family 16 member 3"
                     /calculated_mol_wt=50242
     Site            18..38
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Region          21..410
                     /region_name="MFS_MCT3_4"
                     /note="Monocarboxylate transporters 9 and 14, and similar
                     proteins of the Major Facilitator Superfamily of
                     transporters; cd17430"
                     /db_xref="CDD:340988"
     Site            order(32..33,36..37,40,75,126..127,129..131,134,153,
                     156..157,160,239,242..243,246..248,251,278,282,335..336,
                     340,344,360,363..364,367..368,371)
                     /site_type="other"
                     /note="putative chemical substrate binding pocket
                     [chemical binding]"
                     /db_xref="CDD:340988"
     Site            62..82
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            85..105
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            110..130
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            150..170
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            180..200
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            232..252
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            268..288
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            299..319
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            322..342
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            356..376
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            392..412
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Region          429..446
                     /region_name="Basolateral sorting signal.
                     /evidence=ECO:0000250|UniProtKB:O15427"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            430
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:19144319; propagated from
                     UniProtKB/Swiss-Prot (P57787.1)"
     Region          446..470
                     /region_name="Basolateral sorting signal.
                     /evidence=ECO:0000250|UniProtKB:O15427"
                     /note="propagated from UniProtKB/Swiss-Prot (P57787.1)"
     Site            465
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:O15427; propagated from
                     UniProtKB/Swiss-Prot (P57787.1)"
     Site            469
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:O15427; propagated from
                     UniProtKB/Swiss-Prot (P57787.1)"
     CDS             1..470
                     /gene="Slc16a3"
                     /gene_synonym="Mct3; Mct4"
                     /coded_by="NM_001038653.2:160..1572"
                     /db_xref="CCDS:CCDS25761.1"
                     /db_xref="GeneID:80879"
                     /db_xref="MGI:MGI:1933438"
ORIGIN      
        1 mggavvdegp tgikapdggw gwavlfgcfi itgfsyafpk avsvffkelm hefgigysdt
       61 awissillam lygtgplcsv cvnrfgcrpv mlvgglfasl gmvaasfcrs iiqiylttgv
      121 itglglalnf qpslimlnry fnkrrpiang laaagspvfl calsplgqll qdhygwrggf
      181 lilgglllnc cvcaalmrpl vapqvgggte prgpqrppqr lldlsvfrdr gfliyavaas
      241 imvlglfvpp vfvvsyakdm gvpdtkaafl ltilgfidif arptagfitg lkkvrpysvy
      301 lfsfamffng ftdltgstat dygglvvfci ffgisygmvg alqfevlmai vgtqkfssai
      361 glvllleava vligppsggk lldatkvyky vfilagaevl tsslvlllgn ffcigkrkrp
      421 evtepeevas eeklhkppvd vgvdsreveh flkaepekng evvhtpetsv
//
